| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G S Spencer, D J Hill, G J Garssen, J P William. Somatostatin inhibits insulin-stimulated amino acid uptake into cultured rat myoblasts. Acta endocrinologica. vol 114. issue 4. 1987-06-10. PMID:2883796. |
these findings lend support to the concept of an endocrine role for somatostatin in vivo and suggest that a peripheral antagonism may exist between circulating insulin and somatostatin on anabolic processes such as nutrient uptake into cells. |
1987-06-10 |
2023-08-11 |
rat |
| K Hermansen, A M Kappelgaar. Characterization of growth hormone-releasing hormone stimulation of the endocrine pancreas: studies with alpha- and beta-adrenergic and cholinergic antagonists. Acta endocrinologica. vol 114. issue 4. 1987-06-10. PMID:2883798. |
the 40 aminoacids residue of pancreatic growth hormone-releasing hormone stimulates the secretion of insulin, glucagon, an somatostatin from the pancreas. |
1987-06-10 |
2023-08-11 |
Not clear |
| K Hermansen, A M Kappelgaar. Characterization of growth hormone-releasing hormone stimulation of the endocrine pancreas: studies with alpha- and beta-adrenergic and cholinergic antagonists. Acta endocrinologica. vol 114. issue 4. 1987-06-10. PMID:2883798. |
to determine whether this stimulation of islet hormone secretion is mediated via adrenergic or cholinergic receptor sites, we studied the effects of 30 nmol/l of the growth hormone-releasing hormone on the release of insulin, glucagon, and somatostatin in the presence of either alpha-adrenergic (phentolamine), beta-adrenergic (propranolol) or cholinergic (atropine) blocking agents. |
1987-06-10 |
2023-08-11 |
Not clear |
| B Hagander, I Björck, N G Asp, S Efendić, J Holm, P Nilsson-Ehle, I Lundquist, B Schersté. Rye products in the diabetic diet. Postprandial glucose and hormonal responses in non-insulin-dependent diabetic patients as compared to starch availability in vitro and experiments in rats. Diabetes research and clinical practice. vol 3. issue 2. 1987-06-09. PMID:2436870. |
the levels of insulin, c-peptide, gastric inhibitory polypeptide (gip), glucagon, somatostatin, triglyceride and glycerol were followed after the breakfast meals. |
1987-06-09 |
2023-08-11 |
rat |
| T Hanafusa, H Fujino-Kurihara, A Miyazaki, K Yamada, H Nakajima, J Miyagawa, N Kono, S Taru. Expression of class II major histocompatibility complex antigens on pancreatic B cells in the NOD mouse. Diabetologia. vol 30. issue 2. 1987-06-09. PMID:3552824. |
double staining with anti-insulin, glucagon, somatostatin or pancreatic polypeptide antibodies revealed that i-a positive cells corresponded with insulin cells, while other types of pancreatic islet cells were virtually negative for i-a. |
1987-06-09 |
2023-08-11 |
mouse |
| T A Lyle, R M Freidinger, R F Nutt, C F Homnick, R Saperstein, D F Vebe. Glucagon releasing activity of a cyclic peptide related to somatostatin. International journal of peptide and protein research. vol 29. issue 2. 1987-06-08. PMID:2883151. |
a possible benefit of creating smaller and more rigid active analogs of somatostatin is the discovery of compounds which selectively inhibit the secretion of insulin, glucagon or growth hormone. |
1987-06-08 |
2023-08-11 |
Not clear |
| T A Lyle, R M Freidinger, R F Nutt, C F Homnick, R Saperstein, D F Vebe. Glucagon releasing activity of a cyclic peptide related to somatostatin. International journal of peptide and protein research. vol 29. issue 2. 1987-06-08. PMID:2883151. |
a series of cyclic tetrapeptide analogs related to somatostatin was synthesized, and one member of this series was found to cause an unexpected stimulation of glucagon secretion while having little if any effect on either insulin or growth hormone secretion. |
1987-06-08 |
2023-08-11 |
Not clear |
| F Laurent, H Karmann, P Mialh. Insulin, glucagon and somatostatin content in normal and diabetic duck pancreas. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 19. issue 3. 1987-06-05. PMID:2883101. |
insulin, glucagon and somatostatin content in normal and diabetic duck pancreas. |
1987-06-05 |
2023-08-11 |
Not clear |
| L J Klaff, G J Taborsk. Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883057. |
we have previously shown that a nonimmunoreactive analogue of somatostatin, (d-ala5, d-trp8)-somatostatin, differentially inhibits pancreatic somatostatin secretion without inhibiting insulin or glucagon secretion. |
1987-06-01 |
2023-08-11 |
dog |
| L J Klaff, G J Taborsk. Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883057. |
during normoglycemia, suppression of pancreatic somatostatin with this analogue increases glucagon and insulin secretion, suggesting that pancreatic somatostatin tonically inhibits glucagon and insulin secretion by a paracrine mechanism. |
1987-06-01 |
2023-08-11 |
dog |
| L J Klaff, G J Taborsk. Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883057. |
pancreatic insulin output increased 10-fold, pancreatic somatostatin output increased from 1.2 +/- 0.3 to 3.0 +/- 0.8 ng/min, and pancreatic glucagon output was suppressed from 1.4 +/- 0.7 to 0.5 +/- 0.1 ng/min. |
1987-06-01 |
2023-08-11 |
dog |
| L J Klaff, G J Taborsk. Pancreatic somatostatin is a mediator of glucagon inhibition by hyperglycemia. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883057. |
reversed both the stimulation of somatostatin and the suppression of glucagon without significantly changing either the plasma glucose level or the pancreatic insulin output. |
1987-06-01 |
2023-08-11 |
dog |
| E Ipp, Y Sinai, B Bar-Oz, R Nesher, E Ceras. Somatostatin impairs clearance of exogenous insulin in humans. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883058. |
somatostatin impairs clearance of exogenous insulin in humans. |
1987-06-01 |
2023-08-11 |
Not clear |
| E Ipp, Y Sinai, B Bar-Oz, R Nesher, E Ceras. Somatostatin impairs clearance of exogenous insulin in humans. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883058. |
to test whether clearance of an exogenously infused hormone is affected, we infused insulin with or without somatostatin in two sets of studies. |
1987-06-01 |
2023-08-11 |
Not clear |
| E Ipp, Y Sinai, B Bar-Oz, R Nesher, E Ceras. Somatostatin impairs clearance of exogenous insulin in humans. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883058. |
when somatostatin was infused together with insulin, plasma glucose fell to lower levels (41 +/- 4.2 vs. 62 +/- 9.5 mg/dl; p less than .01) and plasma iri rose higher (39 +/- 8.5 vs. 27 +/- 5.9 microu/ml; p less than .01) than when insulin was infused alone. |
1987-06-01 |
2023-08-11 |
Not clear |
| E Ipp, Y Sinai, B Bar-Oz, R Nesher, E Ceras. Somatostatin impairs clearance of exogenous insulin in humans. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883058. |
c-peptide was equally suppressed by hypoglycemia regardless of whether somatostatin was administered, indicating suppression of endogenous insulin during these studies. |
1987-06-01 |
2023-08-11 |
Not clear |
| E Ipp, Y Sinai, B Bar-Oz, R Nesher, E Ceras. Somatostatin impairs clearance of exogenous insulin in humans. Diabetes. vol 36. issue 5. 1987-06-01. PMID:2883058. |
we conclude that somatostatin infusion impairs the clearance of exogenous insulin. |
1987-06-01 |
2023-08-11 |
Not clear |
| b' C G Ostenson, A Nyl\\xc3\\xa9n, V Grill, M Gutniak, S Efendi\\xc4\\x8. Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect. Diabetologia. vol 29. issue 12. 1987-05-29. PMID:3106122.' |
however, when diabetic rats had been treated with insulin for 6-7 days, glibenclamide suppressed glucagon release at low calcium levels in the absence of stimulated insulin and somatostatin release. |
1987-05-29 |
2023-08-11 |
rat |
| b' C G Ostenson, A Nyl\\xc3\\xa9n, V Grill, M Gutniak, S Efendi\\xc4\\x8. Sulfonylurea-induced inhibition of glucagon secretion from the perfused rat pancreas: evidence for a direct, non-paracrine effect. Diabetologia. vol 29. issue 12. 1987-05-29. PMID:3106122.' |
it is concluded that, at low calcium concentrations, sulfonylureas suppress glucagon secretion by a direct action on the a cell and not through paracrine interactions by insulin and somatostatin. |
1987-05-29 |
2023-08-11 |
rat |
| S A Wolfe-Coote, D F Du Toi. Distribution of cell types of the islets of Langerhans throughout the pancreas of the Chacma baboon. The Anatomical record. vol 217. issue 2. 1987-05-27. PMID:2883914. |
four slides in each batch were immunolabelled consecutively for insulin, glucagon, somatostatin, and pancreatic polypeptide, the fifth acting as one of the range of controls in each batch. |
1987-05-27 |
2023-08-11 |
Not clear |