| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S S Seeram, K Hiraga, A Saji, M Tashiro, K Od. Identification of reactive site of a proteinaceous metalloproteinase inhibitor from Streptomyces nigrescens TK-23. Journal of biochemistry. vol 121. issue 6. 1997-12-12. PMID:9354381. |
hence, for identification of the reactive site, mutants were constructed by substituting val65 with various amino acid residues (leu, ile, phe, tyr, gly, ser, lys, and glu). |
1997-12-12 |
2023-08-12 |
Not clear |
| J F Christian, M Unno, J T Sage, P M Champion, E Chien, S G Sliga. Spectroscopic effects of polarity and hydration in the distal heme pocket of deoxymyoglobin. Biochemistry. vol 36. issue 37. 1997-10-14. PMID:9287162. |
the fe-his vibration for the phe, leu, and gly mutants is shifted to a lower frequency by 1-2 cm-1 relative to the tyr mutant, wild type (wt), and native deoxymb. |
1997-10-14 |
2023-08-12 |
Not clear |
| F Casseron, G Rychen, X Rubert-Aleman, G J Martin, F Lauren. 15N enrichments of casein and plasma protein amino acids in cows ingesting 15N-labelled ammonium sulphate. The Journal of dairy research. vol 64. issue 3. 1997-10-02. PMID:9275255. |
chromatographic fractionation of the amino acid mixture (protein hydrolysates) resulted in nine groups containing between one and four amino acids: asp, ser and thr; glu; pro; gly; ala; val and met; ileu and leu; tyr; phe; his and lys; and arg. |
1997-10-02 |
2023-08-12 |
Not clear |
| W Bal, J Lukszo, K S Kasprza. Mediation of oxidative DNA damage by nickel(II) and copper(II) complexes with the N-terminal sequence of human protamine HP2. Chemical research in toxicology. vol 10. issue 8. 1997-10-01. PMID:9282841. |
the promotion by the complexes of dg and dna oxidation with h2o2 was accompanied by oxidative damage to the complexes themselves, consisting of decreasing contents of their his (to approximately 50% of control in either complex) and especially tyr (down to 48% of control in cu(ii)- and 19% in ni(ii)-hp2[1-15]) residues, as well as appearance of aspartic acid, the known oxidation product of his residues in peptides (up to 22% vs gly for cu(ii)- and 10% for ni(ii)-hp2(1-15)). |
1997-10-01 |
2023-08-12 |
human |
| D A Lambert, A L Catapano, L C Smith, J T Sparrow, A M Gott. A new fluorometric method for measuring the action of C apolipoproteins on milk lipoprotein lipase. Clinica chimica acta; international journal of clinical chemistry. vol 264. issue 1. 1997-09-29. PMID:9267705. |
replacing tyrosine 62 in apo c ii by glycine removed all lipoprotein lipase activating capacity, while making tyr 62 less accessible for binding to lipids and enzyme decreased apo c ii activating capacity. |
1997-09-29 |
2023-08-12 |
cattle |
| B Persson, P Argo. Prediction of membrane protein topology utilizing multiple sequence alignments. Journal of protein chemistry. vol 16. issue 5. 1997-09-11. PMID:9246628. |
the ratios are calculated for asn, asp, gly, phe, pro, trp, tyr, and val, mostly found on the extracellular side, and for ala, arg, cys, and lys, mostly occurring on the intracellular side. |
1997-09-11 |
2023-08-12 |
Not clear |
| D Pietraforte, M Minett. Direct ESR detection or peroxynitrite-induced tyrosine-centred protein radicals in human blood plasma. The Biochemical journal. vol 325 ( Pt 3). 1997-09-11. PMID:9271088. |
furthermore peptides containing a tyr in the central portion of the molecule were able to form a stable peroxynitrite-dependent g = 2.004 signal, whereas peptides in which tyr was substituted with gly, trp or phe and peptides with tyr at the n-terminus or near the c-terminus did not form radicals that were stable at 37 degrees c. we suggest that tyr residues are at least the major radical sources of the peroxynitrite-dependent g = 2.004 signal at 37 degrees c in plasma or in isolated proteins. |
1997-09-11 |
2023-08-12 |
human |
| A R Rezai. Role of Leu99 of thrombin in determining the P2 specificity of serpins. Biochemistry. vol 36. issue 24. 1997-07-10. PMID:9200692. |
to investigate the contribution of leu99 to the p2 binding specificity of thrombin, three mutants of thrombin were prepared in which leu99 was substituted with tyr (l99y), thr (l99t), or gly (l99g). |
1997-07-10 |
2023-08-12 |
Not clear |
| T K Huffaker, S Binford, A K Patick, C Pinko, C C Kan, L S Zalma. Comparison of human cytomegalovirus (HCMV) protease sequences among laboratory strains and seven clinical isolates. Antiviral research. vol 33. issue 3. 1997-05-08. PMID:9037377. |
the clinical isolates had amino acid substitutions relative to the laboratory strains, with a ser to pro change at position 8, a his to tyr change at position 44 and s gly to ser change at position 47. |
1997-05-08 |
2023-08-12 |
human |
| J B Thoden, F J Ruzicka, P A Frey, I Rayment, H M Holde. Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site. Biochemistry. vol 36. issue 6. 1997-03-17. PMID:9063869. |
those amino acid residues critically involved in sugar binding include asn 153 and gly 159 from the first subunit and lys 311, phe 312, val 314, tyr 316, glu 317, and gln 323 from the second subunit. |
1997-03-17 |
2023-08-12 |
Not clear |
| A M Pendás, V Knäuper, X S Puente, E Llano, M G Mattei, S Apte, G Murphy, C López-Otí. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. The Journal of biological chemistry. vol 272. issue 7. 1997-03-14. PMID:9020145. |
however, it lacks a series of structural features distinctive of the diverse mmp subclasses, including the asp, tyr, and gly residues located close to the zinc-binding site in collagenases, the fibronectin-like domain of gelatinases, the transmembrane domain of membrane-type (mt) mmps, and the furin-activation sequence common to stromelysin-3 and mt-mmps. |
1997-03-14 |
2023-08-12 |
human |
| D van der Spoel, A R van Buuren, D P Tieleman, H J Berendse. Molecular dynamics simulations of peptides from BPTI: a closer look at amide-aromatic interactions. Journal of biomolecular NMR. vol 8. issue 3. 1997-03-12. PMID:8953214. |
the first, ytgp (tyr-thr-gly-pro), shows an electrostatic interaction between the aromatic ring of tyr and the backbone amide hydrogen atom of gly. |
1997-03-12 |
2023-08-12 |
cattle |
| M J Everett, Y F Jin, V Ricci, L J Piddoc. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrobial agents and chemotherapy. vol 40. issue 10. 1997-02-27. PMID:8891148. |
all isolates contained a mutation in gyra of a serine at position 83 (ser83) to an leu, and 26 isolates also contained a mutation of asp87 to one of four amino acids: asn (n = 14), tyr (n = 6), gly (n = 5), or his (n = 1). |
1997-02-27 |
2023-08-12 |
human |
| S Conrad, M Oethinger, K Kaifel, G Klotz, R Marre, W V Ker. gyrA mutations in high-level fluoroquinolone-resistant clinical isolates of Escherichia coli. The Journal of antimicrobial chemotherapy. vol 38. issue 3. 1997-02-24. PMID:8889719. |
the additional mutations at amino acid codon 87 in the 35 double-mutants were diverse, resulting in asp-87 substitutions by residues asn (23 isolates), gly (7 isolates), tyr (4 isolates), or his (1 isolate) without a discernable correlation with fluoroquinolone mics or with phenotypic resistance to chemically unrelated antibacterial agents. |
1997-02-24 |
2023-08-12 |
Not clear |
| K Shao, S Purohit, O P Bah. Effect of modification of all loop regions in the alpha- and beta-subunits of human choriogonadotropin on its signal transduction activity. Molecular and cellular endocrinology. vol 122. issue 2. 1997-02-21. PMID:8902847. |
these replacements included beta 22gly, beta 24pro and beta 25val with glu, arg and phe in beta 1, 45leu gln gly val leu pro ala leu pro53 with tyr lys asn pro ala arg pro leu ile in beta 2 and 73pro arg gly with ala his his in the beta 3 loop. |
1997-02-21 |
2023-08-12 |
human |
| H Nicholson, B F Anderson, T Bland, S C Shewry, J W Tweedie, E N Bake. Mutagenesis of the histidine ligand in human lactoferrin: iron binding properties and crystal structure of the histidine-253-->methionine mutant. Biochemistry. vol 36. issue 2. 1997-02-21. PMID:9003186. |
his 253 in the n-terminal half-molecule of human lactoferrin, lfn (residues 1-333), has been changed to gly, ala, pro, thr, leu, phe, met, tyr, glu, gln, and cys by oligonucleotide-directed mutagenesis. |
1997-02-21 |
2023-08-12 |
human |
| E S Eberhardt, P K Wittmayer, B M Templer, R T Raine. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability. Protein science : a publication of the Protein Society. vol 5. issue 8. 1997-02-06. PMID:8844858. |
here, the role of tyr 97 was examined by replacing tyr 97 with a phenylalanine, alanine, or glycine residue. |
1997-02-06 |
2023-08-12 |
cattle |
| R S Farid, M E Bianchi, L Falciola, B N Engelsberg, P C Billing. Differential binding of HMG1, HMG2, and a single HMG box to cisplatin-damaged DNA. Toxicology and applied pharmacology. vol 141. issue 2. 1997-02-06. PMID:8975778. |
two constructs containing a phe to ala substitution at position 19 and a tyr to gly substitution at position 71, are noteworthy; these peptides exhibited reduced affinity for cddp-dna. |
1997-02-06 |
2023-08-12 |
Not clear |
| A Fiser, I Simon, G J Barto. Conservation of amino acids in multiple alignments: aspartic acid has unexpected conservation. FEBS letters. vol 397. issue 2-3. 1997-01-13. PMID:8955352. |
with the exception of arg, lys, gly, glu, asp and tyr, a relative conservation of > 2 suggests the amino acid will have a relative accessibility of < 50%. |
1997-01-13 |
2023-08-12 |
Not clear |
| Y N Hou, M Vlaskovska, G Cebers, L Kasakov, S Liljequist, L Tereniu. A mu-receptor opioid agonist induces AP-1 and NF-kappa B transcription factor activity in primary cultures of rat cortical neurons. Neuroscience letters. vol 212. issue 3. 1997-01-06. PMID:8843097. |
the specific mu-receptor opioid agonist, tyr, d-ala2, gly, n-me-phe4, gly-ol5 (damgo), was found to increase ap-1 and nf-kappa b activity in primary cultures of neurons from rat cerebral cortex. |
1997-01-06 |
2023-08-12 |
rat |