| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Friederike Matthaeus, Patrick Schloss, Thorsten La. Differential Uptake Mechanisms of Fluorescent Substrates into Stem-Cell-Derived Serotonergic Neurons. ACS chemical neuroscience. vol 6. issue 12. 2016-09-21. PMID:26503837. |
the actions of the neurotransmitters serotonin, dopamine, and norepinephrine are partly terminated by diffusion and in part by their uptake into neurons via the selective, high-affinity transporters for serotonin (sert), dopamine (dat), and norepinephrine (net), respectively. |
2016-09-21 |
2023-08-13 |
Not clear |
| Aaron Janowsky, Dilip K Tosh, Amy J Eshleman, Kenneth A Jacobso. Rigid Adenine Nucleoside Derivatives as Novel Modulators of the Human Sodium Symporters for Dopamine and Norepinephrine. The Journal of pharmacology and experimental therapeutics. vol 357. issue 1. 2016-07-19. PMID:26813929. |
several compounds inhibited or enhanced binding at the norepinephrine transporter (net) and serotonin transporter (sert) and inhibited function in the micromolar range; truncation at the 4'-position in compound 23 allowed for weak inhibition of the sert. |
2016-07-19 |
2023-08-13 |
human |
| Thomas Kirmeier, Ranganath Gopalakrishnan, Vanessa Gormanns, Anna M Werner, Serena Cuboni, Georg C Rudolf, Georg Höfner, Klaus T Wanner, Stephan A Sieber, Ulrike Schmidt, Florian Holsboer, Theo Rein, Felix Hausc. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. PloS one. vol 11. issue 2. 2016-07-14. PMID:26863431. |
to control for this, we evaluated the binding parameters of azidobupramine to known target sites such as the transporters for serotonin (sert), norepinephrine (net), and dopamine (dat). |
2016-07-14 |
2023-08-13 |
Not clear |
| Kadri Andre, Olli Kampman, Ari Illi, Merja Viikki, Eija Setälä-Soikkeli, Nina Mononen, Terho Lehtimäki, Susann Haraldsson, Pasi A Koivisto, Esa Leinone. SERT and NET polymorphisms, temperament and antidepressant response. Nordic journal of psychiatry. vol 69. issue 7. 2016-06-22. PMID:25739526. |
the genetic variations in norepinephrine transporter (net) and serotonin transporter (sert) genes have been associated with personality traits, several psychiatric disorders and the efficacy of antidepressant treatment. |
2016-06-22 |
2023-08-13 |
Not clear |
| Fabio Del Bello, Farhana Sakloth, John S Partilla, Michael H Baumann, Richard A Glenno. Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine. Bioorganic & medicinal chemistry. vol 23. issue 17. 2016-06-20. PMID:26233799. |
here, we prepared n-methyl-(3,4-ethylenedioxyphenyl)-2-aminopropane (edma; 3), both of its optical isomers, and β-keto edma (i.e., edmc; 4) to examine their effects at transporters for serotonin (sert), dopamine (dat), and norepinephrine (net). |
2016-06-20 |
2023-08-13 |
Not clear |
| Jeffrey S Stehouwer, Mark M Goodma. Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine. PET clinics. vol 4. issue 1. 2016-05-10. PMID:20216936. |
this review focuses on the development of fluorine-18 radiolabeled pet tracers for imaging the dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter (net). |
2016-05-10 |
2023-08-12 |
Not clear |
| Barbara Bottalico, Radovan Pilka, Irene Larsson, Bertil Casslen, Karel Marsal, Stefan R Hansso. Plasma membrane and vesicular monoamine transporters in normal endometrium and early pregnancy decidua. Molecular human reproduction. vol 9. issue 7. 2016-04-23. PMID:12802045. |
extracellular monoamine levels are regulated primarily through re-uptake by specific membrane-bound transporter proteins dopamine transporter (dat), norepinephrine transporter (net) and serotonin transporter (sert). |
2016-04-23 |
2023-08-12 |
Not clear |
| Dorte Lassen, Per Damkier, Kim Brøse. The Pharmacogenetics of Tramadol. Clinical pharmacokinetics. vol 54. issue 8. 2016-04-20. PMID:25910878. |
the metabolic enzymes cytochrome p450 (cyp) 3a4, cyp2b6, and cyp2d6 and the various transporters [adenosine triphosphate-binding cassette b1/multidrug resistance 1/p-glycoprotein, organic cation transporter 1, serotonin transporter (sert), norepinephrine transporter (net)] and receptor genes (opioid receptor μ 1 gene) give possible genetic differences that might affect the pharmacokinetics and/or pharmacodynamics of tramadol. |
2016-04-20 |
2023-08-13 |
Not clear |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the efficacy of ce-104 in blocking mat [dopamine transporter (dat), serotonin transporter (sert), and norepinephrine transporter] was determined using in vitro neurotransmitter uptake assay. |
2016-03-04 |
2023-08-13 |
human |
| Yogesh D Aher, Saraswathi Subramaniyan, Bharanidharan Shanmugasundaram, Ajinkya Sase, Sivaprakasam R Saroja, Marion Holy, Harald Höger, Tetyana Beryozkina, Harald H Sitte, Johann J Leban, Gert Lube. A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System. Frontiers in behavioral neuroscience. vol 10. 2016-03-04. PMID:26941626. |
the drug inhibited dopamine (ic50: 27.88 μm) and norepinephrine uptake (ic50: 160.40 μm), but had a negligible effect on sert. |
2016-03-04 |
2023-08-13 |
human |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Monoamine transporter and receptor interaction profiles of novel psychoactive substances: para-halogenated amphetamines and pyrovalerone cathinones. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 3. 2015-12-15. PMID:25624004. |
we tested the potency of these compounds to inhibit the norepinephrine (ne), dopamine (da), and serotonin (5-ht) transporters (net, dat, and sert, respectively) using human embryonic kidney 293 cells that express the respective human transporters. |
2015-12-15 |
2023-08-13 |
human |
| Ole V Mortensen, Sandhya Kortager. Designing modulators of monoamine transporters using virtual screening techniques. Frontiers in pharmacology. vol 6. 2015-10-20. PMID:26483692. |
the plasma-membrane monoamine transporters (mats), including the serotonin (sert), norepinephrine (net) and dopamine (dat) transporters, serve a pivotal role in limiting monoamine-mediated neurotransmission through the reuptake of their respective monoamine neurotransmitters. |
2015-10-20 |
2023-08-13 |
drosophila_melanogaster |
| Stefanie H Grimm, Georg Höfner, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the triple reuptake inhibitor indatraline enabling its quantification in MS Binding Assays. Analytical and bioanalytical chemistry. vol 407. issue 2. 2015-09-28. PMID:25450050. |
we herein present the first lc-ms/ms quantification method for indatraline, a highly potent nonselective inhibitor of the three monoamine transporters (for dopamine, dat; norepinephrine, net; serotonin, sert), and its application to ms binding assays. |
2015-09-28 |
2023-08-13 |
Not clear |
| Luise Liebig, Andreas von Ameln-Mayerhofer, Harald Hentschk. MDMA modulates spontaneous firing of subthalamic nucleus neurons in vitro. Experimental brain research. vol 233. issue 1. 2015-09-10. PMID:25234400. |
effects of mdma on transporters for serotonin (sert) and norepinephrine (net) were investigated by coapplication of the reuptake inhibitors citalopram and desipramine, respectively. |
2015-09-10 |
2023-08-13 |
Not clear |
| Yasemin Karabacak, Sunetra Sase, Yogesh D Aher, Ajinkya Sase, Sivaprakasam R Saroja, Ana Cicvaric, Harald Höger, Michael Berger, Vasiliy Bakulev, Harald H Sitte, Johann Leban, Francisco J Monje, Gert Lube. The effect of modafinil on the rat dopamine transporter and dopamine receptors D1-D3 paralleling cognitive enhancement in the radial arm maze. Frontiers in behavioral neuroscience. vol 9. 2015-09-08. PMID:26347626. |
reuptake inhibition of dopamine, serotonin (sert) and norepinephrine (net) by modafinil was tested. |
2015-09-08 |
2023-08-13 |
rat |
| Bronwyn Kivell, Zeljko Uzelac, Santhanalakshmi Sundaramurthy, Jeyaganesh Rajamanickam, Amy Ewald, Vladimir Chefer, Vanaja Jaligam, Elizabeth Bolan, Bridget Simonson, Balasubramaniam Annamalai, Padmanabhan Mannangatti, Thomas E Prisinzano, Ivone Gomes, Lakshmi A Devi, Lankupalle D Jayanthi, Harald H Sitte, Sammanda Ramamoorthy, Toni S Shippenber. Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism. Neuropharmacology. vol 86. 2015-07-14. PMID:25107591. |
while sala increased dat activity, sala treatment decreased serotonin transporter (sert) activity and had no effect on norepinephrine transporter (net) activity. |
2015-07-14 |
2023-08-13 |
Not clear |
| Mariane Cristovão Bagatin, Camila Santos Suniga Tozatti, Layara Akemi Abiko, Diego Alberto dos Santos Yamazaki, Priscila Rebeca Alves Silva, Leonardo Martins Perego, Elisabeth Aparecida Audi, Flavio Augusto Vicente Seixas, Ernani Abicht Basso, Gisele de Freitas Gauz. Molecular docking and panicolytic effect of 8-prenylnaringenin in the elevated T-maze. Chemical & pharmaceutical bulletin. vol 62. issue 12. 2015-07-14. PMID:25450631. |
to evaluate the interactions of 8-pn with monoamine transporters, a docking study was performed for both the r and s configurations of 8-pn towards sert, norepinephrine (net) and dopamine transporters (dat). |
2015-07-14 |
2023-08-13 |
rat |
| Javier A Urra, Franz Villaroel-Espíndola, Alejandra A Covarrubias, Joan Enric Rodríguez-Gil, Alfredo Ramírez-Reveco, Ilona I Conch. Presence and function of dopamine transporter (DAT) in stallion sperm: dopamine modulates sperm motility and acrosomal integrity. PloS one. vol 9. issue 11. 2015-07-08. PMID:25402186. |
in the present study, using immunodetection methods, we revealed the presence of several proteins important for the dopamine uptake and signalling in mammalian sperm, specifically monoamine transporters as dopamine (dat), serotonin (sert) and norepinephrine (net) transporters in equine sperm. |
2015-07-08 |
2023-08-13 |
Not clear |
| Thomas Steinkellner, Liudmilla Mus, Birgit Eisenrauch, Andreea Constantinescu, Damiana Leo, Lisa Konrad, Mattias Rickhag, Gunnar Sørensen, Evgenia V Efimova, Eryan Kong, Matthäus Willeit, Tatyana D Sotnikova, Oliver Kudlacek, Ulrik Gether, Michael Freissmuth, Daniela D Pollak, Raul R Gainetdinov, Harald H Sitt. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 11. 2015-06-15. PMID:24871545. |
cocaine acts as a blocker at the transporters for dopamine (dat), serotonin (sert), and norepinephrine (net), but amphetamines are substrates that do not only block the uptake of monoamines but also induce substrate efflux by promoting reverse transport. |
2015-06-15 |
2023-08-13 |
mouse |
| Simon D Brandt, Michael H Baumann, John S Partilla, Pierce V Kavanagh, John D Power, Brian Talbot, Brendan Twamley, Olivia Mahony, John O'Brien, Simon P Elliott, Roland P Archer, Julian Patrick, Kuldip Singh, Nicola M Dempster, Simon H Cosbe. Characterization of a novel and potentially lethal designer drug (±)-cis-para-methyl-4-methylaminorex (4,4'-DMAR, or 'Serotoni'). Drug testing and analysis. vol 6. issue 7-8. 2015-03-30. PMID:24841869. |
(±)-cis-4,4'-dmar was a potent, efficacious substrate-type releaser at transporters for dopamine, norepinephrine and serotonin with ec50 values of 8.6 ± 1.1 nm (dat), 26.9 ± 5.9 nm (net) and 18.5 ± 2.8 nm (sert), respectively. |
2015-03-30 |
2023-08-13 |
rat |