| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Malte Feja, Linda Hayn, Michael Koc. Nucleus accumbens core and shell inactivation differentially affects impulsive behaviours in rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 54. 2015-05-12. PMID:24810333. |
the nucleus accumbens (nac) might be a key substrate in cortico-limbic-striatal circuits involved in impulsive behaviour. |
2015-05-12 |
2023-08-13 |
rat |
| Rhona B C Clarke, Louise Adermark, PeiPei Chau, Bo Söderpalm, Mia Ericso. Increase in nucleus accumbens dopamine levels following local ethanol administration is not mediated by acetaldehyde. Alcohol and alcoholism (Oxford, Oxfordshire). vol 49. issue 5. 2015-05-12. PMID:25063803. |
ethanol (etoh) activates the mesolimbic dopamine system and increases dopamine levels in the nucleus accumbens (nac), which is believed to underlie the rewarding effects of alcohol. |
2015-05-12 |
2023-08-13 |
Not clear |
| Gislaine Z Réus, Helena M Abaleira, Monique Michels, Débora B Tomaz, Maria Augusta B dos Santos, Anelise S Carlessi, Beatriz I Matias, Daniela D Leffa, Adriani P Damiani, Vitor de C Gomes, Vanessa M Andrade, Felipe Dal-Pizzol, Jesus Landeira-Fernadez, João Queved. Anxious phenotypes plus environmental stressors are related to brain DNA damage and changes in NMDA receptor subunits and glutamate uptake. Mutation research. vol 772. 2015-05-11. PMID:25772108. |
the anxious phenotype induced dna damage in the hippocampus, amygdala and nucleus accumbens (nac). |
2015-05-11 |
2023-08-13 |
rat |
| Linlin Sun, Ling Hu, Yijing Li, Cailian Cu. Mesoaccumbens dopamine signaling alteration underlies behavioral transition from tolerance to sensitization to morphine rewarding properties during morphine withdrawal. Brain structure & function. vol 219. issue 5. 2015-05-11. PMID:23775491. |
although the firing activity of dopamine (da) neurons in the ventral tegmental area (vta) and the behavioral response to morphine rewarding properties alter as opiate withdrawal, little is known about the dynamic changes in da signal pathway from the vta to the nucleus accumbens (nac) during prolonged withdrawal, and whether the changes are indicative of vulnerability to relapse of drug abuse. |
2015-05-11 |
2023-08-12 |
rat |
| Sharanya M Kousik, Paul M Carvey, T Celeste Napie. Methamphetamine self-administration results in persistent dopaminergic pathology: implications for Parkinson's disease risk and reward-seeking. The European journal of neuroscience. vol 40. issue 4. 2015-05-11. PMID:24890790. |
ventral tegmental area (vta) and nucleus accumbens (nac)], critical for meth-induced reward, was also evaluated. |
2015-05-11 |
2023-08-13 |
rat |
| Lindsey P Pattison, Scot McIntosh, Tammy Sexton, Steven R Childers, Scott E Hemb. Changes in dopamine transporter binding in nucleus accumbens following chronic self-administration cocaine: heroin combinations. Synapse (New York, N.Y.). vol 68. issue 10. 2015-05-11. PMID:24916769. |
concurrent use of cocaine and heroin (speedball) has been shown to exert synergistic effects on dopamine neurotransmission in the nucleus accumbens (nac), as observed by significant increases in extracellular dopamine levels and compensatory elevations in the maximal reuptake rate of dopamine. |
2015-05-11 |
2023-08-13 |
rat |
| Li-Jun Heng, Bo Huang, Heng Guo, Lian-Ting Ma, Wei-Xin Yuan, Jian Song, Peng Wang, Guo-Zheng Xu, Guo-Dong Ga. Blocking TRPV1 in nucleus accumbens inhibits persistent morphine conditioned place preference expression in rats. PloS one. vol 9. issue 8. 2015-05-11. PMID:25118895. |
it has been recently proved to be expressed in nucleus accumbens (nac), a region playing an essential role in mediating opioid craving and taking behaviors. |
2015-05-11 |
2023-08-13 |
human |
| Timothy W Whitfield, Joel E Schlosburg, Sunmee Wee, Adam Gould, Olivier George, Yanabel Grant, Eva R Zamora-Martinez, Scott Edwards, Elena Crawford, Leandro F Vendruscolo, George F Koo. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 10. 2015-05-06. PMID:25762676. |
rats with an sha history showed an increase in prodynorphin immunoreactivity in both the nucleus accumbens (nac) core and shell, but lga animals showed a selective increase in the nac shell. |
2015-05-06 |
2023-08-13 |
rat |
| A A Feduccia, J A Simms, D Mill, H Y Yi, S E Bartlet. Varenicline decreases ethanol intake and increases dopamine release via neuronal nicotinic acetylcholine receptors in the nucleus accumbens. British journal of pharmacology. vol 171. issue 14. 2015-04-21. PMID:24628360. |
the proposed mechanism of action for varenicline to reduce ethanol consumption has been through modulation of dopamine (da) release in the nucleus accumbens (nac) via α4*-containing nachrs in the ventral tegmental area (vta). |
2015-04-21 |
2023-08-12 |
Not clear |
| Somayeh Ahmadiantehrani, Segev Barak, Dorit Ro. GDNF is a novel ethanol-responsive gene in the VTA: implications for the development and persistence of excessive drinking. Addiction biology. vol 19. issue 4. 2015-04-20. PMID:23298382. |
here, we tested whether ethanol alters gdnf expression in the ventral tegmental area (vta; gdnf's site of action) and/or the nucleus accumbens (nac; the main source of gdnf), and if so, determine the role of the endogenous growth factor in the regulation of ethanol consumption. |
2015-04-20 |
2023-08-12 |
mouse |
| Luis M Carcoba, James E Orfila, Luis A Natividad, Oscar V Torres, Joseph A Pipkin, Patrick L Ferree, Eddie Castañeda, Donald E Moss, Laura E O'Del. Cholinergic transmission during nicotine withdrawal is influenced by age and pre-exposure to nicotine: implications for teenage smoking. Developmental neuroscience. vol 36. issue 3-4. 2015-04-17. PMID:24854235. |
the first study compared extracellular levels of acetylcholine (ach) in the nucleus accumbens (nac) during nicotine exposure and precipitated withdrawal using microdialysis procedures. |
2015-04-17 |
2023-08-13 |
rat |
| Brandon L Warren, Omar K Sial, Lyonna F Alcantara, Maria A Greenwood, Jacob S Brewer, John P Rozofsky, Eric M Parise, Carlos A Bolaños-Guzmá. Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress. Developmental neuroscience. vol 36. issue 3-4. 2015-04-17. PMID:24943326. |
therefore, the following set of experiments was designed to assess changes in transcription and translation of key proteins within the nucleus accumbens (nac). |
2015-04-17 |
2023-08-13 |
mouse |
| Elena Martín-García, Julien Courtin, Prisca Renault, Jean-François Fiancette, Hélène Wurtz, Amélie Simonnet, Florian Levet, Cyril Herry, Véronique Deroche-Gamone. Frequency of cocaine self-administration influences drug seeking in the rat: optogenetic evidence for a role of the prelimbic cortex. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 10. 2015-04-15. PMID:24633559. |
the medial prefrontal cortex (mpfc), basolateral amygdala (bla), and nucleus accumbens (nac) have been shown to have a role in cocaine seeking. |
2015-04-15 |
2023-08-12 |
human |
| Yoshiaki Miyamoto, Yudai Ishikawa, Noriyuki Iegaki, Kazuyuki Sumi, Kequan Fu, Keiji Sato, Yoko Furukawa-Hibi, Shin-Ichi Muramatsu, Toshitaka Nabeshima, Kyosuke Uno, Atsumi Nitt. Overexpression of Shati/Nat8l, an N-acetyltransferase, in the nucleus accumbens attenuates the response to methamphetamine via activation of group II mGluRs in mice. The international journal of neuropsychopharmacology. vol 17. issue 8. 2015-04-14. PMID:24559655. |
a novel n-acetyltransferase, shati/nat8l, was identified in the nucleus accumbens (nac) of mice with methamphetamine (meth) treatment. |
2015-04-14 |
2023-08-12 |
mouse |
| Svilen D Angelov, Carolin Dietrich, Joachim K Krauss, Kerstin Schwab. Effect of deep brain stimulation in rats selectively bred for reduced prepulse inhibition. Brain stimulation. vol 7. issue 4. 2015-04-13. PMID:24794286. |
deep brain stimulation (dbs) of the centromedian-parafascicular complex (cm-pf), globus pallidus internus (in rats the entopeduncular nucleus - epn), and the ventral striatum (in rats the nucleus accumbens - nac) has been used for treatment in ts. |
2015-04-13 |
2023-08-13 |
rat |
| Xin-She Liu, Ying Hou, Ting-Lin Yan, Yan-Yan Guo, Wei Han, Fang-Lin Guan, Teng Chen, Tao L. Dopamine D3 receptor-regulated NR2B subunits of N-methyl-d-aspartate receptors in the nucleus accumbens involves in morphine-induced locomotor activity. CNS neuroscience & therapeutics. vol 20. issue 9. 2015-04-13. PMID:24797707. |
dopamine and glutamate receptors are densely expressed in the nucleus accumbens (nac). |
2015-04-13 |
2023-08-13 |
Not clear |
| Deveroux Ferguson, Ningyi Shao, Elizabeth Heller, Jian Feng, Rachael Neve, Hee-Dae Kim, Tanessa Call, Samantha Magazu, Li Shen, Eric J Nestle. SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 7. 2015-04-13. PMID:25698746. |
previous studies have shown that chronic cocaine administration induces sirt1, a class iii histone deacetylase, in the nucleus accumbens (nac), a key brain reward region, and that such induction influences the gene regulation and place conditioning effects of cocaine. |
2015-04-13 |
2023-08-13 |
mouse |
| Samira Razavi, Ali Haeri-Rohani, Akram Eidi, Mohammad R Zarrindas. Involvement of D₁/D₂ dopamine antagonists upon open-arms exploratory behaviours induced by intra-nucleus accumbens shell administration of N-methyl-D-aspartate. Folia neuropathologica. vol 52. issue 2. 2015-04-06. PMID:25118902. |
we have studied the effect of nucleus accumbens (nac) shell glutamatergic system activation on anxiety-related behaviours as well as aversive learning and memory in adult male wistar rats using the n-methyl-d-aspartate (nmda) receptor agonist, nmda. |
2015-04-06 |
2023-08-13 |
rat |
| Tsuyoshi Nakai, Taku Nagai, Rui Wang, Shinnosuke Yamada, Keisuke Kuroda, Kozo Kaibuchi, Kiyofumi Yamad. Alterations of GABAergic and dopaminergic systems in mutant mice with disruption of exons 2 and 3 of the Disc1 gene. Neurochemistry international. vol 74. 2015-04-02. PMID:24973713. |
meth-induced da release was significantly potentiated in the nucleus accumbens (nac) of female disc1(Δ2-3/Δ2-3) mice, although there were no significant differences in the expression levels of dat. |
2015-04-02 |
2023-08-13 |
mouse |
| Chelsea A Vadnie, David J Hinton, Sun Choi, YuBin Choi, Christina L Ruby, Alfredo Oliveros, Miguel L Prieto, Jun Hyun Park, Doo-Sup Cho. Activation of neurotensin receptor type 1 attenuates locomotor activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24929110. |
since the nucleus accumbens (nac) and medial prefrontal cortex (mpfc) have been implicated in the behavioral effects of nt, we examined whether microinjection of pd149163 into these regions reduces locomotion. |
2015-03-30 |
2023-08-13 |
mouse |