| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Sogawa, N Sogawa, J Tagawa, A Fujino, K Ohyama, M Asanuma, M Funada, S Kitayam. 5-Methoxy-N,N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicology letters. vol 170. issue 1. 2007-06-01. PMID:17382495. |
in the present study, we investigated the actions of 5-meo-dipt against monoamine neurotransmitter transporters, including the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using cos-7 cells heterologously expressing these transporters and rat brain synaptosomes. |
2007-06-01 |
2023-08-12 |
rat |
| J W Schwartz, D Piston, L J DeFelic. Molecular microfluorometry: converting arbitrary fluorescence units into absolute molecular concentrations to study binding kinetics and stoichiometry in transporters. Handbook of experimental pharmacology. issue 175. 2007-05-23. PMID:16722229. |
cotransport in norepinephrine (net), epinephrine (epit), dopamine (dat), and serotonin (sert) transporters couples downhill na+ flux to uphill transmitter flux. |
2007-05-23 |
2023-08-12 |
Not clear |
| Xiang Liu, Samuel D Banister, MacDonald J Christie, Richard Banati, Steve Meikle, Mark J Coster, Michael Kassio. Trishomocubanes: novel sigma ligands modulate cocaine-induced behavioural effects. European journal of pharmacology. vol 555. issue 1. 2007-04-26. PMID:17113074. |
both compounds have negligible affinity for the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters. |
2007-04-26 |
2023-08-12 |
Not clear |
| Piotr Popik, Martyna Krawczyk, Krystyna Golembiowska, Gabriel Nowak, Aaron Janowsky, Phil Skolnick, Arnold Lippa, Anthony S Basil. Pharmacological profile of the "triple" monoamine neurotransmitter uptake inhibitor, DOV 102,677. Cellular and molecular neurobiology. vol 26. issue 4-6. 2007-04-24. PMID:16636898. |
radioligand binding to the dopamine (dat), norepinephrine (net), and serotonin (sert) transporters is inhibited with k (i) values of 222, 1030, and 740 nm, respectively. |
2007-04-24 |
2023-08-12 |
mouse |
| Jeffrey S Stehouwer, Nachwa Jarkas, Fanxing Zeng, Ronald J Voll, Larry Williams, Michael J Owens, John R Votaw, Mark M Goodma. Synthesis, radiosynthesis, and biological evaluation of carbon-11 labeled 2beta-carbomethoxy-3beta-(3'-((Z)-2-haloethenyl)phenyl)nortropanes: candidate radioligands for in vivo imaging of the serotonin transporter with positron emission tomography. Journal of medicinal chemistry. vol 49. issue 23. 2007-01-19. PMID:17154506. |
2beta-carbomethoxy-3beta-(3'-((z)-2-iodoethenyl)phenyl)nortropane (mzient, 1) and 2beta-carbomethoxy-3beta-(3'-((z)-2-bromoethenyl)phenyl)nortropane (mzbrent, 2) were synthesized and evaluated for binding to the human serotonin, dopamine, and norepinephrine transporters (sert, dat, and net, respectively) using transfected cells. |
2007-01-19 |
2023-08-12 |
human |
| Yu-Shin Ding, Kuo-Shyan Lin, Jean Loga. PET imaging of norepinephrine transporters. Current pharmaceutical design. vol 12. issue 30. 2007-01-03. PMID:17073682. |
the fact that all three monoamine (dopamine, norepinephrine, and serotonin) transporters (dat, net and sert) are involved in various neurological and psychiatric diseases further emphasizes the need to develop suitable net ligands so that researchers will be able to probe the contributions of each monoamine transporter system to specific cns disorders. |
2007-01-03 |
2023-08-12 |
Not clear |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
we postulated that modafinil enhances wakefulness by modulating dopamine (dat), norepinephrine (net), or serotonin (sert) transporter activities. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Zhihua Xie, Zhicheng Lin, Amy Jassen, Helen Panas, Laurie Lynch, Ryan Johnson, Eli Livni, Thomas J Spencer, Ali A Bonab, Gregory M Miller, Alan J Fischma. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885432. |
in vitro, modafinil inhibited [(3)h]dopamine (ic(50) = 6.4 microm), [(3)h]norepinephrine (ic(50) = 35.6 microm), and [(3)h]serotonin (ic(50) > 500 microm) transport via the human dat, net, and sert. |
2006-12-04 |
2023-08-12 |
human |
| Bertha K Madras, Michele A Fahey, Martin Goulet, Zhicheng Lin, Jacob Bendor, Claudia Goodrich, Peter C Meltzer, David R Elmaleh, Eli Livni, Ali A Bonab, Alan J Fischma. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. The Journal of pharmacology and experimental therapeutics. vol 319. issue 2. 2006-12-04. PMID:16885433. |
four potent dat inhibitors, with relatively high norepinephrine transporter, but low sert affinities, that occupied the dat improved activity in parkinsonian monkeys, whereas three high-affinity dat inhibitors with low dat occupancy did not. |
2006-12-04 |
2023-08-12 |
monkey |
| Mu-Fa Zou, Jianjing Cao, Theresa Kopajtic, Rajeev I Desai, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationship studies on a novel series of (S)-2beta-substituted 3alpha-[bis(4-fluoro- or 4-chlorophenyl)methoxy]tropane analogues for in vivo investigation. Journal of medicinal chemistry. vol 49. issue 21. 2006-12-04. PMID:17034144. |
when the (s)-2-carboalkoxy substituent was replaced with (s)-2-ethenyl, the resulting analogue 11 demonstrated the highest dat binding affinity in the series (k(i) = 1.81 nm) with dat selectivity over serotonin transporters (sert; 989-fold), norepinephrine transporters (net; 261-fold) and muscarinic receptors (90-fold). |
2006-12-04 |
2023-08-12 |
human |
| David A Gutman, Michael J Owen. Serotonin and norepinephrine transporter binding profile of SSRIs. Essential psychopharmacology. vol 7. issue 1. 2006-11-30. PMID:16989291. |
for the majority of antidepressants, these changes are the result of their ability to block serotonin and/or norepinephrine activity at their "presynaptic uptake sites" (i.e., at the serotonin transporter [sert] or the norepinephrine transporter [net]). |
2006-11-30 |
2023-08-12 |
Not clear |
| Motoyasu Yamashita, Setsu Fukushima, Hao-wei Shen, F Scott Hall, George R Uhl, Yohtaro Numachi, Hideaki Kobayashi, Ichiro Sor. Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 31. issue 10. 2006-11-01. PMID:16407898. |
treatments with high dose psychostimulants that block dat as well as the norepinephrine (net) and serotonin (sert) transporters (60 mg/kg cocaine or methylphenidate) significantly impaired ppi in wild-type mice. |
2006-11-01 |
2023-08-12 |
mouse |
| Fanxing Zeng, Nachwa Jarkas, Michael J Owens, Clinton D Kilts, Charles B Nemeroff, Mark M Goodma. Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position. Bioorganic & medicinal chemistry letters. vol 16. issue 17. 2006-10-16. PMID:16784855. |
a series of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position was synthesized, and their binding affinities were determined in cells transfected to express human norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat) via competition binding assays. |
2006-10-16 |
2023-08-12 |
human |
| Rong Chen, Michael R Tilley, Hua Wei, Fuwen Zhou, Fu-Ming Zhou, San Ching, Ning Quan, Robert L Stephens, Erik R Hill, Timothy Nottoli, Dawn D Han, Howard H G. Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 24. 2006-09-11. PMID:16754872. |
there are three known high-affinity targets for cocaine: the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-09-11 |
2023-08-12 |
mouse |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-09-11 |
2023-08-12 |
Not clear |
| Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Jeffrey Deschamps, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Further structural exploration of trisubstituted asymmetric pyran derivatives (2S,4R,5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: a proposed pharmacophore model for high-affinity interaction with the dopamine, serotonin, and norepinephrine transporters. Journal of medicinal chemistry. vol 49. issue 14. 2006-09-11. PMID:16821783. |
among the trisubstituted compounds, (-)-4b exhibited the highest potency for the net and the sert (k(i) of 2.13 and 15.3 nm, respectively) and was a serotonin norepinephrine reuptake inhibitor (snri). |
2006-09-11 |
2023-08-12 |
Not clear |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Design, synthesis, and preliminary SAR study of 3- and 6-side-chain-extended tetrahydro-pyran analogues of cis- and trans-(6-benzhydryl-tetrahydropyran-3-yl)-benzylamine. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16481172. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2006-08-14 |
2023-08-12 |
Not clear |
| Terrence L Boos, Elisabeth Greiner, W Jason Calhoun, Thomas E Prisinzano, Barbara Nightingale, Christina M Dersch, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & medicinal chemistry. vol 14. issue 11. 2006-08-14. PMID:16563775. |
a series of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-(substituted benzyl) piperidines with substituents at the ortho and meta positions in the aromatic ring of the n-benzyl side chain were synthesized and their affinities and selectivities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined. |
2006-08-14 |
2023-08-12 |
Not clear |
| Dawn D Han, Howard H G. Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC pharmacology. vol 6. 2006-08-03. PMID:16515684. |
the transporters for the monoamines dopamine, norepinephrine, and serotonin (dat, net, and sert) are targets for several popular psychostimulant drugs of abuse. |
2006-08-03 |
2023-08-12 |
mouse |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands. Bioorganic & medicinal chemistry letters. vol 15. issue 24. 2006-06-27. PMID:16213721. |
a series of n-8-substituted benztropinamines was synthesized and evaluated for binding at the dopamine (dat), serotonin (sert), norepinephrine (net) transporters, and muscarinic m1 receptors. |
2006-06-27 |
2023-08-12 |
Not clear |