| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William C Griffin, Vorani S Ramachandra, Lori A Knackstedt, Howard C Becke. Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. Frontiers in pharmacology. vol 6. 2015-03-10. PMID:25755641. |
previous work has shown that extracellular glutamate in the nucleus accumbens (nac) is significantly elevated in ethanol-dependent mice and that pharmacologically manipulating glutamate concentrations in the nac will alter ethanol drinking, indicating that glutamate homeostasis plays a crucial role in ethanol drinking in this model. |
2015-03-10 |
2023-08-13 |
mouse |
| Natalie S McGuier, Audrey E Padula, Patrick J Mulholland, L Judson Chandle. Homer2 deletion alters dendritic spine morphology but not alcohol-associated adaptations in GluN2B-containing N-methyl-D-aspartate receptors in the nucleus accumbens. Frontiers in pharmacology. vol 6. 2015-03-10. PMID:25755642. |
repeated exposure to ethanol followed by withdrawal leads to alterations in glutamatergic signaling and impaired synaptic plasticity in the nucleus accumbens (nac) in both clinical and preclinical models of ethanol exposure. |
2015-03-10 |
2023-08-13 |
mouse |
| In Soo Ryu, Eun Sang Cho. Cocaine challenge increases the expression of immunoglobulin heavy chain binding protein in the rat nucleus accumbens. Neuroscience letters. vol 577. 2015-03-09. PMID:24970755. |
this study was performed to investigate that cocaine challenge after cocaine abstinence is associated with the er stress response in the nucleus accumbens (nac). |
2015-03-09 |
2023-08-13 |
rat |
| Pedro A Pereira, João Neves, Manuel Vilela, Sérgio Sousa, Catarina Cruz, M Dulce Madeir. Chronic alcohol consumption leads to neurochemical changes in the nucleus accumbens that are not fully reversed by withdrawal. Neurotoxicology and teratology. vol 44. 2015-03-06. PMID:24893293. |
neuropeptide y (npy)- and acetylcholine-containing interneurons of the nucleus accumbens (nac) seem to play a major role in the rewarding effects of alcohol. |
2015-03-06 |
2023-08-13 |
rat |
| Fang Shen, Na Wang, Chong Qi, Yi-Jing Li, Cai-Lian Cu. The NO/sGC/PKG signaling pathway in the NAc shell is necessary for the acquisition of morphine-induced place preference. Behavioral neuroscience. vol 128. issue 4. 2015-03-04. PMID:25046820. |
we therefore investigated the effect of the no/sgc/pkg signaling pathway in the nucleus accumbens (nac) on morphine-induced conditioned place preference (cpp). |
2015-03-04 |
2023-08-13 |
Not clear |
| Zhenzhen Hu, Eun-Hye Oh, Yeon Bok Chung, Jin Tae Hong, Ki-Wan O. Predominant D1 Receptors Involvement in the Over-expression of CART Peptides after Repeated Cocaine Administration. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. vol 19. issue 2. 2015-03-02. PMID:25729269. |
a higher proportion of cart(+) cells in the cocaine-treated mice were present in the nucleus accumbens (nac) shell than in the dorsolateral (dl) part of caudate putamen (cp). |
2015-03-02 |
2023-08-13 |
mouse |
| Ken T Wakabayashi, Eugene A Kiyatki. Central and peripheral contributions to dynamic changes in nucleus accumbens glucose induced by intravenous cocaine. Frontiers in neuroscience. vol 9. 2015-03-02. PMID:25729349. |
here, we used enzyme-based glucose sensors coupled with high-speed amperometry in freely moving rats to examine how intravenous cocaine at a behaviorally active dose affects extracellular glucose levels in the nucleus accumbens (nac), a critical structure within the motivation-reinforcement circuit. |
2015-03-02 |
2023-08-13 |
rat |
| Louise Adermark, Bo Söderpalm, John M Burkhard. Brain region specific modulation of ethanol-induced depression of GABAergic neurons in the brain reward system by the nicotine receptor antagonist mecamylamine. Alcohol (Fayetteville, N.Y.). vol 48. issue 5. 2015-02-23. PMID:24961541. |
the mechanisms underlying ethanol-induced activation of the mesolimbic dopamine system are not fully understood, but increased extracellular dopamine in the nucleus accumbens (nac) has been shown to involve nicotinic acetylcholine receptors (nachrs). |
2015-02-23 |
2023-08-13 |
mouse |
| Argel Aguilar-Valles, Thomas Vaissière, Erica M Griggs, Mikael A Mikaelsson, Irma F Takács, Erica J Young, Gavin Rumbaugh, Courtney A Mille. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation. Biological psychiatry. vol 76. issue 1. 2015-02-19. PMID:24183790. |
the nucleus accumbens (nac) is essential to these drug-associated memories, but underlying mechanisms are poorly understood. |
2015-02-19 |
2023-08-12 |
Not clear |
| J R Gugusheff, Z Y Ong, B S Muhlhausle. Naloxone treatment alters gene expression in the mesolimbic reward system in 'junk food' exposed offspring in a sex-specific manner but does not affect food preferences in adulthood. Physiology & behavior. vol 133. 2015-02-19. PMID:24727340. |
we measured mrna expression of key components of the reward pathway (mu-opioid receptor, proenkephalin, tyrosine hydroxylase, d1 and d2 receptors and the dopamine active transporter (dat)) in the nucleus accumbens (nac) and ventral tegmental area (vta) of the offspring of control and cafeteria fed (jf) dams at weaning and after a 10-day naloxone treatment post-weaning and determined food preferences in adulthood in the remaining offspring. |
2015-02-19 |
2023-08-13 |
Not clear |
| Francesca Panin, Alessandra Lintas, Marco Dian. Nicotine-induced increase of dopaminergic mesoaccumbal neuron activity is prevented by acute restraint stress. In vivo electrophysiology in rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 7. 2015-02-12. PMID:24530274. |
in line with this hypothesis, a recent microdialysis study in rats has shown that acute restraint stress exposure prevents the nicotine-induced mesolimbic dopaminergic activation in the nucleus accumbens (nac) shell via a corticosterone-mediated mechanism. |
2015-02-12 |
2023-08-12 |
human |
| Elif Engin, Konstantin I Bakhurin, Kiersten S Smith, Rochelle M Hines, Lauren M Reynolds, Wannan Tang, Rolf Sprengel, Stephen J Moss, Uwe Rudolp. Neural basis of benzodiazepine reward: requirement for α2 containing GABAA receptors in the nucleus accumbens. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 8. 2015-02-12. PMID:24553732. |
through a viral-mediated knockdown of α2gabaars in the nucleus accumbens (nac), we demonstrated that α2 in the nac is necessary for the preference for midazolam. |
2015-02-12 |
2023-08-12 |
mouse |
| A Raftogianni, A Stamatakis, A Diamantopoulou, A-M Kollia, F Stylianopoulo. Effects of an early experience of reward through maternal contact or its denial on the dopaminergic system of the rat brain. Neuroscience. vol 269. 2015-02-12. PMID:24680882. |
we determined the effects of these two early experiences in the prefrontal cortex (pfc) and the nucleus accumbens (nac), the levels of dopamine (da) and its metabolites [3,4-dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva)] by high-performance liquid chromatography and those of d1 and d2 receptors by autoradiographic in vitro binding both on pnd 13 and in adulthood. |
2015-02-12 |
2023-08-12 |
rat |
| Aile N van Huijstee, Huibert D Mansvelde. Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. Frontiers in cellular neuroscience. vol 8. 2015-02-05. PMID:25653591. |
this drug-induced synaptic potentiation in the vta subsequently triggers synaptic changes in downstream areas of the mesocorticolimbic system, such as the nucleus accumbens (nac) and the prefrontal cortex (pfc), with further drug exposure. |
2015-02-05 |
2023-08-13 |
Not clear |
| D M Bortz, C V Jørgensen, J D Mikkelsen, J P Brun. Transient inactivation of the ventral hippocampus in neonatal rats impairs the mesolimbic regulation of prefrontal glutamate release in adulthood. Neuropharmacology. vol 84. 2015-02-02. PMID:24747179. |
cognitive deficits in schizophrenia (sz) reflect maturational disruptions within a neural system that includes the ventral hippocampus (vh), nucleus accumbens (nac), basal forebrain, and prefrontal cortex (pfc). |
2015-02-02 |
2023-08-13 |
rat |
| Johann du Hoffmann, Saleem M Nicol. Dopamine invigorates reward seeking by promoting cue-evoked excitation in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 43. 2015-01-23. PMID:25339748. |
nucleus accumbens (nac) dopamine is required for reward-predictive cues to activate vigorous reward seeking, but the underlying neural mechanism is unknown. |
2015-01-23 |
2023-08-13 |
rat |
| Stefan Koelsch, Stavros Skoura. Functional centrality of amygdala, striatum and hypothalamus in a "small-world" network underlying joy: an fMRI study with music. Human brain mapping. vol 35. issue 7. 2015-01-22. PMID:25050430. |
the sf showed functional connectivity during joy with the mediodorsal thalamus (md) and nucleus accumbens (nac), suggesting that sf, md, and nac modulate approach behavior in response to positive social signals such as joyful music. |
2015-01-22 |
2023-08-13 |
Not clear |
| Yao-Ying Ma, Brian R Lee, Xiusong Wang, Changyong Guo, Lei Liu, Ranji Cui, Yan Lan, Judith J Balcita-Pedicino, Marina E Wolf, Susan R Sesack, Yavin Shaham, Oliver M Schlüter, Yanhua H Huang, Yan Don. Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections. Neuron. vol 83. issue 6. 2015-01-21. PMID:25199705. |
glutamatergic projections from the medial prefrontal cortex (mpfc) to nucleus accumbens (nac) contribute to cocaine relapse. |
2015-01-21 |
2023-08-13 |
rat |
| Elizabeth E Steinberg, Josiah R Boivin, Benjamin T Saunders, Ilana B Witten, Karl Deisseroth, Patricia H Jana. Positive reinforcement mediated by midbrain dopamine neurons requires D1 and D2 receptor activation in the nucleus accumbens. PloS one. vol 9. issue 4. 2015-01-19. PMID:24733061. |
here, we examine in transgenic rats whether dopamine neuron-specific icss relies on the connection between the vta and the nucleus accumbens (nac), a brain region also implicated in positive reinforcement. |
2015-01-19 |
2023-08-13 |
human |
| Jacki M Rorabaugh, Jennifer M Stratford, Nancy R Zahnise. A relationship between reduced nucleus accumbens shell and enhanced lateral hypothalamic orexin neuronal activation in long-term fructose bingeing behavior. PloS one. vol 9. issue 4. 2015-01-16. PMID:24736531. |
repeated ingestion of sucrose, a disaccharide of fructose and glucose, increases neuronal activity in hedonic centers, the nucleus accumbens (nac) shell and core, but not the hypothalamus. |
2015-01-16 |
2023-08-13 |
rat |