| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vera P Krymskay. Targeting the phosphatidylinositol 3-kinase pathway in airway smooth muscle: rationale and promise. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. vol 21. issue 2. 2007-06-12. PMID:17402792. |
however, recent discovery of the tumor suppressor proteins tuberous sclerosis complex 1 (tsc1) and tsc2, also known as hamartin and tuberin, as downstream effectors of pi3k and upstream regulators of the mammalian target of rapamycin (mtor) and s6 kinase 1(s6k1) shed a new light on the pi3k signaling cascade in regulating cell growth and proliferation. |
2007-06-12 |
2023-08-12 |
Not clear |
| Hongbing Zhang, Natalia Bajraszewski, Erxi Wu, Hongwei Wang, Annie P Moseman, Sandra L Dabora, James D Griffin, David J Kwiatkowsk. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. The Journal of clinical investigation. vol 117. issue 3. 2007-05-04. PMID:17290308. |
inactivating mutations of either the tsc1 or the tsc2 tumor-suppressor genes cause tuberous sclerosis complex (tsc), a benign tumor syndrome in which there is both hyperactivation of mtor and inhibition of rtk/pi3k/akt signaling, partially due to reduced pdgfr expression. |
2007-05-04 |
2023-08-12 |
mouse |
| Emilie Vander Haar, Seong-Il Lee, Sricharan Bandhakavi, Timothy J Griffin, Do-Hyung Ki. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nature cell biology. vol 9. issue 3. 2007-04-24. PMID:17277771. |
it was reported that akt activates mtor by phosphorylation and inhibition of tuberous sclerosis complex 2 (tsc2). |
2007-04-24 |
2023-08-12 |
Not clear |
| Ryosuke Watanabe, Yukihiro Tambe, Hirokazu Inoue, Takahiro Isono, Masataka Haneda, Ken-Ichi Isobe, Toshiyuki Kobayashi, Okio Hino, Hidetoshi Okabe, Tokuhiro Chan. GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress. International journal of molecular medicine. vol 19. issue 3. 2007-03-16. PMID:17273797. |
during conditions of cell stress, gadd34 forms a stable complex with tuberous sclerosis complex (tsc) 1/2, causes tsc2 dephosphorylation, and inhibits signaling by mammalian target of the rapamycin (mtor). |
2007-03-16 |
2023-08-12 |
Not clear |
| Boyi Gan, Youngdong Yoo, Jun-Lin Gua. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth. The Journal of biological chemistry. vol 281. issue 49. 2007-01-25. PMID:17043358. |
tuberous sclerosis complex 1 (tsc1) and tsc2 tumor suppressor proteins have been shown to negatively regulate cell growth through inhibition of the mammalian target of rapamycin (mtor) pathway. |
2007-01-25 |
2023-08-12 |
Not clear |
| Cristina Malagelada, Elizabeth J Ryu, Subhas C Biswas, Vernice Jackson-Lewis, Lloyd A Green. RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 39. 2006-11-27. PMID:17005863. |
the mechanism by which 6-ohda and rtp801 induce neuron death appears to involve repression of mammalian target of rapamycin (mtor) kinase activity, and such death is inhibited by shrnas targeting tsc2 (tuberous sclerosis complex), a protein with which rtp801 interacts to block mtor activation. |
2006-11-27 |
2023-08-12 |
Not clear |
| Edward W Arvisais, Angela Romanelli, Xiaoying Hou, John S Davi. AKT-independent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha. The Journal of biological chemistry. vol 281. issue 37. 2006-10-31. PMID:16816403. |
treatment with pgf2alpha did not increase akt phosphorylation but increased the phosphorylation of erk and the tumor suppressor protein tuberous sclerosis complex 2 (tsc2), an upstream regulator of mtor. |
2006-10-31 |
2023-08-12 |
Not clear |
| Thomas C Vary, Christopher J Lync. Meal feeding stimulates phosphorylation of multiple effector proteins regulating protein synthetic processes in rat hearts. The Journal of nutrition. vol 136. issue 9. 2006-10-05. PMID:16920842. |
likewise, the extent of phosphorylation of tsc2, a potential upstream regulator of mtor, was not significantly altered during meal feeding. |
2006-10-05 |
2023-08-12 |
rat |
| Xiuyun Jiang, Raymond S Yeun. Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707451. |
recent studies have identified tsc1 and tsc2, two tumor suppressor genes involved in tuberous sclerosis complex, as regulators of the mammalian target of rapamycin (mtor) pathway. |
2006-07-18 |
2023-08-12 |
Not clear |
| Eileen Connolly, Steve Braunstein, Silvia Formenti, Robert J Schneide. Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells. Molecular and cellular biology. vol 26. issue 10. 2006-06-09. PMID:16648488. |
in transformed breast epithelial cells under hypoxia, the mtor and s6 kinases are constitutively activated and the mtor negative regulator tuberous sclerosis complex 2 (tsc2) protein fails to function. |
2006-06-09 |
2023-08-12 |
Not clear |
| P J Atherton, J Babraj, K Smith, J Singh, M J Rennie, H Wackerhag. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 19. issue 7. 2005-12-22. PMID:15716393. |
in contrast, hfs acutely increased phosphorylation of pkb at ser473 5.3-fold and the phosphorylation of tsc2, mtor, gsk-3beta at pkb-sensitive sites. |
2005-12-22 |
2023-08-12 |
rat |
| Mark Rolfe, Laura E McLeod, Phillip F Pratt, Christopher G Prou. Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2). The Biochemical journal. vol 388. issue Pt 3. 2005-12-13. PMID:15757502. |
pe stimulation of cardiomyocytes induced the phosphorylation of tsc2 (tuberous sclerosis complex 2), a negative regulator of mtor activity. |
2005-12-13 |
2023-08-12 |
Not clear |
| Annett Hahn-Windgassen, Veronique Nogueira, Chia-Chen Chen, Jennifer E Skeen, Nahum Sonenberg, Nissim Ha. Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. The Journal of biological chemistry. vol 280. issue 37. 2005-10-20. PMID:16027121. |
the known pathway by which akt activates mtor is via direct phosphorylation and inhibition of tuberous sclerosis complex 2 (tsc2), which is a negative regulator of mtor. |
2005-10-20 |
2023-08-12 |
Not clear |
| Andrew R Tee, John Blenis, Christopher G Prou. Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS letters. vol 579. issue 21. 2005-10-03. PMID:16098514. |
in this study, we show that rheb like-1 protein (rhebl1) rescues mtor signaling during nutrient withdrawal and that tuberous sclerosis complex-1 (tsc) and tsc2 impairs rhebl1-mediated signaling through mtor. |
2005-10-03 |
2023-08-12 |
Not clear |
| Avi Sofer, Kui Lei, Cory M Johannessen, Leif W Ellise. Regulation of mTOR and cell growth in response to energy stress by REDD1. Molecular and cellular biology. vol 25. issue 14. 2005-09-01. PMID:15988001. |
the tuberous sclerosis tumor suppressors tsc1 and tsc2 regulate the mtor pathway to control translation and cell growth in response to nutrient and growth factor stimuli. |
2005-09-01 |
2023-08-12 |
Not clear |
| Ewan M Smith, Stephen G Finn, Andrew R Tee, Gareth J Browne, Christopher G Prou. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. The Journal of biological chemistry. vol 280. issue 19. 2005-07-12. PMID:15772076. |
recent work demonstrated the importance of the tuberous sclerosis protein tsc2 for regulation of mtor by insulin. |
2005-07-12 |
2023-08-12 |
Not clear |
| Jennifer A Chan, Hongbing Zhang, Penelope S Roberts, Sergiusz Jozwiak, Grajkowska Wieslawa, Joanna Lewin-Kowalik, Katarzyna Kotulska, David J Kwiatkowsk. Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation. Journal of neuropathology and experimental neurology. vol 63. issue 12. 2005-01-14. PMID:15624760. |
pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of tsc1 or tsc2 leads to mtor activation. |
2005-01-14 |
2023-08-12 |
Not clear |
| David J Kwiatkowsk. Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer biology & therapy. vol 2. issue 5. 2004-03-08. PMID:14614311. |
rhebbing up mtor: new insights on tsc1 and tsc2, and the pathogenesis of tuberous sclerosis. |
2004-03-08 |
2023-08-12 |
human |
| Thurl E Harris, John C Lawrenc. TOR signaling. Science's STKE : signal transduction knowledge environment. vol 2003. issue 212. 2004-02-23. PMID:14668532. |
the signaling pathway downstream of akt leading to mtor involves the protein products of the genes mutated in tuberous sclerosis, tsc1 and tsc2, and the small guanosine triphosphatase, rheb. |
2004-02-23 |
2023-08-12 |
Not clear |
| Ariel F Castro, John F Rebhun, Geoffrey J Clark, Lawrence A Quillia. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. The Journal of biological chemistry. vol 278. issue 35. 2003-10-02. PMID:12842888. |
recently the tuberous sclerosis complex 2 (tsc2) tumor suppressor gene product has been identified as a negative regulator of protein synthesis upstream of the mtor and ribosomal s6 kinases. |
2003-10-02 |
2023-08-12 |
Not clear |