| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D David Smith, Shankar Saha, Guoyong Fang, Courtney Schaffert, David J J Waugh, Wanyun Zeng, Geza Toth, Martin Hulce, Peter W Abe. Modifications to the N-terminus but not the C-terminus of calcitonin gene-related peptide(8-37) produce antagonists with increased affinity. Journal of medicinal chemistry. vol 46. issue 12. 2003-07-11. PMID:12773046. |
the c-terminal phe was replaced by gly, cyclohexylalanine (cha), tyr, all four isomers of beta-methylphenylalanine (beta-mephe), and l- and d-tetrahydroisoquinoline carboxylic acid (tic), resulting in analogues 3-11. |
2003-07-11 |
2023-08-12 |
human |
| E Peggion, S Mammi, E Schievano, L Schiebler, M Corich, M Rosenblatt, M Chore. Structure-function relationship studies of bovine parathyroid hormone [bPTH(1-34)] analogues containing alpha-amino-iso-butyric acid (Aib) residues. Biopolymers. vol 68. issue 3. 2003-07-01. PMID:12601801. |
in order to assess the relevance of the local conformation around gly(12) upon biological function, we synthesized and characterized the following pth(1-34) analogues containing aib residues: (i) a-v-s-e-i-q-f-nl-h-n-aib-g-k-h-l-s-s-nl-e-r-v-e-nal-l-r-k-k-l-q-d-v-h-n-y-nh(2) ([nle(8,18), aib(11), nal(23),tyr(34)]bpth(1-34)-nh(2)); (ii) a-v-s-e-i-q-f-nl-h-n-l-aib-k-h-l-s-s-nl-e-r-v-e-nal-l-r-k-k-l-q-d-v-h-n-y-nh(2) ([nle(8,18), aib(12),nal(23),tyr(34)]bpth(1-34)-nh(2)); (iii) a-v-s-e-i-q-f-nl-h-n-l-g-aib-h-l-s-s-nl-e-r-v-e-nal-l-r-k-k-l-q-d-v-h-n-y-nh(2) ([nle(8,18), aib(13), nal(23),tyr(34)]bpth(1-34)-nh(2)); (iv) a-v-s-e-i-q-f-nl-h-n-aib-aib-k-h-l-s-s-nl-e-r-v-e-nal-l-r-k-k-l-q-d-v-h-n-ynh(2) ([nle(8,18), aib(11,12), nal(23),tyr(34)]bpth(1-34)-nh(2)); (v) a-v-s-e-i-q-f-nl-h-n-l-aib-aib-h-l-s-s-nl-e-r-v-e-nal-l-r-k-k-l-q-d-v-h-n-y-nh(2) ([nle(8,18), aib(12,13),nal(23),tyr(34)]bpth(1-34)-nh(2)). |
2003-07-01 |
2023-08-12 |
cattle |
| Hideyuki Hayashi, Hiroyuki Mizuguchi, Ikuko Miyahara, Yoshitaka Nakajima, Ken Hirotsu, Hiroyuki Kagamiyam. Conformational change in aspartate aminotransferase on substrate binding induces strain in the catalytic group and enhances catalysis. The Journal of biological chemistry. vol 278. issue 11. 2003-05-14. PMID:12488449. |
the maleate-bound v39f enzyme showed an altered side-chain packing pattern in the 37-39 region, and the lack of repulsion between gly(38) carbonyl o and tyr(225) oeta seemed to be the cause of the reduced pk(a) value. |
2003-05-14 |
2023-08-12 |
Not clear |
| Reuben E Huber, Shamina Hakda, Calvino Cheng, Claire G Cupples, Robert A Edward. Trp-999 of beta-galactosidase (Escherichia coli) is a key residue for binding, catalysis, and synthesis of allolactose, the natural lac operon inducer. Biochemistry. vol 42. issue 6. 2003-05-02. PMID:12578395. |
several site specific substitutions (phe, gly, tyr, leu) for trp-999 were made. |
2003-05-02 |
2023-08-12 |
Not clear |
| Toshihiro Sato, Yoshimi Shimada, Naoko Nagasawa, Shigetada Nakanishi, Hisato Jingam. Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state. The Journal of biological chemistry. vol 278. issue 6. 2003-03-21. PMID:12444084. |
the mutations of the tyr(74), arg(78), and gly(293) residues, which interact with the gamma-carboxyl group of glutamate, lost their responsiveness to glutamate but not to quisqualate. |
2003-03-21 |
2023-08-12 |
Not clear |
| J M Izco, M Tormo, R Jiménez-Flore. Rapid simultaneous determination of organic acids, free amino acids, and lactose in cheese by capillary electrophoresis. Journal of dairy science. vol 85. issue 9. 2003-02-10. PMID:12362443. |
a capillary electrophoresis (ce) method for the simultaneous separation of 11 metabolically important organic acids (oxalic, formic, citric, succinic, orotic, uric, acetic, pyruvic, propionic, lactic, and butyric), 10 amino acids (asp, glu, tyr, gly, ala, ser, leu, phe, lys, and trp), and lactose has been optimized, validated, and tested in dairy products. |
2003-02-10 |
2023-08-12 |
Not clear |
| Hye-Young Yoon, Eun Hee Cho, Hyeok Yil Kwon, Soo Young Choi, Sung-Woo Ch. Importance of glutamate 279 for the coenzyme binding of human glutamate dehydrogenase. The Journal of biological chemistry. vol 277. issue 44. 2003-01-17. PMID:12193607. |
the importance of the glu(279) residue in the binding of nad(+) was further examined by cassette mutagenesis with mutant enzymes containing arg, gly, leu, met, or tyr at position 279. |
2003-01-17 |
2023-08-12 |
human |
| K Y Zhu, Y Huang, L M Ta. [Changes of amino acids in cerebrospinal fluid of patients with cerebral infarction]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University. vol 25. issue 3. 2003-01-13. PMID:12212163. |
using high performance liquid chromatography, we measured the asp, glu, ser, gly, thr, arg, ala, tyr, met, val, phe, ile, ley, lys, gaba concentrations in cerebrospinal fluid(csf) of 15 patients with ischemic cerebral infarction and 10 control subjects. |
2003-01-13 |
2023-08-12 |
human |
| Vera Knäuper, Louise Bailey, Joanna R Worley, Paul Soloway, Margaret L Patterson, Gillian Murph. Cellular activation of proMMP-13 by MT1-MMP depends on the C-terminal domain of MMP-13. FEBS letters. vol 532. issue 1-2. 2003-01-13. PMID:12459476. |
only the initial cleavage at gly(35)-ile(36) was dependent on mt1-mmp activity, as conversion to the active enzyme (tyr(85) n-terminus) required a functional mmp-13 active site. |
2003-01-13 |
2023-08-12 |
mouse |
| M R Smiricky, C M Grieshop, D M Albin, J E Wubben, V M Gabert, G C Fahe. The influence of soy oligosaccharides on apparent and true ileal amino acid digestibilities and fecal consistency in growing pigs. Journal of animal science. vol 80. issue 9. 2003-01-06. PMID:12350021. |
there was a linear decrease (p < 0.05) in apparent and true dm, val, gly, and tyr digestibilities when increasing levels of ss were added to the sbm diet. |
2003-01-06 |
2023-08-12 |
Not clear |
| Y Sato, K Ohe, M Murakami, M Fukuyama, K Furuhata, S Kishikawa, Y Suzuki, A Kiuchi, M Hara, Y Ishikawa, A Tanen. Phylogenetic analysis of field isolates of feline calcivirus (FCV) in Japan by sequencing part of its capsid gene. Veterinary research communications. vol 26. issue 3. 2002-12-31. PMID:12090292. |
similarly, the amino acid at position 539 in the f region was alanine (ala) or proline (pro) in group i, while it was valine (val) in group ii; glycine (gly) at position 557 in group i was serine (ser) in group ii; and phenylalanine (phe) or leucine (leu) at position 566 in genogroup i was tyrosine (tyr) in group ii. |
2002-12-31 |
2023-08-12 |
Not clear |
| Hirokazu Satoh, Yoshimi Nakano, Hideki Shibata, Masatoshi Mak. The penta-EF-hand domain of ALG-2 interacts with amino-terminal domains of both annexin VII and annexin XI in a Ca2+-dependent manner. Biochimica et biophysica acta. vol 1600. issue 1-2. 2002-12-31. PMID:12445460. |
both the n-terminal regulatory domain of annexin xi (anx11n) and the alg-2-binding domain of alix/aip1 are rich in pro, gly, ala, tyr and gln. |
2002-12-31 |
2023-08-12 |
Not clear |
| Luis Fabián Canosa, Xinwei Lin, Richard E Pete. Regulation of expression of somatostatin genes by sex steroid hormones in goldfish forebrain. Neuroendocrinology. vol 76. issue 1. 2002-12-20. PMID:12097812. |
recently, our laboratory has identified three distinct pre-pro-somatostatin (pss) genes in goldfish brain: pss-i encodes for somatostatin (srih)-14, pss-ii encodes srih-28, which contains [glu(1), tyr(7), gly(10)] srih-14 at its c-terminus, and pss-iii encodes [pro(2)] srih-14. |
2002-12-20 |
2023-08-12 |
Not clear |
| Xiao-Zhen Liang, Bernett T K Lee, Sek-Man Won. Covariation in the capsid protein of hibiscus chlorotic ringspot virus induced by serial passaging in a host that restricts movement leads to avirulence in its systemic host. Journal of virology. vol 76. issue 23. 2002-12-13. PMID:12414972. |
a remarkable covariation of eight site-specific amino acids was found in the hcrsv capsid protein (cp) after serial passages in c. quinoa: val(49)-->ile, ile(95)-->val, lys(270)-->arg, gly(272)-->asp, tyr(274)-->his, ala(311)-->asp, asp(334)-->ala, and ala(335)-->thr. |
2002-12-13 |
2023-08-12 |
Not clear |
| Ana M Edwards, Marcelo Ruiz, Eduardo Silva, Eduardo Liss. Lysozyme modification by the fenton reaction and gamma radiation. Free radical research. vol 36. issue 3. 2002-10-28. PMID:12071346. |
the modification order was tyr > met = cys > lys > ile + leu > gly > pro = phe > thr + ala > trp = ser > arg > asp + glu, with 42 mol of modified residues per initial mole of native enzyme. |
2002-10-28 |
2023-08-12 |
Not clear |
| Stephen J Royle, Laura K Bobanović, Ruth D Murrell-Lagnad. Identification of a non-canonical tyrosine-based endocytic motif in an ionotropic receptor. The Journal of biological chemistry. vol 277. issue 38. 2002-10-24. PMID:12105201. |
three amino acids in the c terminus of p2x(4) (tyr(378), gly(381), and leu(382)) compose a non-canonical tyrosine-based sorting signal of the form yxxgl. |
2002-10-24 |
2023-08-12 |
rat |
| Eugene Myshkin, Neocles B Leontis, George S Bullerjah. Computational simulation of the docking of Prochlorothrix hollandica plastocyanin to potosystem I: modeling the electron transfer complex. Biophysical journal. vol 82. issue 6. 2002-10-21. PMID:12023253. |
free energy calculations for complex formation with wild-type pc, as well as the hydrophobic patch tyr(12)gly and pro(14)leu pc mutants, were carried out using a molecular mechanics poisson-boltzman, surface area approach (mm/pbsa). |
2002-10-21 |
2023-08-12 |
Not clear |
| Kewei Wang, Papasani V Subbaia. Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase. The Biochemical journal. vol 365. issue Pt 3. 2002-09-24. PMID:11966470. |
replacing trp(61) with another aromatic residue [trp(61)-->tyr (w61y)] resulted in an increase in all activities (14-157%), whereas replacing it with an aliphatic residue [trp(61)-->gly (w61g)] caused a dramatic loss of lcat (-90%) and pla(2) (-82%) activities, but not the esterase activity (-5%). |
2002-09-24 |
2023-08-12 |
Not clear |
| Till Opatz, Rob M J Liskam. Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: identification of iron binders. Journal of combinatorial chemistry. vol 4. issue 4. 2002-08-06. PMID:12099844. |
in the synthesis of the first library, the two outer arms consisted of amino acid ala, arg, asp, gln, gly, lys, phe, ser, tyr, or val and the middle arm consisted of amino acid asn, glu, his, leu, or pro. |
2002-08-06 |
2023-08-12 |
Not clear |
| Till Opatz, Rob M J Liskam. Synthesis and screening of libraries of synthetic tripodal receptor molecules with three different amino acid or peptide arms: identification of iron binders. Journal of combinatorial chemistry. vol 4. issue 4. 2002-08-06. PMID:12099844. |
the first outer arm consisted of amino acid(s) ala, arg, gln, phe, or ser, the second outer arm consisted of amino acid(s) asp, gly, lys, tyr, or val, and the middle arm consisted of amino acid(s) asn, glu, his, leu, or pro, leading to a 27 000 member library of synthetic tripodal receptor molecules. |
2002-08-06 |
2023-08-12 |
Not clear |