| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshihiro Dohi, Shigeo Kitayama, Key Kumagai, Wataru Hashimoto, Katsuya Morit. [Pharmacology of monoamine neurotransmitter transporters]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 120. issue 5. 2003-03-12. PMID:12491807. |
following exocytotic release, the biogenic amine neurotransmitters, norepinephrine, dopamine, and serotonin are removed from the synaptic cleft by the respective transporter, net, dat, and sert, located on the plasma membrane and then re-stored into synaptic vesicles by vesicular monoamine transporter, vmat. |
2003-03-12 |
2023-08-12 |
Not clear |
| Päivi Marjamäki, Jörg Zessin, Olli Eskola, Tove Grönroos, Merja Haaparanta, Jörgen Bergman, Pertti Lehikoinen, Sarita Forsback, Peter Brust, Jörg Steinbach, Olof Soli. S-[18F]fluoromethyl-(+)-McN5652, a PET tracer for the serotonin transporter: evaluation in rats. Synapse (New York, N.Y.). vol 47. issue 1. 2003-03-07. PMID:12422372. |
the specificity and selectivity of [(18)f]fme-mcn binding to sert was studied by preinjecting blocking doses of serotonin, norepinephrine, and dopamine transporter inhibitors. |
2003-03-07 |
2023-08-12 |
rat |
| M K Hahn, R D Blakel. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. The pharmacogenomics journal. vol 2. issue 4. 2003-02-10. PMID:12196911. |
the norepinephrine, dopamine and serotonin transporters (net, dat and sert, respectively), limit cellular signaling by recapturing released neurotransmitter, and serve as targets for antidepressants and drugs of abuse, emphasizing the integral role these molecules play in neurotransmission and pathology. |
2003-02-10 |
2023-08-12 |
human |
| Bruce R Stevens, Daniel H Feldman, Zhilin Liu, William R Harve. Conserved tyrosine-147 plays a critical role in the ligand-gated current of the epithelial cation/amino acid transporter/channel CAATCH1. The Journal of experimental biology. vol 205. issue Pt 16. 2003-02-07. PMID:12124378. |
this tyrosine residue is conserved within the third transmembrane domain in members of the na(+):neurotransmitter transporter family (snf), where it plays a role in binding pharmacological ligands such as cocaine to the serotonin (sert), dopamine (dat) and norepinephrine (net) transporters. |
2003-02-07 |
2023-08-12 |
xenopus_laevis |
| Kentaro Wakayama, Sumio Ohtsuki, Hitomi Takanaga, Ken-ichi Hosoya, Tetsuya Terasak. Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neuroscience research. vol 44. issue 2. 2002-12-04. PMID:12354632. |
mrna expression of norepinephrine transporter (net) and serotonin transporter (sert) has been detected in a conditionally immortalized mouse brain capillary endothelial cell line (tm-bbb4) used as an in vitro model of the bbb, whereas no dopamine transporter (dat) was detected. |
2002-12-04 |
2023-08-12 |
mouse |
| Shunichi Oya, Seok Rye Choi, Heinz Coenen, Hank F Kun. New PET imaging agent for the serotonin transporter: [(18)F]ACF (2-[(2-amino-4-chloro-5-fluorophenyl)thio]-N,N-dimethyl-benzenmethanamine). Journal of medicinal chemistry. vol 45. issue 21. 2002-11-05. PMID:12361398. |
in vitro binding assays using cell membrane homogenates of llc cells expressing sert, dopamine transporters (dat), or norepinephrine transporters (net) showed excellent binding affinity and selectivity for sert (k(i) = 0.05, 3020, and 650 nm for sert, dat, and net, respectively). |
2002-11-05 |
2023-08-12 |
rat |
| Amy Hauck Newman, Santosh Kulkarn. Probes for the dopamine transporter: new leads toward a cocaine-abuse therapeutic--A focus on analogues of benztropine and rimcazole. Medicinal research reviews. vol 22. issue 5. 2002-10-24. PMID:12210554. |
nevertheless, investigation of the serotonin (sert) and norepinephrine (net) transporters, as well as other receptor systems, with which cocaine either directly or indirectly interacts, has suggested that the dat is not solely responsible for the reinforcing effects of cocaine. |
2002-10-24 |
2023-08-12 |
Not clear |
| Thomas Prisinzano, Elisabeth Greiner, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. Journal of medicinal chemistry. vol 45. issue 19. 2002-10-01. PMID:12213078. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the norepinephrine transporter, and the serotonin transporter (sert). |
2002-10-01 |
2023-08-12 |
Not clear |
| Patrick Emond, Johnny Vercouillie, Robert Innis, Sylvie Chalon, Sylvie Mavel, Yves Frangin, Christer Halldin, Jean-Claude Besnard, Denis Guillotea. Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation. Journal of medicinal chemistry. vol 45. issue 6. 2002-04-26. PMID:11881994. |
a series of diphenyl sulfide derivatives substituted at the 1-, 2'-, and 4'-positions has been synthesized and evaluated for their in vitro affinities at the dopamine, serotonin (sert), and norepinephrine transporters. |
2002-04-26 |
2023-08-12 |
Not clear |
| C D Cook, I F Carroll, P M Beardsle. Cocaine-like discriminative stimulus effects of novel cocaine and 3-phenyltropane analogs in the rat. Psychopharmacology. vol 159. issue 1. 2002-03-13. PMID:11797070. |
although cocaine is an indirect da agonist that binds to all three monoamine transporters, there is much evidence implicating a greater role for the dopamine (dat) than norepinephrine (net) and serotonin (sert) transporters in the behavioral effects of cocaine. |
2002-03-13 |
2023-08-12 |
rat |
| X H Gu, R Zong, N S Kula, R J Baldessarini, J L Neumeye. Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 11. issue 23. 2002-03-05. PMID:11714608. |
a series of novel fluoroalkyl-containing tropane derivatives was synthesized, and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) were determined via competitive binding assays. |
2002-03-05 |
2023-08-12 |
Not clear |
| G M Miller, S M Yatin, R De La Garza, M Goulet, B K Madra. Cloning of dopamine, norepinephrine and serotonin transporters from monkey brain: relevance to cocaine sensitivity. Brain research. Molecular brain research. vol 87. issue 1. 2001-08-09. PMID:11223167. |
we used rt-pcr to clone monoamine transporters from macaca mulatta, macaca fasicularis and saimiri sciureus (dopamine transporter; dat) and macaca mulatta (norepinephrine transporter; net and serotonin transporter; sert). |
2001-08-09 |
2023-08-12 |
human |
| M J Millan, A Gobert, F Lejeune, A Newman-Tancredi, J M Rivet, A Auclair, J L Peglio. S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of pharmacology and experimental therapeutics. vol 298. issue 2. 2001-08-09. PMID:11454918. |
s33005 displayed marked affinity for native, rat, and cloned human serotonin (5-ht) transporters (sert) and less pronounced affinity for norepinephrine (ne) transporters (net), while its affinity at dopamine (da) transporters and >50 other sites was negligible. |
2001-08-09 |
2023-08-12 |
human |
| A L Bauman, S Apparsundaram, S Ramamoorthy, B E Wadzinski, R A Vaughan, R D Blakel. Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027216. |
recent studies reveal that dopamine (da), norepinephrine (ne), and serotonin (5-ht) transporters (dat, net, and sert, respectively) are rapidly regulated by direct or receptor-mediated activation of cellular kinases, particularly protein kinase c (pkc). |
2001-06-07 |
2023-08-12 |
human |
| I Sora, F S Hall, A M Andrews, M Itokawa, X F Li, H B Wei, C Wichems, K P Lesch, D L Murphy, G R Uh. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proceedings of the National Academy of Sciences of the United States of America. vol 98. issue 9. 2001-05-21. PMID:11320258. |
cocaine blocks uptake by neuronal plasma membrane transporters for dopamine (dat), serotonin (sert), and norepinephrine (net). |
2001-05-21 |
2023-08-12 |
mouse |
| A K Dutta, X S Fei, R A Vaughan, J D Gaffaney, N Wang, J R Lever, M E Reit. Design, synthesis, and characterization of a novel, 4-[2-(diphenylmethoxy)ethyl]-1-benzyl piperidine-based, dopamine transporter photoaffinity label. Life sciences. vol 68. issue 16. 2001-04-19. PMID:11292062. |
this photolabeling was antagonized by dat-specific blockers and was unaffected by specific sert and norepinephrine transporter (net) blockers indicating interaction of this novel ligand with the dat. |
2001-04-19 |
2023-08-12 |
Not clear |
| S Oya, S R Choi, C Hou, M Mu, M P Kung, P D Acton, M Siciliano, H F Kun. 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand. Nuclear medicine and biology. vol 27. issue 3. 2000-09-26. PMID:10832081. |
adam(7) also showed more than 1,000-fold selectivity for sert over norepinephrine transporter (net) and dopamine transporter (dat) ( k(i)=699 and 840 nm, for net and dat, respectively). |
2000-09-26 |
2023-08-12 |
human |
| L Zhao, K M Johnson, M Zhang, J Flippen-Anderson, A P Kozikowsk. Chemical synthesis and pharmacology of 6- and 7-hydroxylated 2-carbomethoxy-3-(p-tolyl)tropanes: antagonism of cocaine's locomotor stimulant effects. Journal of medicinal chemistry. vol 43. issue 17. 2000-09-21. PMID:10966747. |
some of these compounds were found to retain considerable affinity as inhibitors of the dopamine transporter (dat) and the norepinephrine transporter (net), but they were less potent inhibitors of the serotonin transporter (sert). |
2000-09-21 |
2023-08-12 |
rat |
| D H Feldman, W R Harvey, B R Steven. A novel electrogenic amino acid transporter is activated by K+ or Na+, is alkaline pH-dependent, and is Cl--independent. The Journal of biological chemistry. vol 275. issue 32. 2000-09-14. PMID:10829035. |
amino acids such as l-proline, l-threonine, and l-methionine elicited complex current-voltage relationships in alkaline ph-dependent caatch1 that were reminiscent of the behavior of the dopamine, serotonin, and norepinephrine transporters (dat, sert, net) in the presence of their substrates and pharmacological inhibitors such as cocaine or antidepressants. |
2000-09-14 |
2023-08-12 |
xenopus_laevis |
| A A Wilson, N Ginovart, M Schmidt, J H Meyer, P G Threlkeld, S Houl. Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. Journal of medicinal chemistry. vol 43. issue 16. 2000-09-08. PMID:10956218. |
all four candidates display high affinity for sert and low affinity for the dopamine or norepinephrine transporters using in vitro binding assays. |
2000-09-08 |
2023-08-12 |
human |