| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Weiyan Mo, Haoyuan Luo, Juan Wu, Na Xu, Fuping Zhang, Qihong Qiu, Wenjun Zhu, Min Lian. Gingipains promote RANKL-induced osteoclastogenesis through the enhancement of integrin β3 in RAW264.7 cells. Journal of molecular histology. vol 51. issue 2. 2021-01-18. PMID:32193744. |
real-time reverse transcription polymerase chain reaction analysis demonstrated that gingipains upregulated osteoclastic genes including the protease cathepsin k (ctsk), matrix metalloprotein 9 (mmp9), nuclear factor of activated t cells 1 (nfatc1) and acid phosphatase 5, tartrate resistant (acp5) in a time-dependent manner. |
2021-01-18 |
2023-08-13 |
Not clear |
| Xianglu Ji, Liping Shan, Peng Shen, Ming H. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell death & disease. vol 11. issue 1. 2021-01-15. PMID:31907361. |
results indicated circ_001621-promoted osteosarcoma proliferation and migration via attenuating the inhibition of cyclin-dependent kinase 4 (cdk4) and matrix metallopeptidase 9 (mmp9) by mir-578, respectively. |
2021-01-15 |
2023-08-13 |
mouse |
| Mika Kushamae, Haruka Miyata, Manabu Shirai, Kampei Shimizu, Mieko Oka, Hirokazu Koseki, Yu Abekura, Isao Ono, Kazuhiko Nozaki, Tohru Mizutani, Tomohiro Aok. Involvement of neutrophils in machineries underlying the rupture of intracranial aneurysms in rats. Scientific reports. vol 10. issue 1. 2021-01-14. PMID:33203959. |
to clarify the mechanisms of how neutrophils facilitate this rupture, we used hl-60 cell line and found an enhanced collagenolytic activity, corresponding to matrix metalloproteinase 9 (mmp9), upon inflammatory stimuli. |
2021-01-14 |
2023-08-13 |
rat |
| Yi Tan, Carmelo Sgobio, Thomas Arzberger, Felix Machleid, Qilin Tang, Elisabeth Findeis, Jorg Tost, Tasnim Chakroun, Pan Gao, Mathias Höllerhage, Kai Bötzel, Jochen Herms, Günter Höglinger, Thomas Koeglsperge. Loss of fragile X mental retardation protein precedes Lewy pathology in Parkinson's disease. Acta neuropathologica. vol 139. issue 2. 2021-01-12. PMID:31768670. |
reminiscent of fxs neurons, α-syn-overexpressing cells exhibited an increase in membrane n-type calcium channels, increased phosphorylation of erk1/2, eif4e and s6, increased overall protein synthesis, and increased expression of matrix metalloproteinase 9 (mmp9). |
2021-01-12 |
2023-08-13 |
mouse |
| Fong-Sian Lin, Jian-Jr Lee, Alvin Kai-Xing Lee, Chia-Che Ho, Yen-Ting Liu, Ming-You Shi. Calcium Silicate-Activated Gelatin Methacrylate Hydrogel for Accelerating Human Dermal Fibroblast Proliferation and Differentiation. Polymers. vol 13. issue 1. 2021-01-12. PMID:33375390. |
furthermore, si-gelma enhanced cellular adhesion and proliferation, therefore leading to the increased secretion of collagen i other important extracellular matrix (ecm) remodeling-related proteins including ki67, mmp9, and decorin. |
2021-01-12 |
2023-08-13 |
human |
| Chitra Joseph, Mansour Alsaleem, Nnamdi Orah, Pavan L Narasimha, Islam M Miligy, Sasagu Kurozumi, Ian O Ellis, Nigel P Mongan, Andrew R Green, Emad A Rakh. Elevated MMP9 expression in breast cancer is a predictor of shorter patient survival. Breast cancer research and treatment. vol 182. issue 2. 2021-01-11. PMID:32445177. |
mmp9 is a matricellular protein associated with extracellular matrix (ecm) remodelling, that promotes tumour progression, and modulates the activity of cell adhesion molecules and cytokines. |
2021-01-11 |
2023-08-13 |
Not clear |
| Minghui Ou, Chuntang Zhang, Jing Chen, Shibo Zhao, Shichao Cui, Jie T. Overexpression of MicroRNA-340-5p Inhibits Pulmonary Arterial Hypertension Induced by APE by Downregulating IL-1β and IL-6. Molecular therapy. Nucleic acids. vol 21. 2021-01-10. PMID:32712318. |
meanwhile, mir-340-5p led to the blocked nuclear factor κb (nf-κb) pathway with reduced nf-κb p65, matrix metalloproteinase 2 (mmp2), and mmp9 expression in pasmcs. |
2021-01-10 |
2023-08-13 |
human |
| Qixin Wang, Isaac K Sundar, Jason L Blum, Jill R Ratner, Joseph H Lucas, Tsai-Der Chuang, Ying Wang, Jie Liu, Virender K Rehan, Judith T Zelikoff, Irfan Rahma. Prenatal Exposure to Electronic-Cigarette Aerosols Leads to Sex-Dependent Pulmonary Extracellular-Matrix Remodeling and Myogenesis in Offspring Mice. American journal of respiratory cell and molecular biology. vol 63. issue 6. 2021-01-07. PMID:32853043. |
mmp9 (matrix metalloproteinase 9), a downstream target of pai-1, was downregulated in both sexes exposed to e-cig aerosols with nicotine. |
2021-01-07 |
2023-08-13 |
mouse |
| Xiaodong Li, Qingshan Huang, Shenglin Wang, Zhen Huang, Fengqiang Yu, Jianhua Li. HER4 promotes the growth and metastasis of osteosarcoma via the PI3K/AKT pathway. Acta biochimica et biophysica Sinica. vol 52. issue 4. 2021-01-06. PMID:32181480. |
her4 overexpression upregulated the expression of phosphorylated protein kinase b (pakt), proliferation marker antigen ki67, and metastasis cell marker matrix metalloproteinase 9 (mmp9). |
2021-01-06 |
2023-08-13 |
mouse |
| Minchae Kim, Sora Lee, Chang Seok K. Cellular Behavior of RAW264.7 Cells in 3D Poly(ethylene glycol) Hydrogel Niches. ACS biomaterials science & engineering. vol 5. issue 2. 2021-01-06. PMID:33405849. |
interestingly, we observed the significant upregulation of matrix metalloproteinases (mmps) (i.e., mmp9 and mmp14) as well as m1 polarization markers (i.e., inos, cox2, tnf-α) in 3d, whereas m2 polarization markers (i.e., cd206, arg1, tgf-β) were downregulated. |
2021-01-06 |
2023-08-13 |
Not clear |
| Zhi Jiao, Lei Huang, Jiali Sun, Jie Xie, Tiantian Wang, Xiu Yin, Haozheng Zhang, Jie Che. Six-transmembrane epithelial antigen of the prostate 1 expression promotes ovarian cancer metastasis by aiding progression of epithelial-to-mesenchymal transition. Histochemistry and cell biology. vol 154. issue 2. 2021-01-01. PMID:32382787. |
matrix metalloproteinase-2 (mmp2) and matrix metalloproteinase-9 (mmp9) activities were examined using matrix metalloproteinase zymography assay. |
2021-01-01 |
2023-08-13 |
human |
| Tik-Chee Cheng, Jennifer L Philip, Diana M Tabima, Santosh Kumari, Bakhtiyor Yakubov, Andrea L Frump, Timothy A Hacker, Alessandro Bellofiore, Rongbo Li, Xin Sun, Kara N Goss, Tim Lahm, Naomi C Chesle. Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats. American journal of physiology. Heart and circulatory physiology. vol 319. issue 6. 2020-12-31. PMID:33064565. |
there was an increased protein expression ratio of timp metallopeptidase inhibitor 1 (timp1) to matrix metalloproteinase 9 (mmp9) in female erαmut compared with wt pab rats, suggesting less collagen degradation. |
2020-12-31 |
2023-08-13 |
rat |
| Shyam S Nandi, Kenichi Katsurada, Neeru M Sharma, Daniel R Anderson, Sushil K Mahata, Kaushik P Pate. MMP9 inhibition increases autophagic flux in chronic heart failure. American journal of physiology. Heart and circulatory physiology. vol 319. issue 6. 2020-12-31. PMID:33064567. |
increased matrix metalloprotease 9 (mmp9) after myocardial infarction (mi) exacerbates ischemia-induced chronic heart failure (chf). |
2020-12-31 |
2023-08-13 |
rat |
| Katarina Kalavska, Zuzana Cierna, Marian Karaba, Gabriel Minarik, Juraj Benca, Tatiana Sedlackova, Denisa Kolekova, Ivana Mrvova, Daniel Pindak, Jozef Mardiak, Michal Meg. Prognostic role of matrix metalloproteinase 9 in early breast cancer. Oncology letters. vol 21. issue 2. 2020-12-29. PMID:33363615. |
mmp9 is involved in extracellular matrix degradation during various physiological and pathological conditions, including tumorigenesis. |
2020-12-29 |
2023-08-13 |
Not clear |
| Jing Jin Gu, Jacob Hoj, Clay Rouse, Ann Marie Pendergas. Mesenchymal stem cells promote metastasis through activation of an ABL-MMP9 signaling axis in lung cancer cells. PloS one. vol 15. issue 10. 2020-12-21. PMID:33119681. |
mscs elicit transcriptional alterations in lung cancer cells leading to increased expression of factors implicated in the epithelial-to-mesenchymal transition (emt) and secreted proteins including matrix metalloproteinase-9 (mmp9). |
2020-12-21 |
2023-08-13 |
Not clear |
| Juan Zhao, Xue-Bin Zeng, Hong-Yan Zhang, Jie-Wei Xiang, Yu-Song Li. Long non-coding RNA FOXD2-AS1 promotes cell proliferation, metastasis and EMT in glioma by sponging miR-506-5p. Open medicine (Warsaw, Poland). vol 15. issue 1. 2020-12-19. PMID:33336050. |
in the present study, rt-qpcr was conducted to detect the levels of foxd2-as1 and microrna (mir)-506-5p, and western blot assays were performed to measure the expression of cdk2, cycline1, p21, matrix metalloproteinase (mmp)7, mmp9, n-cadherin, e-cadherin and vimentin in glioma cells. |
2020-12-19 |
2023-08-13 |
human |
| Dan Zhang, Dian Li, Lianju Shen, Dong Hu, Bo Tang, Wenhao Guo, Zhang Wang, Zhaoxia Zhang, Guanghui Wei, Dawei H. Exosomes derived from Piwil2‑induced cancer stem cells transform fibroblasts into cancer‑associated fibroblasts. Oncology reports. vol 43. issue 4. 2020-12-16. PMID:32323829. |
protein expression [matrix metalloproteinase (mmp)2, mmp9, α‑smooth muscle actin (α‑sma) and vimentin and fibroblast‑activating protein (fap)] was examined in fbs by western blot analysis. |
2020-12-16 |
2023-08-13 |
Not clear |
| Mei Chen, Nan Yang, Judith Lechner, Levente Toth, Ruth Hogg, Giuliana Silvestri, Usha Chakravarthy, Heping X. Plasma level of lipocalin 2 is increased in neovascular age-related macular degeneration patients, particularly those with macular fibrosis. Immunity & ageing : I & A. vol 17. issue 1. 2020-12-12. PMID:33292361. |
this study investigated the plasma levels of lcn2, matrix metalloproteinase 9 (mmp9) and lcn2/mmp9 complex in different types of namd and examined whether the levels were related to patients' responsiveness to anti-vegf therapy. |
2020-12-12 |
2023-08-13 |
Not clear |
| Yu Jiang, Yajun Lu, Xu Jiang, Jiawei Hu, Rong Li, Yun Liu, Guoxing Zhu, Xiaoxu Ron. Glucocorticoids induce osteoporosis mediated by glucocorticoid receptor-dependent and -independent pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 125. 2020-12-10. PMID:32044718. |
a dual-luciferase reporter assay further revealed that gcs and nr3c1 transcriptionally regulate matrix metalloproteinase 9 (mmp9), alkaline phosphatase (alp), and acid phosphatase 5a (acp5a). |
2020-12-10 |
2023-08-13 |
zebrafish |
| Xue Wen, Yao Xiong, Ling Jin, Ming Zhang, Lei Huang, Yanhong Mao, Chun Zhou, Yuan Qiao, Yuanzhen Zhan. Bisphenol A Exposure Enhances Endometrial Stromal Cell Invasion and Has a Positive Association with Peritoneal Endometriosis. Reproductive sciences (Thousand Oaks, Calif.). vol 27. issue 2. 2020-12-09. PMID:32046440. |
upregulated matrix metalloproteinase (mmp) 2 and mmp9 are involved in the development of ems. |
2020-12-09 |
2023-08-13 |
human |