| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z Zhuang, S Choi, C Hou, M Mu, M Kung, P D Acton, H F Kun. A novel serotonin transporter ligand: (5-iodo-2-(2-dimethylaminomethylphenoxy)-benzyl alcohol. Nuclear medicine and biology. vol 27. issue 2. 2000-07-27. PMID:10773546. |
dopamine [dat], norepinephrine [net], and sert, respectively), odam showed a strong inhibition on sert (k(i) = 0.12 +/- 0.02 nm). |
2000-07-27 |
2023-08-12 |
rat |
| M M Goodman, C D Kilts, R Keil, B Shi, L Martarello, D Xing, J Votaw, T D Ely, P Lambert, M J Owens, V M Camp, E Malveaux, J M Hoffma. 18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters. Nuclear medicine and biology. vol 27. issue 1. 2000-07-07. PMID:10755640. |
competition binding in cells stably expressing the transfected human dat serotonin transporter (sert) and norepinephrine transporter (net) labeled by [3h]win 35428, [3h]citalopram, and [3h]nisoxetine, respectively, indicated the following order of dat affinity: gbr 12909 > cit >> 2beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(3-fluoropropyl) nortropane (fpct) > fecnt. |
2000-07-07 |
2023-08-12 |
human |
| A Hoepping, K M Johnson, C George, J Flippen-Anderson, A P Kozikowsk. Novel conformationally constrained tropane analogues by 6-endo-trig radical cyclization and stille coupling - switch of activity toward the serotonin and/or norepinephrine transporter. Journal of medicinal chemistry. vol 43. issue 10. 2000-06-29. PMID:10821718. |
its p-methoxy analogue 5c is a mixed inhibitor of norepinephrine and serotonin reuptake (k(i) = 187 nm at the net and 56 nm at the sert). |
2000-06-29 |
2023-08-12 |
rat |
| T Sato, S Kitayama, C Mitsuhata, T Ikeda, K Morita, T Doh. Selective inhibition of monoamine neurotransmitter transporters by synthetic local anesthetics. Naunyn-Schmiedeberg's archives of pharmacology. vol 361. issue 2. 2000-03-08. PMID:10685879. |
procaine also inhibited uptake of norepinephrine (ne) and serotonin (5-ht) by the norepinephrine transporter (net) or serotonin transporter (sert) expressed in cos cells. |
2000-03-08 |
2023-08-12 |
mouse |
| J G Chen, G Rudnic. Permeation and gating residues in serotonin transporter. Proceedings of the National Academy of Sciences of the United States of America. vol 97. issue 3. 2000-03-02. PMID:10655481. |
in norepinephrine transporter (net), cysteine replacement of ile-155 (corresponding to sert ile-179) also rendered the transporter sensitive to mtset inactivation. |
2000-03-02 |
2023-08-12 |
Not clear |
| Y Smicun, S D Campbell, M A Chen, H Gu, G Rudnic. The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain. The Journal of biological chemistry. vol 274. issue 51. 2000-01-27. PMID:10593887. |
chimeric transporters were constructed in which the predicted external loops of the serotonin transporter (sert) were replaced one at a time with a corresponding sequence from the norepinephrine transporter (net). |
2000-01-27 |
2023-08-12 |
Not clear |
| M J Kuhar, K M McGirr, R G Hunter, P D Lambert, B E Garrett, F I Carrol. Studies of selected phenyltropanes at monoamine transporters. Drug and alcohol dependence. vol 56. issue 1. 1999-10-12. PMID:10462087. |
in this study, 18 3-phenyltropane analogues were characterized in uptake and binding studies at dopamine (dat), norepinephrine (net) and serotonin (sert) transporters from the rat, and in binding at dat in rat, rhesus monkey, and human brain tissue. |
1999-10-12 |
2023-08-12 |
human |
| P D Acton, M P Kung, M Mu, K Plössl, C Hou, M Siciliano, S Oya, H F Kun. Single-photon emission tomography imaging of serotonin transporters in the non-human primate brain with the selective radioligand [(123)I]IDAM. European journal of nuclear medicine. vol 26. issue 8. 1999-10-07. PMID:10436198. |
in vitro binding studies suggest a high selectivity of idam for sert (k(i)=0.097 nm), with considerably lower affinities for norepinephrine and dopamine transporters (net k(i)= 234 nm and dat k(i)>10 microm, respectively). |
1999-10-07 |
2023-08-12 |
Not clear |
| M Nishimura, K Sato, S Shimada, M Tohyam. Expression of norepinephrine and serotonin transporter mRNAs in the rat superior cervical ganglion. Brain research. Molecular brain research. vol 67. issue 1. 1999-05-21. PMID:10101235. |
we investigated the gene expression of three monoamine transporters (norepinephrine transporter, net; serotonin transporter, sert; and dopamine transporter, dat) in the rat superior cervical ganglion (scg). |
1999-05-21 |
2023-08-12 |
rat |
| A F Hoffman, C R Lupica, G A Gerhard. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. The Journal of pharmacology and experimental therapeutics. vol 287. issue 2. 1998-12-07. PMID:9808671. |
however, neither the serotonin transporter (sert) inhibitor citalopram nor the norepinephrine transporter (net) inhibitor desipramine (dmi) produced significant effects on da clearance. |
1998-12-07 |
2023-08-12 |
rat |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
we investigated the possible relationships between dna polymorphisms in the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) genes and csf concentrations of homovanillic acid (hva), 5-hydroxyindoleacetic acid (5-hiaa), and 3-methoxy-4-hydroxyphenylglycol (mhpg) in healthy volunteers (n = 66). |
1998-10-06 |
2023-08-12 |
human |
| E G Jönsson, M M Nöthen, J P Gustavsson, H Neidt, R Bunzel, P Propping, G C Sedval. Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationships to monoamine metabolite concentrations in CSF of healthy volunteers. Psychiatry research. vol 79. issue 1. 1998-10-06. PMID:9676821. |
the results suggest that sert and net genotypes may participate differentially in the regulation of the norepinephrine turnover rate under presumed steady-state conditions in the central nervous system. |
1998-10-06 |
2023-08-12 |
human |
| L C Daws, G M Toney, G A Gerhardt, A Fraze. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. The Journal of pharmacology and experimental therapeutics. vol 286. issue 2. 1998-09-02. PMID:9694957. |
the effects of blockade of serotonin (5-ht) and norepinephrine (ne) transporters (sert and net, respectively) on the removal of locally applied 5-ht from extracellular fluid (ecf) were examined using in vivo chronoamperometry. |
1998-09-02 |
2023-08-12 |
rat |
| S A Burchett, M J Banno. Serotonin, dopamine and norepinephrine transporter mRNAs: heterogeneity of distribution and response to 'binge' cocaine administration. Brain research. Molecular brain research. vol 49. issue 1-2. 1998-02-11. PMID:9387868. |
quantitative in situ hybridization was utilized to map the distribution and abundance of the serotonin, dopamine and norepinephrine transporter (sert, dat and net, respectively) mrnas. |
1998-02-11 |
2023-08-12 |
rat |
| A F Hoffman, G A Gerhard. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. Journal of neurochemistry. vol 70. issue 1. 1998-02-02. PMID:9422361. |
to establish that da clearance within the sn was mediated primarily by the da transporter (dat) rather than the norepinephrine transporter (net) or the serotonin transporter (sert), we locally applied uptake inhibitors with different selectivity profiles for the various amine transporters. |
1998-02-02 |
2023-08-12 |
rat |
| M J Owens, W N Morgan, S J Plott, C B Nemerof. Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolites. The Journal of pharmacology and experimental therapeutics. vol 283. issue 3. 1998-01-15. PMID:9400006. |
several new antidepressants that inhibit the serotonin (sert) and norepinephrine transporters (net) have been introduced into clinical practice the past several years. |
1998-01-15 |
2023-08-12 |
human |
| W E Schutzer, C L Bethe. Lack of ovarian steroid hormone regulation of norepinephrine transporter mRNA expression in the non-human primate locus coeruleus. Psychoneuroendocrinology. vol 22. issue 5. 1997-10-23. PMID:9279938. |
decreases in ovarian steroids can negatively affect mood, and drugs which block the norepinephrine transporter (net) or the serotonin transporter (sert) alleviate depression. |
1997-10-23 |
2023-08-12 |
monkey |
| M M Stephan, M A Chen, K M Penado, G Rudnic. An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism. Biochemistry. vol 36. issue 6. 1997-03-17. PMID:9063880. |
we took advantage of native restriction sites in sert to construct a chimeric transporter containing a small (34 amino acid) region of the norepinephrine transporter. |
1997-03-17 |
2023-08-12 |
Not clear |
| H H Gu, S Wall, G Rudnic. Ion coupling stoichiometry for the norepinephrine transporter in membrane vesicles from stably transfected cells. The Journal of biological chemistry. vol 271. issue 12. 1996-07-09. PMID:8636118. |
we prepared membrane vesicles from stable llc-pk1 cells expressing serotonin (5-ht) gamma-aminobutyric acid (gaba) and norepinephrine (ne) transporters (sert, gat-1, and net). |
1996-07-09 |
2023-08-12 |
Not clear |