| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Ademar, Lisa Ulenius, Anna Loftén, Bo Söderpalm, Louise Adermark, Mia Ericso. Separate mechanisms regulating accumbal taurine levels during baseline conditions and following ethanol exposure in the rat. Scientific reports. vol 14. issue 1. 2024-10-15. PMID:39406746. |
ethanol-induced dopamine release in the nucleus accumbens (nac) is associated with reward and reinforcement, and for ethanol to elevate nac dopamine levels, a simultaneous increase in endogenous taurine is required within the same brain region. |
2024-10-15 |
2024-10-18 |
rat |
| Ryan Logan, Micah Shelton, Nicole Horan, Xiangning Xue, Lisa Maturin, Darrell Eacret, Julie Michaud, Navsharan Singh, Benjamin Williams, Mackenzie Gamble, Joseph Seggio, Madeline Kuppe-Fish, BaDoi Phan, George Tseng, Julie Blendy, Leah Solberg Woods, Abraham Palmer, Olivier George, Marianne Sene. Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains. Research square. 2024-10-14. PMID:39399686. |
we compared molecular alterations in the nucleus accumbens (nac) and dorsolateral prefrontal cortex (dlpfc) between humans with oud and rodent models across distinct stages of opioid use and withdrawal (acute and prolonged) using differential gene expression and network-based approaches. |
2024-10-14 |
2024-10-16 |
mouse |
| Jianhong Zhou, Di Luo, Yingjie An, Yuan Gao, Jichuan Zhang, Yanmei Che. Olfactory dysfunction decreased local field potential in the reward system and increased EtOH consumption in mice. Neurochemistry international. 2024-10-11. PMID:39393425. |
we also recorded local field potentials (lfps) from the brain reward system, the ventral tegmental area (vta), nucleus accumbens (nac), and piriform cortex (pir) one and four weeks after the induction of olfactory epithelium lesions using zinc sulfate (znso |
2024-10-11 |
2024-10-14 |
mouse |
| Caryn Willis, Julie D White, Melyssa S Minto, Bryan C Quach, Shizhong Han, Ran Tao, Joo Heon Shin, Amy Deep-Soboslay, Thomas M Hyde, R Dayne Mayfield, Bradley T Webb, Eric O Johnson, Joel E Kleinman, Laura J Bierut, Dana B Hancoc. Gene expression differences associated with alcohol use disorder in human brain. Molecular psychiatry. 2024-10-11. PMID:39394458. |
to improve understanding of neurobiological mechanisms associated with alcohol use disorder (aud) in humans, we compared gene expression data from deceased individuals with and without aud across two addiction-relevant brain regions: the nucleus accumbens (nac) and dorsolateral prefrontal cortex (dlpfc). |
2024-10-11 |
2024-10-14 |
human |
| Jakub Skałbania, Łukasz Tanajewski, Marcin Furtak, Todd A Hare, Marek Wypyc. Pre-choice midbrain fluctuations affect self-control in food choice: A functional magnetic resonance imaging (fMRI) study. Cognitive, affective & behavioral neuroscience. 2024-10-08. PMID:39379768. |
the brain regions of interest (rois) were the ventral tegmental area (vta), putamen, nucleus accumbens (nac), and caudate nucleus. |
2024-10-08 |
2024-10-11 |
human |
| Leanne M Holt, Trevonn M Gyles, Eric M Parise, Angelica Minier-Toribio, Matthew Rivera, Tamara Markovic, Szu-Ying Yeh, Eric J Nestle. Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress. Biological psychiatry. 2024-10-06. PMID:39369762. |
despite this, little is known about the transcriptional responses to stress of astrocytes within the nucleus accumbens (nac), a key brain reward region, and their influence on behavioral outcomes. |
2024-10-06 |
2024-10-09 |
human |
| Philipp Mews, Yentl Van der Zee, Ashik Gurung, Molly Estill, Rita Futamura, Hope Kronman, Aarthi Ramakrishnan, Meagan Ryan, Abner A Reyes, Benjamin A Garcia, Caleb J Browne, Simone Sidoli, Li Shen, Eric J Nestle. Cell type-specific epigenetic priming of gene expression in nucleus accumbens by cocaine. Science advances. vol 10. issue 40. 2024-10-04. PMID:39365860. |
here, we describe an epigenetic mechanism whereby chronic cocaine exposure causes lasting chromatin and downstream transcriptional modifications in the nucleus accumbens (nac), a critical brain region controlling motivation. |
2024-10-04 |
2024-10-07 |
Not clear |
| Ji Zhou, Sebastian Hormigo, Muhammad S Sajid, Manuel A Castro-Alamanco. Role of the nucleus accumbens in signaled avoidance actions. eNeuro. 2024-09-30. PMID:39349060. |
current circuit models of avoidance behaviors indicate that the nucleus accumbens (nac) in the ventral striatum plays a key role in signaled avoidance behaviors, but the nature of this engagement is unclear. |
2024-09-30 |
2024-10-03 |
mouse |
| Kanghoon Jung, Sarah Krüssel, Sooyeon Yoo, Myungmo An, Benjamin Burke, Nicholas Schappaugh, Youngjin Choi, Zirong Gu, Seth Blackshaw, Rui M Costa, Hyung-Bae Kwo. Dopamine-mediated formation of a memory module in the nucleus accumbens for goal-directed navigation. Nature neuroscience. 2024-09-28. PMID:39333785. |
dopaminergic neurons in the ventral tegmental area and their projection to the nucleus accumbens (nac) encode safety signals associated with the shelter. |
2024-09-28 |
2024-10-01 |
mouse |
| Huiru Li, Yi Lu, Wei Xie, Junjie Ye, Qing Wang, Zhenguang Zhang, Yuanming Jiang, Zongfang L. Altered structure and functional connection of subcortical gray matter in female patients with classical trigeminal neuralgia. Brain imaging and behavior. 2024-09-28. PMID:39340625. |
we analyzed the volume and shape of subcortical gray matter (gm), and the functional connectivity (fc) between the accumbens nucleus (nac) and whole brain in right and left ctn patients respectively. |
2024-09-28 |
2024-10-01 |
human |
| Yuran Feng, Jiaxue Sun, Tao Wang, Yu Zheng, Yi Zhao, Youzhuo Li, Shishi Lai, Yu Xu, Mei Zh. Focused Ultrasound Combined With Microbubbles Attenuate Symptoms in Heroin-Addicted Mice. Ultrasound in medicine & biology. 2024-09-24. PMID:39317628. |
to explore the efficacy and mechanisms of stimulating the nucleus accumbens (nac) in heroin-addicted mice using focused ultrasound and microbubbles (mbs). |
2024-09-24 |
2024-09-27 |
mouse |
| Chloé Arrondeau, Ginna Urueña-Méndez, Florian Marchessaux, Raphaël Goutaudier, Nathalie Ginovar. Activation of the mPFC-NAc Pathway Reduces Motor Impulsivity but Does Not Affect Risk-Related Decision-Making in Innately High-Impulsive Male Rats. Journal of neuroscience research. vol 102. issue 9. 2024-09-24. PMID:39314180. |
in rodents, the medial prefrontal cortex (mpfc) and nucleus accumbens (nac) have been separately implicated in impulsive behaviors, but studies on the specific role of the mpfc-nac pathway in these behaviors are limited. |
2024-09-24 |
2024-09-26 |
rat |
| Sara N Bramlett, Stephanie L Foster, David Weinshenker, John R Heple. Endogenous Regulator of G protein Signaling 14 (RGS14) suppresses cocaine-induced emotionally motivated behaviors in female mice. bioRxiv : the preprint server for biology. 2024-09-24. PMID:39314405. |
we report that rgs14 is strongly expressed in discrete regions of the ventral striatum and extended amygdala in wild-type mice, and is co-expressed with d1 and d2 dopamine receptors in neurons of the nucleus accumbens (nac). |
2024-09-24 |
2024-09-26 |
mouse |
| Austin Y Feng, Daniel A N Barbosa, Austen B Casey, Daniel R Rijsketic, Juliana S Salgado, Harvey Huang, Robert C Malenka, Dora Hermes, Kai J Miller, Casey H Halpern, Boris D Heifet. Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS. bioRxiv : the preprint server for biology. 2024-09-24. PMID:39314466. |
nucleus accumbens (nac) deep brain stimulation (dbs) has been increasingly explored as a treatment modality for refractory neuropsychiatric disorders. |
2024-09-24 |
2024-09-26 |
mouse |
| Hezhi Yan, Zhaosong Chu, Zonglin Shen, Lijin Yuan, Yanru Wu, Yi Lu, Hongyan Jiang, Xiufeng X. Disrupted functional connectivity of bilateral nucleus accumbens in major depressive disorder with and without melancholic features. Neuroreport. 2024-09-18. PMID:39292961. |
our study aims to explore the differences in functional connectivity in the nucleus accumbens (nac) between patients with melancholic depression and non-melancholic depression (nmd) and their relation to melancholic depression's pathogenesis. |
2024-09-18 |
2024-09-21 |
Not clear |
| Qiaowei Xie, Rohan Dasari, Mark D Namba, Lauren A Buck, Christine M Side, Kyewon Park, Joshua G Jackson, Jacqueline M Barke. Astrocytic Regulation of Cocaine Locomotor Sensitization in EcoHIV Infected Mice. bioRxiv : the preprint server for biology. 2024-09-16. PMID:39282274. |
this includes development of cocaine locomotor sensitization - or increased locomotor responses to the same doses of cocaine - which depends on nucleus accumbens (nac) neural plasticity. |
2024-09-16 |
2024-09-19 |
mouse |
| Rishi Sharma, Meet Parikh, Abigail Chischolm, Deepak Kempuraj, Mahesh Thakka. Dopamine D2 receptors in the accumbal core region mediates the effects of fentanyl on sleep-wakefulness. Neuroscience. 2024-09-14. PMID:39276843. |
recent studies highlight the role of the dopaminergic system of the nucleus accumbens (nac) in s-w regulation, but its specific involvement in mediating fentanyl's effects on s-w remains unexplored. |
2024-09-14 |
2024-09-18 |
mouse |
| Chih-Ting Wu, Diego Gonzalez Magaña, Jacob Roshgadol, Lin Tian, Karen K Rya. Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice. Appetite. 2024-09-11. PMID:39260700. |
we used modern optical sensors for measuring real-time nucleus accumbens (nac) dopamine dynamics during voluntary sucrose consumption, via fiber photometry, in male c57/bl6j mice maintained on low-protein high-carbohydrate (lphc) or control (con) diet for ∼5 weeks. |
2024-09-11 |
2024-09-14 |
mouse |
| Yasuhiro Funahashi, Rijwan Uddin Ahammad, Xinjian Zhang, Emran Hossen, Masahiro Kawatani, Shinichi Nakamuta, Akira Yoshimi, Minhua Wu, Huanhuan Wang, Mengya Wu, Xu Li, Md Omar Faruk, Md Hasanuzzaman Shohag, You-Hsin Lin, Daisuke Tsuboi, Tomoki Nishioka, Keisuke Kuroda, Mutsuki Amano, Yukihiko Noda, Kiyofumi Yamada, Kenji Sakimura, Taku Nagai, Takayuki Yamashita, Shigeo Uchino, Kozo Kaibuch. Signal flow in the NMDA receptor-dependent phosphoproteome regulates postsynaptic plasticity for aversive learning. Science signaling. vol 17. issue 853. 2024-09-10. PMID:39255336. |
structural plasticity of dendritic spines in the nucleus accumbens (nac) is crucial for learning from aversive experiences. |
2024-09-10 |
2024-09-13 |
Not clear |
| Shahid Nazir Wani, Amarjot Kaur Grewal, Heena Khan, Thakur Gurjeet Sing. Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal. Psychopharmacology. 2024-09-10. PMID:39254835. |
chronic cocaine usage leads to synchronized alterations in gene expression, causing modifications in the nucleus accumbens (nac), a vital part of the reward system of the brain. |
2024-09-10 |
2024-09-13 |
Not clear |