| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M S Rios, I Navascues, J Saban, A Ordoñez, F Sevilla, E Del Poz. Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. The Journal of clinical endocrinology and metabolism. vol 63. issue 5. 1986-11-19. PMID:2876005. |
in conclusion, the somatostatin analog sms 201-995 has a potential value as an adjunct to insulin in the management of idd patients. |
1986-11-19 |
2023-08-11 |
Not clear |
| J C Basabe, L M Karabatas, M Arata, O H Pivetta, J C Crest. Secretion and effect of somatostatin in early stages of the diabetic syndrome in C57BL/KsJ-mdb mice. Diabetologia. vol 29. issue 8. 1986-11-17. PMID:2875912. |
in a previous study in c57bl/ksj (mdb) mice aged 12 to 90 days, we observed alterations in the secretion of insulin and somatostatin and in the inhibitory effect of the latter upon insulin secretion. |
1986-11-17 |
2023-08-11 |
mouse |
| J C Basabe, L M Karabatas, M Arata, O H Pivetta, J C Crest. Secretion and effect of somatostatin in early stages of the diabetic syndrome in C57BL/KsJ-mdb mice. Diabetologia. vol 29. issue 8. 1986-11-17. PMID:2875912. |
the results demonstrate two distinct phases in the development of the syndrome: up to age 6 days, the perifused slices of pancreata of control animals present biphasic glucose-induced patterns of insulin and somatostatin secretion, whereas the diabetic animals show a diminished first peak of insulin secretion, but a similar pattern of somatostatin secretion, to that of the control animals; between ages 7 and 12 days, the pancreata of diabetic mice exhibit insulin hypersecretion in basal conditions, and an absence of the first secretion peak and insulin hypersecretion in the second phase in response to glucose stimulation. |
1986-11-17 |
2023-08-11 |
mouse |
| J C Basabe, L M Karabatas, M Arata, O H Pivetta, J C Crest. Secretion and effect of somatostatin in early stages of the diabetic syndrome in C57BL/KsJ-mdb mice. Diabetologia. vol 29. issue 8. 1986-11-17. PMID:2875912. |
the results show that, in very early stages of the evolution of the diabetic syndrome in c57bl/ksj (mdb) mice, there are already alterations in insulin and somatostatin secretion patterns and in the inhibitory effect of the latter on insulin secretion. |
1986-11-17 |
2023-08-11 |
mouse |
| J V Anderson, S R Bloo. Neuroendocrine tumours of the gut: long-term therapy with the somatostatin analogue SMS 201-995. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876495. |
somatostatin inhibited insulin release, but in only one patient was there a slight deterioration of glucose tolerance. |
1986-11-17 |
2023-08-11 |
Not clear |
| D G Johnston, R R Davies, S J Turne. Effects of somatostatin and SMS 201-995 on carbohydrate metabolism in normal man. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876501. |
native somatostatin has multiple actions, including inhibition of the secretion of insulin, glucagon, thyroid-stimulating hormone (tsh), and various gut hormones. |
1986-11-17 |
2023-08-11 |
human |
| V Schusdziarra, R Schmi. Physiological and pathophysiological aspects of somatostatin. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876504. |
insulin inhibits and glucagon stimulates somatostatin release. |
1986-11-17 |
2023-08-11 |
Not clear |
| V Schusdziarra, R Schmi. Physiological and pathophysiological aspects of somatostatin. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876504. |
elevated levels of circulating glucose reduce the somatostatin response, an effect that cannot be entirely explained by the parallel augmentation of insulin secretion. |
1986-11-17 |
2023-08-11 |
Not clear |
| Y Sako, T Wasada, F Umeda, H Ibayash. Effect of glibenclamide on pancreatic hormone release from isolated perifused islets of normal and cysteamine-treated rats. Metabolism: clinical and experimental. vol 35. issue 10. 1986-11-14. PMID:2876370. |
in normal rat islets, glibenclamide enhanced both insulin and somatostatin release in normoglycemic (50 mg/dl) and glucopenic (0 mg/dl) states, as well as under the condition of arginine stimulation. |
1986-11-14 |
2023-08-11 |
rat |
| D J Garry, R L Sorenson, R P Elde, B E Maley, A Madse. Immunohistochemical colocalization of GABA and insulin in beta-cells of rat islet. Diabetes. vol 35. issue 10. 1986-11-10. PMID:2875911. |
in this study, an immunofluorescence and elution/restaining protocol is used to determine the distribution of gaba and either insulin, glucagon, or somatostatin in a tissue section. |
1986-11-10 |
2023-08-11 |
rat |
| N V Sadovnikova, G N Pluzhnikova, A P Smirnova, N M Ermak, Iu P Shvachki. [Properties of (Ala5, Orn9)-somatostatin. The inhibition of pancreatic and hypophyseal hormone secretion in cell culture]. Problemy endokrinologii. vol 32. issue 4. 1986-11-10. PMID:2876420. |
chemical substitution performed between positions 5 and 9 in somatostatin molecule failed to change essentially hormone's biologic activity in suppression of insulin and glucagon in the culture of pancreatic insular cells isolated from newborn rats. |
1986-11-10 |
2023-08-11 |
rat |
| P Aguirre, R E Scully, H J Wolfe, R A DeLelli. Argyrophil cells in Brenner tumors: histochemical and immunohistochemical analysis. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. vol 5. issue 3. 1986-10-30. PMID:3531049. |
all tumors with argyrophil cells were stained to demonstrate calcitonin, somatostatin, gastrin, adrenocorticotropic hormone, neurotensin, insulin, glucagon, and serotonin; and four of them (three benign and one borderline) were also stained for chromogranins with the monoclonal antibody lk2h10. |
1986-10-30 |
2023-08-11 |
Not clear |
| L Uccioli, G Ghirlanda, P Cotroneo, G Bianchini, A Manto, A Solini, V Annese, A V Grec. Somatostatin response to a mixed meal in normals and in type I diabetics. Peptides. vol 7 Suppl 1. 1986-10-23. PMID:2875450. |
the aim of the study was to evaluate the somatostatin response to a test meal in type i diabetics at the clinical onset of the disease and after two months of intensive insulin therapy. |
1986-10-23 |
2023-08-11 |
human |
| E J Verspohl, U Berger, H P Ammo. The significance of mu- and delta-receptors in rat pancreatic islets for the opioid-mediated insulin release. Biochimica et biophysica acta. vol 888. issue 2. 1986-10-22. PMID:2874836. |
cysteamine pretreatment of rats (depletion of somatostatin containing d-cells and decrease in somatostatin secretion) did not change the met-enkephalin effect on insulin secretion. |
1986-10-22 |
2023-08-11 |
rat |
| M N Hussain, A Sirek, E Cukerman, O V Sire. Insulin dependence of the actions of growth hormone and somatostatin on splanchnic biogenic amines of the dog. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 18. issue 7. 1986-10-21. PMID:2875023. |
insulin dependence of the actions of growth hormone and somatostatin on splanchnic biogenic amines of the dog. |
1986-10-21 |
2023-08-11 |
dog |
| K C Herold, J B Jaspa. Hepatic glucagon clearance during insulin induced hypoglycemia. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 18. issue 7. 1986-10-21. PMID:3527924. |
to directly study the effect of hypoglycemia on hepatic glucagon metabolism, five dogs were given an exogenous infusion of somatostatin followed by an infusion of glucagon and then administered insulin to produce hypoglycemia. |
1986-10-21 |
2023-08-11 |
Not clear |
| B Bierwolf, B Hartrodt, R Neubert, H D Jakubke, W Blec. [Action of [3,14-L-selenocysteine, 8-D-tryptophan]-somatostatin on insulin and glucagon secretion of the isolated perfused pancrease of the Wistar rat]. Biomedica biochimica acta. vol 45. issue 5. 1986-10-10. PMID:2875714. |
by isolated perfused pancreas of wistar rats the glucose (11 mmol/l) and arginine (10 mmol/l) stimulated insulin (iri) and glucagon (irg) secretion was measured in order to investigate the inhibitory activities of somatostatin-14 (ss 14) and the somatostatin analogue [3,14-l-seleno-cysteine, 8-d-tryptophan]-somatostatin (sess). |
1986-10-10 |
2023-08-11 |
rat |
| F Jahoor, D N Herndon, R R Wolf. Role of insulin and glucagon in the response of glucose and alanine kinetics in burn-injured patients. The Journal of clinical investigation. vol 78. issue 3. 1986-10-08. PMID:2875083. |
we investigated the roles of insulin and glucagon as mediators of changes in glucose and alanine kinetics during the hypermetabolic response to injury in 10 burn patients by infusing somatostatin with and without insulin replacement. |
1986-10-08 |
2023-08-11 |
Not clear |
| K Hermansen, O Schmitz, J Arnfred, C E Mogense. Effects of furosemide and indapamide upon pancreatic insulin and somatostatin secretion in vitro. Diabetes research (Edinburgh, Scotland). vol 3. issue 4. 1986-10-06. PMID:2874909. |
effects of furosemide and indapamide upon pancreatic insulin and somatostatin secretion in vitro. |
1986-10-06 |
2023-08-11 |
Not clear |
| K Hermansen, O Schmitz, J Arnfred, C E Mogense. Effects of furosemide and indapamide upon pancreatic insulin and somatostatin secretion in vitro. Diabetes research (Edinburgh, Scotland). vol 3. issue 4. 1986-10-06. PMID:2874909. |
to study if this was due to a direct effect on the endocrine pancreas, we examined the effects of furosemide and indapamide on the release of insulin and somatostatin from the isolated perfused pancreas of normal dogs. |
1986-10-06 |
2023-08-11 |
Not clear |