| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Wang, Quan Li, Xianzhao Wei, Jie Xu, Qi Chen, Shuang Song, Zhe Lu, Zimin Wan. Targeted knockout of TNF-α by injection of lentivirus-mediated siRNA into the subacromial bursa for the treatment of subacromial bursitis in rats. Molecular medicine reports. vol 12. issue 3. 2016-05-17. PMID:26130073. |
morphological observations revealed that the number of inflammatory cells were reduced and damage to tendon fibers was attenuated in this group, suggesting that the downregulation of the protein expression levels of tnf‑α‑associated nuclear factor‑κb, matrix metalloproteinase (mmp)1, mmp9, cyclooxygenase (cox)‑1 and cox‑2 may exert a therapeutic effect on inflammation of the sab caused by rheumatoid arthritis. |
2016-05-17 |
2023-08-13 |
rat |
| Zhiyong Wu, Yongle Ruan, Jinxing Chang, Bowen Li, Wei Re. Angiotensin II is related to the acute aortic dissection complicated with lung injury through mediating the release of MMP9 from macrophages. American journal of translational research. vol 8. issue 3. 2016-05-17. PMID:27186269. |
matrix metalloproteinases (mmps), especially mmp2 and mmp9, have been considered to be closely related to the onset of aortic disease including aad. |
2016-05-17 |
2023-08-13 |
rat |
| Linfang Zhou, Ai Zhang, Kai Wang, Qian Zhou, Tao Dua. Folate ameliorates dexamethasone-induced fetal and placental growth restriction potentially via improvement of trophoblast migration. International journal of clinical and experimental pathology. vol 8. issue 3. 2016-05-16. PMID:26045811. |
the results showed the maternal folate increases the placental size, birth weight, and expression of matrix metalloproteinases 9 (mmp9) in a mice model of dex overexposure. |
2016-05-16 |
2023-08-13 |
mouse |
| Xihai Li, Wenna Liang, Hongzhi Ye, Xiaping Weng, Fayuan Liu, Pingdong Lin, Xianxiang Li. Overexpression of Indian hedgehog partially rescues short stature homeobox 2-overexpression-associated congenital dysplasia of the temporomandibular joint in mice. Molecular medicine reports. vol 12. issue 3. 2016-05-12. PMID:26096903. |
however, overexpression of ihh did not inhibit the shox2 overexpression-associated increase of matrix metalloproteinases (mmps) mmp9, mmp13 and apoptosis in the tmj. |
2016-05-12 |
2023-08-13 |
mouse |
| Abdoulaye J Dabo, Neville Cummins, Edward Eden, Patrick Geraght. Matrix Metalloproteinase 9 Exerts Antiviral Activity against Respiratory Syncytial Virus. PloS one. vol 10. issue 8. 2016-05-10. PMID:26284919. |
increased lung levels of matrix metalloproteinase 9 (mmp9) are frequently observed during respiratory syncytial virus (rsv) infection and elevated mmp9 concentrations are associated with severe disease. |
2016-05-10 |
2023-08-13 |
mouse |
| S Coccher. Biological and clinical effects of sulodexide in arterial disorders and diseases. International angiology : a journal of the International Union of Angiology. vol 33. issue 3. 2016-05-09. PMID:24769553. |
among the latter properties, the inhibiting effect on the enzyme family of matrix metalloproteinases (mmps), and especially on the expression of mmp9 and its precursor, seems of crucial importance given the role of these matrix degrading enzymes in the pathogenesis and progression of atherothrombosis in coronary, carotid and peripheral arteries. |
2016-05-09 |
2023-08-13 |
Not clear |
| Hiroaki Inaba, Atsuo Amano, Richard J Lamont, Yukitaka Murakam. Involvement of protease-activated receptor 4 in over-expression of matrix metalloproteinase 9 induced by Porphyromonas gingivalis. Medical microbiology and immunology. vol 204. issue 5. 2016-05-04. PMID:25670650. |
matrix metalloproteinase 9 (mmp9) which degrades the extracellular matrix and basement membrane components has been implicated in invasion and metastasis of tumor cells. |
2016-05-04 |
2023-08-13 |
Not clear |
| Xu Chen, Chuanzhen Hu, Weibin Zhang, Yuhui Shen, Jun Wang, Fangqiong Hu, Pei Y. Metformin inhibits the proliferation, metastasis, and cancer stem-like sphere formation in osteosarcoma MG63 cells in vitro. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-26. PMID:26164004. |
metformin suppressed os mg63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (mmp2) and mmp9. |
2016-04-26 |
2023-08-13 |
Not clear |
| Yugang Yan, Xueying Chen, Xinying Yang, Jian Zhang, Wenfang Xu, Yingjie Zhan. Synthesis of chiral ND-322, ND-364 and ND-364 derivatives as selective inhibitors of human gelatinase. Bioorganic & medicinal chemistry. vol 23. issue 20. 2016-04-26. PMID:26386821. |
compounds 10 (nd-322) and 15 (nd-364) are potent selective inhibitors for gelatinases, matrix metalloproteinase 2 (mmp2) and matrix metalloproteinase 9 (mmp9). |
2016-04-26 |
2023-08-13 |
human |
| Liangqi Cao, Binhui Xie, Xuewei Yang, Huihong Liang, Xiaofeng Jiang, Dawei Zhang, Ping Xue, De Chen, Zili Sha. MiR-324-5p Suppresses Hepatocellular Carcinoma Cell Invasion by Counteracting ECM Degradation through Post-Transcriptionally Downregulating ETS1 and SP1. PloS one. vol 10. issue 7. 2016-04-22. PMID:26177288. |
matrix metalloproteinase 2 (mmp2) and mmp9, the major regulators of ecm degradation, were found to be downregulated by ectopic mir-324-5p, while upregulated by mir-324-5p inhibitor. |
2016-04-22 |
2023-08-13 |
Not clear |
| Jilin Zhou, Keiko Ueda, Jin Zhao, Janet R Sparro. Correlations between Photodegradation of Bisretinoid Constituents of Retina and Dicarbonyl Adduct Deposition. The Journal of biological chemistry. vol 290. issue 45. 2016-04-22. PMID:26400086. |
additionally, in acellular assays, peptides were cross-linked in the presence of a2e (adduct of two vitamin a aldehyde and ethanolamine) photodegradation products, and in a zymography assay, reaction of collagen iv with products of a2e photodegradation resulted in reduced cleavage by the matrix metalloproteinases mmp2 and mmp9. |
2016-04-22 |
2023-08-13 |
mouse |
| Ting-Hsien Kao, Yi-Jen Peng, Donald M Salter, Herng-Sheng Le. Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society. vol 24. issue 9. 2016-04-21. PMID:25412834. |
the current study was undertaken to identify potential mechanisms of the latter effect including potential interactions between lcn2 and matrix metalloproteinase 9 (mmp9). |
2016-04-21 |
2023-08-13 |
Not clear |
| Leisheng Wang, Junbo Ge, Tian Ma, Yanpin Zheng, Shiqiao Lv, Yu Li, Shaoxian Li. Promoter hypermethylation of the cysteine protease RECK may cause metastasis of osteosarcoma. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 36. issue 12. 2016-04-21. PMID:26130413. |
using human pathological samples, it is demonstrated that reck, a cysteine protease that reversibly regulates expression of matrix metalloproteases like matrix metallopeptidase 9 (mmp9), is transcriptionally inhibited in osteosarcoma, especially metastatic variants. |
2016-04-21 |
2023-08-13 |
human |
| A V Shevchenko, V I Konenkov, M A Korolev, Yu B Ubshaeva, V F Prokofie. [Matrix metalloproteinase 2, 3, and 9 gene polymorphisms in women with rheumatoid arthritis]. Terapevticheskii arkhiv. vol 87. issue 12. 2016-04-21. PMID:26978416. |
to study the promoter regions of the matrix metalloproteinase (mmp)2, mmp3, and mmp9 genes to assess their associations with the risk of rheumatoid arthritis (ra) and with the types of its clinical course in women. |
2016-04-21 |
2023-08-13 |
Not clear |
| Sonja S Mojsilović, Juan F Santibane. Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction. Cell biology international. vol 39. issue 5. 2016-04-19. PMID:25597879. |
transforming growth factor β (tgf-β) modulates capacity of macrophages to produce urokinase type plasminogen activator (upa) and matrix metalloproteinase-9 (mmp9). |
2016-04-19 |
2023-08-13 |
mouse |
| Sonja S Mojsilović, Juan F Santibane. Transforming growth factor-beta differently regulates urokinase type plasminogen activator and matrix metalloproteinase-9 expression in mouse macrophages; analysis of intracellular signal transduction. Cell biology international. vol 39. issue 5. 2016-04-19. PMID:25597879. |
upa and mmp9 actively participate in extracellular matrix reorganization and influence macrophages chemotaxis and cell migration. |
2016-04-19 |
2023-08-13 |
mouse |
| Lavinia Raimondi, Angela De Luca, Nicola Amodio, Mauro Manno, Samuele Raccosta, Simona Taverna, Daniele Bellavia, Flores Naselli, Simona Fontana, Odessa Schillaci, Roberto Giardino, Milena Fini, Pierfrancesco Tassone, Alessandra Santoro, Giacomo De Leo, Gianluca Giavaresi, Riccardo Alessandr. Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation. Oncotarget. vol 6. issue 15. 2016-04-19. PMID:25944696. |
mm cell-derived exosomes play a significant pro-differentiative role in murine raw264.7 cells and human primary osteoclasts, inducing the expression of osteoclast markers such as cathepsin k (ctsk), matrix metalloproteinases 9 (mmp9) and tartrate-resistant acid phosphatase (trap). |
2016-04-19 |
2023-08-13 |
human |
| Derek C Marshall, Susan K Lyman, Scott McCauley, Maria Kovalenko, Rhyannon Spangler, Chian Liu, Michael Lee, Christopher O'Sullivan, Vivian Barry-Hamilton, Haben Ghermazien, Amanda Mikels-Vigdal, Carlos A Garcia, Brett Jorgensen, Arleene C Velayo, Ruth Wang, Joanne I Adamkewicz, Victoria Smit. Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer. PloS one. vol 10. issue 5. 2016-04-13. PMID:25961845. |
expression of matrix metalloproteinase 9 (mmp9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. |
2016-04-13 |
2023-08-13 |
mouse |
| Derek C Marshall, Susan K Lyman, Scott McCauley, Maria Kovalenko, Rhyannon Spangler, Chian Liu, Michael Lee, Christopher O'Sullivan, Vivian Barry-Hamilton, Haben Ghermazien, Amanda Mikels-Vigdal, Carlos A Garcia, Brett Jorgensen, Arleene C Velayo, Ruth Wang, Joanne I Adamkewicz, Victoria Smit. Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer. PloS one. vol 10. issue 5. 2016-04-13. PMID:25961845. |
however, previous efforts to target matrix metalloproteinases (mmps), including mmp9, have utilized broad-spectrum or semi-selective inhibitors. |
2016-04-13 |
2023-08-13 |
mouse |
| Pankaj Chaturvedi, Anuradha Kalani, Ilza Medina, Anastasia Familtseva, Suresh C Tyag. Cardiosome mediated regulation of MMP9 in diabetic heart: role of mir29b and mir455 in exercise. Journal of cellular and molecular medicine. vol 19. issue 9. 2016-04-11. PMID:25824442. |
we hypothesize that exosomes that are released during exercise contain micrornas (mir455, mir29b, mir323-5p and mir466) that bind to the 3' region of mmp9 and downregulate its expression, hence mitigating the deleterious downstream effects of mmp9, which causes extracellular matrix remodeling. |
2016-04-11 |
2023-08-13 |
mouse |