| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georgianna G Gould, Alfonso V Altamirano, Martin A Javors, Alan Fraze. A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16140280. |
venlafaxine blocks both serotonin and norepinephrine transporters (sert and net), with higher affinity for sert. |
2006-05-11 |
2023-08-12 |
rat |
| Georgianna G Gould, Alfonso V Altamirano, Martin A Javors, Alan Fraze. A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological psychiatry. vol 59. issue 5. 2006-05-11. PMID:16140280. |
chronic treatment of rats with selective serotonin reuptake inhibitors decreases sert binding sites, whereas similar treatment with selective norepinephrine reuptake inhibitors decreases net binding sites. |
2006-05-11 |
2023-08-12 |
rat |
| Elisabeth Greiner, Terrence L Boos, Thomas E Prisinzano, Maria G De Martino, Brian Zeglis, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of medicinal chemistry. vol 49. issue 5. 2006-04-25. PMID:16509591. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl]-piperidines and 4-[2-[(bisphenyl)methoxy]ethyl]-piperidines with different types of substituents in the phenylpropyl side-chain were synthesized and examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2006-04-25 |
2023-08-12 |
Not clear |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
catecholamine homeostasis as reflected in brain tissue concentrations and in synthesis and turnover of dopamine and norepinephrine was unchanged in sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |
| Kevin B Freeman, Kenner C Rice, Anthony L Rile. Assessment of monoamine transporter inhibition in the mediation of cocaine-induced conditioned taste aversion. Pharmacology, biochemistry, and behavior. vol 82. issue 3. 2006-03-02. PMID:16337262. |
using the conditioned taste aversion (cta) preparation, the present study examined the role of monoamine uptake inhibition in cocaine's aversive effects by comparing cocaine to three reuptake inhibitors with relative specificity for the transporters of dopamine (dat; gbr 12909), norepinephrine (net; desipramine) and serotonin (sert; clomipramine). |
2006-03-02 |
2023-08-12 |
rat |
| Jean Logan, Yu-Shin Ding, Kuo-Shyan Lin, Deborah Pareto, Joanna Fowler, Anat Biego. Modeling and analysis of PET studies with norepinephrine transporter ligands: the search for a reference region. Nuclear medicine and biology. vol 32. issue 5. 2005-12-07. PMID:15982584. |
the development of positron emission tomography (pet) ligands for the norepinephrine transporter (net) has been slow compared to the development of radiotracers for others systems, such as the dopamine (dat) or the serotonin transporters (sert). |
2005-12-07 |
2023-08-12 |
Not clear |
| Anu J Airaksinen, Marko Huotari, Alexander Shvetsov, Pirjo Vainiotalo, Pekka T Männisto, Leena Tuomisto, Kim A Bergström, Jouko Vepsäläine. Synthesis and biological evaluation of 6/7-exo-methyl-3beta-(4-iodo)phenyltropane-2beta-carboxylic acid methyl esters. European journal of medicinal chemistry. vol 40. issue 3. 2005-08-29. PMID:15725499. |
the effect of 6/7-groups was evaluated by in vitro receptor binding to dopamine (dat), serotonin (sert) and norepinephrine (net) transporters. |
2005-08-29 |
2023-08-12 |
mouse |
| Christian Pifl, Gabor Nagy, Sándor Berényi, Alexandra Kattinger, Harald Reither, Sándor Antu. Pharmacological characterization of ecstasy synthesis byproducts with recombinant human monoamine transporters. The Journal of pharmacology and experimental therapeutics. vol 314. issue 1. 2005-08-26. PMID:15831439. |
mdma and eight chemically defined byproducts of mdma synthesis were investigated for their interaction with the primary sites of action of mdma, namely the human plasmalemmal monamine transporters for norepinephrine, serotonin, and dopamine [(norepinephrine transporter (net), serotonin transporter (sert), and dopamine transporter (dat)]. |
2005-08-26 |
2023-08-12 |
human |
| Nachwa Jarkas, Jonathan McConathy, Ronald J Voll, Mark M Goodma. Synthesis, in vitro characterization, and radiolabeling of N,N-dimethyl-2-(2'-amino-4'-substituted-phenylthio)benzylamines: potential candidates as selective serotonin transporter radioligands. Journal of medicinal chemistry. vol 48. issue 13. 2005-08-23. PMID:15974579. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428 or [(125)i]rti-55, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) (nm)): 14a (0.25) > 16 (0.49) > 20 (0.57) > 14b (1.12) > 13 (1.59) > 33b (1.94) = 35 (2.04) >> 23 (8.50) = 28 (8.55) > 41 (15.11) >> 22 (51) > 33a (83.43) > 27 (92). |
2005-08-23 |
2023-08-12 |
human |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Discovery of novel trisubstituted asymmetric derivatives of (2S,4R,5R)-2-benzhydryl-5-benzylaminotetrahydropyran-4-ol, exhibiting high affinity for serotonin and norepinephrine transporters in a stereospecific manner. Journal of medicinal chemistry. vol 48. issue 15. 2005-08-23. PMID:16033275. |
all synthesized derivatives were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]-5-ht, and [(3)h]ne, respectively. |
2005-08-23 |
2023-08-12 |
Not clear |
| Zhihong Zhu, Ningning Guo, Raj Narendran, David Erritzoe, Jesper Ekelund, Dah-Ren Hwang, Sung-A Bae, Marc Laruelle, Yiyun Huan. The new PET imaging agent [11C]AFE is a selective serotonin transporter ligand with fast brain uptake kinetics. Nuclear medicine and biology. vol 31. issue 8. 2005-07-05. PMID:15607480. |
binding assays indicated that afe displays high affinity for sert (k(i)=1.80 nm for hsert) and lower affinity for norepinephrine transporter (k(i)=946 nm for hnet) or dopamine transporter (k(i)>10,000 nm for hdat). |
2005-07-05 |
2023-08-12 |
rat |
| Nachwa Jarkas, Jonathan McConathy, John R Votaw, Ronald J Voll, Eugene Malveaux, Vernon M Camp, Larry Williams, Robin R Goodman, Clinton D Kilts, Mark M Goodma. Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography. Nuclear medicine and biology. vol 32. issue 1. 2005-06-24. PMID:15691664. |
competition binding assays in cells stably expressing the transfected human dopamine transporter (dat), sert and norepinephrine transporter (net) labeled with [3h]win 35428 or [(125)i]rti-55, [3h]citalopram and [3h]nisoxetine, respectively, indicated the following order of sert affinity: adam>eadam>>fluvoxamine. |
2005-06-24 |
2023-08-12 |
human |
| Chong-Bin Zhu, Ana M Carneiro, Wolfgang R Dostmann, William A Hewlett, Randy D Blakel. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process. The Journal of biological chemistry. vol 280. issue 16. 2005-06-23. PMID:15728187. |
studies with transporter-transfected chinese hamster ovary cells reveal that sert stimulation is shared with the human norepinephrine transporter but not the human dopamine transporter. |
2005-06-23 |
2023-08-12 |
human |
| Gilles Tamagnan, David Alagille, Xing Fu, Nora S Kula, Ross J Baldessarini, Robert B Innis, Ronald M Baldwi. Synthesis and monoamine transporter affinity of new 2beta-carbomethoxy-3beta-[4-(substituted thiophenyl)]phenyltropanes: discovery of a selective SERT antagonist with picomolar potency. Bioorganic & medicinal chemistry letters. vol 15. issue 4. 2005-06-15. PMID:15686927. |
among these, compound 4b exhibited very high affinity for the serotonin transporter (sert: k(i)=17 pm) and good selectivity over dopamine (dat: 710-fold) and norepinephrine transporters (net: 11,100-fold). |
2005-06-15 |
2023-08-12 |
Not clear |
| Débora C Hipólide, Karin M Moreira, Karen B L Barlow, Alan A Wilson, José N Nobrega, Sergio Tufi. Distinct effects of sleep deprivation on binding to norepinephrine and serotonin transporters in rat brain. Progress in neuro-psychopharmacology & biological psychiatry. vol 29. issue 2. 2005-05-09. PMID:15694238. |
in the present study we examined the possibility that such changes may occur at the level of the norepinephrine (net) and serotonin (sert) and transporters. |
2005-05-09 |
2023-08-12 |
rat |
| Yiyun Huang, Sung-A Bae, Zhihong Zhu, Ningning Guo, Bryan L Roth, Marc Laruell. Fluorinated diaryl sulfides as serotonin transporter ligands: synthesis, structure-activity relationship study, and in vivo evaluation of fluorine-18-labeled compounds as PET imaging agents. Journal of medicinal chemistry. vol 48. issue 7. 2005-05-05. PMID:15801845. |
candidate compounds were assayed for their affinities to the monoamine transporters (sert, norepinephrine transporter (net), and dopamine transporter (dat)) in competitive binding experiments in vitro using cloned human transporters. |
2005-05-05 |
2023-08-12 |
human |
| Shijun Zhang, Juan Zhen, Maarten E A Reith, Aloke K Dutt. Structural requirements for 2,4- and 3,6-disubstituted pyran biomimetics of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine compounds to interact with monoamine transporters. Bioorganic & medicinal chemistry. vol 12. issue 23. 2005-04-13. PMID:15519172. |
both cis and trans 2,4- and 3,6-disubstituted derivatives were synthesized to determine the positional importance of n-substitution on affinity for monoamine transporters, that is the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net) in rat brain. |
2005-04-13 |
2023-08-12 |
rat |
| Xuemei Peng, Ao Zhang, Nora S Kula, Ross J Baldessarini, John L Neumeye. Synthesis and amine transporter affinities of novel phenyltropane derivatives as potential positron emission tomography (PET) imaging agents. Bioorganic & medicinal chemistry letters. vol 14. issue 22. 2005-03-22. PMID:15482938. |
novel compounds were evaluated for affinity and selectivity in competitive radioligand binding assays selective for cerebral serotonin (5-ht), dopamine (da), and norepinephrine (ne) transporters (sert, dat, and net). |
2005-03-22 |
2023-08-12 |
Not clear |
| Tetsurou Ikeda, Masaru Kurosawa, Chiharu Uchikawa, Shigeo Kitayama, Nobuyuki Nukin. Modulation of monoamine transporter expression and function by repetitive transcranial magnetic stimulation. Biochemical and biophysical research communications. vol 327. issue 1. 2005-03-11. PMID:15629452. |
in contrast to the sert changes, increased mrna levels of dopamine transporter (dat) and norepinephrine transporter (net) were observed. |
2005-03-11 |
2023-08-12 |
mouse |
| Yiyun Huang, Raj Narendran, Sung-A Bae, David Erritzoe, Ningning Guo, Zhihong Zhu, Dah-Ren Hwang, Marc Laruell. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nuclear medicine and biology. vol 31. issue 6. 2005-02-25. PMID:15246363. |
in vitro, afa displayed high affinity for sert (ki 1.46 +/- 0.15 nm) and lower affinity for norepinephrine transporter (net, ki 141.7 +/- 47.4 nm) or dopamine transporter (dat, ki > 10,000 nm). |
2005-02-25 |
2023-08-12 |
rat |