| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W B Rhoten, C E Hal. Four hormones in the pancreas of the lizard, Anolis carolinensis. The Anatomical record. vol 199. issue 1. 1981-06-25. PMID:6111934. |
the electron microscopic localization of insulin, glucagon, somatostatin, and pancreatic polypeptide (pp) in the pancreas of the iguanid lizard, anolis carolinensis was studied by the unlabeled antibody peroxidase-antiperoxidase immunocytochemical technique. |
1981-06-25 |
2023-08-12 |
Not clear |
| W B Rhoten, C E Hal. Four hormones in the pancreas of the lizard, Anolis carolinensis. The Anatomical record. vol 199. issue 1. 1981-06-25. PMID:6111934. |
insulin, glucagon, and somatostatin were localized absolutely to those cells previously identified on the basis of the characteristics of their secretory granules as being beta cells, alpha cells, and d cells, respectively. |
1981-06-25 |
2023-08-12 |
Not clear |
| J M Guerrero, J C Prieto, F L Elorza, R Ramirez, R Gobern. Interaction of vasoactive intestinal peptide with human blood mononuclear cells. Molecular and cellular endocrinology. vol 21. issue 2. 1981-06-23. PMID:6260561. |
binding studies suggested the presence of 2 classes of binding site: a class with high affinity (kd = 2.4 x 10(-10)m) and low capacity (8 fmoles/10(6) cells), and a class with low affinity (kd = 8.0 x 10(-8)m) and high capacity (800 fmoles/10(6) cells) at 15 degrees c. secretin displaced [125i]vip from the cells with a 400-fold lower affinity than vip, but glucagon, somatostatin and insulin did not show any effect. |
1981-06-23 |
2023-08-12 |
human |
| P J Weiller, M Weiller, S Lam-My, M Pizzi, J Sayag, J C Sarles, M Mongi. [Glucagonoma without diabetes: a case report (author's transl)]. Annales de medecine interne. vol 132. issue 1. 1981-06-23. PMID:6261628. |
possible explanations for this anomaly: compensatory insulin or somatostatin secretion, production of a non functional glucagon, or low levels of circulating glucagon, are envisaged but without a formal response. |
1981-06-23 |
2023-08-12 |
Not clear |
| F Diel, N Bethge, E Schneider, H J Quabb. Somatostatin binding factor from chicken pancreas. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. vol 19. issue 2. 1981-06-13. PMID:6111581. |
insulin, glucagon and corticotropin show a low, and luliberin and reduced somatostatin a high cross-reactivity. |
1981-06-13 |
2023-08-12 |
chicken |
| S L Erlandse. Types of pancreatic islet cells and their immunocytochemical identification. Monographs in pathology. vol 21. 1981-06-13. PMID:6163978. |
the cells responsible for the secretion of insulin, glucagon, gip, pancreatic polypeptide and somatostatin have been firmly established. |
1981-06-13 |
2023-08-12 |
Not clear |
| H Schatz, U Kulle. Studies on the local (paracrine) actions of glucagon, somatostatin and insulin in isolated islets of rat pancreas. FEBS letters. vol 122. issue 2. 1981-05-26. PMID:6110566. |
studies on the local (paracrine) actions of glucagon, somatostatin and insulin in isolated islets of rat pancreas. |
1981-05-26 |
2023-08-12 |
rat |
| A E Bishop, J M Polak, P G Chesa, C M Timson, M G Bryant, S R Bloo. Decrease of pancreatic somatostatin in neonatal nesidioblastosis. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110595. |
a possible deficiency of somatostatin, one of the factors controlling insulin release, has only recently been considered. |
1981-05-26 |
2023-08-12 |
Not clear |
| A E Bishop, J M Polak, P G Chesa, C M Timson, M G Bryant, S R Bloo. Decrease of pancreatic somatostatin in neonatal nesidioblastosis. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110595. |
pancreatic tissue from five babies with severe hypoglycemia, hyperinsulinemia, and nesidioblastosis was examined for insulin, somatostatin, and glucagon by immunocytochemistry and radioimmunoassay. |
1981-05-26 |
2023-08-12 |
Not clear |
| S J Bhathena, J Louie, G P Schechter, R S Redman, L Wahl, L Recan. Identification of human mononuclear leukocytes bearing receptors for somatostatin and glucagon. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110596. |
specific binding to somatostatin, glucagon, and insulin was measured in the three fractions. |
1981-05-26 |
2023-08-12 |
human |
| S J Bhathena, J Louie, G P Schechter, R S Redman, L Wahl, L Recan. Identification of human mononuclear leukocytes bearing receptors for somatostatin and glucagon. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110596. |
binding of glucagon and insulin to the l fraction was very low while, in contrast, somatostatin binding was substantial and linear with lymphocyte number. |
1981-05-26 |
2023-08-12 |
human |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. |
1981-05-26 |
2023-08-12 |
rat |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
this study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (gaba) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. |
1981-05-26 |
2023-08-12 |
rat |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
high glucose (300 mg/dl) conditions stimulated somatostatin and insulin release. |
1981-05-26 |
2023-08-12 |
rat |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
steady-state levels of somatostatin and insulin release under high glucose conditions were 425 +/- 12 pg/ml and 419 +/- 18 microu/ml, respectively. |
1981-05-26 |
2023-08-12 |
rat |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
perfusion with medium containing 1 microm muscimol inhibited glucose-stimulated somatostatin release by 38%, whereas the course of glucose-stimulated insulin release was unaffected. |
1981-05-26 |
2023-08-12 |
rat |
| M S Robbins, L H Grouse, R L Sorenson, R P Eld. Effect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Diabetes. vol 30. issue 2. 1981-05-26. PMID:6110597. |
tentative conclusions from this study are (1) that gaba is potentially a modulator of islet somatostatin but not insulin release, and (2) the fact that somatostatin, an inhibitor of insulin, can be suppressed 38% without coincidental increase in insulin release seems to indicate that, under high glucose conditions, somatostatin is without a significant paracrine effect on the beta-cells. |
1981-05-26 |
2023-08-12 |
rat |
| R D Milner, P K Wirdnam, J Tsanaka. Quantitative morphology of B, A, D, and PP cells in infants of diabetic mothers. Diabetes. vol 30. issue 4. 1981-05-26. PMID:6110602. |
pancreatic specimens from 34 infants of diabetic mothers (idm) and 32 control infants of gestational ages 26-44 wk were examined histologically using immunocytochemical stains for insulin, glucagon, somatostatin, and pancreatic polypeptide (pp). |
1981-05-26 |
2023-08-12 |
Not clear |
| T Wasada, B Howard, K McCorkle, V Harris, R H Unge. High plasma free fatty acid levels contribute to the hypersomatostatinemia of insulin deficiency. Diabetes. vol 30. issue 4. 1981-05-26. PMID:6110603. |
high plasma levels of free fatty acids (ffa) stimulate the secretion of splanchnic somatostatin, and both are elevated in insulin deficiency. |
1981-05-26 |
2023-08-12 |
Not clear |
| b' K Paveli\\xc4\\x87, J Gabrilovac, V Bozikov, J Paveli\\xc4\\x87, M Petek, M Borani\\xc4\\x8. Somatostatin suppresses growth of murine myeloid leukemia in vivo. Blood. vol 57. issue 4. 1981-05-21. PMID:6110447.' |
since somatostatin decreased the level of immunoreactive insulin in mice with myeloid leukemia, and since the treatment with insulin abrogated the antileukemic effect of somatostatin, we attribute retarded growth of this leukemia to decreased secretion of insulin, caused by somatostatin. |
1981-05-21 |
2023-08-12 |
mouse |