| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yiyun Huang, Raj Narendran, Sung-A Bae, David Erritzoe, Ningning Guo, Zhihong Zhu, Dah-Ren Hwang, Marc Laruell. A PET imaging agent with fast kinetics: synthesis and in vivo evaluation of the serotonin transporter ligand [11C]2-[2-dimethylaminomethylphenylthio)]-5-fluorophenylamine ([11C]AFA). Nuclear medicine and biology. vol 31. issue 6. 2005-02-25. PMID:15246363. |
binding in sert-rich brain regions was reduced significantly by pretreatment with either the cold compound 8 or with the selective serotonin reuptake inhibitor (ssri) citalopram, but not by the selective norepinephrine reuptake inhibitor nisoxetine, thus underlining its in vivo binding selectivity and specificity for sert. |
2005-02-25 |
2023-08-12 |
rat |
| F Scott Hall, Ichiro Sora, Jana Drgonova, Xiao-Fei Li, Michelle Goeb, George R Uh. Molecular mechanisms underlying the rewarding effects of cocaine. Annals of the New York Academy of Sciences. vol 1025. 2005-02-18. PMID:15542699. |
we have also identified evidence that, in the absence of dat, there is greater participation in cocaine reward by serotonin (sert) and norepinephrine (net) transporters. |
2005-02-18 |
2023-08-12 |
mouse |
| Peter Grundt, Theresa A Kopajtic, Jonathan L Katz, Amy Hauck Newma. The effect of 6-substituted-4',4"-difluorobenztropines on monoamine transporters and the muscarinic M1 receptor. Bioorganic & medicinal chemistry letters. vol 14. issue 12. 2005-01-06. PMID:15149693. |
a series of racemic 6-hydroxy and carboalkoxy substituted-4('),4"-difluorobenztropines was synthesized and evaluated for binding at the dopamine (dat), the serotonin (sert), the norepinephrine (net) transporters, and the muscarinic m1 receptor. |
2005-01-06 |
2023-08-12 |
Not clear |
| Frederic Bois, Ronald M Baldwin, Nora S Kula, Ross J Baldessarini, Robert B Innis, Gilles Tamagna. Synthesis and monoamine transporter affinity of 3'-analogs of 2-beta-carbomethoxy-3-beta-(4'-iodophenyl)tropane (beta-CIT). Bioorganic & medicinal chemistry letters. vol 14. issue 9. 2004-12-22. PMID:15080991. |
all 3'-substituted compounds displayed affinity for both serotonin (sert) and dopamine (dat), but much less for norepinephrine transporters (net), with selectivity for rat (r) or human (h) sert over net, but only 3'-iodo-substituted phenyltropanes showed selectivity for sert versus dat. |
2004-12-22 |
2023-08-12 |
human |
| B Bottalico, I Larsson, J Brodszki, E Hernandez-Andrade, B Casslén, K Marsál, S R Hansso. Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies. Placenta. vol 25. issue 6. 2004-12-17. PMID:15135235. |
norepinephrine transporter (net), serotonin transporter (sert), vesicular monoamine transporter (vmat2) and organic cation transporters (oct1, 2 and emt) in human placenta from pre-eclamptic and normotensive pregnancies. |
2004-12-17 |
2023-08-12 |
human |
| Rohit Kolhatkar, Charles D Cook, Sujit K Ghorai, Jeffrey Deschamps, Patrick M Beardsley, Maarten E A Reith, Aloke K Dutt. Further structurally constrained analogues of cis-(6-benzhydrylpiperidin-3-yl)benzylamine with elucidation of bioactive conformation: discovery of 1,4-diazabicyclo[3.3.1]nonane derivatives and evaluation of their biological properties for the monoamine transporters. Journal of medicinal chemistry. vol 47. issue 21. 2004-11-10. PMID:15456254. |
all synthesized derivatives were tested for their affinity at the dat, serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [(3)h]win 35, 428, [(3)h]citalopram, and [(3)h]nisoxetine, respectively. |
2004-11-10 |
2023-08-12 |
mouse |
| Beatriz A Roch. Stimulant and reinforcing effects of cocaine in monoamine transporter knockout mice. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612142. |
however, the fact that cocaine similarly binds to the serotonin and norepinephrine transporters (sert and net, respectively), raises the possibility that modulation of mesocorticolimbic dopaminergic transmission might be achieved through alternate pathways. |
2004-07-20 |
2023-08-12 |
mouse |
| Claus Juul Loland, Kristine Norgaard-Nielsen, Ulrik Gethe. Probing dopamine transporter structure and function by Zn2+-site engineering. European journal of pharmacology. vol 479. issue 1-3. 2004-07-20. PMID:14612149. |
the biogenic amine transporters belong to the class of na+/cl--coupled solute carriers and include the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert). |
2004-07-20 |
2023-08-12 |
human |
| Santosh S Kulkarni, Peter Grundt, Theresa Kopajtic, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships at monoamine transporters for a series of N-substituted 3alpha-(bis[4-fluorophenyl]methoxy)tropanes: comparative molecular field analysis, synthesis, and pharmacological evaluation. Journal of medicinal chemistry. vol 47. issue 13. 2004-07-09. PMID:15189035. |
these compounds were evaluated for binding at dat, serotonin (sert) and norepinephrine (net) transporters, and muscarinic m1 receptors in rat brain. |
2004-07-09 |
2023-08-12 |
rat |
| Lifen Xu, Santosh S Kulkarni, Sari Izenwasser, Jonathan L Katz, Theresa Kopajtic, Stacey A Lomenzo, Amy Hauck Newman, Mark L Trudel. Synthesis and monoamine transporter binding of 2-(diarylmethoxymethyl)-3 beta-aryltropane derivatives. Journal of medicinal chemistry. vol 47. issue 7. 2004-05-10. PMID:15027858. |
3 beta-aryltropane analogues wherein the 2-position was substituted with various diarylmethoxyalkyl groups were synthesized and evaluated for binding at the dopamine transporter (dat), serotonin transporter (sert), norepinephrine transporter (net), and muscarinic (m(1)) receptors. |
2004-05-10 |
2023-08-12 |
Not clear |
| Charles B Nemeroff, Michael J Owen. Neuropharmacology of paroxetine. Psychopharmacology bulletin. vol 37 Suppl 1. 2004-01-28. PMID:14566196. |
paroxetine also has been shown to be a potent and selective inhibitor of the human serotonin transporter (sert) and has recently been demonstrated to have moderate affinity for the norepinephrine transporter (net). |
2004-01-28 |
2023-08-12 |
human |
| Georgianna G Gould, Marie-Christine Pardon, David A Morilak, Alan Fraze. Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 9. 2003-10-06. PMID:12825093. |
to study this, we examined changes in binding sites in rat brain for norepinephrine (net) and serotonin transporters (sert), alpha1, alpha2, and beta1 adrenergic receptors after chronic administration of paroxetine (prx), reboxetine (rbx), or prx followed by rbx. |
2003-10-06 |
2023-08-12 |
rat |
| Raul R Gainetdinov, Marc G Caro. Monoamine transporters: from genes to behavior. Annual review of pharmacology and toxicology. vol 43. 2003-09-09. PMID:12359863. |
these transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), which are expressed selectively on the corresponding neurons, are established targets of many psychostimulants, antidepressants, and neurotoxins. |
2003-09-09 |
2023-08-12 |
mouse |
| Ruth E Urwin, Bruce H Bennetts, Bridget Wilcken, Pierre J V Beumont, Janice D Russell, Kenneth P Nun. Investigation of epistasis between the serotonin transporter and norepinephrine transporter genes in anorexia nervosa. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 28. issue 7. 2003-09-02. PMID:12784104. |
we then performed the first reported investigation of epistasis between the sert gene and norepinephrine transporter gene (slc6a2, alias net) in an, as an earlier study suggested that atypical an responds to the dual serotonin-norepinephrine reuptake inhibitor venlafaxine. |
2003-09-02 |
2023-08-12 |
Not clear |
| Mylène Karramkam, Frédéric Dollé, Héric Valette, Laurent Besret, Yann Bramoullé, Françoise Hinnen, Françoise Vaufrey, Carine Franklin, Sébastien Bourg, Christine Coulon, Michèle Ottaviani, Marcel Delaforge, Christian Loc'h, Michel Bottlaender, Christian Crouze. Synthesis of a fluorine-18-labelled derivative of 6-nitroquipazine, as a radioligand for the in vivo serotonin transporter imaging with PET. Bioorganic & medicinal chemistry. vol 10. issue 8. 2003-07-31. PMID:12057650. |
however, the low accumulation of the tracer in the thalamus (rat and monkey) as well as the comparable displacement of the tracer observed with both citalopram, a -ht re-uptake inhibitor and maprotiline, a norepinephrine re-uptake inhibitor (rat), indicate that 5-[(18)f]fluoro-6-nitroquipazine ([(18)f]-1d) does not have the suggested potential for pet imaging of the serotin transporter (sert). |
2003-07-31 |
2023-08-12 |
rat |
| Twum-Ampofo Ansah, Sammanda Ramamoorthy, Sylvia Montañez, Lynette C Daws, Randy D Blakel. Calcium-dependent inhibition of synaptosomal serotonin transport by the alpha 2-adrenoceptor agonist 5-bromo-N-[4,5-dihydro-1H-imidazol-2-yl]-6-quinoxalinamine (UK14304). The Journal of pharmacology and experimental therapeutics. vol 305. issue 3. 2003-07-07. PMID:12626658. |
uk14304-mediated inhibition of sert function was yohimbine-sensitive, as was inhibition triggered by norepinephrine, and was abolished in the absence of added ca2+. |
2003-07-07 |
2023-08-12 |
mouse |
| Rohit B Kolhatkar, Sujit K Ghorai, Clifford George, Maarten E A Reith, Aloke K Dutt. Interaction of cis-(6-benzhydrylpiperidin-3-yl)benzylamine analogues with monoamine transporters: structure-activity relationship study of structurally constrained 3,6-disubstituted piperidine analogues of (2,2-diphenylethyl)-[1-(4-fluorobenzyl)piperidin-4-ylmethyl]amine. Journal of medicinal chemistry. vol 46. issue 11. 2003-06-23. PMID:12747792. |
all novel compounds were tested for their affinity at the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in competing for the binding of [3h]win 35 428, [3h]citalopram, and [3h]nisoxetine, respectively. |
2003-06-23 |
2023-08-12 |
Not clear |
| Elisabeth Greiner, Thomas Prisinzano, Edward M Johnson, Christina M Dersch, Jamila Marcus, John S Partilla, Richard B Rothman, Arthur E Jacobson, Kenner C Ric. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of medicinal chemistry. vol 46. issue 8. 2003-05-08. PMID:12672246. |
a series of 4-[2-[bis(4-fluorophenyl)methoxy]ethyl-1-benzylpiperidines were examined for their ability to bind to the dopamine transporter (dat), the serotonin transporter (sert), and the norepinephrine transporter (net). |
2003-05-08 |
2023-08-12 |
Not clear |
| Mark M Goodman, Ping Chen, Christophe Plisson, Laurent Martarello, James Galt, John R Votaw, Clinton D Kilts, Gene Malveaux, Vernon M Camp, Bing Shi, Timothy D Ely, Leonard Howell, Jon McConathy, Charles B Nemerof. Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography. Journal of medicinal chemistry. vol 46. issue 6. 2003-04-07. PMID:12620070. |
competition binding in cells stably expressing the transfected human sert, dopamine transporter (dat), and norepinephrine transporter (net) using [(3)h]citalopram, [(3)h]win 35,428, and [(3)h]nisoxetine, respectively, demonstrated the following order of sert affinity (k(i) in nm): zient (0.05) > nor-cit (0.12) >> eient (1.15) > fluvoxamine (1.46). |
2003-04-07 |
2023-08-12 |
human |
| Julia Wellsow, Karl-Artur Kovar, Hans-Jürgen Machull. Molecular modeling of potential new and selective PET radiotracers for the serotonin transporter. Positron Emission Tomography. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 5. issue 3. 2003-03-17. PMID:12553893. |
the main purpose of this study was to design potential new and selective pet radiotracers for the sert and to predict their binding affinity at both the sert and the norepinephrine transporter. |
2003-03-17 |
2023-08-12 |
Not clear |