| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiaxin Liang, Mengqian Chen, Daniel Hughes, Alexander A Chumanevich, Serena Altilia, Vimala Kaza, Chang-Uk Lim, Hippokratis Kiaris, Karthikeyan Mythreye, Maria Marjorette Pena, Eugenia V Broude, Igor B Roninso. CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases. Cancer research. vol 78. issue 23. 2019-09-30. PMID:30185549. |
cdk8 mediated colon cancer growth in the liver through downregulation of matrix metalloproteinase (mmp) inhibitor timp3 via tgfβ/smad-driven expression of a timp3-targeting microrna, mir-181b, along with induction of mmp3 in murine or mmp9 in human colon cancer cells via wnt/β-catenin-driven transcription. |
2019-09-30 |
2023-08-13 |
mouse |
| Yuan Gao, En-Jie Liu, Wei-Jin Wang, Ya-Li Wang, Xiao-Guang Li, Xin Wang, Shi-Hong Li, Shu-Juan Zhang, Meng-Zhu Li, Qiu-Zhi Zhou, Xiao-Bing Long, Hua-Qiu Zhang, Jian-Zhi Wan. Microglia CREB-Phosphorylation Mediates Amyloid-β-Induced Neuronal Toxicity. Journal of Alzheimer's disease : JAD. vol 66. issue 1. 2019-09-19. PMID:30282353. |
inhibition of microglia activation by minocycline or creb phosphorylation by h89, an inhibitor of protein kinase a (pka), abolished aβ-induced microglia creb hyperphosphorylation with restoration of neuronal function and attenuation of inflammatory response, i.e., reduced levels of interleukin-6 (il6) and pcreb binding of matrix metalloproteinase-9 (mmp9) dna. |
2019-09-19 |
2023-08-13 |
mouse |
| Petra Keul, Amin Polzin, Klaus Kaiser, Markus Gräler, Lisa Dannenberg, Günter Daum, Gerd Heusch, Bodo Levka. Potent anti-inflammatory properties of HDL in vascular smooth muscle cells mediated by HDL-S1P and their impairment in coronary artery disease due to lower HDL-S1P: a new aspect of HDL dysfunction and its therapy. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 1. 2019-09-17. PMID:30130432. |
we observed that healthy hdl potently inhibited the induction of tnf-α-stimulated inflammatory genes, such as inos (inducible no synthase) and mmp9 (matrix metalloproteinase 9), a process that was entirely dependent on hdl-s1p, as evidenced by loss-of-function using s1p-less hdl and mimicked by genuine s1p. |
2019-09-17 |
2023-08-13 |
mouse |
| Claudia D Costa, Adriana Teleginski, Yusra Al-Lahham, Emanuel M Souza, Glaucio Valdameri, Dayane Alberton, Fabiane G M Rego, Geraldo Pichet. Association of Polymorphism rs17576 of the Metalloproteinase 9 Gene with Gestational Diabetes in Euro-Brazilian Pregnant Women. Clinical laboratory. vol 64. issue 4. 2019-09-16. PMID:29739074. |
metalloproteinase 9 (mmp9) is involved in the degradation of extracellular matrix molecules, and its polymorphism rs17576 (gln279arg) has been associated with diabetes. |
2019-09-16 |
2023-08-13 |
Not clear |
| William H Chappell, Saverio Candido, Stephen L Abrams, Suzanne Russo, Roger Ove, Alberto M Martelli, Lucio Cocco, Giulia Ramazzotti, Melchiorre Cervello, Giuseppe Montalto, Linda S Steelman, Xiaohong Leng, Ralph B Arlinghaus, Massimo Libra, James A McCubre. Roles of p53, NF-κB and the androgen receptor in controlling NGAL expression in prostate cancer cell lines. Advances in biological regulation. vol 69. 2019-09-09. PMID:29861174. |
neutrophil gelatinase-associated lipocalin (ngal a.k.a lipocalin 2, lnc2) is a secreted protein which can form a complex with matrix metalloproteinase-9 (mmp9). |
2019-09-09 |
2023-08-13 |
Not clear |
| Sarah A Marshall, Jonathan T McGuane, Yu May Soh, Helen M Gehring, Emma Simpson, Laura J Parr. Abnormal extracellular matrix remodelling in the cervix of pregnant relaxin-deficient mice is not associated with reduced matrix metalloproteinase expression or activity. Reproduction, fertility, and development. vol 30. issue 9. 2019-09-05. PMID:29533760. |
we hypothesised that abnormal collagen remodelling in the cervix of pregnant relaxin-deficient (rln1-/-) mice is due to excessive collagen (col1a1 and col3a1) and decreased matrix metalloproteinases (mmp2, mmp9, mmp13 and mmp7) and oestrogen receptors (esr1 and esr2). |
2019-09-05 |
2023-08-13 |
mouse |
| Laura A Amundson, Laura L Hernandez, Thomas D Crensha. Gene expression of matrix metalloproteinase 9 (MMP9), matrix metalloproteinase 13 (MMP13), vascular endothelial growth factor (VEGF) and fibroblast growth factor 23 (FGF23) in femur and vertebra tissues of the hypovitaminosis D kyphotic pig model. The British journal of nutrition. vol 120. issue 4. 2019-09-04. PMID:29991364. |
gene expression of matrix metalloproteinase 9 (mmp9), matrix metalloproteinase 13 (mmp13), vascular endothelial growth factor (vegf) and fibroblast growth factor 23 (fgf23) in femur and vertebra tissues of the hypovitaminosis d kyphotic pig model. |
2019-09-04 |
2023-08-13 |
Not clear |
| Laura A Amundson, Laura L Hernandez, Thomas D Crensha. Gene expression of matrix metalloproteinase 9 (MMP9), matrix metalloproteinase 13 (MMP13), vascular endothelial growth factor (VEGF) and fibroblast growth factor 23 (FGF23) in femur and vertebra tissues of the hypovitaminosis D kyphotic pig model. The British journal of nutrition. vol 120. issue 4. 2019-09-04. PMID:29991364. |
matrix metalloproteinases (mmp; specifically, mmp9 and mmp13) and vascular endothelial growth factor (vegf) are important in endochondral ossification and are potentially regulated by d. fibroblast growth factor 23 (fgf23) is interrelated with d homoeostasis and bone mineralisation. |
2019-09-04 |
2023-08-13 |
Not clear |
| Enling Liu, Zheng Liu, Yuxiu Zhou, Mei Chen, Liqun Wang, Jun L. MicroRNA‑142‑3p inhibits trophoblast cell migration and invasion by disrupting the TGF‑β1/Smad3 signaling pathway. Molecular medicine reports. vol 19. issue 5. 2019-08-19. PMID:30864732. |
in addition, overexpression of mir‑142‑3p inhibited the mrna expression and the activities of matrix metalloproteinase‑2 (mmp2) and mmp9, which are closely associated with cell invasion and migration, while inhibition of mir‑142‑3p had the opposite result. |
2019-08-19 |
2023-08-13 |
human |
| Jinsong Zhang, Jiansong Wang, Ting Luan, Yigang Zuo, Jian Chen, Heng Zhang, Zhenni Ye, Haifeng Wang, Bing Ha. Deubiquitinase USP9X regulates the invasion of prostate cancer cells by regulating the ERK pathway and mitochondrial dynamics. Oncology reports. vol 41. issue 6. 2019-08-15. PMID:31002345. |
furthermore, usp9x depletion upregulated matrix metalloproteinase 9 (mmp9) and the phosphorylation of dynamin‑related protein 1 (drp1). |
2019-08-15 |
2023-08-13 |
human |
| Hong-Bo Shen, Yi-Nong Zhou, Jie Zheng, Ruo-Hai Zh. ["Multi-component-multi-target-multi-pathway" mechanism of Kuihua Hugan Tablets based on network pharmacology]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 7. 2019-08-15. PMID:31090306. |
the results of ppi network analysis indicated that albumin(alb), insulin-like growth factor 1(igf1), matrix metalloproteinase-9(mmp9), matrix metalloproteinase-2(mmp2), non-receptor tyrosine kinase proto-oncogene(src), estrogen receptor 1(esr1) and cancer-signal transduction-inflammation-drugs metabolism-related biological processes and metabolic pathways were closely associated with the active ingredients in kuihua hugan tablets. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yan-Nan Chen, Chen-Chen Ren, Li Yang, Man-Man Nai, Yi-Ming Xu, Feng Zhang, Yan Li. MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1. International journal of oncology. vol 54. issue 5. 2019-08-13. PMID:30816441. |
finally, expression levels of let‑7d‑5p, hmga1, p21, b‑cell lymphoma‑2 (bcl‑2)‑associated x (bax), p27, p53 wild‑type (p53wt), p53 mutated (p53mut), proliferating cell nuclear antigen (pcna), cyclin‑dependent kinase 2 (cdk2), matrix metallopeptidase (mmp)2, mmp9 and bcl‑2 were determined. |
2019-08-13 |
2023-08-13 |
human |
| Ya-Nan Song, Luo-Pei Wang, Jie Zheng, Chang-Cheng Zhang, Ting Wang, Ding Yuan, Zhi-Yong Zho. [Effect of saponins extracted from Panax japonicas on inhibiting myocardial fibrosis by TGF-β1/Smad3 signaling pathway in aging rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 43. issue 22. 2019-07-23. PMID:30593247. |
rt-pcr was used to detect the mrna expression levels of myofibroblast marker α-sma, collagen-related protein col1α2, col3α1 and matrix metalloproteinase mmp2, mmp9. |
2019-07-23 |
2023-08-13 |
rat |
| Pengpeng Yan, Huanna Tang, Xiaoying Chen, Shuiyu Ji, Wei Jin, Jiaming Zhang, Jia Shen, Hao Deng, Xiang Zhao, Quanquan Shen, Hongfeng Huan. Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation. Bioscience reports. vol 38. issue 6. 2019-07-19. PMID:30061174. |
tamoxifen attenuated thickening of the peritoneum, and reversed pdf-induced peritoneal expression of e-cadherin, vimentin, matrix metalloproteinase 9 (mmp9), snail, and β-catenin. |
2019-07-19 |
2023-08-13 |
mouse |
| Wen-Sheng Wu, Ren-In You, Chuan-Chu Cheng, Ming-Che Lee, Teng-Yi Lin, Chi-Tan H. Snail collaborates with EGR-1 and SP-1 to directly activate transcription of MMP 9 and ZEB1. Scientific reports. vol 7. issue 1. 2019-07-15. PMID:29259250. |
snail enhances expressions of a lot of mesenchymal genes including the matrix degradation enzyme matrix metalloproteinases 9 (mmp9) and the emt transcription factor zinc finger e-box binding homeobox 1 (zeb1), however, the underlying mechanisms are not clarified. |
2019-07-15 |
2023-08-13 |
Not clear |
| Maryam Akbarzadeh, Ali Akbar Movassaghpour, Hossein Ghanbari, Maryam Kheirandish, Nazila Fathi Maroufi, Reza Rahbarghazi, Mohammad Nouri, Nasser Samad. The potential therapeutic effect of melatonin on human ovarian cancer by inhibition of invasion and migration of cancer stem cells. Scientific reports. vol 7. issue 1. 2019-07-05. PMID:29213108. |
incubation of cscs with melatonin showed a marked decrease in matrix metalloproteinase 9 (mmp9) expression and activity. |
2019-07-05 |
2023-08-13 |
human |
| Xiaobo Zhang, Gang Shi, Feng Gao, Peng Liu, Huaitao Wang, Xiaodong Ta. TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ. Oncology reports. vol 41. issue 4. 2019-07-03. PMID:30720116. |
additionally, the mrna expression of matrix metalloproteinase (mmp2) and mmp9 were determined. |
2019-07-03 |
2023-08-13 |
human |
| Yongkai Wu, Ming Xu, Rong He, Ke Xu, Yegang M. ARHGAP6 regulates the proliferation, migration and invasion of lung cancer cells. Oncology reports. vol 41. issue 4. 2019-07-03. PMID:30816546. |
in the present study, the ras homologue gtpase activation protein 6 (arhgap6), which belongs to the rho gtpase‑activating protein (rhogap) family, was found to have low expression in tumor tissues from patients with lung cancer, accompanied by high expression of matrix metalloproteinase‑9 (mmp9) and vascular endothelial growth factor (vegf). |
2019-07-03 |
2023-08-13 |
Not clear |
| S Q Feng, X Y Zhang, H T Fan, Q J Sun, M Zhan. Up-regulation of LncRNA MEG3 inhibits cell migration and invasion and enhances cisplatin chemosensitivity in bladder cancer cells. Neoplasma. vol 65. issue 6. 2019-07-01. PMID:29940769. |
the expression and activity of matrix metalloproteinase (mmp)2 and mmp9 were down-regulated when meg3 was over-expressed. |
2019-07-01 |
2023-08-13 |
Not clear |
| Qiyu Tang, Weitian Li, Na Dai, Yiming Gao, Yu Han, Guofu Cheng, Changqin G. The Role of Necroptosis, Apoptosis, and Inflammation in Fowl Cholera-Associated Liver Injury in a Chicken Model. Avian diseases. vol 61. issue 4. 2019-06-28. PMID:29337619. |
in addition, mmp9 (matrix metalloproteinase 9) and timp1 (tissue inhibitor of metalloproteinase 1) were observed in hepatic parenchymal cells, inflammatory cells, and interstitial spaces, whereas the apoptotic effector molecule caspase-3 (cysteine-containing aspartic proteolytic enzymes 3) was mainly found in hepatocytes. |
2019-06-28 |
2023-08-13 |
chicken |