| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Stubb. [Physiology and disease of the endocrine function of the pancreas (author's transl)]. Monatsschrift Kinderheilkunde : Organ der Deutschen Gesellschaft fur Kinderheilkunde. vol 128. issue 12. 1981-03-24. PMID:6109237. |
the active endocrine cells and the produced hormones are termed a, b, d, d1, and pp cell and glucagon, insulin, somatostatin, vasoactive intestinal polypeptide (vip) and pancreatic polypeptide (pp) respectively. |
1981-03-24 |
2023-08-12 |
Not clear |
| F Massara, S Martelli, E Cagliero, F Camanni, G M Molinatt. Influence of glucagon on plasma levels of potassium in man. Diabetologia. vol 19. issue 5. 1981-03-17. PMID:6108887. |
somatostatin, in addition to depressing insulin, produced a slight but significant (p < 0.01) increase in potassium (delta max: 0.2-0.8 mmol/1: mean +/- sem, 0.4 +/- 0.1). |
1981-03-17 |
2023-08-12 |
human |
| F Massara, S Martelli, E Cagliero, F Camanni, G M Molinatt. Influence of glucagon on plasma levels of potassium in man. Diabetologia. vol 19. issue 5. 1981-03-17. PMID:6108887. |
infusion of somatostatin together with glucagon suppressed the glucagon-induced increase in insulin and greatly augmented the increase in blood glucose. |
1981-03-17 |
2023-08-12 |
human |
| F Massara, S Martelli, E Cagliero, F Camanni, G M Molinatt. Influence of glucagon on plasma levels of potassium in man. Diabetologia. vol 19. issue 5. 1981-03-17. PMID:6108887. |
potassium rose significantly more (p < 0.02) than after somatostatin alone (delta max: 0.5-1.3 mmol/l; mean 0.9 +/- 0.1), indicating that hyperkalaemia results from hyperglucagonaemia in the absence of insulin. |
1981-03-17 |
2023-08-12 |
human |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin. Diabetes. vol 29. issue 12. 1981-02-26. PMID:6108269. |
somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin. Diabetes. vol 29. issue 12. 1981-02-26. PMID:6108269. |
the pancreatic somatostatin content increased in proportion to the dose of stz (i, 189 +/- 31; ii, 222 +/- 20, iii, 343 +/- 4; iv, 515 +/- 36 ng/g wet wt), while graded reductions of insulin content were observed. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin. Diabetes. vol 29. issue 12. 1981-02-26. PMID:6108269. |
pancreatic somatostatin release increased during arginine infusion (19.2 mm) dose dependently, (i, 543 +/- 36; ii, 946 +/- 64; iii, 1229 +/- 55; iv, 2186 +/- 150 pg/15 min), and it correlated with the graded decreases of insulin release. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Somatostatin release from the isolated, perfused diabetic rat pancreas: inverse relationship between pancreatic somatostatin and insulin. Diabetes. vol 29. issue 12. 1981-02-26. PMID:6108269. |
these results indicate that pancreatic somatostatin content and release increased in stz-diabetic rats in proportion to the degree of insulin deficiency. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Reversal of the enhanced somatostatin release from the isolated, perfused diabetic rat pancreas after the amelioration of diabetes by whole pancreas transplantation. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108274. |
to investigate the pancreatic endocrine function in streptozotocin-diabetic rats before and after the whole pancreas was transplanted, pancreatic insulin, glucagon, and somatostatin content and release were measured. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Reversal of the enhanced somatostatin release from the isolated, perfused diabetic rat pancreas after the amelioration of diabetes by whole pancreas transplantation. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108274. |
studies in vitro using the isolated perfused rat pancreas revealed a significant increase of somatostatin release from the diabetic pancreas, with a marked reduction of insulin release and almost normal glucagon release. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Reversal of the enhanced somatostatin release from the isolated, perfused diabetic rat pancreas after the amelioration of diabetes by whole pancreas transplantation. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108274. |
in the transplanted rats, on the other hand, arginine-induced somatostatin release from the host pancreas was reduced to normal without a significant change in insulin or glucagon release. |
1981-02-26 |
2023-08-12 |
rat |
| S Kadowaki, T Taminato, T Chiba, Y Goto, M Nozawa, Y Seino, S Matsukura, T Fujit. Reversal of the enhanced somatostatin release from the isolated, perfused diabetic rat pancreas after the amelioration of diabetes by whole pancreas transplantation. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108274. |
pancreatic somatostatin release, thus, appears to be effected by changes in circulating insulin, since pancreatic transplantation effectively corrects the circulating insulin level. |
1981-02-26 |
2023-08-12 |
rat |
| R L Sorenson, D V Lindell, R P Eld. Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108275. |
glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas. |
1981-02-26 |
2023-08-12 |
rat |
| R L Sorenson, D V Lindell, R P Eld. Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108275. |
insulin and somatostatin release from the isolated perfused rat pancreas was studied under conditions of 50 and 300 mg/dl glucose as well as a linear 50-300 mg/dl glucose gradient. |
1981-02-26 |
2023-08-12 |
rat |
| R L Sorenson, D V Lindell, R P Eld. Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108275. |
the glucose-stimulated response profile of somatostatin was nearly parallel to that of insulin in both the acute and gradient dose experiments. |
1981-02-26 |
2023-08-12 |
rat |
| R L Sorenson, D V Lindell, R P Eld. Glucose stimulation of somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108275. |
in spite of the marked, fifteenfold stimulation of somatostatin release (1.5 x 10-10 m in the perfusate effluent) by glucose, the concentration of somatostatin was insufficient to significantly alter glucose-stimulated insulin release in the isolated perfused rat pancreas. |
1981-02-26 |
2023-08-12 |
rat |
| Y C Patel, T Wheatley, F Malaisse-Lagae, L Orc. Elevated portal and peripheral blood concentration of immunoreactive somatostatin in spontaneously diabetic (BBL) Wistar rats: suppression with insulin. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6108276. |
elevated portal and peripheral blood concentration of immunoreactive somatostatin in spontaneously diabetic (bbl) wistar rats: suppression with insulin. |
1981-02-26 |
2023-08-12 |
rat |
| C A Meyers, W A Murphy, T W Redding, D H Coy, A V Schall. Synthesis and biological actions of prosomatostatin. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 10. 1981-02-26. PMID:6108563. |
the recently isolated 28-residue sequence of prosomatostatin, a putative somatostatin precursor from pig hypothalamus and intestine, was synthesized by solid-phase methodology, characterized, and tested in rats for its effects on the release of insulin, glucagon, growth hormone, and prolactin. |
1981-02-26 |
2023-08-12 |
rat |
| C A Meyers, W A Murphy, T W Redding, D H Coy, A V Schall. Synthesis and biological actions of prosomatostatin. Proceedings of the National Academy of Sciences of the United States of America. vol 77. issue 10. 1981-02-26. PMID:6108563. |
it inhibited insulin release about 5 times more effectively than somatostatin on a weight basis. |
1981-02-26 |
2023-08-12 |
rat |
| M Itoh, L Mandarino, J E Geric. Antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic A- and B-cell function. Diabetes. vol 29. issue 9. 1981-02-26. PMID:6160072. |
antisomatostatin gamma globulin augments secretion of both insulin and glucagon in vitro: evidence for a physiologic role for endogenous somatostatin in the regulation of pancreatic a- and b-cell function. |
1981-02-26 |
2023-08-12 |
rat |