| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| George Imataka, Satoshi Mori, Kunio Yui, Ken Igawa, Hideaki Shiraishi, Shigemi Yoshihar. The Therapeutic Potential of Oral Everolimus for Facial Angiofibromas in Pediatric Tuberous Sclerosis Complex: A Case-Based Analysis of Efficacy. Diseases (Basel, Switzerland). vol 12. issue 12. 2024-12-27. PMID:39727664. |
tuberous sclerosis complex (tsc) is an autosomal dominant genetic disorder characterized by mutations in the tsc1 and tsc2 genes, leading to the dysregulation of the mammalian target of rapamycin (mtor) pathway. |
2024-12-27 |
2024-12-29 |
Not clear |
| Max Kowalczyk, Yu-Ju Lee, Wei-Hsiang Huan. TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1 Molecular biology of the cell. 2024-11-27. PMID:39602293. |
here we study how loss of tsc2, a regulator of mtor pathway and a causal gene for tuberous sclerosis complex (tsc), affects dentate gyrus granule cell (dgc) morphogenesis and hippocampal-dependent function. |
2024-11-27 |
2024-11-30 |
Not clear |
| Youfang Jiang, Fei Le, Shuangling Huang, Xuezhong Chen, Ziqing Den. MLN4924 resses Head and Neck Squamous Cell Carcinoma Progression by Inactivating the mTOR Signaling Pathway via the NEDD8/CUL4/TSC2 axis. The international journal of biochemistry & cell biology. 2024-11-20. PMID:39566655. |
mechanistic studies demonstrated that mln4924 inhibited the binding of nedd8 to cullin4 (cul4) and prevented the neddylation of tuberous sclerosis complex 2 (tsc2), leading to the inactivation of the mtor pathway. |
2024-11-20 |
2024-11-23 |
Not clear |
| Kristen H Arredondo, Kristina Jülich, E Steve Roac. Tuberous sclerosis complex: Diagnostic features, surveillance, and therapeutic strategies. Seminars in pediatric neurology. vol 51. 2024-10-10. PMID:39389658. |
tuberous sclerosis complex (tsc) is a rare neurocutaneous disorder of mtor pathway dysregulation resulting from pathogenic variants in the tsc1 or tsc2 genes. |
2024-10-10 |
2024-10-13 |
Not clear |
| Alice Man, Matteo Di Scipio, Breanne Dale, Paula Teixeira Marques, Cynthia Sloan Birbeck, Puneet Jain, Elisabetta Trinari, Resham Ejaz, Robyn Whitne. Severe Epilepsy in an Individual With a TSC2 R905Q Variant Prompting Late Diagnosis in Affected Family Members. Pediatric neurology. vol 161. 2024-10-09. PMID:39383590. |
tuberous sclerosis complex (tsc) is a multisystemic disorder caused by inactivating variants in the mtor pathway inhibitor genes tsc1 and tsc2. |
2024-10-09 |
2024-10-12 |
Not clear |
| Shuyun Zhao, Shuai Hao, Jiasheng Zhou, Xinran Chen, Tianhua Zhang, Zhaolai Qi, Ting Zhang, Sajid Jalal, Chuanxin Zhai, Lu Yin, Yufei Bo, Hongming Teng, Yue Wang, Dongyan Gao, Hongbing Zhang, Lin Huan. mTOR/miR-142-3p/PRAS40 signaling cascade is critical for tuberous sclerosis complex-associated renal cystogenesis. Cellular & molecular biology letters. vol 29. issue 1. 2024-09-28. PMID:39333852. |
patients with tuberous sclerosis complex (tsc) develop renal cysts and/or angiomyolipomas (amls) due to inactive mutations of either tsc1 or tsc2 and consequential mtor hyperactivation. |
2024-09-28 |
2024-10-01 |
Not clear |
| Christine Chin-Jung Hsieh, Yu-Chun Lo, Hsin-Hui Wang, Hsin-Ying Shen, You-Yin Chen, Yi-Chao Le. Amelioration of the brain structural connectivity is accompanied with changes of gut microbiota in a tuberous sclerosis complex mouse model. Translational psychiatry. vol 14. issue 1. 2024-01-31. PMID:38296969. |
in our previous study, curcumin, a diet-derived mtor inhibitor has been shown to effectively mitigate learning and memory deficits and anxiety-like behavior in tsc2 |
2024-01-31 |
2024-02-03 |
mouse |
| Vasiliki Karalis, Delaney Wood, Nicole A Teaney, Mustafa Sahi. The role of TSC1 and TSC2 proteins in neuronal axons. Molecular psychiatry. 2024-01-11. PMID:38212374. |
this complex primarily acts as an inhibitor of the mechanistic target of rapamycin (mtor) kinase, and mutations in either tsc1 or tsc2 cause a neurodevelopmental disorder called tuberous sclerosis complex (tsc). |
2024-01-11 |
2024-01-14 |
Not clear |
| Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang, Jaba Mitra, Hu Wang, Taekyung Ryu, Saurav Brahmachari, Senthilkumar S Karuppagounder, Yasuyoshi Kimura, Aanishaa Jhaldiyal, Hyun Hee Kim, Hao Gu, Rong Chen, Javier Redding-Ochoa, Juan Troncoso, Chan Hyun Na, Taekjip Ha, Valina L Dawson, Ted M Dawso. Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. Science translational medicine. vol 15. issue 724. 2023-12-01. PMID:38019930. |
pathologic α-synuclein was found to bind with the tuberous sclerosis protein 2 (tsc2) and to trigger the activation of the mammalian target of rapamycin (mtor) complex 1 (mtorc1), which augmented mrna translation and protein synthesis, leading to neurodegeneration. |
2023-12-01 |
2023-12-07 |
mouse |
| Mohammed Repon Khan, Xiling Yin, Sung-Ung Kang, Jaba Mitra, Hu Wang, Taekyung Ryu, Saurav Brahmachari, Senthilkumar S Karuppagounder, Yasuyoshi Kimura, Aanishaa Jhaldiyal, Hyun Hee Kim, Hao Gu, Rong Chen, Javier Redding-Ochoa, Juan Troncoso, Chan Hyun Na, Taekjip Ha, Valina L Dawson, Ted M Dawso. Enhanced mTORC1 signaling and protein synthesis in pathologic α-synuclein cellular and animal models of Parkinson's disease. Science translational medicine. vol 15. issue 724. 2023-12-01. PMID:38019930. |
pathologic α-synuclein was found to bind with the tuberous sclerosis protein 2 (tsc2) and to trigger the activation of the mammalian target of rapamycin (mtor) complex 1 (mtorc1), which augmented mrna translation and protein synthesis, leading to neurodegeneration. |
2023-11-29 |
2023-12-07 |
mouse |
| He Min, Linhua Yang, Xinsen Xu, Yajun Geng, Fatao Liu, Yingbin Li. SNHG15 promotes gallbladder cancer progression by enhancing the autophagy of tumor cell under nutrition stress. Cell cycle (Georgetown, Tex.). 2023-11-08. PMID:37937948. |
mechanistically, snhg15 could interact with ampk and facilitate the phosphorylation of ampk to tuberous sclerosis complex tsc2, resulting in mtor suppression and autophagy enhancement, and finally, conferring the gbc cell sustain proliferation under nutrition stress. |
2023-11-08 |
2023-11-20 |
Not clear |
| Paolo Curatolo, Mirte Scheper, Leonardo Emberti Gialloreti, Nicola Specchio, Eleonora Aronic. Is tuberous sclerosis complex-associated autism a preventable and treatable disorder? World journal of pediatrics : WJP. 2023-10-25. PMID:37878130. |
tuberous sclerosis complex (tsc) is a genetic disorder caused by inactivating mutations in the tsc1 and tsc2 genes, causing overactivation of the mechanistic (previously referred to as mammalian) target of rapamycin (mtor) signaling pathway in fetal life. |
2023-10-25 |
2023-11-08 |
Not clear |
| Gurneel K Dhanesar, Harish Rengarajan, Baidarbhi Chakrabort. Malignant Perivascular Epithelioid Cell Tumor of the Uterus. Cureus. vol 15. issue 7. 2023-08-14. PMID:37575749. |
they belong to the family of mesenchymal tumors and include angiomyolipomas, clear cell sugar tumors of the lung, and pecomas not otherwise specified (nos). tuberous sclerosis complex 1 (tsc1) and tuberous sclerosis complex 2 (tsc2) gene mutation is associated with pecoma, which causes hyperactivation of the mammalian target of rapamycin (mtor) signaling pathway. |
2023-08-14 |
2023-08-16 |
Not clear |
| Marjan Taherian, Paria Bayati, Mohammad-Ali Assarehzadegan, Mansoureh Soleimani, Hadi Poormoghim, Nazanin Mojtabav. Insights into Overlappings of Fibrosis and Cancer: Exploring the Tumor-related Cardinal Genes in Idiopathic Pulmonary Fibrosis. Iranian journal of allergy, asthma, and immunology. vol 22. issue 2. 2023-07-27. PMID:37496412. |
gene expression analyses indicated a significant elevation of regulatory associated protein of mtor (raptor), ras homolog enriched in brain (rheb), s6 kinase 1, and eukaryotic translation initiation factor 4e-binding protein 1 (4ebp1), as well as a significant reduction of vegfa, tuberous sclerosis complex (tsc2), and lrp1; no changes were observed in the tsc1 mrna level. |
2023-07-27 |
2023-08-14 |
mouse |
| Elisabetta Chiaradia, Ingrid Miller, Giovanni Renzone, Alessia Tognoloni, Alice Polchi, Federico De Marco, Brunella Tancini, Andrea Scaloni, Alessandro Magin. Proteomic analysis of murine Tsc1-deficient neural stem progenitor cells. Journal of proteomics. 2023-05-19. PMID:37207814. |
significance: tuberous sclerosis complex (tsc) is a multisystemic disorder caused by inactivating mutations of tsc1 or tsc2 genes, which induce overactivation of the mtor component. |
2023-05-19 |
2023-08-14 |
Not clear |
| Lijun Lv, Jiyu Guan, Ruixue Zhen, Pin Lv, Mengshi Xu, Xingyuan Liu, Shishi He, Ziyu Fang, Zi Li, Yungang Lan, Huijun Lu, Wenqi He, Feng Gao, Kui Zha. Orf virus induces complete autophagy to promote viral replication via inhibition of AKT/mTOR and activation of the ERK1/2/mTOR signalling pathway in OFTu cells. Veterinary research. vol 54. issue 1. 2023-03-15. PMID:36918891. |
moreover, orfv-induced autophagic activity was found to rely on an increase in the phosphorylation of tuberous sclerosis complex 2 (tsc2) and a decrease in the phosphorylation of mammalian target of rapamycin (mtor), which is mediated by the suppression of the pi3k/akt/mtor signalling pathway and activation of the erk1/2/mtor signalling pathway. |
2023-03-15 |
2023-08-14 |
Not clear |
| Shengzhao Hu, Yingli Chen, Shipeng Huang, Min Liu, Ying Liu, Shaofang Huan. Sodium Danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome and tuberous sclerosis complex-2 (TSC2)/mammalian target of rapamycin (mTOR) pathways. Annals of translational medicine. vol 10. issue 20. 2022-11-17. PMID:36388798. |
sodium danshensu protects against oxygen glucose deprivation/reoxygenation-induced astrocytes injury through regulating nod-like receptor pyrin domain containing 3 (nlrp3) inflammasome and tuberous sclerosis complex-2 (tsc2)/mammalian target of rapamycin (mtor) pathways. |
2022-11-17 |
2023-08-14 |
Not clear |
| Clara Bernardelli, Eloisa Chiaramonte, Silvia Ancona, Silvia M Sirchia, Amilcare Cerri, Elena Lesm. Primary TSC2 International journal of molecular sciences. vol 23. issue 17. 2022-09-09. PMID:36077111. |
primary tsc2 cutaneous lesions are one of the hallmarks of tuberous sclerosis complex (tsc), a genetic disease in which mtor is hyperactivated due to the lack of hamartin or tuberin. |
2022-09-09 |
2023-08-14 |
Not clear |
| Alfredo Cerisola, Lucía Cibils, María Eugenia Chaibún, Virginia Pedemonte, Melania Rosa. [Tuberous sclerosis complex: diagnosis and current treatment]. Medicina. vol 82 Suppl 3. 2022-09-02. PMID:36054862. |
tuberous sclerosis complex is an autosomal dominant genetic multisystemic disorder caused primarily by mutations in one of the two tumor suppressor genes tsc1 or tsc2, resulting in increased activation of the mtor pathway. |
2022-09-02 |
2023-08-14 |
Not clear |
| Paolo Curatolo, Nicola Specchio, Eleonora Aronic. Advances in the genetics and neuropathology of tuberous sclerosis complex: edging closer to targeted therapy. The Lancet. Neurology. vol 21. issue 9. 2022-08-13. PMID:35963265. |
tuberous sclerosis complex is a rare genetic disease associated with mutations in the tsc1 or tsc2 genes, which cause overactivation of the mtor complex. |
2022-08-13 |
2023-08-14 |
Not clear |