| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Myungjin Kim, Jun Hee Le. Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growth. International journal of molecular sciences. vol 16. issue 4. 2016-01-04. PMID:25826530. |
one of the ampk substrates, tuberous sclerosis complex 2 (tsc2), was suggested to mediate ampk-induced silencing of mtor complex 1 (mtorc1) signaling that is critical for cell growth. |
2016-01-04 |
2023-08-13 |
drosophila_melanogaster |
| Peter B Crin. mTOR signaling in epilepsy: insights from malformations of cortical development. Cold Spring Harbor perspectives in medicine. vol 5. issue 4. 2015-12-29. PMID:25833943. |
mutations in mtor regulatory genes (e.g., tsc1, tsc2, akt3, depdc5) have been associated with several focal mcd highly associated with epilepsy such as tuberous sclerosis complex (tsc), hemimegalencephaly (hme; brain malformation associated with dramatic enlargement of one brain hemisphere), and cortical dysplasia. |
2015-12-29 |
2023-08-13 |
Not clear |
| Xin Wu, Yannong Dou, Yan Yang, Difei Bian, Jinque Luo, Bei Tong, Yufeng Xia, Yue Da. Arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of Th1 and Th17 cells via an mTORC1-dependent pathway. Biochemical pharmacology. vol 96. issue 4. 2015-11-09. PMID:26074264. |
interestingly, the inhibitory effect of arctigenin on t cell differentiation disappeared under a status of mtorc1 overactivation via knockdown of tuberous sclerosis complex 2 (tsc2, a negative regulator of mtorc1) or pretreatment of leucine (an agonist of mtor). |
2015-11-09 |
2023-08-13 |
mouse |
| A Tarasewicz, A Dębska-Ślizień, M Bułanowski, A Więcek, B Rutkowsk. Everolimus in immunosuppressive treatment after kidney transplantation in a patient with tuberous sclerosis: case report. Transplantation proceedings. vol 46. issue 8. 2015-10-26. PMID:25380949. |
tuberous sclerosis complex (tsc) is an inherited disorder caused by mutations of tsc1 or tsc2 genes, resulting in constitutive activation of the mammalian target of rapamycin (mtor) and impairment of the cell cycle. |
2015-10-26 |
2023-08-13 |
Not clear |
| Duyu Nie, Zehua Chen, Darius Ebrahimi-Fakhari, Alessia Di Nardo, Kristina Julich, Victoria K Robson, Yung-Chih Cheng, Clifford J Woolf, Myriam Heiman, Mustafa Sahi. The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 30. 2015-10-16. PMID:26224859. |
hyperactivation of the mechanistic target of rapamycin (mtor) kinase, as a result of loss-of-function mutations in tuberous sclerosis complex 1 (tsc1) or tsc2 genes, causes protein synthesis dysregulation, increased cell size, and aberrant neuronal connectivity. |
2015-10-16 |
2023-08-13 |
mouse |
| Irmina Grzegorek, Ewa Zuba-Surma, Mariusz Chabowski, Dariusz Janczak, Andrzej Szuba, Piotr Dziegie. Characterization of cells cultured from chylous effusion from a patient with sporadic lymphangioleiomyomatosis. Anticancer research. vol 35. issue 6. 2015-08-06. PMID:26026094. |
it is caused by a mutation in one of the tuberous sclerosis genes, tsc1 or tsc2, and constitutive activation of the mammalian target of rapamycin (mtor) pathway in smooth muscle-like cells (lam cells). |
2015-08-06 |
2023-08-13 |
Not clear |
| Souheil El-Chemaly, Hilary J Goldberg, Allan R Glanvill. Should mammalian target of rapamycin inhibitors be stopped in women with lymphangioleiomyomatosis awaiting lung transplantation? Expert review of respiratory medicine. vol 8. issue 6. 2015-06-29. PMID:25199529. |
lymphangioleiomyomatosis (lam) is a rare cystic lung disease characterized by proliferation of smooth muscle like cells (lam cells) that have mutations in the tuberous sclerosis gene (tsc2), leading to the activation of the mammalian target of rapamycin (mtor). |
2015-06-29 |
2023-08-13 |
Not clear |
| Kazim Sahin, Brian Cross, Nurhan Sahin, Karina Ciccone, Shadeah Suleiman, Adeboye O Osunkoya, Viraj Master, Wayne Harris, Bradley Carthon, Ramzi Mohammad, Birdal Bilir, Karin Wertz, Carlos S Moreno, Cheryl L Walker, Omer Kucu. Lycopene in the prevention of renal cell cancer in the TSC2 mutant Eker rat model. Archives of biochemistry and biophysics. vol 572. 2015-06-24. PMID:25602702. |
eker rat represents a unique animal model to study rcc since these rats develop spontaneous renal tumors and leiomyoma, which may be due to tuberous sclerosis 2 (tsc2) mutation resulting in the activation of the mammalian target of rapamycin (mtor) pathway. |
2015-06-24 |
2023-08-13 |
rat |
| Jiandong Sun, Yan Liu, Stephanie Moreno, Michel Baudry, Xiaoning B. Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 11. 2015-06-15. PMID:25788687. |
levels of tuberous sclerosis complex 2 (tsc2), a negative regulator of mtor, were increased in as mice compared with wild-type mice; however, tsc2 inhibitory phosphorylation was also increased. |
2015-06-15 |
2023-08-13 |
mouse |
| Lei Liang, Xi-Ling Shou, Hai-Kang Zhao, Gu-Qun Ren, Jian-Bang Wang, Xi-Hui Wang, Wen-Ting Ai, Jackie R Maris, Lindsay K Hueckstaedt, Ai-Qun Ma, Yingmei Zhan. Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKβ-AMPK-dependent regulation of autophagy. Biochimica et biophysica acta. vol 1852. issue 2. 2015-04-17. PMID:24993069. |
high fat diet intake dampened phosphorylation of inhibitor kappa b kinase β(ikkβ), amp-activated protein kinase (ampk) and tuberous sclerosis 2 (tsc2) while promoting phosphorylation of mtor, the effects of which were ablated by catalase. |
2015-04-17 |
2023-08-13 |
mouse |
| Gauhar Rehman, Adeeb Shehzad, Abdul Latif Khan, Muhammad Hamayu. Role of AMP-activated protein kinase in cancer therapy. Archiv der Pharmazie. vol 347. issue 7. 2015-04-09. PMID:24677093. |
ampk has been shown to inhibit mammalian target of rapamycin (mtor) through tuberous sclerosis complex 2 (tsc2) phosphorylation and phosphatase and tensin homolog (pten), considered as central cell growth controller signals in diseases. |
2015-04-09 |
2023-08-12 |
Not clear |
| Yang Sun, Dana Gallacchi, Erik Y Zhang, Samuel B Reynolds, Lauren Robinson, Izabela A Malinowska, Terry T Chiou, Ana M Pereira, Chenggang Li, David J Kwiatkowski, Po-Shun Lee, Jane J Y. Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology. vol 51. issue 6. 2015-01-30. PMID:24874429. |
lam cells typically have inactivating tuberous sclerosis complex 2 (tsc2) mutations and mammalian target of rapamycin (mtor) complex (mtorc) 1 activation. |
2015-01-30 |
2023-08-13 |
mouse |
| Han C Dan, Aaron Ebbs, Manolis Pasparakis, Terry Van Dyke, Daniela S Basseres, Albert S Baldwi. Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα). The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:24990947. |
akt is known to stimulate mtorc1 activity through phosphorylation of tuberous sclerosis complex 2 (tsc2) and pras40, both negative regulators of mtor activity. |
2015-01-28 |
2023-08-13 |
Not clear |
| Jianling Chen, Ian Alberts, Xiaohong L. Dysregulation of the IGF-I/PI3K/AKT/mTOR signaling pathway in autism spectrum disorders. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 35. 2014-12-18. PMID:24662006. |
tuberous sclerosis complex 1 (tsc1) and tsc2 are upstream regulators of mammalian target of rapamycin (mtor) and downstream effectors of the pi3k/akt signaling pathway. |
2014-12-18 |
2023-08-12 |
Not clear |
| Shakeel U R Mir, Steven R Schwarze, Ling Jin, Jinling Zhang, Woodrow Friend, Sumitra Miriyala, Daret St Clair, Rolf J Crave. Progesterone receptor membrane component 1/Sigma-2 receptor associates with MAP1LC3B and promotes autophagy. Autophagy. vol 9. issue 10. 2014-12-16. PMID:24113030. |
we propose that this disruption of autophagy upon pgrmc1 inhibition increases ampk activation, elevating the levels of tsc1 (tuberous sclerosis complex) and tsc2 and inactivating mtor and rps6kb/p70s6k, causing cleaved map1lc3b levels to increase. |
2014-12-16 |
2023-08-12 |
Not clear |
| F Wang, X Chen, C Li, Q Sun, Y Chen, Y Wang, H Peng, Z Liu, R Chen, K Liu, H Yan, B H Ye, D J Kwiatkowski, H Zhan. Pivotal role of augmented αB-crystallin in tumor development induced by deficient TSC1/2 complex. Oncogene. vol 33. issue 34. 2014-10-15. PMID:24077282. |
tuberous sclerosis complex 1 (tsc1) and tsc2 are suppressors of mechanistic target of rapamycin (mtor). |
2014-10-15 |
2023-08-12 |
mouse |
| Angela Fuchs, Katharina König, Lukas C Heukamp, Jana Fassunke, Jutta Kirfel, Sebastian Huss, Albert J Becker, Reinhard Büttner, Michael Majore. Tuberous-sclerosis complex-related cell signaling in the pathogenesis of lung cancer. Diagnostic pathology. vol 9. 2014-09-04. PMID:24593867. |
hamartin (tsc1) and tuberin (tsc2), encoded by the tuberous sclerosis complex (tsc) genes, form a tumor-suppressor heterodimer which is implicated in pi3k-akt signaling and acts as a functional inhibitor of the mammalian target of rapamycin (mtor). |
2014-09-04 |
2023-08-12 |
Not clear |
| Ying Wang, Zhongdong Hu, Zhibo Liu, Rongrong Chen, Haiyong Peng, Jing Guo, Xinxin Chen, Hongbing Zhan. MTOR inhibition attenuates DNA damage and apoptosis through autophagy-mediated suppression of CREB1. Autophagy. vol 9. issue 12. 2014-09-02. PMID:24189100. |
here, we show that loss of tsc2 or pten enhanced etoposide-induced dna damage and apoptosis, which was blunted by suppression of mtor with either rapamycin or rna interference. |
2014-09-02 |
2023-08-12 |
mouse |
| Ting Zhang, Pengyuan Dai, Dong Cheng, Liang Zhang, Zijiang Chen, Xiaoqian Meng, Fumiao Zhang, Xiaoying Han, Jianwei Liu, Jie Pan, Guiwen Yang, Cong Zhan. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction (Cambridge, England). vol 147. issue 2. 2014-08-26. PMID:24196014. |
quantitative pcr analysis demonstrated that at d 100 the expression of cytochromep450 aromatase (cyp19a1), 3β-hydroxysteroid dehydrogenase (hsd3b), mechanistic target of rapamycin (mtor), and nuclear factor-κb (nfkb) decreased significantly, while that of bcl2-associated agonist of cell death (bad) and tuberous sclerosis complex 2 (tsc2) increased significantly in the apoe(-/-) mice. |
2014-08-26 |
2023-08-12 |
mouse |
| Gert Wiegand, Theodor W May, Philipp Ostertag, Rainer Boor, Ulrich Stephani, David Neal Fran. Everolimus in tuberous sclerosis patients with intractable epilepsy: a treatment option? European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society. vol 17. issue 6. 2014-07-03. PMID:23845174. |
tuberous sclerosis complex (tsc) is an often severe neurodevelopmental disorder caused by overactivation of the mtor pathway due to mutations in either the tsc1 or tsc2 genes. |
2014-07-03 |
2023-08-12 |
Not clear |