| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tal Salz, Changwang Deng, Christine Pampo, Dietmar Siemann, Yi Qiu, Kevin Brown, Suming Huan. Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer. Molecular cancer research : MCR. vol 13. issue 3. 2016-02-01. PMID:25373480. |
furthermore, a group of matrix metalloproteinases (including mmp2, mmp9, mmp12, mmp13, and mmp17) were identified which were downregulated upon depletion of hsetd1a and demonstrated a decrease in h3k4me3 at their proximal promoters based on chromatin immunoprecipitation analysis. |
2016-02-01 |
2023-08-13 |
mouse |
| Hua Jin, Xiu Juan Li, Man Hee Park, Soo Mi Ki. FOXM1-mediated downregulation of uPA and MMP9 by 3,3'-diindolylmethane inhibits migration and invasion of human colorectal cancer cells. Oncology reports. vol 33. issue 6. 2016-01-26. PMID:25962429. |
the mrna expression levels of urokinase type plasminogen activator (upa) and matrix metalloprotease 9 (mmp9) were significantly attenuated, whereas expression of e-cadherin mrna was significantly enhanced, following dim treatment. |
2016-01-26 |
2023-08-13 |
human |
| Jingjing Zhang, Jun Zhao, Yujing Bai, Lvzhen Huang, Wenzhen Yu, Xiaoxin L. Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells. Molecular and cellular biochemistry. vol 398. issue 1-2. 2016-01-15. PMID:25200140. |
after the deletion of p75(ntr), rpe-secreted pro-angiogenic factors (vascular endothelial growth factor and platelet-derived growth factor), inflammatory factors [interleukin 1 beta (il1β), il18, and stromal cell-derived factor 1], and matrix metalloproteinases (mmps) (mmp3 and mmp9) were down-regulated under hypoxic conditions. |
2016-01-15 |
2023-08-13 |
human |
| Mohammed Arif, Sonu Chand Thakur, Kasturi Datt. Disrupted hyaluronan binding protein 1 (HABP1) expression: one of the key mediator for ovarian dysfunction in polycystic ovary rat. Molecular and cellular biochemistry. vol 398. issue 1-2. 2016-01-15. PMID:25300617. |
in present study, we employ superovulated (so) and polycystic ovary (pco) rat models and demonstrate that on contrary to so, pco rat ovary illustrates abnormal follicular morphology with differential levels of various ovarian factors [like ha (hyaluronan), tsg-6 (tnf-α-stimulated gene/protein 6), ptx-3 (pentraxin-3), habp1 (hyaluronan binding protein 1), mmp2 (matrix metalloproteinase), mt1-mmp (membrane type 1-matrix metalloproteinase) and cox2 (cyclooxygenase-2)] along with hyperactivities of gelatinases (like mmp9 and -2). |
2016-01-15 |
2023-08-13 |
rat |
| Xin Lian, Yu Jiao, Yu Yang, Zhipeng Wang, Qijia Xuan, Hang Liu, Shan Lu, Zunxian Wang, Yue Liu, Shuo Li, Yuguang Yang, Li Guo, Ling Zhao, Qingyuan Zhan. CrkL regulates SDF-1-induced breast cancer biology through balancing Erk1/2 and PI3K/Akt pathways. Medical oncology (Northwood, London, England). vol 32. issue 1. 2016-01-15. PMID:25476480. |
in vitro studies revealed that sdf-1 induced the activation of crkl, erk1/2, akt and matrix metallopeptidase 9 (mmp9) in mda-mb-231 cells. |
2016-01-15 |
2023-08-13 |
human |
| F Guo, Y B Sun, L Su, S Li, Z F Liu, J Li, X T Hu, J L. Losartan attenuates paraquat-induced pulmonary fibrosis in rats. Human & experimental toxicology. vol 34. issue 5. 2016-01-11. PMID:25233898. |
the levels of hydroxyproline and transforming growth factor β1 (tgf-β1), matrix metallopeptidase 9 (mmp9), and tissue inhibitor of metalloproteinase 1 (timp-1) messenger rna (mrna) expression and relative expression levels of collagen type i and iii were also detected. |
2016-01-11 |
2023-08-13 |
rat |
| Yu Liu, Liang Yang, Bo Liu, Yu-Gang Jian. Podocalyxin promotes glioblastoma multiforme cell invasion and proliferation via β-catenin signaling. PloS one. vol 9. issue 10. 2016-01-08. PMID:25349993. |
stable overexpression of podx in ln-229 and u-118 mg human gbm cells increased the soluble/intracellular β-cat level, topflash luciferase reporter activity, the mrna levels of β-cat signaling target genes, matrix metalloproteinase 9 (mmp9) expression/activity, and cell invasion and proliferation, which was abolished by selective p38 mitogen-activated protein kinase (mapk) inhibitor pd169316 and selective β-cat signaling inhibitor cct031374. |
2016-01-08 |
2023-08-13 |
human |
| Yantao Han, Huihui Zhao, Qixiao Jiang, Hui Gao, Chunbo Wan. Chemopreventive mechanism of polypeptides from Chlamy Farreri (PCF) against UVB-induced malignant transformation of HaCaT cells. Mutagenesis. vol 30. issue 2. 2015-12-30. PMID:25392149. |
the human keratinocyte cell line hacat was repeatly exposed to uvb (10 mj/cm(2), 20 times) and malignant transformation was confirmed by gimesa staining, cell cycle analysis and various assays [anchorage independent growth, matrix metalloproteinase-9 (mmp9) activity, plating efficiency]. |
2015-12-30 |
2023-08-13 |
human |
| Anna Morancho, Feifei Ma, Verónica Barceló, Dolors Giralt, Joan Montaner, Anna Rosel. Impaired vascular remodeling after endothelial progenitor cell transplantation in MMP9-deficient mice suffering cortical cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 35. issue 10. 2015-12-30. PMID:26219597. |
endothelial progenitor cells (epcs) are being investigated for advanced therapies, and matrix metalloproteinase 9 (mmp9) has an important role in stroke recovery. |
2015-12-30 |
2023-08-13 |
mouse |
| Sabine H van Rijt, Deniz A Bölükbas, Christian Argyo, Stefan Datz, Michael Lindner, Oliver Eickelberg, Melanie Königshoff, Thomas Bein, Silke Meiner. Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors. ACS nano. vol 9. issue 3. 2015-12-29. PMID:25703655. |
for example, matrix metalloproteinase 9 (mmp9) is overexpressed in tumors, is known to enhance the metastatic potency of malignant cells, and has been associated with poor prognosis of lung cancer. |
2015-12-29 |
2023-08-13 |
mouse |
| Jin-Xia Wu, Ding-Guo Zhang, Jun-Nian Zheng, Dong-Sheng Pe. Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion. Cellular signalling. vol 27. issue 6. 2015-12-21. PMID:25728512. |
in addition, the ectopic expression of rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase mmp2 and mmp9. |
2015-12-21 |
2023-08-13 |
Not clear |
| Gangarao Davuluri, Katarzyna Augoff, William P Schiemann, Edward F Plow, Khalid Sossey-Alaou. WAVE3-NFκB interplay is essential for the survival and invasion of cancer cells. PloS one. vol 9. issue 10. 2015-12-16. PMID:25329315. |
we have shown that the wave3-mediated activation of cancer cell invasion is due, in part, to its regulation of expression and activity of key metalloproteinases (mmps), including mmp9, which is centrally involved in invadopodia-mediated degradation of the extracellular matrix (ecm). |
2015-12-16 |
2023-08-13 |
Not clear |
| Attapol Tiantong, Hsing-Yi Peng, Shuen-Ei Chen, Piya Piamya, Wen-Bor Liu, Ming-Tsao Chen, Chi Yu, Hajime Nagahata, Chai-Ju Chan. Intramammary infusion of an Enterococcus faecium SF68 preparation promoted the involution of drying off Holstein cows partly related to neutrophil-associated matrix metalloproteinase 9. Animal science journal = Nihon chikusan Gakkaiho. vol 86. issue 1. 2015-12-01. PMID:25041818. |
analyses of individual quarter secretion samples showed faster neutrophil infiltration, earlier modifications in protein composition, including caseins and lactoferrins, as well as more prompt elevation of the specific unit of 92-kda matrix metalloproteinase 9 (mmp9) in sf68-infused quarters compared to the positive controls. |
2015-12-01 |
2023-08-13 |
Not clear |
| Dong Liu, Hong-Guang Zhang, Zi-Ai Zhao, Ming-Tao Chang, Yang Li, Jian Yu, Ye Zhang, Lian-Yang Zhan. Melanocortin MC4 receptor agonists alleviate brain damage in abdominal compartment syndrome in the rat. Neuropeptides. vol 49. 2015-12-01. PMID:25616531. |
then, air was injected into the peritoneal cavity of the rats to maintain an intra-abdominal pressure of 20 mm hg for 4 h. the effects of the melanocortin 4 receptor agonist ro27-3225 in alleviating the rats' iah brain injuries were observed, which indicated that ro27-3225 could reduce brain edema, the expressions of the il-1β and tnf-α inflammatory cytokines, the blood-brain barrier's permeability and the aquaporin4 (aqp4) and matrix metalloproteinase 9 (mmp9) levels. |
2015-12-01 |
2023-08-13 |
rat |
| b' R Mitchell Baldwin, Nasim Haghandish, Manijeh Daneshmand, Shahrier Amin, Genevi\\xc3\\xa8ve Paris, Theresa J Falls, John C Bell, Shahidul Islam, Jocelyn C\\xc3\\xb4t\\xc3\\xa. Protein arginine methyltransferase 7 promotes breast cancer cell invasion through the induction of MMP9 expression. Oncotarget. vol 6. issue 5. 2015-11-25. PMID:25605249.' |
furthermore, we show that prmt7 induces the expression of matrix metalloproteinase 9 (mmp9), a well-known mediator of breast cancer metastasis. |
2015-11-25 |
2023-08-13 |
Not clear |
| Yijing Chu, Huijuan Tang, Yan Guo, Jing Guo, Bangxing Huang, Fang Fang, Jing Cai, Zehua Wan. Adipose-derived mesenchymal stem cells promote cell proliferation and invasion of epithelial ovarian cancer. Experimental cell research. vol 337. issue 1. 2015-11-20. PMID:26209607. |
in addition, after co-culture with adscs, eoc cells secreted higher levels of matrix metalloproteinases (mmps), and inhibition of mmp2 and mmp9 partially relieved the tumor-promoting effects of adscs in vitro. |
2015-11-20 |
2023-08-13 |
mouse |
| Zhonghui Zheng, Muliang Ding, Jiangdong Ni, Deye Song, Jun Huang, Junjie Wan. MiR-142 acts as a tumor suppressor in osteosarcoma cell lines by targeting Rac1. Oncology reports. vol 33. issue 3. 2015-11-17. PMID:25530132. |
furthermore, mir-142 inhibited osteosarcoma cell invasion by inducing e-cadherin expression and reducing expression of matrix metalloproteinase 2 (mmp2) and mmp9. |
2015-11-17 |
2023-08-13 |
Not clear |
| Marc C Moore, Vittoria Pandolfi, Peter S McFetridg. Novel human-derived extracellular matrix induces in vitro and in vivo vascularization and inhibits fibrosis. Biomaterials. vol 49. 2015-11-17. PMID:25725553. |
gene expression profiles of endothelial cells seeded onto the matrix displayed upregulation of angiogenic genes (tgfb1, vegfa), remodeling genes (mmp9, lama5) and vascular development genes (hand2, lect1). |
2015-11-17 |
2023-08-13 |
human |
| Yi Zhang, Tiecheng Pan, Xiaoxuan Zhong, Cai Chen. Androgen receptor promotes esophageal cancer cell migration and proliferation via matrix metalloproteinase 2. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 8. 2015-11-16. PMID:25724186. |
furthermore, ar knockdown led to substantial reductions in matrix metalloproteinase 2 (mmp2) and p-akt levels in escc cell lines, but no significant change in akt and mmp9 expression. |
2015-11-16 |
2023-08-13 |
Not clear |
| Chung-Han Tsai, Hung-Chi Cheng, Yu-Shiuan Wang, Pinpin Lin, Jayu Jen, I-Ying Kuo, Ying-Hua Chang, Pao-Chi Liao, Ruey-Hwa Chen, Wei-Chien Yuan, Han-Shui Hsu, Muh-Hwa Yang, Ming-Ta Hsu, Chu-Yi Wu, Yi-Ching Wan. Small GTPase Rab37 targets tissue inhibitor of metalloproteinase 1 for exocytosis and thus suppresses tumour metastasis. Nature communications. vol 5. 2015-10-29. PMID:25183545. |
hrab37 regulates the exocytosis of timp1 in a nucleotide-dependent manner to inactivate matrix metalloproteinase 9 (mmp9) migration axis in vitro and in vivo. |
2015-10-29 |
2023-08-13 |
human |