| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jacqueline-Marie Ferdinand, Kate Z Peters, Ersin Yavas, Andrew M J Youn. Modulation of stimulated dopamine release in rat nucleus accumbens shell by GABA in vitro: Effect of sub-chronic phencyclidine pretreatment. Journal of neuroscience research. vol 99. issue 7. 2021-11-18. PMID:33848365. |
dopamine signaling in nucleus accumbens (nac) is modulated by γ-aminobutyric acid (gaba), acting through gaba-a and gaba-b receptors: dysregulation of gabaergic control of dopamine function may be important in behavioral deficits in schizophrenia. |
2021-11-18 |
2023-08-13 |
rat |
| Eduardo F Gallo, Julia Greenwald, Jenna Yeisley, Eric Teboul, Kelly M Martyniuk, Joseph M Villarin, Yulong Li, Jonathan A Javitch, Peter D Balsam, Christoph Kellendon. Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Molecular psychiatry. 2021-11-18. PMID:34789847. |
here, we show that d2r upregulation in cins of the nucleus accumbens (nac) lengthens the pause in cin activity ex vivo and enlarges a stimulus-evoked decrease in acetylcholine (ach) levels during behavior. |
2021-11-18 |
2023-08-13 |
Not clear |
| Alexey Bingor, Matityahu Azriel, Lavi Amiad, Rami Yak. Potentiated Response of ERK/MAPK Signaling is Associated with Prolonged Withdrawal from Cocaine Behavioral Sensitization. Journal of molecular neuroscience : MN. vol 71. issue 11. 2021-11-17. PMID:33479915. |
among the neuroadaptations underlying the expression of cocaine-induced behaviors are modifications in glutamate-mediated signaling and synaptic plasticity via activation of mitogen-activated protein kinases (mapks) within the nucleus accumbens (nac). |
2021-11-17 |
2023-08-13 |
Not clear |
| Eric Vornholt, John Drake, Mohammed Mamdani, Gowon McMichael, Zachary N Taylor, Silviu-Alin Bacanu, Michael F Miles, Vladimir I Vladimiro. Identifying a novel biological mechanism for alcohol addiction associated with circRNA networks acting as potential miRNA sponges. Addiction biology. vol 26. issue 6. 2021-11-17. PMID:34164896. |
genome-wide expression of circrna was assessed in the nucleus accumbens (nac) from 32 ad-matched cases/controls. |
2021-11-17 |
2023-08-13 |
human |
| Shu-Chun Chen, Hsi Chen, Seong-Jin Yu, Yun-Hsiang Chen, Yun Wan. Alleviation of Methamphetamine Sensitization by Partially Lesioning Dopaminergic Terminals with 6-Hydroxydopamine in Nucleus Accumbens. Cell transplantation. vol 30. 2021-11-17. PMID:34743572. |
previous studies have reported that the ablation of nucleus accumbens (nac) by electrolytic or thermal lesioning attenuates addictive behavior to opioids in animals. |
2021-11-17 |
2023-08-13 |
mouse |
| Benoit Forget, Elena Martin Garcia, Arthur Godino, Laura Domingo Rodriguez, Vincent Kappes, Pierre Poirier, Andry Andrianarivelo, Eric Senabre Marchan, Marie-Charlotte Allichon, Mélanie Marias, Peter Vanhoutte, Jean-Antoine Girault, Rafael Maldonado, Jocelyne Caboch. Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons. Molecular psychiatry. 2021-11-17. PMID:34785784. |
here, we evaluated the expression of a subset of mirnas proposed to modulate cocaine effects in the nucleus accumbens (nac) and dorsal striatum (ds) upon sustained cocaine exposure in mice and showed that these selected mirnas were preferentially upregulated in the nac. |
2021-11-17 |
2023-08-13 |
mouse |
| Yue-Ying Liu, Le Liu, Lei Zhu, Xiu Yang, Kun Tong, Yue You, Li Yang, Yin Gao, Xu Li, Di-Shi Chen, Jing-Ru Hao, Nan Sun, Can Ga. dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine. Pharmacological research. vol 172. 2021-11-16. PMID:34461223. |
one of the key regions of the reward is the nucleus accumbens (nac) which receives glutamatergic projections from the dorsal hippocampus ca1 (dca1). |
2021-11-16 |
2023-08-13 |
mouse |
| XiangFei Liu, JiaLing Zhou, Tian Zhang, Ken Chen, Min Xu, Lei Wu, Jin Liu, YunKe Huang, BinBin Nie, Xu Shen, Ping Ren, Xi Huan. Meranzin hydrate elicits antidepressant effects and restores reward circuitry. Behavioural brain research. vol 398. 2021-11-15. PMID:32905810. |
a literature search shown that nucleus accumbens (nac) and hypothalamus of the reward system might reveal multiple effects of mh on mdd-fd-cvd comorbidity. |
2021-11-15 |
2023-08-13 |
rat |
| Hannah N Carlson, Carolyn Murphy, Wayne E Prat. Shifting motivational states: The effects of nucleus accumbens dopamine and opioid receptor activation on a modified effort-based choice task. Behavioural brain research. vol 399. 2021-11-15. PMID:33161034. |
the nucleus accumbens (nac) is critical for regulating the appetitive and consummatory phases of motivated behavior. |
2021-11-15 |
2023-08-13 |
rat |
| Zachary Pierce-Messick, Wayne E Prat. Glucagon-like peptide-1 receptors modulate the binge-like feeding induced by µ-opioid receptor stimulation of the nucleus accumbens in the rat. Neuroreport. vol 31. issue 18. 2021-11-15. PMID:33165198. |
for instance, previous reports have shown that stimulating glucagon-like peptide-1 (glp-1) receptors in the nucleus accumbens (nac), an area that directs motivational processes towards food and drugs of abuse, has an anorectic effect. |
2021-11-15 |
2023-08-13 |
rat |
| Masahito Nangaku, Kouhei Yoshino, Yasunori Oda, Makoto Kimura, Hiroshi Kimura, Yuki Hirose, Yukihiko Shirayama, Masaomi Iy. Astroglial glutamate transporter 1 and glutamine synthetase of the nucleus accumbens are involved in the antidepressant-like effects of allopregnanolone in learned helplessness rats. Behavioural brain research. vol 401. 2021-11-15. PMID:33359844. |
the results of this study showed that bilateral microinjection of allo into the lateral ventricles could normalize the levels of glt-1 and gs in the nucleus accumbens (nac) and of gs in the hippocampal ca1 region of lh rats. |
2021-11-15 |
2023-08-13 |
rat |
| Rui Zhang, Peter Manza, Dardo Tomasi, Sung Won Kim, Ehsan Shokri-Kojori, Sukru B Demiral, Danielle S Kroll, Dana E Feldman, Katherine L McPherson, Catherine L Biesecker, Gene-Jack Wang, Nora D Volko. Dopamine D1 and D2 receptors are distinctly associated with rest-activity rhythms and drug reward. The Journal of clinical investigation. vol 131. issue 18. 2021-11-15. PMID:34264865. |
additionally, self-reported drug-rewarding effects of 60 mg oral methylphenidate were assessed.resultswe found that delayed rhythm was associated with higher d1r availability in caudate, which was not attributable to sleep loss or so-called social jet lag, whereas physical inactivity was associated with higher d2/3r availability in nucleus accumbens (nac). |
2021-11-15 |
2023-08-13 |
Not clear |
| Kathryn D Fischer, Lori A Knackstedt, Paul A Rosenber. Glutamate homeostasis and dopamine signaling: Implications for psychostimulant addiction behavior. Neurochemistry international. vol 144. 2021-11-12. PMID:33159978. |
while many brain regions are implicated in addiction behavior, this review focuses on two regions well known for their role in mediating the effects of cocaine and amphetamines, namely the nucleus accumbens (nac) and the ventral tegmental area (vta). |
2021-11-12 |
2023-08-13 |
Not clear |
| Arvie Abiero, Raly James Perez Custodio, Chrislean Jun Botanas, Darlene Mae Ortiz, Leandro Val Sayson, Mikyung Kim, Hyun Jun Lee, Seolmin Yoon, Yong Sup Lee, Jae Hoon Cheong, Hee Jin Ki. 1-Phenylcyclohexan-1-amine hydrochloride (PCA HCl) alters mesolimbic dopamine system accompanied by neuroplastic changes: A neuropsychopharmacological evaluation in rodents. Neurochemistry international. vol 144. 2021-11-12. PMID:33460722. |
we used elisa to measure dopamine (da) levels and western blotting to determine effects on the da-related proteins as well as on phosphorylated creb, deltafosb, and brain-derived neurotrophic factor (bdnf) in the ventral tegmental area (vta) and nucleus accumbens (nac). |
2021-11-12 |
2023-08-13 |
mouse |
| Alessandra Lintas, Raudel Sánchez-Campusano, Alessandro E P Villa, Agnès Gruart, José M Delgado-Garcí. Operant conditioning deficits and modified local field potential activities in parvalbumin-deficient mice. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33536607. |
recordings from prefrontal cortex, nucleus accumbens (nac) and hippocampus showed significant decreases of the spectral power in beta and gamma bands in pvko compared with wt mice particularly during the performance of the operant conditioning task. |
2021-11-12 |
2023-08-13 |
mouse |
| Bin Li, Leilei Chang, Xiaochun Pen. Orexin 2 receptor in the nucleus accumbens is critical for the modulation of acute stress-induced anxiety. Psychoneuroendocrinology. vol 131. 2021-11-12. PMID:34111776. |
the nucleus accumbens (nac) shell holds a key position in the modulation of anxiety-related behaviors. |
2021-11-12 |
2023-08-13 |
rat |
| Xiaoying Tan, Cynthia M Ingraham, William J McBride, Zheng-Ming Din. The involvement of mesolimbic dopamine system in cotinine self-administration in rats. Behavioural brain research. vol 417. 2021-11-12. PMID:34562552. |
mesolimbic dopamine system projecting from the ventral tegmental area (vta) to nucleus accumbens (nac) is closely implicated in drug reinforcement, including nicotine. |
2021-11-12 |
2023-08-13 |
rat |
| Rohan V Bhimani, Megan Vik, Ken T Wakabayashi, Caitlin Szalkowski, Caroline E Bass, Jinwoo Par. Distinct dose-dependent effects of methamphetamine on real-time dopamine transmission in the rat nucleus accumbens and behaviors. Journal of neurochemistry. vol 158. issue 4. 2021-11-11. PMID:34265079. |
in this study, we investigated how systemic administration of escalating, subneurotoxic doses of meth (0.5-5 mg/kg, ip) alter extracellular da regulation in the nucleus accumbens (nac), in both anesthetized and awake-behaving rats through the use of in vivo fast-scan cyclic voltammetry. |
2021-11-11 |
2023-08-13 |
rat |
| Alberto J López, Amy R Johnson, Tanner J Euston, Rashaun Wilson, Suzanne O Nolan, Lillian J Brady, Kimberly C Thibeault, Shannon J Kelly, Veronika Kondev, Patrick Melugin, M Gunes Kutlu, Emily Chuang, TuKiet T Lam, Drew D Kiraly, Erin S Calipar. Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens. Communications biology. vol 4. issue 1. 2021-11-11. PMID:34272455. |
here, we show that sex is a critical biological variable that defines drug-induced plasticity in the nucleus accumbens (nac). |
2021-11-11 |
2023-08-13 |
human |
| Yan Dong, Chong-Yang Li, Xiao-Min Zhang, Ya-Nan Liu, Shuang Yang, Meng-Nan Li, Shi-Lian X. The activation of galanin receptor 2 plays an antinociceptive effect in nucleus accumbens of rats with neuropathic pain. The journal of physiological sciences : JPS. vol 71. issue 1. 2021-11-10. PMID:33546583. |
our previous research has shown that galanin plays an antinociceptive effect via binding to galanin receptors (galrs) in nucleus accumbens (nac). |
2021-11-10 |
2023-08-13 |
rat |