| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J E Geric. Somatostatin and diabetes. The American journal of medicine. vol 70. issue 3. 1981-05-13. PMID:6111219. |
the location of somatostatin in pancreatic islet d cells suggests that it may act as a local regulator of insulin and glucagon secretion. |
1981-05-13 |
2023-08-12 |
Not clear |
| D L Vesel. The interrelationship of somatostatin and guanylate cyclase activity. Molecular and cellular biochemistry. vol 32. issue 3. 1981-04-24. PMID:6110170. |
somatostatin has been shown to inhibit the release of various polypeptide hormones including insulin, glucagon, gastrin, thyroid stimulating hormone, and growth hormone. |
1981-04-24 |
2023-08-12 |
rat |
| K Uvnäs-Wallensten, S Efendic, A Roovete, C Johansso. Decreased release of somatostatin into the portal vein following electrical vagal stimulation in the cat. Acta physiologica Scandinavica. vol 109. issue 4. 1981-04-24. PMID:6110310. |
insulin, glucagon, gastrin and somatostatin were measured in portal vein blood (consisting of blood from the stomach and the pancreas). |
1981-04-24 |
2023-08-12 |
cat |
| P Hellstrand, J Järhul. Effects of nine different gastrointestinal polypeptides on vascular smooth muscle in vitro. Acta physiologica Scandinavica. vol 110. issue 1. 1981-04-24. PMID:6162366. |
the substances tested were bombesin, caerulein, glucagon, insulin, pentagastrin, secretin, somatostatin, substance p and vasoactive intestinal polypeptide (vip). |
1981-04-24 |
2023-08-12 |
rat |
| J Roth, M Ravazzola, M Bendayan, L Orc. Application of the protein A-gold technique for electron microscopic demonstration of polypeptide hormones. Endocrinology. vol 108. issue 1. 1981-04-24. PMID:6780313. |
application of this technique to the endocrine pancreas and gastrointestinal mucosa using antisera against insulin, glucagon, somatostatin, pancreatic polypeptide, gastrin, and neurotensin allowed these polypeptides to be localized in the secretory granules of the corresponding specific cell types. |
1981-04-24 |
2023-08-12 |
Not clear |
| H Drost, D Grüneklee, H K Kley, W Wiegelmann, H L Krüskemper, F A Grie. [Glucagon, growth hormone, and cortisol response to insulin-induced hypoglycemia in insulin-dependent diabetics (IDD) without autonomic neuropathy (author's transl)]. Klinische Wochenschrift. vol 58. issue 21. 1981-03-27. PMID:7005532. |
when inhibiting the secretion of insulin and different contra-insulinary hormones with somatostatin, one is able to demonstrate that glucagon alone is a sufficiently counterregulatory hormone in insulin-induced hypoglycemias. |
1981-03-27 |
2023-08-12 |
Not clear |
| D Giugliano, N Passariello, R Torella, S Gentile, G D'Angel. Somatostatin and insulin secretion in man. III - Lack of interaction with prostaglandins. Il Farmaco; edizione scientifica. vol 35. issue 7. 1981-03-24. PMID:6108875. |
somatostatin and insulin secretion in man. |
1981-03-24 |
2023-08-12 |
Not clear |
| D Giugliano, N Passariello, R Torella, S Gentile, G D'Angel. Somatostatin and insulin secretion in man. III - Lack of interaction with prostaglandins. Il Farmaco; edizione scientifica. vol 35. issue 7. 1981-03-24. PMID:6108875. |
in order to asses potential interactions between somatostatin and prostaglandins during regulation of insulin secretion in vivo, in the present investigation we studied the effect of acetylsalicylic acid, an inhibitor of endogenous pg synthesis, on somatostatin-mediated inhibition of glucose-induced insulin secretion in normal man. |
1981-03-24 |
2023-08-12 |
Not clear |
| G E Sonnenberg, U Keller, A Perruchoud, D Burckhardt, K Gy. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology. vol 80. issue 3. 1981-03-24. PMID:6108898. |
arterial gastrin and insulin levels were lowered during somatostatin infusion by 33% (p < 0.02) and by 75% (p < 0.005), respectively. |
1981-03-24 |
2023-08-12 |
human |
| G E Sonnenberg, U Keller, A Perruchoud, D Burckhardt, K Gy. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology. vol 80. issue 3. 1981-03-24. PMID:6108898. |
arterial gastrin and insulin concentrations were lower (p < 0.01) than in cirrhosis, but the basal levels were lowered by somatostatin to a similar degree in both groups of patients. |
1981-03-24 |
2023-08-12 |
human |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. |
1981-03-24 |
2023-08-12 |
chicken |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
at low background glucose (50 mg/dl), exogenous insulin infused at a concentration of 20,000 microu/ml elicited clear stimulation of somatostatin secretion while simultaneously inhibiting glucagon release. |
1981-03-24 |
2023-08-12 |
chicken |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
when the background glucose concentration was elevated to 750 mg/dl, exogenous insulin, had no effect on either somatostatin or glucagon release. |
1981-03-24 |
2023-08-12 |
chicken |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
when graded doses of exogenous insulin were infused into the chicken pancreas at low background glucose, low concentrations (200 microu/ml) had little effect on somatostatin or glucagon release, but higher concentrations (2000 and 20,000 microu/ml) had clear effects on both somatostatin and glucagon secretion. |
1981-03-24 |
2023-08-12 |
chicken |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
glucagon infused at 100 ng/ml stimulated both insulin and somatostatin release. |
1981-03-24 |
2023-08-12 |
chicken |
| R N Honey, M B Fallon, G C Wei. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109226. |
when somatostatin was infused at 25 ng/ml, clear inhibition of glucagon was seen with insulin inhibited to a lesser extent. |
1981-03-24 |
2023-08-12 |
chicken |
| G J Taborsky, P H Smit. Proportional inhibition of glucose-induced insulin release by somatostatin. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109227. |
proportional inhibition of glucose-induced insulin release by somatostatin. |
1981-03-24 |
2023-08-12 |
Not clear |
| G J Taborsky, P H Smit. Proportional inhibition of glucose-induced insulin release by somatostatin. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109227. |
to test the hypothesis that somatostatin is a proportional inhibitor of glucose-induced insulin release, we examined the effect of somatostatin on the release of insulin stimulated either by endogenous signals (basal), by glucose infusion, or by glucose injection. |
1981-03-24 |
2023-08-12 |
Not clear |
| G J Taborsky, P H Smit. Proportional inhibition of glucose-induced insulin release by somatostatin. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109227. |
somatostatin infusions (1.7 micrograms/min x 30 min) produced a decrement of basal insulin output from the right lobe of the canine pancreas that was proportional to the initial rate of basal insulin secretion (r = -0.87, p < 0.001, n = 16). |
1981-03-24 |
2023-08-12 |
Not clear |
| G J Taborsky, P H Smit. Proportional inhibition of glucose-induced insulin release by somatostatin. Metabolism: clinical and experimental. vol 29. issue 12. 1981-03-24. PMID:6109227. |
glucose infusions of 1-6 mg/kg/min produced much higher rates of insulin output; again, the decrement of insulin output produced by somatostatin correlated with the initial rate of insulin secretion (r = -0.68, p < 0.01, n = 16). |
1981-03-24 |
2023-08-12 |
Not clear |