| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ningning Guo, Le Zhang, Wei Fan, Liping Bai, Xianwen Zhang, Zhizhou Shi, Jie Ba. Inhibition of Geranylgeranylacetone on cholecystokinin-B receptor, BDNF and dopamine D1 receptor induced by morphine. Biochemical and biophysical research communications. vol 588. 2021-12-23. PMID:34942530. |
morphine leads to addiction by activating dopaminergic rewarding system consisted of the ventral tegmental area (vta) and nucleus accumbens (nac). |
2021-12-23 |
2023-08-13 |
mouse |
| Katrina Y Choe, Richard A I Bethlehem, Martin Safrin, Hongmei Dong, Elena Salman, Ying Li, Valery Grinevich, Peyman Golshani, Laura A DeNardo, Olga Peñagarikano, Neil G Harris, Daniel H Geschwin. Oxytocin normalizes altered circuit connectivity for social rescue of the Cntnap2 knockout mouse. Neuron. 2021-12-21. PMID:34932941. |
notably, chemogenetically triggered release of endogenous oxytocin strongly stimulated the nucleus accumbens (nac), a forebrain nucleus implicated in social reward. |
2021-12-21 |
2023-08-13 |
mouse |
| Zhanglei Dong, Gaolong Zhang, Saiqiong Xiang, Chenchen Jiang, Zhichuan Chen, Yan Li, Bingwu Huang, Wenhua Zhou, Qingquan Lian, Binbin W. The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats. Frontiers in behavioral neuroscience. vol 15. 2021-12-20. PMID:34924971. |
the dopamine d1 receptor (d1r) in the nucleus accumbens (nac) was detected to explore the underlying molecular mechanism. |
2021-12-20 |
2023-08-13 |
rat |
| Nitsan Goldstein, Jamie R E Carty, J Nicholas Betle. Specificity of varenicline in blocking mesolimbic circuit activation to natural and drug rewards. Neuroscience. 2021-12-19. PMID:34923039. |
varenicline is an approved smoking cessation drug that has been shown to block nicotine-evoked da increases in the nucleus accumbens (nac) through action on nicotinic acetylcholine receptors. |
2021-12-19 |
2023-08-13 |
mouse |
| Hemmings Wu, Bina Kakusa, Sophie Neuner, Daniel J Christoffel, Boris D Heifets, Robert C Malenka, Casey H Halper. Local accumbens in vivo imaging during deep brain stimulation reveals a strategy-dependent amelioration of hedonic feeding. Proceedings of the National Academy of Sciences of the United States of America. vol 119. issue 1. 2021-12-18. PMID:34921100. |
we used in vivo fiber photometry in wild-type, drd1-cre, and a2a-cre mice to 1) assay subtype-specific medium spiny neuron (msn) activity of the nucleus accumbens (nac) during hedonic feeding of high-fat food, and 2) examine dbs strategy-specific effects on nac activity. |
2021-12-18 |
2023-08-13 |
mouse |
| Kerly Niinep, Kaili Anier, Tony Eteläinen, Petteri Piepponen, Anti Kald. Repeated Ethanol Exposure Alters DNA Methylation Status and Dynorphin/Kappa-Opioid Receptor Expression in Nucleus Accumbens of Alcohol-Preferring AA Rats. Frontiers in genetics. vol 12. 2021-12-13. PMID:34899839. |
our aim was to study the effect of repeated ethanol consumption on epigenetic regulatory enzymes such as dna methyltransferase and demethylase enzymes and whether those changes affected dynorphin/kappa-opioid receptor system in the nucleus accumbens (nac). |
2021-12-13 |
2023-08-13 |
rat |
| Kevin Clare, Chelsea Pan, Gloria Kim, Kicheon Park, Juan Zhao, Nora D Volkow, Zhicheng Lin, Congwu D. Cocaine Reduces the Neuronal Population While Upregulating Dopamine D2-Receptor-Expressing Neurons in Brain Reward Regions: Sex-Effects. Frontiers in pharmacology. vol 12. 2021-12-12. PMID:33912043. |
here, we investigated changes in the total neuronal density and relative concentration of d2r-expressing neurons in the medial prefrontal cortex (mpfc), dorsal striatum (dstr), nucleus accumbens (nac), and ventral tegmental area (vta) in both male and female mice passively exposed to cocaine for two weeks. |
2021-12-12 |
2023-08-13 |
mouse |
| Daniel J Christoffel, Jessica J Walsh, Paul Hoerbelt, Boris D Heifets, Pierre Llorach, Ricardo C Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C Malenk. Selective filtering of excitatory inputs to nucleus accumbens by dopamine and serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 24. 2021-12-11. PMID:34103400. |
the detailed mechanisms by which dopamine (da) and serotonin (5-ht) act in the nucleus accumbens (nac) to influence motivated behaviors in distinct ways remain largely unknown. |
2021-12-11 |
2023-08-13 |
Not clear |
| Daicia C Allen, Vanessa A Jimenez, Timothy L Carlson, Nicole A Walter, Kathleen A Grant, Verginia C Cuzon Carlso. Characterization of DREADD receptor expression and function in rhesus macaques trained to discriminate ethanol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2021-12-11. PMID:34654906. |
this study used a dreadd approach to query the role of the nucleus accumbens (nac) in mediating the interoceptive effects of 1.0 g/kg ethanol (i.g.) |
2021-12-11 |
2023-08-13 |
human |
| Renchao Chen, Timothy R Blosser, Mohamed N Djekidel, Junjie Hao, Aritra Bhattacherjee, Wenqiang Chen, Luis M Tuesta, Xiaowei Zhuang, Yi Zhan. Decoding molecular and cellular heterogeneity of mouse nucleus accumbens. Nature neuroscience. vol 24. issue 12. 2021-12-11. PMID:34663959. |
the nucleus accumbens (nac) plays an important role in regulating multiple behaviors, and its dysfunction has been linked to many neural disorders. |
2021-12-11 |
2023-08-13 |
mouse |
| Alain Oros-González, Itzell Alejandrina Gallardo-Ortíz, Sergio Montes, Leonardo Del Valle-Mondragón, Nayeli Páez-Martíne. Captopril and losartan attenuate behavioural sensitization in mice chronically exposed to toluene. Behavioural brain research. vol 418. 2021-12-11. PMID:34757000. |
at the end of the behavioural studies, animal brains were harvested and ang ii/ang-(1-7) and ang-(1-7)/ang ii ratios were analysed in the nucleus accumbens (nac) and prefrontal cortex (pfcx). |
2021-12-11 |
2023-08-13 |
mouse |
| Travis M Moschak, Regina M Carell. An opposing role for prelimbic cortical projections to the nucleus accumbens core in incubation of craving for cocaine versus water. Drug and alcohol dependence. vol 228. 2021-12-10. PMID:34500244. |
although this phenomenon involves many brain regions, the projections from the prelimbic cortex (prl) to the nucleus accumbens (nac) core have been strongly implicated in incubation of cocaine-seeking. |
2021-12-10 |
2023-08-13 |
Not clear |
| Nurul H M Yusoff, Zurina Hassan, Vikneswaran Murugaiyah, Christian P Mülle. The effect of mitragynine on extracellular activity of brain dopamine and its metabolites. Brain research bulletin. vol 178. 2021-12-09. PMID:34774992. |
affects extracellular activity of dopamine (da) and its metabolites, 3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the prefrontal cortex (pfc), nucleus accumbens (nac) and caudate putamen (cpu) of the brain, compared to morphine (mor; 10 mg/kg, i.p.) |
2021-12-09 |
2023-08-13 |
rat |
| Sinan Canpolat, Nazife Ulker, Ahmet Yardimci, Emre Tancan, Elif Sahin, Serap Ozer Yaman, Ozgur Bulmuş, Ahmet Alver, Mete Ozca. Irisin ameliorates male sexual dysfunction in paroxetine-treated male rats. Psychoneuroendocrinology. vol 136. 2021-12-09. PMID:34861466. |
the significantly reduced serum testosterone levels and α1-adrenoceptors (adra1a) and tyrosine hydroxylase gene (th) expression levels in the nucleus accumbens (nac) in paroxetine-induced sexually dysfunctioning male rats were markedly increased following irisin exposure. |
2021-12-09 |
2023-08-13 |
rat |
| Md Omar Faruk, Daisuke Tsuboi, Yukie Yamahashi, Yasuhiro Funahashi, You-Hsin Lin, Rijwan Uddin Ahammad, Emran Hossen, Mutsuki Amano, Tomoki Nishioka, Anastasios V Tzingounis, Kiyofumi Yamada, Taku Nagai, Kozo Kaibuch. Muscarinic signaling regulates voltage-gated potassium channel KCNQ2 phosphorylation in the nucleus accumbens via protein kinase C for aversive learning. Journal of neurochemistry. 2021-12-08. PMID:34878647. |
the nucleus accumbens (nac) plays critical roles in emotional behaviors, including aversive learning. |
2021-12-08 |
2023-08-13 |
mouse |
| Brandon J Polzin, Sarah A Heimovics, Lauren V Riter. Immunolabeling provides evidence for subregions in the songbird nucleus accumbens and suggests a context-dependent role in song in male European starlings (Sturnus vulgaris). Brain, behavior and evolution. 2021-12-08. PMID:34879382. |
the nucleus accumbens (nac) is a brain region well-known to mediate reward and motivation, which suggests it is an ideal candidate to regulate reward associated with gregarious song. |
2021-12-08 |
2023-08-13 |
Not clear |
| Jenya Kolpakova, Vincent van der Vinne, Pablo Giménez-Gómez, Timmy Le, In-Jee You, Rubing Zhao-Shea, Cristina Velazquez-Marrero, Andrew R Tapper, Gilles E Marti. Binge Alcohol Drinking Alters Synaptic Processing of Executive and Emotional Information in Core Nucleus Accumbens Medium Spiny Neurons. Frontiers in cellular neuroscience. vol 15. 2021-12-07. PMID:34867199. |
the nucleus accumbens (nac) is a forebrain region mediating the positive-reinforcing properties of drugs of abuse, including alcohol. |
2021-12-07 |
2023-08-13 |
mouse |
| Collin D Teague, Eric J Nestle. Key transcription factors mediating cocaine-induced plasticity in the nucleus accumbens. Molecular psychiatry. 2021-12-06. PMID:34079067. |
repeated cocaine use induces coordinated changes in gene expression that drive plasticity in the nucleus accumbens (nac), an important component of the brain's reward circuitry, and promote the development of maladaptive, addiction-like behaviors. |
2021-12-06 |
2023-08-13 |
Not clear |
| Asrin Sharifi, Saeideh Karimi-Haghighi, Ronak Shabani, Hamid Reza Asgari, Reza Ahadi, Abbas Haghparas. Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens. Progress in neuro-psychopharmacology & biological psychiatry. vol 113. 2021-12-06. PMID:34662693. |
moreover, the nucleus accumbens (nac), as a key area in the reward circuit, extensively receives dopaminergic projections from the ventral tegmentum area. |
2021-12-06 |
2023-08-13 |
rat |
| Thilo Rusche, Jörn Kaufmann, Jürgen Voge. Nucleus accumbens projections: Validity and reliability of fiber reconstructions based on high-resolution diffusion-weighted MRI. Human brain mapping. vol 42. issue 18. 2021-12-03. PMID:34528323. |
aims of the present study were: (i) visualization of discrete afferences and efferences of the nucleus accumbens (nac), supposed to be a major hub of neural networks relating to mental disorders, using probabilistic fiber tractography and a data driven approach, and (ii) validation of the applied methodology for standardized routine clinical applications. |
2021-12-03 |
2023-08-13 |
human |