| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elizabeth A Barnes, Heidi L Kenerson, Xiuyun Jiang, Raymond S Yeun. Tuberin regulates E-cadherin localization: implications in epithelial-mesenchymal transition. The American journal of pathology. vol 177. issue 4. 2011-03-11. PMID:20813961. |
the tuberous sclerosis complex 2 (tsc2) gene encodes the protein tuberin, which functions as a key negative regulator of both mammalian target of rapamycin (mtor) c1-dependent cell growth and proliferation. |
2011-03-11 |
2023-08-12 |
human |
| Magdalena Ewa Tyburczy, Katarzyna Kotulska, Piotr Pokarowski, Jakub Mieczkowski, Joanna Kucharska, Wieslawa Grajkowska, Maciej Roszkowski, Sergiusz Jozwiak, Bozena Kaminsk. Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications. The American journal of pathology. vol 176. issue 4. 2010-12-14. PMID:20133820. |
subependymal giant cell astrocytomas (segas) are rare brain tumors associated with tuberous sclerosis complex (tsc), a disease caused by mutations in tsc1 or tsc2, resulting in enhancement of mammalian target of rapamycin (mtor) activity, dysregulation of cell growth, and tumorigenesis. |
2010-12-14 |
2023-08-12 |
human |
| Namiko Abe, Steven H Borson, Michael J Gambello, Fan Wang, Valeria Cavall. Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves. The Journal of biological chemistry. vol 285. issue 36. 2010-10-05. PMID:20615870. |
furthermore, genetic up-regulation of mtor activity by deletion of tuberous sclerosis complex 2 (tsc2) in drgs is sufficient to enhance axonal growth capacity in vitro and in vivo. |
2010-10-05 |
2023-08-12 |
Not clear |
| Ruhee Dere, Patricia D Wilson, Richard N Sandford, Cheryl Lyn Walke. Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR. PloS one. vol 5. issue 2. 2010-09-30. PMID:20169078. |
here we demonstrate a mechanism by which the intracellular, carboxy-terminal tail of polycystin-1 (cp1) regulates mtor signaling by altering the subcellular localization of the tuberous sclerosis complex 2 (tsc2) tumor suppressor, a gatekeeper for mtor activity. |
2010-09-30 |
2023-08-12 |
human |
| Jennifer M Spangle, Karl Münge. The human papillomavirus type 16 E6 oncoprotein activates mTORC1 signaling and increases protein synthesis. Journal of virology. vol 84. issue 18. 2010-09-20. PMID:20631133. |
it was previously reported that the human papillomavirus type 16 (hpv16) e6 oncoprotein may activate the s6 protein kinase (s6k) through binding and e6ap-mediated degradation of the mtor inhibitor tuberous sclerosis complex 2 (tsc2) (z. lu, x. hu, y. li, l. zheng, y. zhou, h. jiang, t. ning, z. basang, c. zhang, and y. ke, j. biol. |
2010-09-20 |
2023-08-12 |
human |
| L Krischock, R Beach, J Taylo. Sirolimus and tuberous sclerosis-associated renal angiomyolipomas. Archives of disease in childhood. vol 95. issue 5. 2010-07-07. PMID:20457704. |
tuberous sclerosis, caused by germline mutations in the tsc1 or tsc2 genes, is associated with aberrant upregulation of the mammalian target of rapamycin (mtor) signalling pathway, resulting in growth of tumours, including renal angiomyolipomas (amls). |
2010-07-07 |
2023-08-12 |
Not clear |
| John D Short, Ruhee Dere, Kevin D Houston, Sheng-Li Cai, Jinhee Kim, Judith M Bergeron, Jianjun Shen, Jiyong Liang, Mark T Bedford, Gordon B Mills, Cheryl Lyn Walke. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Molecular carcinogenesis. vol 49. issue 5. 2010-06-04. PMID:20146253. |
the tuberous sclerosis complex 2 (tsc2) gene product, tuberin, acts as a negative regulator of mtor signaling, and loss of tuberin function leads to tumors of the brain, skin, kidney, heart, and lungs. |
2010-06-04 |
2023-08-12 |
Not clear |
| Bobby Bhatia, Zaher Nahlé, Anna Marie Kenne. Double trouble: when sonic hedgehog signaling meets TSC inactivation. Cell cycle (Georgetown, Tex.). vol 9. issue 3. 2010-05-04. PMID:20081363. |
igf activates the mammalian target of rapamycin (mtor), a growth-promoting kinase normally kept in check by the tumor suppressive tuberous sclerosis complex (tsc), comprised of tsc1 and tsc2. |
2010-05-04 |
2023-08-12 |
mouse |
| Duyu Nie, Alessia Di Nardo, Juliette M Han, Hasani Baharanyi, Ioannis Kramvis, Thanhthao Huynh, Sandra Dabora, Simone Codeluppi, Pier Paolo Pandolfi, Elena B Pasquale, Mustafa Sahi. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nature neuroscience. vol 13. issue 2. 2010-02-18. PMID:20062052. |
tuberous sclerosis complex is a disease caused by mutations in the tsc1 or tsc2 genes, which encode a protein complex that inhibits mtor kinase signaling by inactivating the rheb gtpase. |
2010-02-18 |
2023-08-12 |
mouse |
| Duyu Nie, Alessia Di Nardo, Juliette M Han, Hasani Baharanyi, Ioannis Kramvis, Thanhthao Huynh, Sandra Dabora, Simone Codeluppi, Pier Paolo Pandolfi, Elena B Pasquale, Mustafa Sahi. Tsc2-Rheb signaling regulates EphA-mediated axon guidance. Nature neuroscience. vol 13. issue 2. 2010-02-18. PMID:20062052. |
furthermore, tsc2 deficiency and hyperactive rheb constitutively activated mtor and inhibited ephrin-induced growth cone collapse. |
2010-02-18 |
2023-08-12 |
mouse |
| Lianqin Zhang, Scot R Kimball, Leonard S Jefferson, Jeffrey S Shenberge. Hydrogen peroxide impairs insulin-stimulated assembly of mTORC1. Free radical biology & medicine. vol 46. issue 11. 2009-12-23. PMID:19281842. |
we show that insulin stimulated the phosphorylation of tsc2 leading to a reduction in raptor-mtor binding and in the quantity of proline-rich akt substrate 40 (pras40) precipitating with mtor. |
2009-12-23 |
2023-08-12 |
cattle |
| Milena Morel, Julien Couturier, Raymond Pontcharraud, Roger Gil, Bernard Fauconneau, Marc Paccalin, Guylène Pag. Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity: role of p53, Redd1 and TSC2. Neurobiology of disease. vol 36. issue 1. 2009-12-07. PMID:19631745. |
this study analysed the crosslink between the up regulation of double-stranded rna-dependent-protein kinase (pkr) and the down regulation of mammalian target of rapamycin (mtor) signalling pathways via p53, the protein regulated in the development and dna damage response 1 (redd1) and the tuberous sclerosis complex (tsc2) factors in two beta-amyloid peptide (abeta) neurotoxicity models. |
2009-12-07 |
2023-08-12 |
rat |
| Surojeet Sengupta, Rachel Schiff, Benita S Katzenellenboge. Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER2 overexpressing, estrogen receptor-positive breast cancer cells. Breast cancer research and treatment. vol 117. issue 2. 2009-11-17. PMID:18807177. |
pi3k/akt and mapk pathways are known to result in the phosphorylation and functional inactivation of tuberin (tsc2) of tuberous sclerosis complex thereby negating its inhibitory effects on mtor, which in turn stimulates the translational machinery. |
2009-11-17 |
2023-08-12 |
Not clear |
| Hui H Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M Squillace, Chin-Lee Wu, Brendan D Mannin. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PloS one. vol 4. issue 7. 2009-11-10. PMID:19593385. |
one direct substrate that is inhibited by akt-mediated phosphorylation is the tuberous sclerosis complex 2 (tsc2) protein, which associates with tsc1 and acts as a critical negative regulator of the mammalian target of rapamycin (mtor) complex 1 (mtorc1). |
2009-11-10 |
2023-08-12 |
Not clear |
| Bobby Bhatia, Paul A Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Daniel J Brat, Jack L Arbiser, Eric C Holland, Michael D Taylor, Anna Marie Kenne. Tuberous sclerosis complex suppression in cerebellar development and medulloblastoma: separate regulation of mammalian target of rapamycin activity and p27 Kip1 localization. Cancer research. vol 69. issue 18. 2009-10-07. PMID:19738049. |
one of the consequences of igf signaling is inactivation of the mammalian target of rapamycin (mtor)-suppressing tuberous sclerosis complex (tsc), comprised of tsc1 and tsc2, leading to increased mrna translation. |
2009-10-07 |
2023-08-12 |
mouse |
| Mitsunori Miyazaki, Karyn A Esse. REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. American journal of physiology. Cell physiology. vol 296. issue 3. 2009-04-27. PMID:19129461. |
knock down of tuberous sclerosis complex 2 (tsc2) using small interfering (si)rna potently activated mtor signaling and was sufficient to rescue redd2 inhibition of mtor activity, suggesting that redd2 functions by modulating tsc2 function. |
2009-04-27 |
2023-08-12 |
Not clear |
| Christopher B Marshall, Jason Ho, Claudia Buerger, Michael J Plevin, Guang-Yao Li, Zhihong Li, Mitsuhiko Ikura, Vuk Stamboli. Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR. Science signaling. vol 2. issue 55. 2009-03-18. PMID:19176517. |
tuberous sclerosis complex 2 (tsc2), whose gene is frequently mutated in tuberous sclerosis, increases the guanosine triphosphatase (gtpase) activity of the small heterotrimeric gtp-binding protein (g protein) rheb, thus resulting in the decreased activity of the mammalian target of rapamycin (mtor), the master regulator of cell growth. |
2009-03-18 |
2023-08-12 |
Not clear |
| Julian R Sampso. Therapeutic targeting of mTOR in tuberous sclerosis. Biochemical Society transactions. vol 37. issue Pt 1. 2009-02-11. PMID:19143643. |
both diseases are caused by mutations of tsc1 or tsc2 (tsc is tuberous sclerosis complex) that impair gap (gtpase-activating protein) activity of the tsc1-tsc2 complex for rheb, leading to inappropriate activity of signalling downstream of mtorc1 (mtor complex 1). |
2009-02-11 |
2023-08-12 |
mouse |
| Valerio Napolioni, Romina Moavero, Paolo Curatol. Recent advances in neurobiology of Tuberous Sclerosis Complex. Brain & development. vol 31. issue 2. 2009-02-09. PMID:19028034. |
tuberous sclerosis complex (tsc) is a multisystem genetic disorder with variable phenotypic expression, due to a mutation in one of the two genes, tsc1 and tsc2, and a subsequent hyperactivation of the downstream mtor pathway, resulting in increased cell growth and proliferation. |
2009-02-09 |
2023-08-12 |
Not clear |
| Jeremy Marsh, Purna Mukherjee, Thomas N Seyfrie. Akt-dependent proapoptotic effects of dietary restriction on late-stage management of a phosphatase and tensin homologue/tuberous sclerosis complex 2-deficient mouse astrocytoma. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 14. issue 23. 2009-02-05. PMID:19047102. |
many astrocytomas are also tuberous sclerosis complex 2 (tsc2) protein deficient and exhibit constitutive mammalian target of rapamycin (mtor) activity. |
2009-02-05 |
2023-08-12 |
mouse |