| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marissa B Borrego, Kolter B Grigsby, Kayla G Townsley, Amy Chan, Evan J Firsick, Alex Tran, Antonia Savarese, Angela R Ozbur. Central nucleus of the amygdala projections onto the nucleus accumbens core regulate binge-like alcohol drinking in a CRF-dependent manner. Neuropharmacology. vol 203. 2021-12-03. PMID:34748860. |
the nucleus accumbens (nac) is important for regulating a number of behaviors, including alcohol and substance use. |
2021-12-03 |
2023-08-13 |
mouse |
| Zhiyuan Liu, Qiumin Le, Yanbo Lv, Xi Chen, Jian Cui, Yiming Zhou, Deqin Cheng, Chaonan Ma, Xiujuan Su, Lei Xiao, Ruyi Yang, Jiayi Zhang, Lan Ma, Xing Li. A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state. Cell research. 2021-12-01. PMID:34848869. |
dopamine (da) level in the nucleus accumbens (nac) is critical for reward and aversion encoding. |
2021-12-01 |
2023-08-13 |
Not clear |
| Lillian J Brady, Kirsty R Erickson, Kelsey E Lucerne, Aya Osman, Drew D Kiraly, Erin S Calipar. Granulocyte colony-stimulating factor (G-CSF) enhances cocaine effects in the nucleus accumbens via a dopamine release-based mechanism. Psychopharmacology. vol 238. issue 12. 2021-11-30. PMID:34487190. |
we have previously demonstrated in animal models that cocaine use upregulates the expression of granulocyte colony-stimulating factor (g-csf)-a pleiotropic cytokine-in the serum and the nucleus accumbens (nac). |
2021-11-30 |
2023-08-13 |
Not clear |
| Ruud van Zessen, Yue Li, Lucile Marion-Poll, Nicolas Hulo, Jérôme Flakowski, Christian Lüsche. Dynamic dichotomy of accumbal population activity underlies cocaine sensitization. eLife. vol 10. 2021-11-30. PMID:34608866. |
locomotor sensitization (ls) is an early behavioral adaptation to addictive drugs, driven by the increase of dopamine in the nucleus accumbens (nac). |
2021-11-30 |
2023-08-13 |
mouse |
| Alexander K Zinsmaier, Yan Dong, Yanhua H Huan. Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens. Molecular psychiatry. 2021-11-26. PMID:33963288. |
the nucleus accumbens (nac) integrates and prioritizes different emotional and motivational inputs to the reward system by processing convergent glutamatergic projections from the medial prefrontal cortex, basolateral amygdala, ventral hippocampus, and other limbic and paralimbic brain regions. |
2021-11-26 |
2023-08-13 |
Not clear |
| Mariya Tsyglakova, Alisa M Huskey, Emily H Hurst, Natalie M Telep, Mary C Wilding, Meghan E Babington, Jennifer R Rainville, Georgia E Hode. Sex and region-specific effects of variable stress on microglia morphology. Brain, behavior, & immunity - health. vol 18. 2021-11-26. PMID:34820640. |
here we report changes in microglia morphology in the nucleus accumbens (nac) and subregions of the hippocampus (hpc) in both male and female mice following variable stress of 6 or 28 days in duration. |
2021-11-26 |
2023-08-13 |
mouse |
| Kensuke Hirose, Yuka Nakaya, Kohei Kitano, Yasuhiko Saito, Ryosuke Kaneko, Yuchio Yanagawa, Kiyofumi Yamamoto, Tetsuo Shirakawa, Masayuki Kobayash. Differential regulation of medium spiny and cholinergic neurons in the nucleus accumbens core by the insular and medial prefrontal cortices in the rat. Pflugers Archiv : European journal of physiology. vol 473. issue 12. 2021-11-25. PMID:34724104. |
the nucleus accumbens (nac) receives cortical projections principally from the insular cortex (ic) and medial prefrontal cortex (mpfc). |
2021-11-25 |
2023-08-13 |
rat |
| Diego García-González, Ionut Dumitru, Annalisa Zuccotti, Ting-Yun Yen, Vicente Herranz-Pérez, Linette Liqi Tan, Angela Neitz, José Manuel García-Verdugo, Rohini Kuner, Julieta Alfonso, Hannah Monye. Neurogenesis of medium spiny neurons in the nucleus accumbens continues into adulthood and is enhanced by pathological pain. Molecular psychiatry. vol 26. issue 9. 2021-11-24. PMID:32612250. |
interestingly, a fraction of adult v-svz-derived neuroblasts dispersed in close association with the radial glia-like fibers in the nucleus accumbens (nac). |
2021-11-24 |
2023-08-13 |
mouse |
| Jennifer S Steger, Benjamin B Land, Julia C Lemos, Charles Chavkin, Paul E M Phillip. Insidious Transmission of a Stress-Related Neuroadaptation. Frontiers in behavioral neuroscience. vol 14. 2021-11-24. PMID:33132859. |
it has previously been shown that in stress-naïve male mice, crf acts in the core of the nucleus accumbens (nac) to produce appetitive effects and to increase dopamine release; yet in stress-exposed male mice, crf loses its capacity to modulate nac dopamine release and is aversive. |
2021-11-24 |
2023-08-13 |
mouse |
| Fardad Pirri, Ardeshir Akbarabadi, Mitra-Sadat Sadat-Shirazi, Setareh Nouri Zadeh-Tehrani, Sarah Mahboubi, Ali Karimi Goudarzi, Mohammad-Reza Zarrindas. Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 3. 2021-11-24. PMID:33534920. |
besides, the rewarding effect of cannabinoids was investigated using the administration of cb1 receptor agonist (acpa, 0.25, 0.5, 1 µg/rat) and inverse agonist (am-251, 30, 60, and 90 ng/rat) in the nucleus accumbens (nac). |
2021-11-24 |
2023-08-13 |
rat |
| Mijung Yeom, Sora Ahn, Ju-Young Oh, Song-Yi Kim, Hyangsook Lee, Dae-Hyun Hahm, Hi-Joon Par. Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31743694. |
in the nucleus accumbens (nac), dorsal striatum (ds) and ventral tegmental area (vta), protein levels of dopamine- and plasticity-related signaling molecules were determined by western immunoblotting assay. |
2021-11-22 |
2023-08-13 |
mouse |
| Yu Tang, Maohua Wang, Ting Zheng, Fengying Yuan, Han Yang, Fugang Han, Guangxiang Che. Grey matter volume alterations in trigeminal neuralgia: A systematic review and meta-analysis of voxel-based morphometry studies. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31756417. |
the results revealed that tn patients had gm volume abnormalities mainly in the basal ganglia, including the putamen, nucleus accumbens (nac), caudate nucleus and amygdala, as well as the cingulate cortex (cc), thalamus, insula and superior temporal gyrus (stg). |
2021-11-22 |
2023-08-13 |
Not clear |
| Mieke van Holstein, Paula E MacLeod, Stan B Floresc. Basolateral amygdala - nucleus accumbens circuitry regulates optimal cue-guided risk/reward decision making. Progress in neuro-psychopharmacology & biological psychiatry. vol 98. 2021-11-22. PMID:31811876. |
studies in humans and animals have implicated neural circuits that include the basolateral amygdala (bla) and nucleus accumbens (nac) in facilitating risk/reward decision making. |
2021-11-22 |
2023-08-13 |
rat |
| Patrick Bach, Anne Koopmann, Falk Kiefe. The Impact of Appetite-Regulating Neuropeptide Leptin on Alcohol Use, Alcohol Craving and Addictive Behavior: A Systematic Review of Preclinical and Clinical Data. Alcohol and alcoholism (Oxford, Oxfordshire). vol 56. issue 2. 2021-11-22. PMID:32490525. |
in the ventral tegmental area (vta), leptin attenuates the firing rate of dopaminergic neurons that project to the nucleus accumbens (nac), which serves as relay to other brain areas of the "addiction network", such as the prefrontal cortex. |
2021-11-22 |
2023-08-13 |
Not clear |
| Meenu Minhas, Cheryl L Limebeer, Evan Strom, Linda A Parker, Francesco Ler. High fructose corn syrup alters behavioural and neurobiological responses to oxycodone in rats. Pharmacology, biochemistry, and behavior. vol 205. 2021-11-22. PMID:33845083. |
male sprague-dawley rats had access to hfcs (0 or 50%) over 26 days in their home cages and were subsequently tested on place conditioning induced by 0, 0.16 and 2.5 mg/kg oxy (3 pairings of drug and saline, each 30 min), as well as on locomotor responses to 0, 0.16 and 2.5 mg/kg oxy, and in-vivo microdialysis was employed to measure dopamine (da) levels in the nucleus accumbens (nac) in response to 0 and 2.5 mg/kg oxy. |
2021-11-22 |
2023-08-13 |
rat |
| Dan P Covey, Edith Hernandez, Miguel Á Luján, Joseph F Chee. Chronic Augmentation of Endocannabinoid Levels Persistently Increases Dopaminergic Encoding of Reward Cost and Motivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 41. issue 32. 2021-11-22. PMID:34230105. |
dopamine (da) signaling in the nucleus accumbens (nac) facilitates goal-seeking, but how nac da release encodes motivationally salient stimuli to influence effortful investment is not clear. |
2021-11-22 |
2023-08-13 |
mouse |
| Benjamin C Coleman, Kevin M Manz, Brad A Gruete. Kappa opioid receptor modulation of excitatory drive onto nucleus accumbens fast-spiking interneurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 13. 2021-11-22. PMID:34400782. |
the dynorphin/kappa opioid receptor (kor) system within the nucleus accumbens (nac) contributes to affective states. |
2021-11-22 |
2023-08-13 |
mouse |
| Ethan M Anderson, Marcelo F Lopez, Abigail Kastner, Patrick J Mulholland, Howard C Becker, Christopher W Cowa. The histone methyltransferase G9a mediates stress-regulated alcohol drinking. Addiction biology. 2021-11-21. PMID:34013595. |
the epigenetic enzyme g9a is a histone methyltransferase that dimethylates lysine 9 on histone h3 (h3k9me2), and in the adult nucleus accumbens (nac), g9a regulates multiple behaviors associated with substance use disorder. |
2021-11-21 |
2023-08-13 |
mouse |
| Viktor Román, Rita Kedves, Kristóf Kelemen, Zsolt Némethy, Beáta Sperlágh, Balázs Lendvai, E Sylvester Viz. Contribution of analog signaling to neurotransmitter interactions and behavior: Role of transporter-mediated nonquantal dopamine release. Physiological reports. vol 9. issue 21. 2021-11-19. PMID:34762352. |
in mouse slice preparations, (+/-)-3,4-methylenedioxy-methamphetamine (mdma, or ecstasy) and β-phenylethylamine (β-pea)-induced da release in the striatum and nucleus accumbens (nac), two regions of the brain involved in reward-driven and social behavior and inhibited the axonal stimulation-induced release of tritiated acetylcholine ([ |
2021-11-19 |
2023-08-13 |
mouse |
| Benjamin M Siemsen, Justine D Landin, Jon A McFaddin, Kaylee N Hooker, Lawrence J Chandler, Michael D Scofiel. Chronic intermittent ethanol and lipopolysaccharide exposure differentially alter Iba1-derived microglia morphology in the prelimbic cortex and nucleus accumbens core of male Long-Evans rats. Journal of neuroscience research. vol 99. issue 8. 2021-11-18. PMID:32621337. |
here we have used iba1-staining combined with high-resolution confocal imaging and 3d reconstruction to examine microglial structure in the prelimbic (pl) cortex and nucleus accumbens (nac) in male long-evans rats. |
2021-11-18 |
2023-08-13 |
rat |