| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Valeria Arkadash, Evette S Radisky, Niv Pap. Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell. Oncotarget. vol 9. issue 62. 2019-11-20. PMID:30174795. |
here, we used a combination of yeast surface display and dual-color selective library screening to obtain selective inhibitors for each of the matrix metalloproteinases (mmps) mmp14 and mmp9 by modifying the non-specific n-terminal domain of the tissue inhibitor of metalloproteinase-2 (n-timp2). |
2019-11-20 |
2023-08-13 |
Not clear |
| Bianhua Shi, Jiayu Bao, Yongbin Liu, Juan Sh. Death receptor 6 promotes ovarian cancer cell migration through KIF11. FEBS open bio. vol 8. issue 9. 2019-11-20. PMID:30186750. |
in addition, dr6 enhanced ovarian carcinoma cell migration ability, and decreased expression of dr6 inhibited the expression of matrix metalloprotease (mmp) 2 and mmp9, and increased the expression of e-cadherin. |
2019-11-20 |
2023-08-13 |
human |
| Zuopei Wang, Yi Lu, Bo Sheng, Yi Ding, Xiaoke Chen. Catalpol inhibits TGF-β1-induced epithelial-mesenchymal transition in human non-small-cell lung cancer cells through the inactivation of Smad2/3 and NF-κB signaling pathways. Journal of cellular biochemistry. 2019-11-20. PMID:30203551. |
our results showed that catalpol significantly inhibited the tgf-β1-induced cell migration and invasion of a549 cells, as well as repressed matrix metalloproteinase (mmp)2 and mmp9 expression induced by tgf-β1 in a549 cells. |
2019-11-20 |
2023-08-13 |
human |
| Jiali Sun, Guoxin Ji, Jie Xie, Zhi Jiao, Haozheng Zhang, Jie Che. Six-transmembrane epithelial antigen of the prostate 1 is associated with tumor invasion and migration in endometrial carcinomas. Journal of cellular biochemistry. 2019-11-20. PMID:30714206. |
matrix metalloproteinase (mmp) zymography assay was used to detect the activities of mmp2 and mmp9. |
2019-11-20 |
2023-08-13 |
Not clear |
| Iwona Sidorkiewicz, Barbara Piskór, Emilia Dąbrowska, Katarzyna Guzińska-Ustymowicz, Anna Pryczynicz, Monika Zbucka-Krętowska, Sławomir Ławick. Plasma Levels and Tissue Expression of Selected Cytokines, Metalloproteinases and Tissue Inhibitors in Patients With Cervical Cancer. Anticancer research. vol 39. issue 11. 2019-11-14. PMID:31704874. |
thus, the aim of this study was to compare the concentration of plasma levels and tissue expression of macrophage colony-stimulating factor (m-csf), vascular endothelial growth factor (vegf), matrix metalloproteinases (mmp)-2 and mmp9, and their tissue inhibitors timp1 and timp2 in patients with cervical cancer, patients with high-grade cervical intraepithelial dysplasia (cin3) and patients with ectropion. |
2019-11-14 |
2023-08-13 |
Not clear |
| Xiaoju Liang, Lijun Zhang, Deliang Cheng, Xiaodi Lian. [MiR-101-3p alleviates IL-1β-induced chondrocyte injury by targeting stanniocalcin 1]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 9. 2019-11-12. PMID:31645485. |
western blotting assay was used to detect the expression levels of pro-inflammatory and ecm-related protein, such as matrix metalloproteinase 9 (mmp9) and collagen type ii. |
2019-11-12 |
2023-08-13 |
Not clear |
| Ying Hua, Fayou Zhou, Liping Chen, Sheng Li, Xiaolei Tan. [HpaA promotes gastric mucosa injury via stimulating IL-21 secretion of T cells]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 35. issue 8. 2019-11-04. PMID:31638572. |
the levels of il-21, matrix metalloproteinase-2 (mmp2) and mmp9 from the biopsy were detected by reverse transcription pcr and western blot analysis. |
2019-11-04 |
2023-08-13 |
Not clear |
| Ran Wei, Janet Pik Ching Wong, Peng Lyu, Xinping Xi, Olivia Tong, Shu-Dong Zhang, Hiu Fung Yuen, Senji Shirasawa, Hang Fai Kwo. In vitro and clinical data analysis of Osteopontin as a prognostic indicator in colorectal cancer. Journal of cellular and molecular medicine. vol 22. issue 9. 2019-10-31. PMID:29851214. |
opn overexpression also induced pi3k signalling, expression of snail and matrix metallopeptidase 9 (mmp9), and suppressed the expression of e-cadherin in kras mutant cells. |
2019-10-31 |
2023-08-13 |
human |
| Frederico Rezende Ghersel, Ricardo Peres Souto, Ester Wilma Pacheco Gonzales, Denise Souza Paulo, César Eduardo Fernandes, Emerson Oliveir. Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. vol 41. issue 3. 2019-10-29. PMID:30939607. |
assessment of metalloproteinase matrix 9 (mmp9) gene polymorphisms risk factors for pelvic organ prolapse in the brazilian population. |
2019-10-29 |
2023-08-13 |
Not clear |
| Rosa Di Liddo, Thomas Bertalot, Alessio Borean, Ivan Pirola, Alberto Argentoni, Sandra Schrenk, Carola Cenzi, Stefano Capelli, Maria Teresa Conconi, Pier Paolo Parnigott. Leucocyte and Platelet-rich Fibrin: a carrier of autologous multipotent cells for regenerative medicine. Journal of cellular and molecular medicine. vol 22. issue 3. 2019-10-21. PMID:29314633. |
expressing integrins (cd49f, cd103), vascular adhesion molecules (cd106, cd166), endoglin (cd105) and remodelling matrix enzymes (mmp2, mmp9, mmp13), they showed a transendothelial migratory potential besides multipotency. |
2019-10-21 |
2023-08-13 |
Not clear |
| Gisou Mohaddes, Shirin Babri, Fezzeh Hossienzade. Administration of ghrelin associated with decreased expression of matrix metalloproteinase-9 following normobaric systemic hypoxia in the brain. Endocrine regulations. vol 52. issue 3. 2019-10-17. PMID:31517605. |
several studies suggest a role for matrix metal-loproteinase-9 (mmp9) in the bbb disruption and cerebral edema formation. |
2019-10-17 |
2023-08-13 |
Not clear |
| Yu-Hsuan Hsiao, Nien-Chi Chen, Yen-Chun Koh, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hsiung Pa. Pterostilbene Inhibits Adipocyte Conditioned-Medium-Induced Colorectal Cancer Cell Migration through Targeting FABP5-Related Signaling Pathway. Journal of agricultural and food chemistry. vol 67. issue 37. 2019-10-10. PMID:31419115. |
the results demonstrated that pts could downregulate the expression of acm-induced fatty acid-binding protein 5 (fabp5) and prometastatic factors such as vascular endothelial growth factor, matrix metalloproteinase-2 (mmp2), mmp9, and extracellular tumor necrosis factor α via inhibiting acm-induced nuclear factor-kappa b (nf-κb), β-catenin, and peroxisome proliferator-activated receptor γ (ppar-γ). |
2019-10-10 |
2023-08-13 |
Not clear |
| Xiaoqian Wang, Bing Yang, Yuanping She, Yuan Y. The lncRNA TP73-AS1 promotes ovarian cancer cell proliferation and metastasis via modulation of MMP2 and MMP9. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-08. PMID:29904939. |
the protein levels of matrix metallopeptidase 2 (mmp2) and mmp9 were measured by western blot. |
2019-10-08 |
2023-08-13 |
Not clear |
| Qiang Guo, Zhen Cao, Bo Wu, Fangxiao Chen, Jennifer Tickner, Ziyi Wang, Heng Qiu, Chao Wang, Kai Chen, Renxiang Tan, Qile Gao, Jiake X. Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption. Journal of cellular physiology. vol 234. issue 1. 2019-10-02. PMID:30078210. |
using reverse transcription-polymerase chain reaction and western blot analysis, we found that kavain downregulates the expression of osteoclast marker genes, such as nuclear factor of activated t cells, cytoplasmic 1 (nfatc1), v-atpase d2 (atp6v0d2), dendrocyte expressed seven transmembrane protein (dcstamp), matrix metallopeptidase 9 (mmp9), cathepsin k (ctsk), and acp5. |
2019-10-02 |
2023-08-13 |
mouse |
| Wang Jiashi, Qiu Chuang, Zhang Zhenjun, Wang Guangbin, Li Bin, He Min. MicroRNA-506-3p inhibits osteosarcoma cell proliferation and metastasis by suppressing RAB3D expression. Aging. vol 10. issue 6. 2019-09-30. PMID:29905536. |
suppression of mir-506-3p in osteosarcoma led to increased expression of rab3d, which in turn led to increased cdk4 (cyclin-dependent kinase 4) and mmp9 (matrix metalloprotein 9) activities. |
2019-09-30 |
2023-08-13 |
Not clear |
| Yiming Zhu, Tao Ni, Wensheng Deng, Jiayun Lin, Lei Zheng, Chihao Zhang, Meng Lu. Effects of NLRP6 on the proliferation and activation of human hepatic stellate cells. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:29966662. |
in a human hepatic stellate cell line, lx-2, overexpression of nlrp6 suppressed cell proliferation, hydroxyproline accumulation, as well as the expression of type i and type iii collagens (col-i and col-iii), α-smooth muscle actin (α-sma) and matrix metalloproteinases (mmp2 and mmp9), whereas nlrp6 knockdown displayed reverse effects. |
2019-09-30 |
2023-08-13 |
human |
| Jiaxin Liang, Mengqian Chen, Daniel Hughes, Alexander A Chumanevich, Serena Altilia, Vimala Kaza, Chang-Uk Lim, Hippokratis Kiaris, Karthikeyan Mythreye, Maria Marjorette Pena, Eugenia V Broude, Igor B Roninso. CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer research. vol 78. issue 23. 2019-09-30. PMID:30185549. |
cdk8 mediated colon cancer growth in the liver through downregulation of matrix metalloproteinase (mmp) inhibitor timp3 via tgfβ/smad-driven expression of a timp3-targeting microrna, mir-181b, along with induction of mmp3 in murine or mmp9 in human colon cancer cells via wnt/β-catenin-driven transcription. |
2019-09-30 |
2023-08-13 |
mouse |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
inhibition of microglia activation by minocycline or creb phosphorylation by h89, an inhibitor of protein kinase a (pka), abolished aβ-induced microglia creb hyperphosphorylation with restoration of neuronal function and attenuation of inflammatory response, i.e., reduced levels of interleukin-6 (il6) and pcreb binding of matrix metalloproteinase-9 (mmp9) dna. |
2019-09-19 |
2023-08-13 |
mouse |
| Petra Keul, Amin Polzin, Klaus Kaiser, Markus Gräler, Lisa Dannenberg, Günter Daum, Gerd Heusch, Bodo Levka. Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-09-17. PMID:30130432. |
we observed that healthy hdl potently inhibited the induction of tnf-α-stimulated inflammatory genes, such as inos (inducible no synthase) and mmp9 (matrix metalloproteinase 9), a process that was entirely dependent on hdl-s1p, as evidenced by loss-of-function using s1p-less hdl and mimicked by genuine s1p. |
2019-09-17 |
2023-08-13 |
mouse |
| Claudia D Costa, Adriana Teleginski, Yusra Al-Lahham, Emanuel M Souza, Glaucio Valdameri, Dayane Alberton, Fabiane G M Rego, Geraldo Pichet. Association of Polymorphism rs17576 of the Metalloproteinase 9 Gene with Gestational Diabetes in Euro-Brazilian Pregnant Women. Clinical laboratory. vol 64. issue 4. 2019-09-16. PMID:29739074. |
metalloproteinase 9 (mmp9) is involved in the degradation of extracellular matrix molecules, and its polymorphism rs17576 (gln279arg) has been associated with diabetes. |
2019-09-16 |
2023-08-13 |
Not clear |