| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jian Wang, Leilei Chen, Yan Li, Xin-Yuan Gua. Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. PloS one. vol 6. issue 9. 2012-06-08. PMID:21966391. |
in addition, ctsz could also upregulate proteins associated with extracellular matrix remodeling such as mmp2, mmp3 and mmp9. |
2012-06-08 |
2023-08-12 |
mouse |
| Sachiko Murase, Ronald D McKa. Matrix metalloproteinase-9 regulates survival of neurons in newborn hippocampus. The Journal of biological chemistry. vol 287. issue 15. 2012-06-06. PMID:22351756. |
here, we show that levels of the matrix metalloproteinase-9 (mmp9) decrease, and the level of the ecm protein laminin increases in rat hippocampus during the period of neuronal death. |
2012-06-06 |
2023-08-12 |
mouse |
| Nicole K Nickerson, Khalid S Mohammad, Jennifer L Gilmore, Erin Crismore, Angela Bruzzaniti, Theresa A Guise, John Fole. Decreased autocrine EGFR signaling in metastatic breast cancer cells inhibits tumor growth in bone and mammary fat pad. PloS one. vol 7. issue 1. 2012-06-04. PMID:22276166. |
shegfr-mda-231 cells also produced decreased levels of the proangiogenic molecules macrophage colony stimulating factor-1 (mcsf-1) and matrix metalloproteinase 9 (mmp9), both of which were decreased by egfr inhibitors in a panel of egfr-positive breast cancer cells. |
2012-06-04 |
2023-08-12 |
mouse |
| Min Feng, Quanrongzi Wang, Feng Zhang, Ling L. Ex vivo induced regulatory T cells regulate inflammatory response of Kupffer cells by TGF-beta and attenuate liver ischemia reperfusion injury. International immunopharmacology. vol 12. issue 1. 2012-05-29. PMID:22155100. |
treatment with tgf-β suppressed matrix metalloprotease (mmp9) production in kcs and protected liver from iri. |
2012-05-29 |
2023-08-12 |
mouse |
| Yu-Lun Liao, Ling-Yueh Hu, Kuo-Wang Tsai, Chew-Wun Wu, Wen-Ching Chan, Sung-Chou Li, Chun-Hung Lai, Meng-Ru Ho, Wen-Liang Fang, Kuo-Hung Huang, Wen-Chang Li. Transcriptional regulation of miR-196b by ETS2 in gastric cancer cells. Carcinogenesis. vol 33. issue 4. 2012-05-29. PMID:22298639. |
the levels of vimentin, matrix metalloproteinase (mmp)-2 and mmp9 were drastically induced, but levels of e-cadherin were decreased in shets2- or mir-196b-transfected cells. |
2012-05-29 |
2023-08-12 |
Not clear |
| Apostolia Fragkouli, Costas Papatheodoropoulos, Spiros Georgopoulos, Antonios Stamatakis, Fotini Stylianopoulou, Effie C Tsilibary, Athina K Tzini. Enhanced neuronal plasticity and elevated endogenous sAPPα levels in mice over-expressing MMP9. Journal of neurochemistry. vol 121. issue 2. 2012-05-21. PMID:22192143. |
evidence accumulating during the past few years points to a significant role of matrix metalloproteinase 9 (mmp9) enzymatic activity in synaptic plasticity and cognitive processes. |
2012-05-21 |
2023-08-12 |
mouse |
| Raluca Reitmeir, Ertugrul Kilic, Barbara S Reinboth, Zeyun Guo, Ayman ElAli, Anil Zechariah, Ulkan Kilic, Dirk M Herman. Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain. Acta neuropathologica. vol 123. issue 2. 2012-05-14. PMID:22109109. |
corticobulbar plasticity was accompanied by the deactivation of the matrix metalloproteinase mmp9 in the lesioned hemisphere and the transient downregulation of the axonal growth inhibitors ng2 proteoglycan and brevican and the guidance molecules ephrin b1/2 in the contralesional hemisphere. |
2012-05-14 |
2023-08-12 |
mouse |
| Seon Ah Song, Kyung Hyun Yoo, Je Yeong Ko, Bo Hye Kim, Yeon Joo Yook, Jong Hoon Par. Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9. Biochemical and biophysical research communications. vol 419. issue 3. 2012-05-08. PMID:22342670. |
the results indicated that over-expression of the mxi1 gene plays a role in the regulation of tubulogenesis by regulating some genes participating in renal epithelial branching tubulogenesis such as matrix metalloproteinase 9 (mmp9), integrins, fibronectin, and e-cadherin. |
2012-05-08 |
2023-08-12 |
mouse |
| S J Gilbert, E J Blain, A Al-Sabah, Y Zhang, V C Duance, D J Maso. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. European cells & materials. vol 23. 2012-05-03. PMID:22287113. |
pro- and active matrix metalloproteinase-9 (mmp9) and mmp9 mrna were significantly upregulated by osm+il-1 through a pkr dependent mechanism. |
2012-05-03 |
2023-08-12 |
human |
| Ghulam Mohammad, Renu A Kowlur. Diabetic retinopathy and signaling mechanism for activation of matrix metalloproteinase-9. Journal of cellular physiology. vol 227. issue 3. 2012-04-25. PMID:21567393. |
in the pathogenesis of diabetic retinopathy, h-ras (a small molecular weight g-protein) and matrix metalloproteinase-9 (mmp9) act as pro-apoptotic, accelerating the apoptosis of retinal capillary cells, a phenomenon that predicts its development and the activation of mmp9 is under the control of h-ras. |
2012-04-25 |
2023-08-12 |
mouse |
| Suksanti Prakobwong, Porntip Pinlaor, Lakhanawan Charoensuk, Jarinya Khoontawad, Puangrat Yongvanit, Yusuke Hiraku, Somchai Pinlao. The liver fluke Opisthorchis viverrini expresses nitric oxide synthase but not gelatinases. Parasitology international. vol 61. issue 1. 2012-04-05. PMID:21718800. |
host cells induce nitric oxide synthase (nos)-dependent dna damage and secrete ras-related c3 botulinum toxin substrate (rac)1, heme oxygenase (ho)-1, and gelatinases (matrix metalloproteinase (mmp)2 and mmp9). |
2012-04-05 |
2023-08-12 |
Not clear |
| Somak Das, Subhendu Mukherjee, Istvan Lekli, Narasimman Gurusamy, Jayeeta Bardhan, Utpal Raychoudhury, Runu Chakravarty, Sandip Banerji, Anne A Knowlton, Dipak K Da. Tocotrienols confer resistance to ischemia in hypercholesterolemic hearts: insight with genomics. Molecular and cellular biochemistry. vol 360. issue 1-2. 2012-03-22. PMID:21918828. |
based on genomic profiles, the following cholesterol-related proteins were examined: fabp, tgf-β (cholesterol suppresses tgf-β), et-1 (increased by hypercholesterolemia), spot 14 (linked with hypercholesterolemia), and matrix metalloproteinase (mmp) 2 and mmp9 (cholesterol regulates mmp2 and mmp9 expression) in the heart. |
2012-03-22 |
2023-08-12 |
Not clear |
| Jon M Carthy, Zongshu Luo, Bruce M McManu. WNT3A induces a contractile and secretory phenotype in cultured vascular smooth muscle cells that is associated with increased gap junction communication. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 2. 2012-03-19. PMID:22105568. |
the wnt3a-treated smooth muscle cells displayed increased extracellular matrix synthesis, as measured by collagen i and iii mrna expression, along with increased expression of mmp2 and mmp9, but decreased timp2 levels. |
2012-03-19 |
2023-08-12 |
Not clear |
| Niko Braun, Peter Fritz, Dagmar Biegger, Martin Kimmel, Fabian Reimold, Christoph Ulmer, M Dominik Alsche. Difference in the expression of hormone receptors and fibrotic markers in the human peritoneum--implications for therapeutic targets to prevent encapsulating peritoneal sclerosis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. vol 31. issue 3. 2012-02-13. PMID:21454390. |
we also investigated estrogen receptor (er), matrix metalloproteinase 9 (mmp9), and transforming growth factor β1 (tgfβ1) in the context of their potential role in tamoxifen therapy. |
2012-02-13 |
2023-08-12 |
human |
| Apostolia Fragkouli, Athina K Tzinia, Ioannis Charalampopoulos, Achille Gravanis, Effie C Tsilibar. Matrix metalloproteinase-9 participates in NGF-induced α-secretase cleavage of amyloid-β protein precursor in PC12 cells. Journal of Alzheimer's disease : JAD. vol 24. issue 4. 2012-02-09. PMID:21321391. |
in the present study, we used pc12 cells to study the effects of ngf on aβpp processing and provide evidence that ngf, through binding to its high affinity receptor, trka moderately down-regulates the expression of the β-secretase β-site aβpp cleaving enzyme-1 and, most importantly, upregulates the expression of two enzymes with α-secretase activity, a disintegrin and metalloprotease-17 and to a greater extent matrix metalloproteinase-9 (mmp9) in a phosphoinositide kinase-3 dependent manner. |
2012-02-09 |
2023-08-12 |
Not clear |
| B Julie He, Mei-Ling A Joiner, Madhu V Singh, Elizabeth D Luczak, Paari Dominic Swaminathan, Olha M Koval, William Kutschke, Chantal Allamargot, Jinying Yang, Xiaoqun Guan, Kathy Zimmerman, Isabella M Grumbach, Robert M Weiss, Douglas R Spitz, Curt D Sigmund, W Matthijs Blankesteijn, Stephane Heymans, Peter J Mohler, Mark E Anderso. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature medicine. vol 17. issue 12. 2012-02-02. PMID:22081025. |
aldosterone induces camkii oxidation by recruiting nadph oxidase, and this oxidized and activated camkii promotes matrix metalloproteinase 9 (mmp9) expression in cardiomyocytes. |
2012-02-02 |
2023-08-12 |
mouse |
| Tao-Sheng Li, Satoshi Ikeda, Masayuki Kubo, Mako Ohshima, Hiroshi Kurazumi, Yoshihiro Takemoto, Kazuhiro Ueda, Kimikazu Haman. Diabetic impairment of C-kit bone marrow stem cells involves the disorders of inflammatory factors, cell adhesion and extracellular matrix molecules. PloS one. vol 6. issue 10. 2012-01-30. PMID:21984919. |
interestingly, diabetes-related alterations of the extracellular matrix and adhesion molecules were varied; pecam, mmp10, lamc1, itgb7, mmp9, and timp4 were up-regulated, but col11a1, fn1, admts2, and itgav were down-regulated. |
2012-01-30 |
2023-08-12 |
mouse |
| B Huang, X Zhao, L-B Zheng, L Zhang, B Ni, Y-W Wan. Different expression of tissue inhibitor of metalloproteinase family members in rat dorsal root ganglia and their changes after peripheral nerve injury. Neuroscience. vol 193. 2012-01-18. PMID:21782897. |
matrix metalloproteinase 9 (mmp9) and mmp2 are important in the development and maintenance of neuropathic pain behavior induced by peripheral nerve injury. |
2012-01-18 |
2023-08-12 |
rat |
| Kyoko Kushiro, Nomelí P Núñe. Ob/ob serum promotes a mesenchymal cell phenotype in B16BL6 melanoma cells. Clinical & experimental metastasis. vol 28. issue 8. 2012-01-10. PMID:21879359. |
moreover, ob/ob serum increased matrix metalloproteast 9 (mmp9) activity and decreased the expression of e-cadherin and the metastasis suppressor gene kiss1. |
2012-01-10 |
2023-08-12 |
mouse |
| Carine Savarin, Stephen A Stohlman, Anna M Rietsch, Niranjan Butchi, Richard M Ransohoff, Cornelia C Bergman. MMP9 deficiency does not decrease blood-brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitis. Glia. vol 59. issue 11. 2012-01-06. PMID:21800363. |
expression of matrix metalloproteinases (mmps), especially mmp9 correlates with blood-brain barrier (bbb) disruption during many neuroinflammatory diseases. |
2012-01-06 |
2023-08-12 |
mouse |