| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Emily N Lum, Rianne R Campbell, Charlotte Rostock, Karen K Szumlinsk. mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions. Neuropharmacology. vol 79. 2014-12-03. PMID:24467847. |
jnj-16259685 (0-30 pg/side) was infused into the shell subregion of the nucleus accumbens (nac) of c57bl/6j and homer2 knock-out (ko) mice, either alone or in combination with the plc inhibitor u-73122 (5.8 fg/side). |
2014-12-03 |
2023-08-12 |
mouse |
| Zhenyu Cai, Dalei Zhang, Ying Ying, Min Yan, Jianhua Yang, Fangyun Xu, Kiwan Oh, Zhenzhen H. Inhibitory modulation of CART peptides in accumbal neuron through decreasing interaction of CaMKIIα with dopamine D3 receptors. Brain research. vol 1557. 2014-12-03. PMID:24560901. |
previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (cart) peptide into the nucleus accumbens (nac; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants. |
2014-12-03 |
2023-08-12 |
rat |
| Martin O Job, Joanna Perry, Li L Shen, Michael J Kuha. Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences. Neuropeptides. vol 48. issue 2. 2014-12-03. PMID:24630272. |
cocaine-and-amphetamine regulated transcript peptide (cart peptide) is known for having an inhibitory effect on dopamine (da)- and cocaine-mediated actions and is postulated to be a homeostatic, regulatory factor in the nucleus accumbens (nac). |
2014-12-03 |
2023-08-12 |
rat |
| A J Robison, Vincent Vialou, Hao-Sheng Sun, Benoit Labonte, Sam A Golden, Caroline Dias, Gustavo Turecki, Carol Tamminga, Scott Russo, Michelle Mazei-Robison, Eric J Nestle. Fluoxetine epigenetically alters the CaMKIIα promoter in nucleus accumbens to regulate ΔFosB binding and antidepressant effects. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24240473. |
recent work in addiction models demonstrates that the transcription factor Δfosb and protein kinase calmodulin-dependent protein kinase ii (camkii) are co-regulated in nucleus accumbens (nac), a brain reward region implicated in both addiction and depression models including social defeat. |
2014-12-01 |
2023-08-12 |
mouse |
| Ning Wang, Ping Su, Ying Zhang, Jie Lu, Baoming Xing, Kai Kang, Wenqi Li, Yun Wan. Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24362306. |
importantly, injection of the peptide tat-s421, an engineered tat fusion-peptide targeting s421 (tat-s421), into the rat dorsal striatum inhibits cocaine-induced locomotor hyperactivity and injection of tat-s421 into the rat hippocampus or the shell of the nucleus accumbens (nac) also inhibits cocaine-induced conditioned place preference (cpp). |
2014-12-01 |
2023-08-12 |
rat |
| Li Wang, Minjie Shen, Yongchun Yu, Yezheng Tao, Ping Zheng, Feifei Wang, Lan M. Optogenetic activation of GABAergic neurons in the nucleus accumbens decreases the activity of the ventral pallidum and the expression of cocaine-context-associated memory. The international journal of neuropsychopharmacology. vol 17. issue 5. 2014-12-01. PMID:24456857. |
gabaergic medium-sized spiny neurons (msns) in the nucleus accumbens (nac) differentially express d1 and d2 dopamine receptors. |
2014-12-01 |
2023-08-12 |
mouse |
| Rainer Spanagel, Hamid R Noori, Markus Heili. Stress and alcohol interactions: animal studies and clinical significance. Trends in neurosciences. vol 37. issue 4. 2014-12-01. PMID:24636458. |
specifically, glucocorticoids, acting within the nucleus accumbens (nac), are important mediators of this stress-induced alcohol intake. |
2014-12-01 |
2023-08-12 |
Not clear |
| Chunxia Chen, Zhihuan Nong, Jiangchun Huang, Zhaoni Chen, Shijun Zhang, Yang Jiao, Xiaoyu Chen, Renbin Huan. Yulangsan polysaccharide attenuates withdrawal symptoms and regulates the NO pathway in morphine-dependent rats. Neuroscience letters. vol 570. 2014-12-01. PMID:24747687. |
furthermore, monoaminergic neurotransmitters, including da and ne, were detected at elevated levels in the ventral tegmental area (vta), hippocampus (hip) and prefrontal cortex (pfc), respectively, while the level of da was decreased and ne was increased in the nucleus accumbens (nac). |
2014-12-01 |
2023-08-13 |
rat |
| Andrew F MacAskill, John M Cassel, Adam G Carte. Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens. Nature neuroscience. vol 17. issue 9. 2014-12-01. PMID:25108911. |
repeated exposure to cocaine alters the structural and functional properties of medium spiny neurons (msns) in the nucleus accumbens (nac). |
2014-12-01 |
2023-08-13 |
mouse |
| Kenneth Blum, Marlene Oscar-Berman, Rajendra D Badgaiyan, Tomas Palomo, Mark S Gol. Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior. Medical hypotheses. vol 82. issue 5. 2014-11-28. PMID:24636783. |
we also propose that alcohol seeking behavior in schizophrenics, may serve as a physiological self-healing process linked to the increased function of the gamma endorphins, thereby reducing abnormal dopaminergic activity at the nucleus accumbens (nac). |
2014-11-28 |
2023-08-12 |
Not clear |
| Martijn Figee, Pelle de Koning, Sanne Klaassen, Nienke Vulink, Mariska Mantione, Pepijn van den Munckhof, Richard Schuurman, Guido van Wingen, Thérèse van Amelsvoort, Jan Booij, Damiaan Deny. Deep brain stimulation induces striatal dopamine release in obsessive-compulsive disorder. Biological psychiatry. vol 75. issue 8. 2014-11-26. PMID:23938318. |
deep brain stimulation (dbs) targeted at the nucleus accumbens (nac) has recently become an effective treatment for therapy-refractory obsessive-compulsive disorder, but its effect on dopaminergic transmission is unknown. |
2014-11-26 |
2023-08-12 |
Not clear |
| Danielle C Malkusz, Sonia Y Bernal, Theodore Banakos, Gina Malkusz, Andrew Mohamed, Tracy Vongwattanakit, Richard J Bodna. Evaluation of saccharin intake and expression of fructose-conditioned flavor preferences following opioid receptor antagonism in the medial prefrontal cortex, amygdala or lateral hypothalamus in rats. Neuroscience letters. vol 564. 2014-11-26. PMID:24560952. |
further, ntx microinjections into the nucleus accumbens (nac) shell or core failed to alter the expression of preferences conditioned by the sweet taste or post-oral actions of sugars. |
2014-11-26 |
2023-08-12 |
rat |
| Kaili Anier, Kristina Malinovskaja, Katrin Pruus, Anu Aonurm-Helm, Alexander Zharkovsky, Anti Kald. Maternal separation is associated with DNA methylation and behavioural changes in adult rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 3. 2014-11-25. PMID:23972903. |
we have three main findings: (1) ms increased dna methyltransferases (dnmts) expression in the nucleus accumbens (nac) of infant and adult rats; (2) ms induced dna hypomethylation on a global level in the nac, and hypermethylation of the promoter regions of the protein phosphatase 1 catalytic subunit (pp1c) and adenosine a2areceptor (a2ar) genes, which was associated with their transcriptional downregulation in the nac; (3) ms-induced molecular changes paralleled an increased response to cocaine-induced locomotor activity and exploratory behaviour in adult rats. |
2014-11-25 |
2023-08-12 |
rat |
| Na Yan, Ning Chen, Honghua Zhu, Jianguo Zhang, Moira Sim, Yu Ma, Wei Wan. High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit. PloS one. vol 8. issue 11. 2014-11-24. PMID:24244479. |
deep brain stimulation (dbs) of the nucleus accumbens (nac) is a potential remedial therapy for drug craving and relapse, but the mechanism is poorly understood. |
2014-11-24 |
2023-08-12 |
rat |
| E Park, J Y Kim, J-H Lee, J W Jahn. Increased depression-like behaviors with dysfunctions in the stress axis and the reward center by free access to highly palatable food. Neuroscience. vol 262. 2014-11-24. PMID:24406442. |
at the end of restraint session, rats were sacrificed and the tissue sections of the nucleus accumbens (nac) were processed for c-fos immunohistochemistry. |
2014-11-24 |
2023-08-12 |
rat |
| Changjiu Zhao, Brian Earl Eisinger, Terri M Driessen, Stephen C Gammi. Addiction and reward-related genes show altered expression in the postpartum nucleus accumbens. Frontiers in behavioral neuroscience. vol 8. 2014-11-21. PMID:25414651. |
nucleus accumbens (nac) is a key cns region for natural rewards and addictions, but to date no study has evaluated on a large scale the events in nac that underlie the maternal change in natural rewards. |
2014-11-21 |
2023-08-13 |
mouse |
| John A Richey, Alison Rittenberg, Lauren Hughes, Cara R Damiano, Antoinette Sabatino, Stephanie Miller, Eleanor Hanna, James W Bodfish, Gabriel S Dichte. Common and distinct neural features of social and non-social reward processing in autism and social anxiety disorder. Social cognitive and affective neuroscience. vol 9. issue 3. 2014-11-18. PMID:23223206. |
analyses modeling all three groups revealed increased nucleus accumbens (nac) activation in sad relative to asd during monetary reward anticipation, whereas both the sad and asd group demonstrated decreased bilateral nac activation relative to the control group during social reward anticipation. |
2014-11-18 |
2023-08-12 |
Not clear |
| Michael P Saddoris, Regina M Carell. Cocaine self-administration abolishes associative neural encoding in the nucleus accumbens necessary for higher-order learning. Biological psychiatry. vol 75. issue 2. 2014-11-18. PMID:24035479. |
likely targets for these changes are the core and shell of the nucleus accumbens (nac), which are critical for mediating the rewarding aspects of drugs of abuse as well as supporting associative learning. |
2014-11-18 |
2023-08-12 |
human |
| Susanne Jonsson, Mia Ericson, Bo Söderpal. Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. Alcoholism, clinical and experimental research. vol 38. issue 3. 2014-11-18. PMID:24224855. |
that the initial encounter with etoh causes an elevation of dopamine in the nucleus accumbens (nac), inducing feelings of well-being and creating an incentive to continue the behavior, has been repeatedly reported in both animals and humans. |
2014-11-18 |
2023-08-12 |
rat |
| Hasan Alhaddad, Nathaniel T Kim, Munaf Aal-Aaboda, Yusuf S Althobaiti, James Leighton, Sai H S Boddu, Yangjie Wei, Youssef Sar. Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Frontiers in behavioral neuroscience. vol 8. 2014-11-17. PMID:25400560. |
importantly, we found that ms-153 upregulated the glt1 level in the nucleus accumbens (nac) but not in the prefrontal cortex (pfc). |
2014-11-17 |
2023-08-13 |
rat |