| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Candi L Lasarge, Steve C Danze. Mechanisms regulating neuronal excitability and seizure development following mTOR pathway hyperactivation. Frontiers in molecular neuroscience. vol 7. 2014-06-24. PMID:24672426. |
animal models deleting pten, tsc1, and tsc2 consistently produce epilepsy phenotypes, demonstrating that increased mtor signaling can provoke neuronal hyperexcitability. |
2014-06-24 |
2023-08-12 |
mouse |
| Ryan C Riddle, Julie L Frey, Ryan E Tomlinson, Mathieu Ferron, Yuanyuan Li, Douglas J DiGirolamo, Marie-Claude Faugere, Mehboob A Hussain, Gerard Karsenty, Thomas L Clemen. Tsc2 is a molecular checkpoint controlling osteoblast development and glucose homeostasis. Molecular and cellular biology. vol 34. issue 10. 2014-06-12. PMID:24591652. |
here, we show that loss of tsc2 in osteoblasts constitutively activates mtor and destabilizes irs1, causing osteoblasts to differentiate poorly and become resistant to insulin. |
2014-06-12 |
2023-08-12 |
mouse |
| Ji-Young Ha, Ji-Soo Kim, Young-Hee Kang, Eugene Bok, Yoon-Seong Kim, Jin H So. Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24444419. |
here, we demonstrate that the os-induced tnfaip8 l1/oxi-β could increase autophagy by a unique mechanism that increases the stability of tuberous sclerosis complex 2 (tsc2), a critical negative regulator of mtor. |
2014-06-04 |
2023-08-12 |
Not clear |
| Esther Lopez-Rivera, Padmini Jayaraman, Falguni Parikh, Michael A Davies, Suhendan Ekmekcioglu, Sudeh Izadmehr, Denái R Milton, Jerry E Chipuk, Elizabeth A Grimm, Yeriel Estrada, Julio Aguirre-Ghiso, Andrew G Sikor. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer research. vol 74. issue 4. 2014-04-22. PMID:24398473. |
inos expression and no were associated with reversible nitrosylation of tuberous sclerosis complex (tsc) 2, and inhibited dimerization of tsc2 with its inhibitory partner tsc1, enhancing gtpase activity of its target ras homolog enriched in brain (rheb), a critical activator of mtor signaling. |
2014-04-22 |
2023-08-12 |
human |
| Min Qi, Haiyan Zhou, Simiao Fan, Zhao Li, Guodong Yao, Shin-Ichi Tashiro, Satoshi Onodera, Mingyu Xia, Takashi Ikejim. mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in psedolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells. European journal of pharmacology. vol 715. issue 1-3. 2014-04-14. PMID:23810968. |
activation of mtor by insulin or inhibition of endogenous tsc2 levels by sirna obviously delayed pab-induced senescence. |
2014-04-14 |
2023-08-12 |
Not clear |
| Brittany L Jacobs, Jae-Sung You, John W Frey, Craig A Goodman, David M Gundermann, Troy A Hornberge. Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome. The Journal of physiology. vol 591. issue 18. 2014-04-03. PMID:23732640. |
the goal of this study was to determine whether the mechanical activation of mechanistic target of rapamycin (mtor) signalling is associated with changes in phosphorylation of tuberous sclerosis complex-2 (tsc2) and targeting of mtor and tsc2 to the lysosome. |
2014-04-03 |
2023-08-12 |
mouse |
| Altaf Mohammed, Naveena B Janakiram, Misty Brewer, Rebekah L Ritchie, Anuj Marya, Stan Lightfoot, Vernon E Steele, Chinthalapally V Ra. Antidiabetic Drug Metformin Prevents Progression of Pancreatic Cancer by Targeting in Part Cancer Stem Cells and mTOR Signaling. Translational oncology. vol 6. issue 6. 2014-01-27. PMID:24466367. |
the pancreatic tissue and/or serum of mice fed metformin showed a significant inhibition of mammalian target of rapamycin (mtor), extracellular signal-regulated kinases (erk), phosphorylated extracellular signal-regulated kinases (perk), and insulin-like growth factor 1 (igf-1) with an increase in phosphorylated 5' adenosine monophosphate kinase (pampk), tuberous sclerosis complex 1 (tsc1, tsc2), c-protein and an autophagy related protein 2 (atg2). |
2014-01-27 |
2023-08-12 |
mouse |
| H Peng, J Liu, Q Sun, R Chen, Y Wang, J Duan, C Li, B Li, Y Jing, X Chen, Q Mao, K-F Xu, C L Walker, J Li, J Wang, H Zhan. mTORC1 enhancement of STIM1-mediated store-operated Ca2+ entry constrains tuberous sclerosis complex-related tumor development. Oncogene. vol 32. issue 39. 2013-11-15. PMID:23108404. |
the protein complex of tuberous sclerosis complex (tsc)1 and tsc2 tumor suppressors is a key negative regulator of mammalian target of rapamycin (mtor). |
2013-11-15 |
2023-08-12 |
Not clear |
| Marco Cambiaghi, Marco Cursi, Laura Magri, Valerio Castoldi, Giancarlo Comi, Fabio Minicucci, Rossella Galli, Letizia Leocan. Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of tuberous sclerosis complex. Neuropharmacology. vol 67. 2013-11-04. PMID:23159330. |
tuberous sclerosis complex (tsc) is a multisystem genetic disorder caused by mutation in either tsc1 or tsc2 genes that leads to the hyper activation of the mtor pathway, a key signalling pathway for synaptic plasticity. |
2013-11-04 |
2023-08-12 |
mouse |
| James L Figarola, Samuel Rahba. Small‑molecule COH-SR4 inhibits adipocyte differentiation via AMPK activation. International journal of molecular medicine. vol 31. issue 5. 2013-10-29. PMID:23525347. |
ampk activation by coh-sr4 also resulted in the phosphorylation of raptor and tuberous sclerosis protein 2 (tsc2), two proteins involved in the mammalian target of rapamycin (mtor) signaling pathways. |
2013-10-29 |
2023-08-12 |
Not clear |
| Anil J Trindade, Douglas A Medvetz, Nicole A Neuman, Faina Myachina, Jane Yu, Carmen Priolo, Elizabeth P Hensk. MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM). PloS one. vol 8. issue 3. 2013-09-30. PMID:23555865. |
lam is caused by mutations in the tuberous sclerosis complex genes (tsc1 or tsc2), resulting in hyperactive mammalian target of rapamycin (mtor) signaling. |
2013-09-30 |
2023-08-12 |
Not clear |
| Hannah Crossland, Abid A Kazi, Charles H Lang, James A Timmons, Philippe Pierre, Daniel J Wilkinson, Kenneth Smith, Nathaniel J Szewczyk, Philip J Atherto. Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway. American journal of physiology. Endocrinology and metabolism. vol 305. issue 2. 2013-09-19. PMID:23695213. |
igf-i-induced increases in myotube width (+41 ± 7% vs. non-igf-i-treated) and total protein (+44 ± 6%) were, after 24 h, attenuated in fak-kd cells, whereas mps was suppressed in fak-kd vs. scr after 4 h. these blunted responses were associated with attenuated igf-i-induced fak tyr³⁹⁷ phosphorylation and markedly suppressed phosphorylation of tuberous sclerosis complex 2 (tsc2) and critical downstream mtor signaling (ribosomal s6 kinase, eif4f assembly) in fak shrna cells (all p < 0.05 vs. igf-i-treated scr cells). |
2013-09-19 |
2023-08-12 |
Not clear |
| Yan Chen Shang, Zhao Zhong Chong, Shaohui Wang, Kenneth Maies. Tuberous sclerosis protein 2 (TSC2) modulates CCN4 cytoprotection during apoptotic amyloid toxicity in microglia. Current neurovascular research. vol 10. issue 1. 2013-07-29. PMID:23244622. |
however, a minimal level of tsc2 activity is necessary to modulate wisp1 cytoprotection that may require modulation of mtor activity, since gene knockdown of tsc2 impairs the ability of wisp1 to protect microglia against apoptotic membrane phosphatidylserine (ps) exposure, nuclear dna degradation, mitochondrial membrane depolarization, and cytochrome c release during aβ. |
2013-07-29 |
2023-08-12 |
Not clear |
| Hung-Li Wang, Ning-Chun Chang, Yi-Hsin Weng, Tu-Hsueh Ye. XLID CUL4B mutants are defective in promoting TSC2 degradation and positively regulating mTOR signaling in neocortical neurons. Biochimica et biophysica acta. vol 1832. issue 4. 2013-06-13. PMID:23348097. |
by promoting tsc2 degradation, cul4b could positively regulate mtor activity in neocortical neurons of frontal cortex. |
2013-06-13 |
2023-08-12 |
Not clear |
| B Duchemann, B Duchemain, S Wong, V Baruch-Hennequin, S Rivera, L Quero, C Hennequi. [Hypersensitivity to radiation therapy in a patient with tuberous sclerosis: biological considerations about a clinical case]. Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique. vol 17. issue 1. 2013-04-18. PMID:23270679. |
tuberous sclerosis is characterized by a loss of the tsc2 function, with a permanent activation of the mtor pathway. |
2013-04-18 |
2023-08-12 |
Not clear |
| Wenjuan Ru, Yanxi Peng, Ling Zhong, Shao-Jun Tan. A role of the mammalian target of rapamycin (mTOR) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (TSC2). Journal of molecular neuroscience : MN. vol 47. issue 2. 2013-03-26. PMID:22492229. |
a role of the mammalian target of rapamycin (mtor) in glutamate-induced down-regulation of tuberous sclerosis complex proteins 2 (tsc2). |
2013-03-26 |
2023-08-12 |
Not clear |
| M Luz Ruiz-Falcó Roja. [Therapeutic update in tuberous sclerosis complex: the role of mTOR pathway inhibitors]. Revista de neurologia. vol 54 Suppl 3. 2013-01-29. PMID:22605628. |
it has been shown that in tuberous sclerosis complex the genes tsc1 and tsc2 alter the mtor enzyme cascade, which sets off inhibition of this pathway. |
2013-01-29 |
2023-08-12 |
Not clear |
| Sangyeul Han, Sun Kim, Samira Bahl, Lin Li, Clara F Burande, Nicole Smith, Marianne James, Roberta L Beauchamp, Pradeep Bhide, Aaron DiAntonio, Vijaya Rames. The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. The Journal of biological chemistry. vol 287. issue 36. 2012-11-19. PMID:22798074. |
our earlier studies identified pam to be associated with tuberous sclerosis complex (tsc) proteins, ubiquitinating tsc2 and regulating mammalian/mechanistic target of rapamycin (mtor) signaling. |
2012-11-19 |
2023-08-12 |
mouse |
| Naveen Sharma, Carlos M Castorena, Gregory D Carte. Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats. PloS one. vol 7. issue 6. 2012-11-08. PMID:22701721. |
accordingly, we analyzed the phosphorylation status of 11 key signaling proteins from the insulin/igf-1 (ir(tyr1162/1163), igf-1r(tyr1135/1136), irs-1(ser312), pten(ser380), akt(ser473), gsk3α(ser21), gsk3β(ser9)) and mtor (tsc2(ser939), mtor(ser2448), p70s6k(thr412), rps6(ser235/236)) pathways in 11 diverse tissues [liver, kidney, lung, aorta, two brain regions (cortex and cerebellum), and two slow-twitch and three fast-twitch skeletal muscles] from 9-month-old male al and cr fischer 344 x brown norway rats. |
2012-11-08 |
2023-08-12 |
rat |
| Peter T Tsai, Court Hull, YunXiang Chu, Emily Greene-Colozzi, Abbey R Sadowski, Jarrett M Leech, Jason Steinberg, Jacqueline N Crawley, Wade G Regehr, Mustafa Sahi. Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. Nature. vol 488. issue 7413. 2012-10-11. PMID:22763451. |
tuberous sclerosis complex (tsc) is a genetic disorder with high rates of comorbid asds that result from mutation of either tsc1 or tsc2, whose protein products dimerize and negatively regulate mammalian target of rapamycin (mtor) signalling. |
2012-10-11 |
2023-08-12 |
mouse |