| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Colette A Steinegger, Niklaus Zoelch, Andreas Hock, Anke Henning, Etna J E Engeli, Erich Seifritz, Lea M Hulka, Marcus Herdene. Neurometabolic alterations in the nucleus accumbens of smokers assessed with Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33825270. |
recent findings in animal models highlight the role of alterations in glutamatergic projections from the prefrontal cortex onto the nucleus accumbens (nac) in relapse vulnerability. |
2021-11-10 |
2023-08-13 |
Not clear |
| Suchan Chang, Yu Fan, Soo Min Lee, Yeonhee Ryu, Bong Hyo Lee, Sang Chan Kim, Kyle B Bills, Scott C Steffensen, Chae Ha Yang, Hee Young Ki. Acupuncture reduces cocaine psychomotor responses by activating the rostromedial tegmental nucleus. Addiction biology. vol 26. issue 6. 2021-11-10. PMID:33969586. |
while previous studies have demonstrated that acupuncture modulates da transmission in the mesolimbic reward system originating in the ventral tegmental area (vta) and projecting to the nucleus accumbens (nac) and can reduce drug self-administration, the central links between peripheral acupuncture signals and brain reward systems are not well-characterized. |
2021-11-10 |
2023-08-13 |
Not clear |
| Rebecca S Hofford, Nicholas L Mervosh, Tanner J Euston, Katherine R Meckel, Amon T Orr, Drew D Kiral. Alterations in microbiome composition and metabolic byproducts drive behavioral and transcriptional responses to morphine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 12. 2021-11-10. PMID:34127799. |
here we show that male mice with their gut microbiome depleted by nonabsorbable antibiotics (abx) exhibit decreased formation of morphine conditioned place preference across a range of doses (2.5-15 mg/kg), have decreased locomotor sensitization to morphine, and demonstrate marked changes in gene expression within the nucleus accumbens (nac) in response to high-dose morphine (20 mg/kg × 7 days). |
2021-11-10 |
2023-08-13 |
mouse |
| Anna Maria Borruto, Yannick Fotio, Serena Stopponi, Michele Petrella, Sara De Carlo, Ana Domi, Massimo Ubaldi, Friedbert Weiss, Roberto Ciccociopp. NOP receptor antagonism attenuates reinstatement of alcohol-seeking through modulation of the mesolimbic circuitry in male and female alcohol-preferring rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 12. 2021-11-10. PMID:34285372. |
we then investigated the effects of ly2817412 (1.0, 3.0, 6.0 μg/μl/rat) microinjected into three candidate mesolimbic brain regions: the ventral tegmental area (vta), the central nucleus of the amygdala (cea), and the nucleus accumbens (nac). |
2021-11-10 |
2023-08-13 |
rat |
| Munir Gunes Kutlu, Jennifer E Zachry, Patrick R Melugin, Stephanie A Cajigas, Maxime F Chevee, Shannon J Kelly, Banu Kutlu, Lin Tian, Cody A Siciliano, Erin S Calipar. Dopamine release in the nucleus accumbens core signals perceived saliency. Current biology : CB. vol 31. issue 21. 2021-11-10. PMID:34529938. |
a large body of work has aimed to define the precise information encoded by dopaminergic projections innervating the nucleus accumbens (nac). |
2021-11-10 |
2023-08-13 |
mouse |
| Loreto S San Martin, Lorena Armijo-Weingart, Anibal Araya, Gonzalo E Yévenes, Robert J Harvey, Luis G Aguay. Contribution of GlyR α3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. Frontiers in molecular neuroscience. vol 14. 2021-11-10. PMID:34744627. |
recent data from several laboratories have shown that glyrs are expressed in the brain reward circuitry and that α1 and α2 are the principal subunits expressed in the nucleus accumbens (nac). |
2021-11-10 |
2023-08-13 |
Not clear |
| Bai-Chuang Shyu, Zhi-Yue Gao, José Jiun-Shian Wu, Alan Bo Han He, Cai-N Cheng, Andrew Chih Wei Huan. Methamphetamine and Modulation Functionality of the Prelimbic Cortex for Developing a Possible Treatment of Alzheimer's Disease in an Animal Model. Frontiers in aging neuroscience. vol 13. 2021-11-10. PMID:34744692. |
this study examined whether a low dose of mamph can induce conditioned taste aversion (cta) learning, or can increase plasma corticosterone levels, neural activity, and neural plasticity in the medial prefrontal cortex (mpfc) (responsible for cognitive function), the nucleus accumbens (nac) and the amygdala (related to rewarding and aversive emotion), and the hippocampus (responsible for spatial learning). |
2021-11-10 |
2023-08-13 |
rat |
| Jamie L Hanson, Alexia V Williams, Debra A Bangasser, Catherine J Peñ. Impact of Early Life Stress on Reward Circuit Function and Regulation. Frontiers in psychiatry. vol 12. 2021-11-10. PMID:34744836. |
a major component of this risk may be early life stress-induced alterations in motivation and reward processing, mediated by changes in the nucleus accumbens (nac) and ventral tegmental area (vta). |
2021-11-10 |
2023-08-13 |
human |
| Maxine K Loh, J Amiel Rosenkran. Shifts in Medial Orbitofrontal Cortex Activity from Adolescence to Adulthood. Cerebral cortex (New York, N.Y. : 1991). 2021-11-09. PMID:34297804. |
action selection biased by information gathered by the mo is likely carried out by efferents into the nucleus accumbens (nac), which guides reward-directed behaviors. |
2021-11-09 |
2023-08-13 |
rat |
| Michał Sobstyl, Anna Kupryjaniuk, Paweł Mierzejewsk. Nucleus accumbens as a stereotactic target for the treatment of addictions in humans: a literature review. Neurologia i neurochirurgia polska. vol 55. issue 5. 2021-11-09. PMID:34633060. |
more recently, a limited number of basic and clinical studies have indicated that dbs of the nucleus accumbens (nac) and other neighbouring structures of the reward circuit may be an effective intervention for patients with treatment-refractory addiction. |
2021-11-09 |
2023-08-13 |
Not clear |
| Qiang Shan, You Hu, Shijie Chen, Yao Tia. Nucleus accumbens dichotomically controls social dominance in male mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-11-09. PMID:34750567. |
the brain regions associated with this behavior have been intensely investigated, and early neuroimaging research on human subjects implies that the nucleus accumbens (nac) might be involved in encoding social dominance. |
2021-11-09 |
2023-08-13 |
mouse |
| Zhenzhen Chen, Zhenyu Tang, Ke Zou, Zhihong Huang, Liuer Liu, Yuanjian Yang, Wei Wan. D-Serine produces antidepressant-like effects in mice through suppression of BDNF signaling pathway and regulation of synaptic adaptations in the nucleus accumbens. Molecular medicine (Cambridge, Mass.). vol 27. issue 1. 2021-11-08. PMID:34654365. |
the current study aimed to systematically evaluate the role and mechanisms of d-serine in depressive behavior in nucleus accumbens (nac). |
2021-11-08 |
2023-08-13 |
mouse |
| Ming-Shuo Shao, Xiao Yang, Chen-Chun Zhang, Chang-You Jiang, Ying Mao, Wen-Dong Xu, Lan Ma, Fei-Fei Wan. O-GlcNAcylation in Ventral Tegmental Area Dopaminergic Neurons Regulates Motor Learning and the Response to Natural Reward. Neuroscience bulletin. 2021-11-06. PMID:34741260. |
here, we found that injection of thiamet g, an o-glcnacase (oga) inhibitor, in the vta and nucleus accumbens (nac) of mice, facilitated neuronal o-glcnacylation and decreased the operant response to sucrose as well as the latency to fall in rotarod test. |
2021-11-06 |
2023-08-13 |
mouse |
| Jessica Hayes, Bettina Laursen, Elin Eneberg, Jan Kehler, Lars Kyhn Rasmussen, Morten Langgard, Jesper F Bastlund, Todor V Gerdjiko. Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia. Neuropharmacology. vol 186. 2021-11-05. PMID:33444639. |
to address this, we recorded single unit activity in medial prefrontal cortex (mpfc) and nucleus accumbens (nac) in lister hooded rats treated with the pde1b inhibitor lu af64386 and tested in the 5-choice serial reaction time task (5-csrtt). |
2021-11-05 |
2023-08-13 |
rat |
| Conor H Murray, Daniel T Christian, Mike Milovanovic, Jessica A Loweth, Eun-Kyung Hwang, Aaron J Caccamise, Jonathan R Funke, Marina E Wol. mGlu5 function in the nucleus accumbens core during the incubation of methamphetamine craving. Neuropharmacology. vol 186. 2021-11-05. PMID:33444640. |
we used the incubation of drug craving model, in which cue-induced craving progressively intensifies after withdrawal from drug self-administration, to conduct the first studies of the following aspects of mglu5 function in the rat nucleus accumbens (nac) core during abstinence from methamphetamine self-administration: 1) functionality of the major form of synaptic depression in nac medium spiny neurons, which is induced postsynaptically via mglu5 and expressed presynaptically via cannabinoid type 1 receptors (cb1rs), 2) mglu5 surface expression and physical associations between mglu5, homer proteins, and diacylglycerol lipase-α, and 3) the effect of systemic and intra-nac core administration of the mglu5 nam 3-((2-methyl-4-)ethynyl)pyridine (mtep) on expression of incubated methamphetamine craving. |
2021-11-05 |
2023-08-13 |
rat |
| Mohit Kumar, Jennifer R Rainville, Kori Williams, Joshua A Lile, Georgia E Hodes, Fair M Vassoler, Jill R Turne. Sexually dimorphic neuroimmune response to chronic opioid treatment and withdrawal. Neuropharmacology. vol 186. 2021-11-05. PMID:33485944. |
in contrast, reduced levels of pro-inflammatory cytokines/chemokines (il-1β, il-6, il-9, il-12, ccl11) was observed in the nucleus accumbens (nac) of oxycodone and withdrawal-treated males as compared to female mice. |
2021-11-05 |
2023-08-13 |
mouse |
| Kunjumon Ittira Vadakka. Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens. World journal of psychiatry. vol 11. issue 10. 2021-11-05. PMID:34733636. |
the actual mechanism is expected to explain several disparate findings in nucleus accumbens (nac), a brain region associated with pleasure, in an interconnected manner. |
2021-11-05 |
2023-08-13 |
Not clear |
| Rocío Guerrero-Bautista, Aurelio Franco-García, Juana M Hidalgo, Francisco Fernández-Gómez, M Victoria Milanés, Cristina Núñe. Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP. Journal of psychopharmacology (Oxford, England). vol 34. issue 11. 2021-11-04. PMID:32648812. |
cocaine may cause persistent changes in the brain, which are more apparent in da transporter (dat) and da receptor availability within the nucleus accumbens (nac). |
2021-11-04 |
2023-08-13 |
Not clear |
| You-Hsin Lin, Yukie Yamahashi, Keisuke Kuroda, Md Omar Faruk, Xinjian Zhang, Kiyofumi Yamada, Akihiro Yamanaka, Taku Nagai, Kozo Kaibuch. Accumbal D2R-medium spiny neurons regulate aversive behaviors through PKA-Rap1 pathway. Neurochemistry international. vol 143. 2021-11-04. PMID:33301817. |
the nucleus accumbens (nac) plays a crucial role in various mental activities, including positive and negative reinforcement. |
2021-11-04 |
2023-08-13 |
mouse |
| Fei Zeng, Qiaosheng Zhang, Yaling Liu, Guanghao Sun, Anna Li, Robert S Talay, Jing Wan. AMPAkines potentiate the corticostriatal pathway to reduce acute and chronic pain. Molecular brain. vol 14. issue 1. 2021-11-04. PMID:33653395. |
specifically, the projection from the prelimbic cortex (pl) to the nucleus accumbens (nac) has been shown to regulate sensory and affective aspects of pain in a number of rodent models. |
2021-11-04 |
2023-08-13 |
rat |