| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rongzi Shan, Joanna Szmydynger-Chodobska, Otis U Warren, Farah Mohammad, Brian J Zink, Adam Chodobsk. A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults. Journal of neurotrauma. vol 33. issue 1. 2016-09-27. PMID:25794137. |
four candidate biomarkers were identified: copeptin; galectin 3 (lgals3); matrix metalloproteinase 9 (mmp9); and occludin (ocln). |
2016-09-27 |
2023-08-13 |
human |
| Yun Luo, Qi-Wei Jiang, Jie-Ying Wu, Jian-Ge Qiu, Wen-Ji Zhang, Xiao-Long Mei, Zhi Shi, Jin-Ming D. Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer. Oncotarget. vol 6. issue 26. 2016-09-27. PMID:26087186. |
tlr9 signaling network analysis of the migration and invasion related genes identified several genes, like matrix metallopeptidase 2 (mmp2), matrix metallopeptidase 9 (mmp9), chemokine receptor 4 (cxcr4) and interleukin 8 (il8), formed the core interaction network based on their known biological relationships. |
2016-09-27 |
2023-08-13 |
Not clear |
| Mahesh Sapkota, Liang Li, Hyukjae Choi, William H Gerwick, Yunjo So. Bromo-honaucin A inhibits osteoclastogenic differentiation in RAW 264.7 cells via Akt and ERK signaling pathways. European journal of pharmacology. vol 769. 2016-09-26. PMID:26550952. |
the inhibitory effects on in-vitro osteoclastogenesis was evaluated by counting the number of tartarate resistant acid phospatase (trap) positive multinucleated cells and by measuring the expression level of osteoclast-specific genes like matrix metalloproteinase 9 (mmp9), cathepsin k (cath k), grb2-associated-binding protein 2 (gab2), c-terminal myc kinase (c-myc), c-terminal src kinase (c-src) and microphthalmia-associated transcription factor (mitf). |
2016-09-26 |
2023-08-13 |
Not clear |
| Xiang-Yan Chen, Jie Zhou, Li-Ping Luo, Bin Han, Fei Li, Jing-Yao Chen, Yan-Feng Zhu, Wei Chen, Xiao-Ping Y. Black Rice Anthocyanins Suppress Metastasis of Breast Cancer Cells by Targeting RAS/RAF/MAPK Pathway. BioMed research international. vol 2015. 2016-09-15. PMID:26649302. |
treatment of mda-mb-453 cells (her2(+)) with bracs inhibited cell migration and invasion, suppressed the activation of mitogen-activated protein kinase kinase kinase (raf), mitogen-activated protein kinase kinase (mek), and c-jun n-terminal kinase (jnk), and downregulated the secretion of matrix metalloproteinase 2 (mmp2) and mmp9. |
2016-09-15 |
2023-08-13 |
human |
| Qinghua Liu, Donghui Pan, Chao Cheng, Anyu Zhang, Chao Ma, Lizhen Wang, Dazhi Zhang, Hongrui Liu, Hongdie Jiang, Tao Wang, Yuping Xu, Runlin Yang, Fei Chen, Min Yang, Changjing Zu. Targeting of MMP2 activity in malignant tumors with a 68Ga-labeled gelatinase inhibitor cyclic peptide. Nuclear medicine and biology. vol 42. issue 12. 2016-09-13. PMID:26344861. |
elevated levels of gelatinases (matrix metalloproteinases 2/9, i.e., mmp2 and mmp9) are associated with tumor progression, invasion and metastasis, so these enzymes are potential targets for tumor imaging. |
2016-09-13 |
2023-08-13 |
Not clear |
| Qingbin Li, Baoshi Chen, Jinquan Cai, Ying Sun, Guangzhi Wang, Yongli Li, Ruiyan Li, Yan Feng, Bo Han, Jianlong Li, Yu Tian, Liye Yi, Chuanlu Jian. Comparative Analysis of Matrix Metalloproteinase Family Members Reveals That MMP9 Predicts Survival and Response to Temozolomide in Patients with Primary Glioblastoma. PloS one. vol 11. issue 3. 2016-08-29. PMID:27022952. |
comparative analysis of matrix metalloproteinase family members reveals that mmp9 predicts survival and response to temozolomide in patients with primary glioblastoma. |
2016-08-29 |
2023-08-13 |
Not clear |
| Qiu Tang, Jun Jiang, Jian Li. CCR5 Blockade Suppresses Melanoma Development Through Inhibition of IL-6-Stat3 Pathway via Upregulation of SOCS3. Inflammation. vol 38. issue 6. 2016-08-22. PMID:26047948. |
ccr5 blockade also induces suppressor of cytokine signaling 3 (socs3) upregulations, and anti-ccr5 antibody fails to suppress expression of phospho-stat3 (p-stat3), matrix metallopeptidase 9 (mmp9), and il-6 in cells transfected with socs3 short-interfering rna (sirna). |
2016-08-22 |
2023-08-13 |
Not clear |
| Shanchuan Zhang, Lili Tian, Penghua Ma, Qiang Sun, Kai Zhang, GuanchaoWang, Hongchen Liu, Baohua X. Potential role of differentially expressed lncRNAs in the pathogenesis of oral squamous cell carcinoma. Archives of oral biology. vol 60. issue 10. 2016-08-15. PMID:26276270. |
by further conducting ppi network with lncrna co-expressed degs, we found that oscc-associated genes including mmp1 (matrix metallopeptidase), mmp3, mmp9, plau (plasminogen activator, urokinase) and il8 (interleukin 8) were targeted by fth1p3, pdia3f and gtf2ird2p1. |
2016-08-15 |
2023-08-13 |
Not clear |
| Xiaoling Zhu, Limin Cai, Qinggang Meng, Xiaoming Ji. Gelsolin inhibits the proliferation and invasion of the 786-0 clear cell renal cell carcinoma cell line in vitro. Molecular medicine reports. vol 12. issue 5. 2016-08-15. PMID:26398833. |
in addition, the expression levels of invasion‑associated proteins, matrix metalloproteinase (mmp)2, mmp9 and e‑cadherin were analyzed by elisa and western blotting. |
2016-08-15 |
2023-08-13 |
Not clear |
| Qing Zhang, Junlong Zhuang, Yongming Deng, Xiaozhi Zhao, Bo Tang, Dongwei Yao, Wei Zhao, Cunjie Chang, Qun Lu, Wei Chen, Shiwei Zhang, Changwei Ji, Lin Cao, Hongqian Gu. GOLPH3 is a potential therapeutic target and a prognostic indicator of poor survival in bladder cancer treated by cystectomy. Oncotarget. vol 6. issue 31. 2016-08-08. PMID:26375441. |
golph3 silencing inhibited akt/m-tor signaling, increased the cyclin-dependent kinase (cdk) inhibitor p27 and decreased the cdk regulator cyclin d1 and matrix metallopeptidase 9 (mmp9). |
2016-08-08 |
2023-08-13 |
mouse |
| Dan Liao, Haohai Huang, Zhu Zhu, Tong Li, Huahui Li, Guo-Liang Huang, Zhiwei H. Prognostic value of matrix metalloproteinase 9 in nasopharyngeal carcinoma: a meta-analysis. Minerva medica. vol 107. issue 1. 2016-08-08. PMID:26799856. |
recent studies have shown that matrix metalloproteinase 9 (mmp9) plays a vital role in tumor metastasis and is overexpressed in many human cancers. |
2016-08-08 |
2023-08-13 |
human |
| Won-Young Lee, Jeong Tae Do, Chankyu Park, Jin Hoi Kim, Hak-Jae Chung, Kyung-Woon Kim, Chang-Hyun Gil, Nam-Hyung Kim, Hyuk Son. Identification of Putative Biomarkers for the Early Stage of Porcine Spermatogonial Stem Cells Using Next-Generation Sequencing. PloS one. vol 11. issue 1. 2016-08-01. PMID:26800048. |
the following genes upregulated in psscs compared to 5-day-old testes were selected for additional analysis: matrix metallopeptidase 9 (mmp9), matrix metallopeptidase 1 (mmp1), glutathione peroxidase 1 (gpx1), chemokine receptor 1 (ccr1), insulin-like growth factor binding protein 3 (igfbp3), cd14, cd209, and kruppel-like factor 9 (klf9). |
2016-08-01 |
2023-08-13 |
Not clear |
| Jingfeng Chen, Silu Wang, Jiadong Su, Guanyu Chu, Heyi You, Zongjing Chen, Hongwei Sun, Bicheng Chen, Mengtao Zho. Interleukin-32α inactivates JAK2/STAT3 signaling and reverses interleukin-6-induced epithelial-mesenchymal transition, invasion, and metastasis in pancreatic cancer cells. OncoTargets and therapy. vol 9. 2016-07-29. PMID:27471397. |
epithelial-mesenchymal transition-related markers, including e-cadherin, n-cadherin, vimentin, snail, and zeb1, as well as extracellular matrix metalloproteinases (mmps), including mmp2, mmp7, and mmp9, were detected by immunofluorescence, western blotting, and real-time polymerase chain reaction. |
2016-07-29 |
2023-08-13 |
human |
| Sean M Bugel, Leah C Wehmas, Jane K La Du, Robert L Tangua. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. vol 296. 2016-07-28. PMID:26908177. |
the most robustly misregulated transcripts in the tail were matrix metalloproteinases mmp9 and mmp13a, induced 127 and 1145 fold, respectively. |
2016-07-28 |
2023-08-13 |
zebrafish |
| Jianzhong Hu, Shuangfei Ni, Yong Cao, Tao Zhang, Tianding Wu, Xianzhen Yin, Ye Lang, Hongbin L. The Angiogenic Effect of microRNA-21 Targeting TIMP3 through the Regulation of MMP2 and MMP9. PloS one. vol 11. issue 2. 2016-07-26. PMID:26872030. |
an increased level of mirna-21 by mimics promoted the survival, migration and tube formation of endothelial cells, which simultaneously inhibited tissue inhibitor of metalloproteinase-3 (timp3) expression and promoted matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9) expression and secretion. |
2016-07-26 |
2023-08-13 |
rat |
| Walter Maetzler, Willy Deleersnijder, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetand, Isabel Wurster, Tim W Rattay, Lorenzo Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Ber. GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia. PloS one. vol 11. issue 3. 2016-07-25. PMID:26938614. |
based on animal and ex-vivo experiments, growth/differentiation factor-15 (gdf15, also called macrophage inhibitory cytokine-1, mic1), a member of the transforming growth factor-beta family, and matrix metalloproteinase-9 (mmp9), a member of the matrix metalloprotease family may be potential markers for lewy body disorders, i.e. |
2016-07-25 |
2023-08-13 |
Not clear |
| Walter Maetzler, Willy Deleersnijder, Valérie Hanssens, Alice Bernard, Kathrin Brockmann, Justus Marquetand, Isabel Wurster, Tim W Rattay, Lorenzo Roncoroni, Eva Schaeffer, Stefanie Lerche, Anja Apel, Christian Deuschle, Daniela Ber. GDF15/MIC1 and MMP9 Cerebrospinal Fluid Levels in Parkinson's Disease and Lewy Body Dementia. PloS one. vol 11. issue 3. 2016-07-25. PMID:26938614. |
gdf15 has a prominent role in development, cell proliferation, differentiation, and repair, whereas mmp9 degrades, as a proteolytic enzyme, components of the extracellular matrix. |
2016-07-25 |
2023-08-13 |
Not clear |
| Pei-Tzu Li, Yi-Jane Tsai, Ming-Jen Lee, Chin-Tin Che. Increased Histone Deacetylase Activity Involved in the Suppressed Invasion of Cancer Cells Survived from ALA-Mediated Photodynamic Treatment. International journal of molecular sciences. vol 16. issue 10. 2016-07-12. PMID:26473836. |
the activated hdac deacetylated histone h3 and further resulted in the reduced migration and invasion, which correlated with the reduced expression of the invasion-related genes, matrix metalloproteinase 9 (mmp9), paternally expressed gene 1 (peg1), and mir-355, the intronic mirna. |
2016-07-12 |
2023-08-13 |
Not clear |
| Xiaohui Zhang, Min Feng, Xin Liu, Li Bai, Ming Kong, Yu Chen, Sujun Zheng, Shuang Liu, Yu-Jui Yvonne Wan, Zhongping Duan, Yuan-Ping Ha. Persistence of cirrhosis is maintained by intrahepatic regulatory T cells that inhibit fibrosis resolution by regulating the balance of tissue inhibitors of metalloproteinases and matrix metalloproteinases. Translational research : the journal of laboratory and clinical medicine. vol 169. 2016-07-12. PMID:26613891. |
as a consequence of tregs depletion, the expression of matrix metalloproteinases (mmps) and tissue inhibitors of metalloproteinases (timps) was altered; mmp9 and timp1 were reduced, whereas mmp2 and mmp14 were enhanced. |
2016-07-12 |
2023-08-13 |
mouse |
| Caitlin A Orner, Michael B Geary, Warren C Hammert, Regis J O'Keefe, Alayna E Loisell. Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing. Plastic and reconstructive surgery. vol 137. issue 3. 2016-07-08. PMID:26910699. |
matrix metalloproteinase 9 (mmp9) is a gelatinase that contributes to degradation of extracellular matrix and is expressed during flexor tendon healing. |
2016-07-08 |
2023-08-13 |
mouse |