| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anna Marie Buchanan, Brenna Parke, Parastoo Hashem. Experimental Methods for Investigating Uptake 2 Processes In Vivo. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34196807. |
uptake 1 describes uptake of the monoamine via its designated transporter (sert for serotonin, net for norepinephrine, and dat for dopamine), whereas uptake 2 details multiple transporter types on neurons and glia taking up different types of modulators, not necessarily specific to the monoamine. |
2021-10-28 |
2023-08-13 |
human |
| Lynette C Daw. Organic Cation Transporters in Psychiatric Disorders. Handbook of experimental pharmacology. vol 266. 2021-10-28. PMID:34282486. |
other classes of antidepressant work by blocking the norepinephrine or dopamine transporters (net and dat), the high-affinity, low-capacity uptake-1 transporters for norepinephrine and dopamine, or by blocking combinations of sert, net, and dat. |
2021-10-28 |
2023-08-13 |
Not clear |
| Shreyas Bhat, Marco Niello, Klaus Schicker, Christian Pifl, Harald H Sitte, Michael Freissmuth, Walter Sandtne. Handling of intracellular K eLife. vol 10. 2021-10-19. PMID:34061030. |
handling of intracellular k the concentrative power of the transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) is thought to be fueled by the transmembrane na |
2021-10-19 |
2023-08-13 |
Not clear |
| Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liecht. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. vol 22. issue 15. 2021-09-08. PMID:34361040. |
we assessed several pyrovalerone and related cathinone derivatives at the human norepinephrine (net), dopamine (dat), and serotonin (sert) uptake transporters using hek293 cells overexpressing each respective transporter. |
2021-09-08 |
2023-08-13 |
human |
| Jean-Louis Montastruc, Vanessa Rousseau, Claire de Canecaude, Anne Roussin, François Montastru. Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study. European journal of clinical pharmacology. vol 76. issue 9. 2021-05-12. PMID:32483650. |
the mechanism remains discussed, some authors suggesting a role of sert (serotonin transporter) inhibition whereas others discussing net (norepinephrine transporter) involvement. |
2021-05-12 |
2023-08-13 |
Not clear |
| Marco Niello, Daniela Cintulová, Philip Raithmayr, Marion Holy, Kathrin Jäntsch, Claire Colas, Gerhard F Ecker, Harald H Sitte, Marko D Mihovilovi. Effects of Hydroxylated Mephedrone Metabolites on Monoamine Transporter Activity Frontiers in pharmacology. vol 12. 2021-04-28. PMID:33897439. |
it elicits the release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2021-04-28 |
2023-08-13 |
Not clear |
| Masaru Ihara, Han Zhang, Mariko O Ihara, Daisuke Kato, Hiroaki Tanak. Proposal for fluorescence-based in vitro assay using human and zebrafish monoamine transporters to detect biological activities of antidepressants in wastewater. The Science of the total environment. vol 770. 2021-03-18. PMID:33513512. |
we used app, a fluorescent substrate for monoamine transporters, to measure the activity of wastewater extracts at inhibiting app uptake through the human serotonin transporter (hsert), norepinephrine transporter (hnet), and dopamine transporter, and the zebrafish sert (zsert). |
2021-03-18 |
2023-08-13 |
human |
| Prerna Jha, Lotten Ragnarsson, Richard J Lewi. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32210813. |
the human norepinephrine transporter (hnet) is a member of the neurotransmitter/sodium symporter family, which also includes the neuronal monoamine transporters for serotonin (sert) and dopamine (dat). |
2020-09-28 |
2023-08-13 |
human |
| Zi-Wen Zhong, Wen-Chang Zhou, Xing-Feng Sun, Qi-Chao Wu, Wan-Kun Chen, Chang-Hong Mia. Dezocine regulates the malignant potential and aerobic glycolysis of liver cancer targeting Akt1/GSK-3β pathway. Annals of translational medicine. vol 8. issue 7. 2020-09-28. PMID:32395524. |
former studies find dezocine inhibits the norepinephrine transporters (net) and serotonin transporters (sert) and sigma-1opioid receptors. |
2020-09-28 |
2023-08-13 |
Not clear |
| Talia Zeppelin, Lucy Kate Ladefoged, Steffen Sinning, Birgit Schiøt. Substrate and inhibitor binding to the serotonin transporter: Insights from computational, crystallographic, and functional studies. Neuropharmacology. vol 161. 2020-07-14. PMID:30807752. |
the serotonin transporter (sert) belongs to the monoamine transporter family, which also includes the dopamine and norepinephrine transporters. |
2020-07-14 |
2023-08-13 |
Not clear |
| Donna Walther, Abdelrahman R Shalabi, Michael H Baumann, Richard A Glenno. Systematic Structure-Activity Studies on Selected 2-, 3-, and 4-Monosubstituted Synthetic Methcathinone Analogs as Monoamine Transporter Releasing Agents. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30354055. |
to formulate structure-activity relationship (sar) generalities, we examined the releasing ability of several simple methcathinone analogs at the three monoamine transporters (i.e., the dopamine, norepinephrine, and serotonin transporters, dat, net, and sert, respectively) using in vitro assay methods. |
2020-02-18 |
2023-08-13 |
Not clear |
| Anna Rickli, Marius C Hoener, Matthias E Liecht. Pharmacological profiles of compounds in preworkout supplements ("boosters"). European journal of pharmacology. vol 859. 2020-01-28. PMID:31265842. |
we investigated whether substances that are contained in commercially available athletic multiple-ingredient preworkout supplements exert amphetamine-type activity at norepinephrine, dopamine, and serotonin transporters (net, dat, and sert, respectively). |
2020-01-28 |
2023-08-13 |
human |
| Felix P Mayer, Daniela Cintulova, Dorothea A Pittrich, Laurin Wimmer, Dino Luethi, Marion Holy, Kathrin Jaentsch, Sonja Tischberger, Guenter Gmeiner, Marius C Hoener, Matthias E Liechti, Marko D Mihovilovic, Harald H Sitt. Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter. Neuropharmacology. vol 148. 2019-12-27. PMID:30610839. |
mephedrone (4-methyl-n-methylcathinone) is a psychostimulant that promotes release of monoamines via the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-12-27 |
2023-08-13 |
human |
| Felix P Mayer, Diethart Schmid, Marion Holy, Lynette C Daws, Harald H Sitt. "Polytox" synthetic cathinone abuse: A potential role for organic cation transporter 3 in combined cathinone-induced efflux. Neurochemistry international. vol 123. 2019-12-26. PMID:30248432. |
mdpv and mephedrone interfere with the function of the high affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert), resulting in increased extracellular levels of these monoamines, though their mechanism of action differs. |
2019-12-26 |
2023-08-13 |
Not clear |
| Umberto M Battisti, Ramsey Sitta, Alan Harris, Farhana Sakloth, Donna Walther, Iwona Ruchala, S Stevens Negus, Michael H Baumann, Richard A Glennon, Jose M Elti. Effects of N-Alkyl-4-Methylamphetamine Optical Isomers on Plasma Membrane Monoamine Transporters and Abuse-Related Behavior. ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29697951. |
4-methylamphetamine (4-ma) is an emerging drug of abuse that acts as a substrate at plasma membrane transporters for dopamine (dat), norepinephrine (net), and serotonin (sert), thereby causing nonexocytotic release of monoamine transmitters via reverse transport. |
2019-09-30 |
2023-08-13 |
rat |
| Peter S Hasenhuetl, Shreyas Bhat, Felix P Mayer, Harald H Sitte, Michael Freissmuth, Walter Sandtne. A kinetic account for amphetamine-induced monoamine release. The Journal of general physiology. vol 150. issue 3. 2019-09-24. PMID:29439119. |
the plasmalemmal monoamine transporters for dopamine, norepinephrine, and serotonin (sert) are targets for amphetamines. |
2019-09-24 |
2023-08-13 |
Not clear |
| Jose Luiz Costa, Kelly Francisco Cunha, Rafael Lanaro, Ricardo Leal Cunha, Donna Walther, Michael H Bauman. Analytical quantification, intoxication case series, and pharmacological mechanism of action for N-ethylnorpentylone (N-ethylpentylone or ephylone). Drug testing and analysis. vol 11. issue 3. 2019-08-27. PMID:30207090. |
the activity of n-ethylnorpentylone at plasma membrane transporters for dopamine (dat), norepinephrine (net) and 5-ht (sert) was assessed using in vitro assays measuring uptake inhibition and evoked release of [ |
2019-08-27 |
2023-08-13 |
human |
| J A Suyama, M L Banks, S S Negu. Effects of repeated treatment with methcathinone, mephedrone, and fenfluramine on intracranial self-stimulation in rats. Psychopharmacology. vol 236. issue 3. 2019-08-27. PMID:30232529. |
synthetic cathinones constitute a class of abused drugs that can act at dopamine, norepinephrine, and serotonin transporters (dat, net, and sert, respectively). |
2019-08-27 |
2023-08-13 |
rat |
| Brenda M Gannon, Michael H Baumann, Donna Walther, Cristian Jimenez-Morigosa, Agnieszka Sulima, Kenner C Rice, Gregory T Collin. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 43. issue 12. 2019-03-11. PMID:30305739. |
synthetic cathinones are common constituents of abused "bath salts" preparations and represent a large family of structurally related compounds that function as cocaine-like inhibitors or amphetamine-like substrates of dopamine (dat), norepinephrine (net), and serotonin (sert) transporters. |
2019-03-11 |
2023-08-13 |
rat |
| Julian Maier, Felix P Mayer, Dino Luethi, Marion Holy, Kathrin Jäntsch, Harald Reither, Lena Hirtler, Marius C Hoener, Matthias E Liechti, Christian Pifl, Simon D Brandt, Harald H Sitt. The psychostimulant (±)-cis-4,4'-dimethylaminorex (4,4'-DMAR) interacts with human plasmalemmal and vesicular monoamine transporters. Neuropharmacology. vol 138. 2019-02-13. PMID:29908239. |
we used in vitro uptake inhibition and transporter release assays to determine the effects of 4,4'-dmar on human high-affinity transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2019-02-13 |
2023-08-13 |
human |