| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew J Muelbl, Breanna L Glaeser, Alok S Shah, Rachel A Chiariello, Natalie N Nawarawong, Brian D Stemper, Matthew D Budde, Christopher M Olse. Repeated blast mild traumatic brain injury and oxycodone self-administration produce interactive effects on neuroimaging outcomes. Addiction biology. vol 27. issue 2. 2022-03-01. PMID:35229952. |
we found interactive effects of rbtbi and oxycodone on fractional anisotropy (fa) in the nucleus accumbens (nac) and that fa in the medial prefrontal cortex (mpfc) was correlated with drug seeking. |
2022-03-01 |
2023-08-13 |
rat |
| Sarah L Withey, Lei Cao, Fernando B de Moura, Kenroy R Cayetano, Michael L Rohan, Jack Bergman, Stephen J Kohu. Fentanyl-induced changes in brain activity in awake nonhuman primates at 9.4 Tesla. Brain imaging and behavior. 2022-02-28. PMID:35226333. |
subsequently, test sessions were conducted in which a dose of fentanyl that reliably maintains intravenous (iv) self-administration behavior in monkeys, 1 μg/kg, was administered and the effects on patterns of brain activity were assessed using: (1) a pharmacological regressor to elucidate fentanyl-induced patterns of neural activity, and (2) seed-based approaches targeting bilateral anterior cingulate, thalamus, or nucleus accumbens (nac) to determine alterations in cstc functional connectivity. |
2022-02-28 |
2023-08-13 |
monkey |
| Johannes W de Jong, Kurt M Fraser, Stephan Lamme. Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It? Annual review of neuroscience. 2022-02-28. PMID:35226827. |
conversely, da release in the nucleus accumbens (nac), the prominent projection target of these neurons, has been implicated in reinforcement learning, motivation, aversion, and incentive salience. |
2022-02-28 |
2023-08-13 |
Not clear |
| Yuxiang Li, Haiyang Xu, Javed M Chitaman, Jian Fen. Whole Genome DNA Methylation Profiling of D2 Medium Spiny Neurons in Mouse Nucleus Accumbens Using Two Independent Library Preparation Methods. Genes. vol 13. issue 2. 2022-02-25. PMID:35205351. |
here, we applied two separate protocols, accel-ngs methyl-seq (am-seq) and enzymatic methyl-seq (em-seq), to profile the methylome of d2 dopamine receptor-expressing medium spiny neurons (d2-msns) in mouse nucleus accumbens (nac). |
2022-02-25 |
2023-08-13 |
mouse |
| Luiz Gustavo Soares Carvalho Crespo, Joaquim Barbosa Leite Junior, João Marcos de Mello Bastos, Richard Ian Samuels, Norberto Cysne Coimbra, Robert J Carey, Marinete Pinheiro Carrer. Context evoked morphine conditioned effects can be equivalent to morphine induced drug effects in terms of behavioral response and ERK activation in reward associated subcortical brain structures. Pharmacology, biochemistry, and behavior. 2022-02-19. PMID:35181379. |
to assess acute unconditioned effects, rats that received morphine (mor-1) or vehicle (veh-1), were immediately placed onto an arena for a 5-min locomotion recording session after which erk was measured in the ventral tegmental area (vta) and nucleus accumbens (nac). |
2022-02-19 |
2023-08-13 |
rat |
| Ying Hao Yu, Yeou San Lim, Chen Yin Ou, Kai Chieh Chang, Arthur C Tsai, Fang Chih Chang, Andrew Chih Wei Huan. The Medial Prefrontal Cortex, Nucleus Accumbens, Basolateral Amygdala, and Hippocampus Regulate the Amelioration of Environmental Enrichment and Cue in Fear Behavior in the Animal Model of PTSD. Behavioural neurology. vol 2022. 2022-02-18. PMID:35178125. |
the present study addressed this issue and examined whether the medial prefrontal cortex (mpfc, including the cingulate cortex 1 (cg1), prelimbic cortex (prl), and infralimbic cortex (il)), the nucleus accumbens (nac), the basolateral amygdala (bla), and the hippocampus (e.g., ca1, ca3, and dentate gyrus (dg)) regulated the amelioration of the ee, cue, or the combination of ee and cue. |
2022-02-18 |
2023-08-13 |
Not clear |
| David A Gallegos, Melyssa Minto, Fang Liu, Mariah F Hazlett, S Aryana Yousefzadeh, Luke C Bartelt, Anne E Wes. Cell-type specific transcriptional adaptations of nucleus accumbens interneurons to amphetamine. Molecular psychiatry. 2022-02-17. PMID:35173267. |
parvalbumin-expressing (pv+) interneurons of the nucleus accumbens (nac) play an essential role in the addictive-like behaviors induced by psychostimulant exposure. |
2022-02-17 |
2023-08-13 |
mouse |
| Carina Soares-Cunha, Ana Verónica Domingues, Raquel Correia, Bárbara Coimbra, Natacha Vieitas-Gaspar, Nivaldo A P de Vasconcelos, Luísa Pinto, Nuno Sousa, Ana João Rodrigue. Distinct role of nucleus accumbens D2-MSN projections to ventral pallidum in different phases of motivated behavior. Cell reports. vol 38. issue 7. 2022-02-16. PMID:35172164. |
the nucleus accumbens (nac) is a key region in motivated behaviors. |
2022-02-16 |
2023-08-13 |
Not clear |
| Nagiua Cuomo-Haymour, Hannes Sigrist, Christian Ineichen, Giancarlo Russo, Ursina Nüesch, Felix Gantenbein, Luka Kulic, Irene Knuesel, Giorgio Bergamini, Christopher Robert Pryc. Evidence for Effects of Extracellular Vesicles on Physical, Inflammatory, Transcriptome and Reward Behaviour Status in Mice. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35162951. |
recipient mice received plasma evs isolated from lps-treated or sal-treated donor mice or vehicle only, either intravenously or into the nucleus accumbens (nac), on three consecutive days. |
2022-02-15 |
2023-08-13 |
mouse |
| Yasumi Ohta, Takaaki E Murakami, Mamiko Kawahara, Makito Haruta, Hironari Takehara, Hiroyuki Tashiro, Kiyotaka Sasagawa, Jun Ohta, Metin Akay, Yasemin M Aka. Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques. International journal of molecular sciences. vol 23. issue 3. 2022-02-15. PMID:35163036. |
the da neurons in the ventral tegmental area (vta) and their projection areas, which include the prefrontal cortex (pfc), nucleus accumbens (nac), and amygdala, play a primary role in the process of reward-driven behavior induced by the drugs of addiction, including nicotine and alcohol. |
2022-02-15 |
2023-08-13 |
mouse |
| Jing Liu, Lingxiao Cao, Hailong Li, Yingxue Gao, Xuan Bu, Kaili Liang, Weijie Bao, Suming Zhang, Hui Qiu, Xue Li, Xinyue Hu, Lu Lu, Lianqing Zhang, Xinyu Hu, Xiaoqi Huang, Qiyong Gon. Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. 2022-02-13. PMID:35151769. |
quantitative coordinate-based meta-analysis was conducted for seed regions in the striatum (putamen, caudate, nucleus accumbens [nac]), thalamus, and anterior cingulate cortex (acc) because there were an adequate number of studies. |
2022-02-13 |
2023-08-13 |
Not clear |
| Amy C Leach, Elizabeth G Pitts, Cody A Siciliano, Mark J Ferri. α7 nicotinic acetylcholine receptor modulation of accumbal dopamine release covaries with novelty seeking. The European journal of neuroscience. 2022-02-10. PMID:35141983. |
dopamine release dynamics in the nucleus accumbens (nac) covaries with response to novelty and differences in dopaminergic signaling are thought to be a major underlying driver of the link between novelty seeking and drug use vulnerability. |
2022-02-10 |
2023-08-13 |
rat |
| Nicole L Jenni, Griffin Rutledge, Stan B Floresc. Distinct medial orbitofrontal-striatal circuits support dissociable component processes of risk/reward decision making. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-02-09. PMID:35135853. |
the present study examined the contribution of mofc circuits linking the nucleus accumbens (nac) and dorsomedial striatum (dms) to risk/reward decision making using pharmacological disconnections. |
2022-02-09 |
2023-08-13 |
rat |
| K L Volcko, D J Brakey, T E McNamara, M J Meyer, N J McKay, J Santollo, D Daniel. Control of water intake by a pathway from the nucleus of the solitary tract to the paraventricular hypothalamic nucleus. Appetite. 2022-02-08. PMID:35131386. |
ex-4 reduced water consumption when injected into the paraventricular hypothalamic nucleus (pvh) and nucleus of the solitary tract (nts), but not when injected into the nucleus accumbens (nac). |
2022-02-08 |
2023-08-13 |
Not clear |
| Kenji Yamaguchi, Yoshitomo Maeda, Takeshi Sawada, Yusuke Iino, Mio Tajiri, Ryosuke Nakazato, Shin Ishii, Haruo Kasai, Sho Yagishit. A behavioural correlate of the synaptic eligibility trace in the nucleus accumbens. Scientific reports. vol 12. issue 1. 2022-02-05. PMID:35121769. |
the trace produces a sensitive period for reward-related dopamine to induce synaptic plasticity in the nucleus accumbens (nac). |
2022-02-05 |
2023-08-13 |
Not clear |
| Kineret Inbar, Liran A Levi, Yonatan M Kupchi. Cocaine induces input and cell-type-specific synaptic plasticity in ventral pallidum-projecting nucleus accumbens medium spiny neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-02-05. PMID:35121830. |
cocaine use and abstinence induce long-term synaptic alterations in the excitatory input to nucleus accumbens (nac) medium spiny neurons (msns). |
2022-02-05 |
2023-08-13 |
Not clear |
| Changyong Guo, Di Wen, Yihong Zhang, Richie Mustaklem, Basil Mustaklem, Miou Zhou, Tao Ma, Yao-Ying M. Amyloid-β oligomers in the nucleus accumbens decrease motivation via insertion of calcium-permeable AMPA receptors. Molecular psychiatry. 2022-02-02. PMID:35105968. |
here, we focused on the nucleus accumbens (nac), a critical brain region processing motivation, also known to display ad-associated pathological changes in human cases. |
2022-02-02 |
2023-08-13 |
human |
| Guangjian Qi, Pei Zhang, Tongxia Li, Ming Li, Qian Zhang, Feng He, Lijun Zhang, Hongwei Cai, Xinyuan Lv, Haifa Qiao, Xiaoqian Chen, Jie Ming, Bo Tia. NAc-VTA circuit underlies emotional stress-induced anxiety-like behavior in the three-chamber vicarious social defeat stress mouse model. Nature communications. vol 13. issue 1. 2022-02-01. PMID:35102141. |
moreover, vta dopaminergic neurons receiving nucleus accumbens (nac) projections are activated in ces mice. |
2022-02-01 |
2023-08-13 |
mouse |
| Hong-Ju Yang, Briana J Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L Gardner, Zheng-Xiong X. Elevation of extracellular glutamate by blockade of astrocyte glutamate transporters inhibits cocaine reinforcement in rats via a NMDA-GluN2B receptor mechanism. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-01-29. PMID:35091501. |
in this study, we systemically evaluated the effects of multiple glutamate transporter (glt) inhibitors on extracellular glutamate and dopamine (da) in the nucleus accumbens (nac), intravenous cocaine self-administration, intracranial brain-stimulation reward, and reinstatement of cocaine seeking in male and female rats. |
2022-01-29 |
2023-08-13 |
rat |
| Scott Edwards, Chelsea N Callicoatte, Angela E Barattini, Jessica A Cucinello-Ragland, Alex Melain, Kimberly N Edwards, Nicholas W Gilpin, Elizabeth M Avegno, Amanda R Pahn. Pramipexole treatment attenuates mechanical hypersensitivity in male rats experiencing chronic inflammatory pain. Neuropharmacology. 2022-01-27. PMID:35085583. |
we also examined the effects of pramipexole treatment on glutamatergic and presynaptic signaling in pain- and reward-related brain regions including the nucleus accumbens (nac), dorsal striatum (ds), ventral tegmental area (vta), cingulate cortex (cc), central amygdala (cea), and periaqueductal gray (pag). |
2022-01-27 |
2023-08-13 |
rat |