| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Munki Jeong, Euitaek Jung, Young Han Lee, Jeong Kon Seo, Seunghyun Ahn, Dongsoo Koh, Yoongho Lim, Soon Young Shi. A Novel Synthetic Compound (E)-5-((4-oxo-4H-chromen-3-yl)methyleneamino)-1-phenyl-1H-pyrazole-4-carbonitrile Inhibits TNFα-Induced International journal of molecular sciences. vol 21. issue 14. 2021-03-05. PMID:32708426. |
gelatinases such as matrix metallopeptidase 2 (mmp2) and mmp9 play crucial roles in cancer cell migration, invasion, and metastasis. |
2021-03-05 |
2023-08-13 |
Not clear |
| Haibo Xia, Yan Wu, Jing Zhao, Wenqi Li, Lu Lu, Huimin Ma, Cheng Cheng, Jing Sun, Quanyong Xiang, Tao Bian, Qizhan Li. The aberrant cross-talk of epithelium-macrophages via METTL3-regulated extracellular vesicle miR-93 in smoking-induced emphysema. Cell biology and toxicology. 2021-03-04. PMID:33660100. |
in macrophages, mir-93 activated the jnk pathway by targeting dual-specificity phosphatase 2 (dusp2), which elevated the levels of matrix metalloproteinase 9 (mmp9) and matrix metalloproteinase 12 (mmp12) and induced elastin degradation, leading to emphysema. |
2021-03-04 |
2023-08-13 |
Not clear |
| Zheng Zou, Yu-Shu Dong, Dong-Dong Liu, Gen Li, Guang-Zhi Hao, Xu Gao, Peng-Yu Pan, Guo-Biao Lian. MAP4K4 induces early blood-brain barrier damage in a murine subarachnoid hemorrhage model. Neural regeneration research. vol 16. issue 2. 2021-02-25. PMID:32859792. |
map4k4 recombinant protein aggravated neurological impairment, brain edema, and blood-brain barrier damage; upregulated the expression of phosphorylated nuclear factor kappa b (p-p65) and matrix metalloproteinase 9 (mmp9); and degraded tight junction proteins (zo-1 and claudin 5). |
2021-02-25 |
2023-08-13 |
mouse |
| Dongfeng Zhao, Bing Shu, Chenglong Wang, Yongjian Zhao, Weidong Cheng, Nannan Sha, Chenguang Li, Qiang Wang, Sheng Lu, Yongjun Wan. Oleanolic acid exerts inhibitory effects on the late stage of osteoclastogenesis and prevents bone loss in osteoprotegerin knockout mice. Journal of cellular biochemistry. vol 121. issue 1. 2021-02-22. PMID:31318102. |
furthermore, oa suppresses the activities of osteoclast genes, such as tartrate resistant acid phosphatase (trap), cathepsink (ctsk), and matrix metalloproteinase 9 (mmp9). |
2021-02-22 |
2023-08-13 |
mouse |
| Diana O Perkins, Clark D Jeffries, Kim Q D. Potential Roles of Redox Dysregulation in the Development of Schizophrenia. Biological psychiatry. vol 88. issue 4. 2021-02-18. PMID:32560962. |
in a rodent schizophrenia model characterized by impaired glutathione synthesis, the gclm knockout mouse, oxidative stress activated mmp9 (matrix metalloprotease 9) via its redox-responsive regulatory sites, causing a cascade of molecular events leading to microglia activation, perineural net degradation, and impaired nmda receptor function. |
2021-02-18 |
2023-08-13 |
mouse |
| Xinli Guo, Zhou Fang, Min Zhang, Deyu Yang, Shuyue Wang, Kehai Li. A Co-Delivery System of Curcumin and p53 for Enhancing the Sensitivity of Drug-Resistant Ovarian Cancer Cells to Cisplatin. Molecules (Basel, Switzerland). vol 25. issue 11. 2021-02-12. PMID:32512936. |
then, cur was coupled to pei-k14 by matrix metalloproteinase 9 (mmp9)-cleavable peptide to prepare cur-pei-k14. |
2021-02-12 |
2023-08-13 |
Not clear |
| Pei-Fei Li, Zhi-Xin Zhang, Xin Yuan, Hao-Jun Song, Xiao-Yun Ding, Lei X. Hsa_circ_0001696 modulates cell proliferation and migration in colorectal cancer. Oncology letters. vol 21. issue 2. 2021-02-10. PMID:33552272. |
in addition, western blot analysis demonstrated that the protein expression levels of cyclin-dependent kinase 4 (cdk4), cyclin d, cyclin e and matrix metalloproteinase 9 (mmp9) increased. |
2021-02-10 |
2023-08-13 |
human |
| Maywan Hariono, Rina F Nuwarda, Muhammad Yusuf, Rollando Rollando, Riris I Jenie, Belal Al-Najjar, Jeffry Julianus, Kevin C Putra, Ervan S Nugroho, Yohanes K Wisnumurti, Sangga P Dewa, Benedictus W Jati, Reynaldo Tiara, Ratna D Ramadani, Lailatul Qodria, Habibah A Waha. Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling. Journal of chemical information and modeling. vol 60. issue 1. 2021-02-09. PMID:31825614. |
arylamide as potential selective inhibitor for matrix metalloproteinase 9 (mmp9): design, synthesis, biological evaluation, and molecular modeling. |
2021-02-09 |
2023-08-13 |
Not clear |
| Maywan Hariono, Rina F Nuwarda, Muhammad Yusuf, Rollando Rollando, Riris I Jenie, Belal Al-Najjar, Jeffry Julianus, Kevin C Putra, Ervan S Nugroho, Yohanes K Wisnumurti, Sangga P Dewa, Benedictus W Jati, Reynaldo Tiara, Ratna D Ramadani, Lailatul Qodria, Habibah A Waha. Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling. Journal of chemical information and modeling. vol 60. issue 1. 2021-02-09. PMID:31825614. |
previous studies have reported that compounds bearing an arylamide linked to a heterocyclic planar ring have successfully inhibited the hemopexin-like domain (pex9) of matrix metalloproteinase 9 (mmp9). |
2021-02-09 |
2023-08-13 |
Not clear |
| Maywan Hariono, Rina F Nuwarda, Muhammad Yusuf, Rollando Rollando, Riris I Jenie, Belal Al-Najjar, Jeffry Julianus, Kevin C Putra, Ervan S Nugroho, Yohanes K Wisnumurti, Sangga P Dewa, Benedictus W Jati, Reynaldo Tiara, Ratna D Ramadani, Lailatul Qodria, Habibah A Waha. Arylamide as Potential Selective Inhibitor for Matrix Metalloproteinase 9 (MMP9): Design, Synthesis, Biological Evaluation, and Molecular Modeling. Journal of chemical information and modeling. vol 60. issue 1. 2021-02-09. PMID:31825614. |
pex9 has been suggested to be more selectively targeted than mmp9's catalytic domain in a degrading extracellular matrix under some pathologic conditions, especially in cancer. |
2021-02-09 |
2023-08-13 |
Not clear |
| Qionglong Jin, Jie Lu, Renhui Gao, Jiaying Xu, Xiaoyan Pan, Lichang Wan. Systematically Deciphering the Pharmacological Mechanism of Fructus Aurantii via Network Pharmacology. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-02-06. PMID:33542744. |
prostaglandin g/h synthase 2 (ptgs2), heat shock protein 90 (hsp90), cell division protein kinase 6 (cdk6), caspase 3 (casp3), apoptosis regulator bcl-2 (bcl-2), and matrix metalloproteinase-9 (mmp9) were identified as key targets of fa in the treatment of multiple diseases. |
2021-02-06 |
2023-08-13 |
Not clear |
| Yuan Yuan, Hisao Naito, Kazuya Kitamori, Sayuki Hashimoto, Tomomi Asano, Tamie Nakajim. The antihypertensive agent hydralazine reduced extracellular matrix synthesis and liver fibrosis in nonalcoholic steatohepatitis exacerbated by hypertension. PloS one. vol 15. issue 12. 2021-02-03. PMID:33315911. |
the hfc diet induced higher overexpression of serum tissue inhibitor of metalloproteinase-1 (timp1) and greater suppression of matrix metalloproteinase-2 (mmp2):timp1, mmp8:timp1, and mmp9:timp1 ratios, as a proxy of the activities of these mmps in shr. |
2021-02-03 |
2023-08-13 |
rat |
| Delsuz Rezaee, Mojgan Bandehpour, Bahram Kazemi, Mohammad Saleh. Role of intrauterine administration of transfected peripheral blood mononuclear cells by GM-CSF on embryo implantation and pregnancy rate in mice. Molecular human reproduction. vol 26. issue 2. 2021-02-03. PMID:31899496. |
attachment of mouse embryos and the mrna expression levels of leukemia inhibitory factor (lif), vascular endothelial growth factor (vegf), matrix metalloproteinase 9 (mmp9), gmcsf-receptor (gmcsf-r) and interleukin 6 (il6) in vitro were assessed by real-time pcr in endometrial cells. |
2021-02-03 |
2023-08-13 |
mouse |
| Dingani Nkosi, Li Sun, Leanne C Duke, David G Mecke. Epstein-Barr virus LMP1 manipulates the content and functions of extracellular vesicles to enhance metastatic potential of recipient cells. PLoS pathogens. vol 16. issue 12. 2021-01-29. PMID:33382850. |
the lmp1 containing evs induced transcriptome reprogramming in the recipient cells by altering gene expression of different targets including cadherins, matrix metalloproteinases 9 (mmp9), mmp2 and integrin-α5 which contribute to extracellular matrix (ecm) remodeling. |
2021-01-29 |
2023-08-13 |
Not clear |
| Nguyen H Nguyen, Minh Tan Nguyen, Peter J Little, Anh Thu Do, Phuong Trinh Tran, Xuan Nam Vo, Bich Hang D. Vernolide-A and Vernodaline: Sesquiterpene Lactones with Cytotoxicity against Cancer. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. vol 39. issue 4. 2021-01-27. PMID:33389902. |
the antiproliferation and antimetastatic activities arise from targeting extracellular signal-regulated kinase 1 (erk-1), extracellular signal-regulated kinase 2 (erk-2), nuclear factor-κb (nf-κb), signal transducer and activator of transcription 3 (stat3), matrix metalloproteinase 2 (mmp-2), and matrix metalloproteinase 9 (mmp9). |
2021-01-27 |
2023-08-13 |
Not clear |
| Masaya Nagaishi, Yoshiko Fujii, Yoshiki Sugiura, Issei Takano, Tomoji Takigawa, Hideaki Yokoo, Kensuke Suzuk. Increased Twist and ZEB2 expression in a cutaneous metastasis of high-grade glioma. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 40. issue 2. 2021-01-19. PMID:31863511. |
immunohistochemical analysis for emt-related biomarkers demonstrated increased twist, zinc finger e-box-binding homeobox 2 (zeb2), matrix metalloproteinase 2 (mmp2), and mmp9 expressions in tumor cells of the metastatic lesion compared with those of the primary lesion. |
2021-01-19 |
2023-08-13 |
Not clear |
| Guodong Zhang, Wu Feng, Jingkun W. Down-regulation of SEPT9 inhibits glioma progression through suppressing TGF-β-induced epithelial-mesenchymal transition (EMT). Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2021-01-19. PMID:32106387. |
moreover, epithelial-mesenchymal transition (emt) markers, including n-cadherin, matrix metalloproteinase-9 (mmp9), vimentin and twist, were significantly reduced by sept9 knockdown; however, the expression of e-cadherin was elevated by sept9 silence. |
2021-01-19 |
2023-08-13 |
mouse |
| Weiyan Mo, Haoyuan Luo, Juan Wu, Na Xu, Fuping Zhang, Qihong Qiu, Wenjun Zhu, Min Lian. Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells. Journal of molecular histology. vol 51. issue 2. 2021-01-18. PMID:32193744. |
real-time reverse transcription polymerase chain reaction analysis demonstrated that gingipains upregulated osteoclastic genes including the protease cathepsin k (ctsk), matrix metalloprotein 9 (mmp9), nuclear factor of activated t cells 1 (nfatc1) and acid phosphatase 5, tartrate resistant (acp5) in a time-dependent manner. |
2021-01-18 |
2023-08-13 |
Not clear |
| Xianglu Ji, Liping Shan, Peng Shen, Ming H. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell death & disease. vol 11. issue 1. 2021-01-15. PMID:31907361. |
results indicated circ_001621-promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (cdk4) and matrix metallopeptidase 9 (mmp9) by mir-578, respectively. |
2021-01-15 |
2023-08-13 |
mouse |
| Mika Kushamae, Haruka Miyata, Manabu Shirai, Kampei Shimizu, Mieko Oka, Hirokazu Koseki, Yu Abekura, Isao Ono, Kazuhiko Nozaki, Tohru Mizutani, Tomohiro Aok. Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms in rats. Scientific reports. vol 10. issue 1. 2021-01-14. PMID:33203959. |
to clarify the mechanisms of how neutrophils facilitate this rupture, we used hl-60 cell line and found an enhanced collagenolytic activity, corresponding to matrix metalloproteinase 9 (mmp9), upon inflammatory stimuli. |
2021-01-14 |
2023-08-13 |
rat |