| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rheaclare Fraser-Spears, Anwen M Krause-Heuer, Mohamed Basiouny, Felix P Mayer, Retrouvailles Manishimwe, Naomi A Wyatt, Jeremy C Dobrowolski, Maxine P Roberts, Ivan Greguric, Naresh Kumar, Wouter Koek, Harald H Sitte, Paul D Callaghan, Benjamin H Fraser, Lynette C Daw. Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter. European journal of pharmacology. vol 842. 2019-02-04. PMID:30473490. |
here, we extend these findings to determine the affinity of these analogs for oct2, oct3 and pmat, as well as serotonin, norepinephrine and dopamine transporters (sert, net and dat) using a combination of uptake competition with [ |
2019-02-04 |
2023-08-13 |
mouse |
| Felix P Mayer, Nadine V Burchardt, Ann M Decker, John S Partilla, Yang Li, Gavin McLaughlin, Pierce V Kavanagh, Walter Sandtner, Bruce E Blough, Simon D Brandt, Michael H Baumann, Harald H Sitt. Fluorinated phenmetrazine "legal highs" act as substrates for high-affinity monoamine transporters of the SLC6 family. Neuropharmacology. vol 134. issue Pt A. 2018-11-07. PMID:28988906. |
here we tested 3-fpm and its positional isomers, 2-fpm and 4-fpm, for their abilities to interact with plasma membrane monoamine transporters for dopamine (dat), norepinephrine (net) and serotonin (sert). |
2018-11-07 |
2023-08-13 |
Not clear |
| Martina Kristofova, Yogesh D Aher, Marija Ilic, Bojana Radoman, Predrag Kalaba, Vladimir Dragacevic, Nilima Y Aher, Johann Leban, Volker Korz, Lisa Zanon, Winfried Neuhaus, Marcus Wieder, Thierry Langer, Ernst Urban, Harald H Sitte, Harald Hoeger, Gert Lubec, Jana Aradsk. A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval. Behavioural brain research. vol 343. 2018-09-18. PMID:29410048. |
ce-123 blocked uptake of [3h] dopamine (ic50 = 4.606 μm) while effects on serotonin (sert) and the norepinephrine transporter (net) were negligible. |
2018-09-18 |
2023-08-13 |
human |
| Shaili Aggarwal, Ole V Mortense. Overview of Monoamine Transporters. Current protocols in pharmacology. vol 79. 2018-07-26. PMID:29261228. |
the dopamine (dat), serotonin (sert), and norepinephrine (net) transporters, which are collectively referred to as monoamine transporters (mats), play significant roles in regulating the neuronal response to these neurotransmitters. |
2018-07-26 |
2023-08-13 |
Not clear |
| Patrick Neiens, Angela De Simone, Anna Ramershoven, Georg Höfner, Lars Allmendinger, Klaus T Wanne. Development and validation of an LC-ESI-MS/MS method for the quantification of D-84, reboxetine and citalopram for their use in MS Binding Assays addressing the monoamine transporters hDAT, hSERT and hNET. Biomedical chromatography : BMC. vol 32. issue 7. 2018-06-25. PMID:29500932. |
in this study, we present an lc-esi-ms/ms method for the quantification of (r,r)-4-(2-benzhydryloxyethyl)-1-(4-fluorobenzyl)piperidin-3-ol [(r,r)-d-84, (r,r)-1], (s,s)-reboxetine [(s,s)-2], and (s)-citalopram [(s)-3] employed as highly selective nonlabeled reporter ligands in ms binding assays addressing the dopamine [dat, (r,r)-d-84], norepinephrine [net, (s,s)-reboxetine] and serotonin transporter [sert, (s)-citalopram], respectively. |
2018-06-25 |
2023-08-13 |
Not clear |
| Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhee. Differential effects of perinatal exposure to antidepressants on learning and memory, acoustic startle, anxiety, and open-field activity in Sprague-Dawley rats. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 61. 2018-05-18. PMID:28655626. |
selective serotonin (5-ht) reuptake inhibitors (ssris) act on the 5-ht transporter (sert) whereas norepinephrine-dopamine reuptake inhibitors (ndris) act on the norepinephrine and dopamine transporters. |
2018-05-18 |
2023-08-13 |
rat |
| Ernesto Solis, John S Partilla, Farhana Sakloth, Iwona Ruchala, Kathryn L Schwienteck, Louis J De Felice, Jose M Eltit, Richard A Glennon, S Stevens Negus, Michael H Bauman. N-Alkylated Analogs of 4-Methylamphetamine (4-MA) Differentially Affect Monoamine Transporters and Abuse Liability. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 42. issue 10. 2018-04-24. PMID:28530234. |
clandestine chemists synthesize novel stimulant drugs by exploiting structural templates known to target monoamine transporters for dopamine, norepinephrine, and serotonin (dat, net, and sert, respectively). |
2018-04-24 |
2023-08-13 |
rat |
| Jia Zhang, Yan Fan, Muhammad U Raza, Yanqiang Zhan, Xiang-Dong Du, Paresh D Patel, Meng-Yang Zh. The regulation of corticosteroid receptors in response to chronic social defeat. Neurochemistry international. vol 108. 2018-04-13. PMID:28577990. |
our previous studies demonstrated that chronic social defeat (csd) up-regulated expression of the serotonin transporter (sert) and norepinephrine transporter (net) in the brain, which was mediated by corticosteroid receptors. |
2018-04-13 |
2023-08-13 |
Not clear |
| Suraj Adhikary, Daniel J Deredge, Anu Nagarajan, Lucy R Forrest, Patrick L Wintrode, Satinder K Sing. Conformational dynamics of a neurotransmitter:sodium symporter in a lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 10. 2018-04-10. PMID:28223522. |
the symporters for the biogenic amines serotonin (sert), dopamine (dat), and norepinephrine (net) are targets of multiple psychoactive agents, and their dysfunction has been implicated in numerous neuropsychiatric ailments. |
2018-04-10 |
2023-08-13 |
Not clear |
| Xiaolei Pan, Kavita A Iyer, Hebing Liu, Douglas H Sweet, Małgorzata Duka. A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorganic & medicinal chemistry letters. vol 27. issue 18. 2017-09-15. PMID:28811134. |
the serotonin or norepinephrine transporters; sert and net, respectively). |
2017-09-15 |
2023-08-13 |
human |
| Gavin McLaughlin, Noreen Morris, Pierce V Kavanagh, John D Power, Geraldine Dowling, Brendan Twamley, John O'Brien, Brian Talbot, Donna Walther, John S Partilla, Michael H Baumann, Simon D Brand. Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone. Drug testing and analysis. vol 9. issue 3. 2017-07-18. PMID:27524685. |
all three substances were also studied for their uptake and releasing properties at dopamine transporters (dat), norepinephrine transporters (net) and serotonin transporters (sert) using in vitro monoamine transporter assays in rat brain synaptosomes and compared to mephedrone. |
2017-07-18 |
2023-08-13 |
rat |
| S Stevens Negus, Matthew L Bank. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure-Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs. Current topics in behavioral neurosciences. vol 32. 2017-07-11. PMID:27696217. |
many cathinone analogs act as substrates or inhibitors at dopamine, norepinephrine, and serotonin transporters (dat, net, sert, respectively). |
2017-07-11 |
2023-08-13 |
rat |
| Melissa M Conti, Samantha M Meadows, Mitchell Melikhov-Sosin, David Lindenbach, Joy Hallmark, David F Werner, Christopher Bisho. Monoamine transporter contributions to l-DOPA effects in hemi-parkinsonian rats. Neuropharmacology. vol 110. issue Pt A. 2017-07-10. PMID:27452719. |
serotonin and norepinephrine transporters (sert and net, respectively) have affinity for dopamine uptake especially when dopamine transporters (dat) are scant. |
2017-07-10 |
2023-08-13 |
rat |
| Samantha E Yohn, Emily E Errante, Aaron Rosenbloom-Snow, Matthew Somerville, Margaret Rowland, Kristin Tokarski, Nadia Zafar, Merce Correa, John D Salamon. Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology. Neuropharmacology. vol 109. 2017-06-19. PMID:27329556. |
the present studies investigated the ability of drugs that block dopamine transport (dat), norepinephrine transport (net), and serotonin transport (sert) to modulate work output in rats responding on a test of effort-related decision making (i.e., a progressive ratio (prog)/chow feeding choice task). |
2017-06-19 |
2023-08-13 |
rat |
| Victoria S Marshe, Malgorzata Maciukiewicz, Soham Rej, Arun K Tiwari, Etienne Sibille, Daniel M Blumberger, Jordan F Karp, Eric J Lenze, Charles F Reynolds, James L Kennedy, Benoit H Mulsant, Daniel J Mülle. Norepinephrine Transporter Gene Variants and Remission From Depression With Venlafaxine Treatment in Older Adults. The American journal of psychiatry. vol 174. issue 5. 2017-06-19. PMID:28068779. |
the primary objective of this study was to investigate five putatively functional variants of the norepinephrine transporter (slc6a2, net) and serotonin transporter (slc6a4, sert) genes and remission in depressed older adults treated with venlafaxine. |
2017-06-19 |
2023-08-13 |
Not clear |
| Blake A Hutsell, Michael H Baumann, John S Partilla, Matthew L Banks, Rakesh Vekariya, Richard A Glennon, S Stevens Negu. Abuse-related neurochemical and behavioral effects of cathinone and 4-methylcathinone stereoisomers in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 26. issue 2. 2016-12-13. PMID:26738428. |
for neurochemical studies, drug effects were evaluated on monoamine release through dopamine, norepinephrine, and serotonin transporters (dat, net and sert, respectively) in rat brain synaptosomes. |
2016-12-13 |
2023-08-13 |
rat |
| Louis J De Felic. Chloride requirement for monoamine transporters. Pflugers Archiv : European journal of physiology. vol 468. issue 3. 2016-11-04. PMID:26794730. |
this review focuses on the cl(-) requirement for dopamine, serotonin, and norepinephrine (da, 5-ht, and ne) transport and induced current via the transporters for these transmitters, dat, sert, and net. |
2016-11-04 |
2023-08-13 |
Not clear |
| Melissa M Conti, Adam A A Goldenberg, Alexandra Kuberka, Mohamed Mohamed, Satie Eissa, David Lindenbach, Christopher Bisho. Effect of tricyclic antidepressants on L-DOPA-induced dyskinesia and motor improvement in hemi-parkinsonian rats. Pharmacology, biochemistry, and behavior. vol 142. 2016-10-31. PMID:26791104. |
therefore, in order to examine the differential roles of monoamine transporters in l-dopa's behavioral effects, three tricyclic antidepressants (tca) with graded affinity for serotonin (sert) vs. norepinephrine (net) transporters were tested in hemi-parkinsonian rats: clomipramine (sert>net), amitriptyline (sert=net), and desipramine (sert
| 2016-10-31 |
2023-08-13 |
rat |
|
| Ajinkya Sase, Yogesh D Aher, Sivaprakasam R Saroja, Minu Karthika Ganesan, Sunetra Sase, Marion Holy, Harald Höger, Vasiliy Bakulev, Gerhard F Ecker, Thierry Langer, Harald H Sitte, Johann Leban, Gert Lube. A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes. Neuropharmacology. vol 102. 2016-10-07. PMID:26407764. |
binding of ce-103 to the dopamine (dat), serotonin (sert) and norepinephrine (net) transporters and dopamine reuptake inhibition was tested as well as blood brain permeation and a screen for gpcr targets. |
2016-10-07 |
2023-08-13 |
rat |
| Julie A Marusich, Kateland R Antonazzo, Bruce E Blough, Simon D Brandt, Pierce V Kavanagh, John S Partilla, Michael H Bauman. The new psychoactive substances 5-(2-aminopropyl)indole (5-IT) and 6-(2-aminopropyl)indole (6-IT) interact with monoamine transporters in brain tissue. Neuropharmacology. vol 101. 2016-09-22. PMID:26362361. |
here, the monoamine-releasing properties of 5-it, its structural isomer 6-(2-aminopropyl)indole (6-it), and mdma were compared using in vitro release assays at transporters for dopamine (dat), norepinephrine (net), and serotonin (sert) in rat brain synaptosomes. |
2016-09-22 |
2023-08-13 |
mouse |