| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stephen J Kohut, Kathleen L Decicco-Skinner, Shirin Johari, Zachary E Hurwitz, Michael H Baumann, Anthony L Rile. Differential modulation of cocaine's discriminative cue by repeated and variable stress exposure: relation to monoamine transporter levels. Neuropharmacology. vol 63. issue 2. 2012-11-19. PMID:22516586. |
dopamine (dat), serotonin (sert) and norepinephrine (net) transporter levels in mesocorticolimbic areas were also measured using western blotting after stress exposure to determine if the relative ratio of these proteins may explain differences in behavior. |
2012-11-19 |
2023-08-12 |
rat |
| Joel G Anderson, Paula T Cooney, Keith M Erikso. Inhibition of DAT function attenuates manganese accumulation in the globus pallidus. Environmental toxicology and pharmacology. vol 23. issue 2. 2012-10-02. PMID:17387379. |
our primary goal of this study was to examine the potential roles of the monoamine transporters, dopamine transporter (dat), serotonin transporter (sert) and norepinephrine transporter (net), in neuronal mn transport. |
2012-10-02 |
2023-08-12 |
rat |
| Xue Y Zhu, Jagan R Etukala, Suresh V K Eyunni, Vincent Setola, Bryan L Roth, Seth Y Ablordeppe. Benzothiazoles as probes for the 5HT1A receptor and the serotonin transporter (SERT): a search for new dual-acting agents as potential antidepressants. European journal of medicinal chemistry. vol 53. 2012-09-25. PMID:22520153. |
in addition, compound 20 binds with low affinity to the dopamine transporter (dat), the norepinephrine transporter (net) and 5ht(2c) receptor, which are desirable properties as selectivity for sert (and not dat or net) is associated with an absence of cardiovascular side effects. |
2012-09-25 |
2023-08-12 |
Not clear |
| Carmela M Reichel, Lauren A Ramsey, Marek Schwendt, Jacqueline F McGinty, Ronald E Se. Methamphetamine-induced changes in the object recognition memory circuit. Neuropharmacology. vol 62. issue 2. 2012-07-27. PMID:22115899. |
subsequently, transporters for serotonin (sert) and norepinephrine (net) were quantified using western blot in tissue obtained from the hippocampus, perirhinal cortex, and prefrontal cortex. |
2012-07-27 |
2023-08-12 |
human |
| F S Hall, J M Schwarzbaum, M T G Perona, J S Templin, M G Caron, K-P Lesch, D L Murphy, G R Uh. A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. Neuroscience. vol 175. 2012-06-01. PMID:21129446. |
norepinephrine and serotonin involvement in nociceptive functions is supported by observations of analgesic effects of norepinephrine transporter (net) and serotonin transporter (sert) inhibitors such as amitriptyline. |
2012-06-01 |
2023-08-12 |
mouse |
| F S Hall, J M Schwarzbaum, M T G Perona, J S Templin, M G Caron, K-P Lesch, D L Murphy, G R Uh. A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. Neuroscience. vol 175. 2012-06-01. PMID:21129446. |
nonetheless, the necessary exclusion of these subjects because of profound baseline hypoalgesia strongly supports the role of norepinephrine and net in basal nociceptive behavior while indicating a much smaller role for serotonin and sert. |
2012-06-01 |
2023-08-12 |
mouse |
| David L Bourdet, Pamela R Tsuruda, Glenmar P Obedencio, Jacqueline A M Smit. Prediction of human serotonin and norepinephrine transporter occupancy of duloxetine by pharmacokinetic/pharmacodynamic modeling in the rat. The Journal of pharmacology and experimental therapeutics. vol 341. issue 1. 2012-05-04. PMID:22235148. |
the current studies evaluate the ability of a rodent pharmacokinetic/pharmacodynamic (pk/pd) modeling approach to translate ex vivo occupancy determined in rats to that observed after positron emission tomography (pet) imaging in humans for the dual serotonin transporter (sert) and norepinephrine transporter (net) inhibitor duloxetine. |
2012-05-04 |
2023-08-12 |
human |
| Cynthia M Nijenhuis, Peter G J ter Horst, Lolkje T W de Jong-van den Berg, Bob Wilffer. Disturbed development of the enteric nervous system after in utero exposure of selective serotonin re-uptake inhibitors and tricyclic antidepressants. Part 1: Literature review. British journal of clinical pharmacology. vol 73. issue 1. 2012-03-30. PMID:21815911. |
tcas could influence the development of the ens, besides through inhibition of the sert, through inhibition of the norepinephrine transporter (net). |
2012-03-30 |
2023-08-12 |
Not clear |
| Shaine A Cararas, Sari Izenwasser, Dean Wade, Amy Housman, Abha Verma, Stacey A Lomenzo, Mark L Trudel. Further structure-activity relationship studies on 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives at monoamine transporters. Bioorganic & medicinal chemistry. vol 19. issue 24. 2012-03-19. PMID:22055716. |
the synthesis and structure-activity relationships of 8-substituted-3-[2-(diarylmethoxyethylidenyl)]-8-azabicyclo[3.2.1]octane derivatives were investigated at the dopamine transporter (dat), the serotonin transporter (sert) and norepinephrine transporter (net). |
2012-03-19 |
2023-08-12 |
Not clear |
| J-W Tian, W-L Jiang, Y Zhong, Q Meng, Y Gai, H-B Zhu, J Hou, Y Xing, Y-X L. Preclinical pharmacology of TP1, a novel potent triple reuptake inhibitor with antidepressant properties. Neuroscience. vol 196. 2012-02-23. PMID:21925241. |
triple reuptake inhibitors (tris) that block the dopamine transporter (dat), norepinephrine transporter (net), and serotonin transporter (sert) are being developed as a new class of antidepressant that may have better efficacy and fewer side effects compared with traditional antidepressants. |
2012-02-23 |
2023-08-12 |
human |
| Chiharu Sogawa, Norio Sogawa, Kazumi Ohyama, Ruri Kikura-Hanajiri, Yukihiro Goda, Ichiro Sora, Shigeo Kitayam. Methylone and monoamine transporters: correlation with toxicity. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886563. |
we examined here the effects of methylone on the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), using a heterologous expression system in cho cells, in association with its cytotoxicity. |
2011-11-10 |
2023-08-12 |
Not clear |
| Liming Shao, Michael C Hewitt, Scott C Malcolm, Fengjiang Wang, Jianguo Ma, Una C Campbell, Nancy A Spicer, Sharon R Engel, Larry W Hardy, Zhi-Dong Jiang, Rudy Schreiber, Kerry L Spear, Mark A Varne. Synthesis and pharmacological characterization of bicyclic triple reuptake inhibitor 3-aryl octahydrocyclopenta[c]pyrrole analogues. Journal of medicinal chemistry. vol 54. issue 15. 2011-10-07. PMID:21739935. |
the present work expands the chemical space known to offer potent inhibition of the serotonin transporter (sert), norepinephrine transporter (net), and dopamine transporter (dat) and discloses novel bicyclic octahydrocyclopenta[c]pyrrole and octahydro-1h-isoindole scaffolds as potent triple reuptake inhibitors (tris) for the potential treatment of depression. |
2011-10-07 |
2023-08-12 |
mouse |
| Jacob Andersen, Nicolai Stuhr-Hansen, Linda Zachariassen, Søren Toubro, Stinna M R Hansen, Jonas N N Eildal, Andrew D Bond, Klaus P Bøgesø, Benny Bang-Andersen, Anders S Kristensen, Kristian Strømgaar. Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 29. 2011-10-03. PMID:21730142. |
inhibitors of the serotonin transporter (sert) and norepinephrine transporter (net) are widely used in the treatment of major depressive disorder. |
2011-10-03 |
2023-08-12 |
human |
| Stacey J Sukoff Rizzo, Sarah K Leonard, Adam Gilbert, Paul Dollings, Deborah L Smith, Mei-Yi Zhang, Li Di, Brian J Platt, Sarah Neal, Jason M Dwyer, Corey N Bender, Jean Zhang, Tim Lock, Dianne Kowal, Angela Kramer, Andrew Randall, Christine Huselton, Karthick Vishwanathan, Susanna Y Tse, John Butera, Robert H Ring, Sharon Rosenzweig-Lipson, Zoë A Hughes, John Dunlo. The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? The Journal of pharmacology and experimental therapeutics. vol 338. issue 1. 2011-08-30. PMID:21508084. |
in vitro selectivity profiling of met-1 demonstrated physiologically relevant transporter binding affinity at serotonin transporter (sert), dopamine transporter (dat), and norepinephrine transporter (net) (323, 3020, and 3410 nm, respectively); whereas the parent compound amn082 had appreciable affinity at net (1385 nm). |
2011-08-30 |
2023-08-12 |
rat |
| Jingying Liu, Lin Zhu, Karl Plössl, Brian P Lieberman, Hank F Kun. Synthesis and evaluation of novel N-fluoropyridyl derivatives of tropane as potential PET imaging agents for the dopamine transporter. Bioorganic & medicinal chemistry letters. vol 21. issue 10. 2011-08-23. PMID:21458259. |
a series of novel n-fluoropyridyl-containing tropane derivatives were synthesized and their binding affinities for the dopamine transporter (dat), serotonin transporter (sert) and norepinephrine (net) were determined via competitive radioligand binding assays. |
2011-08-23 |
2023-08-12 |
Not clear |
| Bhaskar Gopishetty, Stuart Hazeldine, Soumava Santra, Mark Johnson, Gyan Modi, Solav Ali, Juan Zhen, Maarten Reith, Aloke Dutt. Further structure-activity relationship studies on 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol: identification of compounds with triple uptake inhibitory activity as potential antidepressant agents. Journal of medicinal chemistry. vol 54. issue 8. 2011-07-04. PMID:21446715. |
the novel compounds were tested for their affinities for the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net) in the brain by measuring their potency in inhibiting the uptake of [(3)h]da, [(3)h]5-ht, and [(3)h]ne, respectively. |
2011-07-04 |
2023-08-12 |
rat |
| Teodora-Adriana Perles-Barbacaru, Daniel Procissi, Andrey V Demyanenko, F Scott Hall, George R Uhl, Russell E Jacob. Quantitative pharmacologic MRI: mapping the cerebral blood volume response to cocaine in dopamine transporter knockout mice. NeuroImage. vol 55. issue 2. 2011-06-10. PMID:21185387. |
cocaine acts to block the dopamine, norepinephrine, and serotonin transporters (dat, net, and sert) that clear their respective neurotransmitters from the synapses, helping to terminate cognate neurotransmission. |
2011-06-10 |
2023-08-12 |
mouse |
| Susanna Nencetti, Maria R Mazzoni, Gabriella Ortore, Annalina Lapucci, Janette Giuntini, Elisabetta Orlandini, Irene Banti, Elisa Nuti, Antonio Lucacchini, Gino Giannaccini, Armando Rossell. Synthesis, molecular docking and binding studies of selective serotonin transporter inhibitors. European journal of medicinal chemistry. vol 46. issue 3. 2011-06-02. PMID:21272963. |
with the aim of obtaining compounds possessing high sert selectivity, in the present work we synthesized and studied the inhibition of serotonin (sert), dopamine (dat) and norepinephrine (net) transporters by docking studies and experimental binding measurements of a series of 4-(aryl)piperidin-3-one o-4-benzyl oxime hydrochlorides (1-10) of both e and z configuration. |
2011-06-02 |
2023-08-12 |
Not clear |
| Anja W Fjorback, Heidi K Müller, Jana Haase, Merete K Raarup, Ove Wibor. Modulation of the dopamine transporter by interaction with Secretory Carrier Membrane Protein 2. Biochemical and biophysical research communications. vol 406. issue 2. 2011-05-05. PMID:21295544. |
the monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert) facilitate the homeostatic balance of neurotransmitters in the synaptic cleft and thus, play a fundamental role in regulating neuronal activity. |
2011-05-05 |
2023-08-12 |
Not clear |
| Peng Zhang, George Cyriac, Theresa Kopajtic, Yongfang Zhao, Jonathan A Javitch, Jonathan L Katz, Amy Hauck Newma. Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters. Journal of medicinal chemistry. vol 53. issue 16. 2010-09-16. PMID:20672825. |
to further explore structure-activity relationships at the serotonin transporter (sert), a series of (+/-)-4- and 5-substituted citalopram analogues were designed, synthesized, and evaluated for binding at the sert, dopamine transporter (dat) and norepinephrine transporter (net) in native rodent tissue. |
2010-09-16 |
2023-08-12 |
Not clear |