| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christiane Fuchs, Margit Rosner, Helmut Dolznig, Mario Mikula, Nina Kramer, Markus Hengstschläge. Tuberin and PRAS40 are anti-apoptotic gatekeepers during early human amniotic fluid stem-cell differentiation. Human molecular genetics. vol 21. issue 5. 2012-07-05. PMID:22090422. |
here, we report that sirna-mediated knockdown of the endogenous tuberous sclerosis complex-2 (tsc2) gene product tuberin or of proline-rich akt substrate of 40 kda (pras40), the two major negative regulators of mammalian target of rapamycin (mtor), leads to massive apoptotic cell death during eb development of human afs cells without affecting the endodermal, mesodermal and ectodermal cell differentiation spectrum. |
2012-07-05 |
2023-08-12 |
human |
| Pei Wang, Yun-Feng Guan, Hui Du, Qi-Wei Zhai, Ding-Feng Su, Chao-Yu Mia. Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. vol 8. issue 1. 2012-06-06. PMID:22113203. |
immunochemistry (lc3-ii), electron microscope and immunoblotting assays (lc3-ii, beclin-1, mammalian target of rapamycin [mtor], s6k1 and tuberous sclerosis complex-2 [tsc2]) were performed to assess autophagy. |
2012-06-06 |
2023-08-12 |
rat |
| Wei Chen, Tao Ma, Xu-ning Shen, Xue-feng Xia, Guo-dong Xu, Xue-li Bai, Ting-bo Lian. Macrophage-induced tumor angiogenesis is regulated by the TSC2-mTOR pathway. Cancer research. vol 72. issue 6. 2012-05-14. PMID:22287548. |
in human peripheral monocytes stimulated by lipopolysaccharide, mtor was inhibited by rapamycin or activated by rna interference-mediated knockdown of the mtor repressor tuberous sclerosis complex 2 (tsc2). |
2012-05-14 |
2023-08-12 |
human |
| Guido Martignoni, Franco Bonetti, Marco Chilosi, Matteo Brunelli, Diego Segala, Mahul B Amin, Pedram Argani, John N Eble, Stefano Gobbo, Maurizio Pe. Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. vol 25. issue 1. 2012-05-01. PMID:21874011. |
it has been demonstrated that most of these lesions are determined by mutations affecting genes of the tuberous sclerosis complex, tuberous sclerosis 1 (tsc1) and tuberous sclerosis 2 (tsc2), with eventual deregulation of the rheb/mtor/rps6kb2 pathway, and it has been observed that some pecomas regressed during sirolimus therapy, an mtor inhibitor. |
2012-05-01 |
2023-08-12 |
Not clear |
| Thomas G Sommermann, Kathleen O'Neill, David R Plas, Ellen Cahir-McFarlan. IKKβ and NF-κB transcription govern lymphoma cell survival through AKT-induced plasma membrane trafficking of GLUT1. Cancer research. vol 71. issue 23. 2012-04-04. PMID:21987722. |
activated nf-κb promoted akt-mediated phosphorylation of the glut1 regulator, akt substrate of 160kd (as160), but was not required for akt phosphorylation of the mtor regulator tuberous sclerosis 2 (tsc2). |
2012-04-04 |
2023-08-12 |
Not clear |
| Peter B Crin. mTOR: A pathogenic signaling pathway in developmental brain malformations. Trends in molecular medicine. vol 17. issue 12. 2012-04-02. PMID:21890410. |
aberrant hyperactivation of mtor as a consequence of loss-of-function gene mutations encoding mtor inhibitor proteins such as tsc1, tsc2, pten and stradα has been recently linked to developmental cortical malformations associated with epilepsy and neurobehavioral disabilities. |
2012-04-02 |
2023-08-12 |
Not clear |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Chandi Charan Mandal, Lenin Mahimainathan, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhur. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22184110. |
tuberous sclerosis complex 2 (tsc2) and phosphatase and tensin homolog deleted on chromosome 10 (pten) function to block growth factor-induced mammalian target of rapamycin (mtor) signaling and are mutated in autosomal dominant hamartoma syndromes. |
2012-03-25 |
2023-08-12 |
mouse |
| Falguni Das, Nandini Ghosh-Choudhury, Nirmalya Dey, Chandi Charan Mandal, Lenin Mahimainathan, Balakuntalam S Kasinath, Hanna E Abboud, Goutam Ghosh Choudhur. Unrestrained mammalian target of rapamycin complexes 1 and 2 increase expression of phosphatase and tensin homolog deleted on chromosome 10 to regulate phosphorylation of Akt kinase. The Journal of biological chemistry. vol 287. issue 6. 2012-03-25. PMID:22184110. |
tsc2 deficiency induces constitutive activation of mtor, leading to a state of insulin resistance due to a negative feedback regulation, resulting in reduced akt phosphorylation. |
2012-03-25 |
2023-08-12 |
mouse |
| Duyu Nie, Mustafa Sahi. A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures. Methods in molecular biology (Clifton, N.J.). vol 821. 2012-03-16. PMID:22125080. |
tuberous sclerosis complex (tsc) is an autosomal dominant disease caused by mutations in either of two genes, tsc1 or tsc2, whose protein products form a complex that is essential in the regulation of mammalian target of rapamycin (mtor) activity. |
2012-03-16 |
2023-08-12 |
Not clear |
| Hiroyuki Mori, Kun-Liang Gua. Tissue-specific ablation of Tsc1 in pancreatic beta-cells. Methods in molecular biology (Clifton, N.J.). vol 821. 2012-03-16. PMID:22125081. |
tuberous sclerosis complex 1 (tsc1) is a tumor suppressor that associates with tsc2 to inactivate rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mtor) complex 1 (mtorc1). |
2012-03-16 |
2023-08-12 |
mouse |
| Xin Tong, Kimberly A Smith, Jill C Pellin. Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes. Molecular carcinogenesis. vol 51. issue 3. 2012-03-09. PMID:21538580. |
although ampk is traditionally thought to play a major role in the regulation of cellular lipid and protein metabolism, recent discoveries reveal that ampk inhibits mammalian target of rapamycin (mtor) signaling and connects with several tumor suppressors such as liver kinase b1 (lkb1), p53, and tuberous sclerosis complex 2 (tsc2), indicating that ampk may be a potential target for cancer prevention and treatment. |
2012-03-09 |
2023-08-12 |
human |
| Yoshihiro Tanaka, Joo Hyun Park, Pradeep S Tanwar, Tomoko Kaneko-Tarui, Shilpi Mittal, Ho-Joon Lee, Jose M Teixeir. Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility. Endocrinology. vol 153. issue 1. 2012-03-05. PMID:22128018. |
tumors develop with dysregulated activation of mammalian target of rapamycin (mtor), the kinase activity of which is kept in an inactive state by a tumor suppressor dimer containing tuberous sclerosis 1 (tsc1) and tsc2. |
2012-03-05 |
2023-08-12 |
mouse |
| Sandra L Dabora, David Neal Franz, Stephen Ashwal, Arthur Sagalowsky, Francis J DiMario, Daniel Miles, Drew Cutler, Darcy Krueger, Raul N Uppot, Rahmin Rabenou, Susana Camposano, Jan Paolini, Fiona Fennessy, Nancy Lee, Chelsey Woodrum, Judith Manola, Judy Garber, Elizabeth A Thiel. Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF- D levels decrease. PloS one. vol 6. issue 9. 2012-02-14. PMID:21915260. |
tuberous sclerosis (tsc) related tumors are characterized by constitutively activated mtor signaling due to mutations in tsc1 or tsc2. |
2012-02-14 |
2023-08-12 |
Not clear |
| M Rosner, M Hengstschläge. Nucleocytoplasmic localization of p70 S6K1, but not of its isoforms p85 and p31, is regulated by TSC2/mTOR. Oncogene. vol 30. issue 44. 2012-01-26. PMID:21602892. |
the tuberous sclerosis complex gene 2 (tsc2)/mammalian target of rapamycin (mtor) pathway controls many cellular functions via phosphorylation of ribosomal protein s6 kinases (s6ks). |
2012-01-26 |
2023-08-12 |
Not clear |
| Jianling Xie, Godwin A Ponuwei, Claire E Moore, Gary B Willars, Andrew R Tee, Terence P Herber. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Cellular signalling. vol 23. issue 12. 2012-01-13. PMID:21763421. |
we also show that camp inhibits insulin and amino acid-stimulated mtorc1 activation independently of rheb, rag gtpases, tsc2, pkb, mapk and ampk, indicating that camp may act independently of known regulatory inputs into mtor. |
2012-01-13 |
2023-08-12 |
mouse |
| Scott G Turner, Katherine B Peters, James J Vredenburgh, Annick Desjardins, Henry S Friedman, David A Reardo. Everolimus tablets for patients with subependymal giant cell astrocytoma. Expert opinion on pharmacotherapy. vol 12. issue 14. 2012-01-13. PMID:21806479. |
abnormal mammalian target of rapamycin (mtor) complex signaling and defects in tsc1 and tsc2 have been associated with the development of subependymal giant cell astrocytomas (segas) in tuberous sclerosis complex (tsc) patients. |
2012-01-13 |
2023-08-12 |
Not clear |
| Shouwei Han, Ying Zheng, Jesse Roma. Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2. PPAR research. vol 2007. 2011-07-14. PMID:17597835. |
we set out to test the hypothesis that ppargamma ligands activate tuberous sclerosis complex-2 (tsc2), a tumor suppressor gene that inhibits mtor signaling. |
2011-07-14 |
2023-08-12 |
Not clear |
| François Vigneron, Pierre Dos Santos, Sandrine Lemoine, Maryline Bonnet, Liliane Tariosse, Thierry Couffinhal, Cécile Duplaà, Béatrice Jaspard-Vinass. GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways. Cardiovascular research. vol 90. issue 1. 2011-07-11. PMID:21233250. |
a downstream target might be mammalian target of rapamycin (mtor) since wnt can impair tuberous sclerosis complex-2 (tsc2) phosphorylation by inhibiting gsk-3β. |
2011-07-11 |
2023-08-12 |
Not clear |
| David M Feliciano, Tiffany Su, Jean Lopez, Jean-Claude Platel, Angélique Borde. Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice. The Journal of clinical investigation. vol 121. issue 4. 2011-06-21. PMID:21403402. |
tuberous sclerosis complex (tsc) is an autosomal dominant disorder characterized by mutations in tsc1 or tsc2 that lead to mammalian target of rapamycin (mtor) hyperactivity. |
2011-06-21 |
2023-08-12 |
mouse |
| Juinn-Lin Liu, Zhenyu Mao, Gary E Gallick, W K Alfred Yun. AMPK/TSC2/mTOR-signaling intermediates are not necessary for LKB1-mediated nuclear retention of PTEN tumor suppressor. Neuro-oncology. vol 13. issue 2. 2011-05-09. PMID:21123367. |
because mtor can be alternatively downregulated by tuberous sclerosis complex 2 (tsc2) activation mediated by 5' adenosine monophosphate-activated protein kinase (ampk), we proposed that the activation of ampk α1/2 by lkb1 and/or by calmodulin-dependent protein kinase kinase (camkk) would also block the nuclear export of pten in a manner similar to that of inhibitors of pi3k, mtor, and s6k. |
2011-05-09 |
2023-08-12 |
mouse |