| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ruijuan Chen, Wenli Chen, Xiaoling Huang, Qinglin Ru. Tanshinone IIA attenuates heart failure via inhibiting oxidative stress in myocardial infarction rats. Molecular medicine reports. vol 23. issue 6. 2021-05-10. PMID:33786621. |
cardiac fibrosis was evaluated using masson's staining, and the levels of collagen i, collagen iii, tgf‑β, α‑smooth muscle actin (α‑sma), matrix metalloproteinase (mmp) 2 and mmp9 were determined using pcr or western blotting. |
2021-05-10 |
2023-08-13 |
rat |
| Rui Tong, Jingru Zhang, Chunyan Wang, Xuemei Li, Tingting Yu, Ling Wan. LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR-574-5p. Clinical and experimental pharmacology & physiology. vol 47. issue 3. 2021-05-07. PMID:31587336. |
western blotting analysis showed that ptcsc3 overexpression decreased the expression of cyclind1, matrix metalloproteinases 9 (mmp9), n-cadherin and β-catenin and increased e-cadherin expression. |
2021-05-07 |
2023-08-13 |
Not clear |
| Xue-Min Qiu, Zhen-Zhen Lai, Si-Yao Ha, Hui-Li Yang, Li-Bing Liu, Yan Wang, Jia-Wei Shi, Lu-Yu Ruan, Jiang-Feng Ye, Jiang-Nan Wu, Qiang Fu, Xiao-Fang Yi, Kai-Kai Chang, Ming-Qing L. IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis. Reproduction (Cambridge, England). vol 159. issue 3. 2021-05-07. PMID:31869309. |
recombinant human il-10 and ifn-γ promoted the viability, invasiveness and transcription levels of matrix metalloproteinase (mmp)2, mmp9, and prostaglandin-endoperoxide synthase 2 of escs, particularly combined treatment with il-10 and ifn-γ. |
2021-05-07 |
2023-08-13 |
human |
| Xiaohui Peng, Zhongwu Guo, Yinlong Zhang, Baichen Sun, Qi Zhan. EFEMP1 in Direct Inguinal Hernia: correlation with TIMP3 and Regulation Toward Elastin Homoeostasis as Well as Fibroblast Mobility. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2021-05-07. PMID:33131351. |
this basic research aimed to detect the inner-correlation of egf containing fibulin extracellular matrix protein 1 (efemp1), timp metallopeptidase inhibitor 3 (timp3), matrix metalloprotease 9 (mmp9), elastin (eln) in direct inguinal hernia (ih), and their effect on fibroblasts motility. |
2021-05-07 |
2023-08-13 |
Not clear |
| Shujie Huang, Meixian Chen, Huizhen Yu, Kaiyang Lin, Yansong Guo, Pengli Zh. Co‑expression of tissue kallikrein 1 and tissue inhibitor of matrix metalloproteinase 1 improves myocardial ischemia‑reperfusion injury by promoting angiogenesis and inhibiting oxidative stress. Molecular medicine reports. vol 23. issue 2. 2021-05-06. PMID:33355364. |
ad‑htk1/htimp1 also significantly enhanced microvessel formation, decreased matrix metalloproteinase (mmp)2 and mmp9 expression, and reduced oxidative stress in myocardial i/r model rats. |
2021-05-06 |
2023-08-13 |
human |
| Pengyu Cai, Mingxiu Wu, Bin Zhang, Shuyi Wu, Haiyun Wei, Li We. Long non‑coding RNA SNHG12 regulates cell proliferation, invasion and migration in endometrial cancer by targeting miR‑4429. Molecular medicine reports. vol 22. issue 4. 2021-05-03. PMID:32945395. |
the protein expression levels of matrix metalloproteinase (mmp)2 and mmp9 were detected by western blotting. |
2021-05-03 |
2023-08-13 |
Not clear |
| Qiu-Ting Li, Yi-Ming Feng, Zun-Hui Ke, Meng-Jun Qiu, Xiao-Xiao He, Meng-Meng Wang, Ya-Nan Li, Jing Xu, Liang-Liang Shi, Zhi-Fan Xion. KCNN4 promotes invasion and metastasis through the MAPK/ERK pathway in hepatocellular carcinoma. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. vol 68. issue 1. 2021-04-30. PMID:31431469. |
matrix metallopeptidase 9 and extracellular signal regulated kinase 1/2 (erk1/2) were important biomarkers of mapk/erk pathway, knockdown of kcnn4 reduced the expression of mmp9 and erk1/2. |
2021-04-30 |
2023-08-13 |
Not clear |
| Maywan Hariono, Rollando Rollando, Jasson Karamoy, Pandu Hariyono, M Atmono, Maria Djohan, Wiwy Wiwy, Rina Nuwarda, Christopher Kurniawan, Nurul Salin, Habibah Waha. Bioguided Fractionation of Local Plants against Matrix Metalloproteinase9 and Its Cytotoxicity against Breast Cancer Cell Models: In Silico and In Vitro Study. Molecules (Basel, Switzerland). vol 25. issue 20. 2021-04-29. PMID:33066411. |
matrix metalloproteinase9 (mmp9) is known to be highly expressed during metastatic cancer where most known potential inhibitors failed in the clinical trials. |
2021-04-29 |
2023-08-13 |
Not clear |
| Xiuying Wang, Yuanyuan Lin, Yi Zhen. Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration. Molecular medicine reports. vol 22. issue 3. 2021-04-26. PMID:32705198. |
interestingly, aconitine also markedly downregulated the expression of matrix metalloproteinase 2 (mmp2) and mmp9, which are associated with tumor invasion. |
2021-04-26 |
2023-08-13 |
human |
| Jidong Zou, Jiantong Qian, Haiyan Fu, Fawen Yin, Wanjun Zhao, Liang X. MicroRNA‑15b‑5p exerts its tumor repressive role via targeting GDI2: A novel insight into the pathogenesis of thyroid carcinoma. Molecular medicine reports. vol 22. issue 4. 2021-04-26. PMID:32945458. |
mir‑15b‑5p reduced the protein expression levels of matrix metalloproteinase (mmp)2 and mmp9, which were related to cell invasion. |
2021-04-26 |
2023-08-13 |
Not clear |
| Tingting Lin, Jiaqi Tao, Ying Chen, Yitong Zhang, Fenglan Li, Yutong Zhang, Xueqing Han, Zihui Zhao, Guiyan Liu, Hui L. Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components. Biological trace element research. 2021-04-25. PMID:33895963. |
in the se-deficient group, the levels of collagen i, collagen iii, matrix metalloproteinase 9 (mmp9), and other fibrosis-related proteins changed significantly in vivo and in vitro. |
2021-04-25 |
2023-08-13 |
mouse |
| Matiss Ozols, Alexander Eckersley, Christopher I Platt, Callum Stewart-McGuinness, Sarah A Hibbert, Jerico Revote, Fuyi Li, Christopher E M Griffiths, Rachel E B Watson, Jiangning Song, Mike Bell, Michael J Sherrat. Predicting Proteolysis in Complex Proteomes Using Deep Learning. International journal of molecular sciences. vol 22. issue 6. 2021-04-22. PMID:33803033. |
the first goal of this study was to experimentally evaluate the ability of existing protease cleavage site prediction models (prosper and deepcleave) to identify experimentally determined mmp9 cleavage sites in two purified proteins and in a complex human dermal fibroblast-derived extracellular matrix (ecm) proteome. |
2021-04-22 |
2023-08-13 |
human |
| Tiao Bu, Lingling Wang, Xiaolong Wu, Linxi Li, Baiping Mao, Chris K C Wong, Adolfo Perrotta, Bruno Silvestrini, Fei Sun, C Yan Chen. A laminin-based local regulatory network in the testis that supports spermatogenesis. Seminars in cell & developmental biology. 2021-04-21. PMID:33879391. |
emerging evidence has shown that biologically active fragments are derived from basement membrane and apical es laminin chains through proteolytic cleavage mediated by matrix metalloproteinase 9 (mmp9) and mmp2, respectively. |
2021-04-21 |
2023-08-13 |
rat |
| Xiuhui Wu, Leng Liu, Hongxia Zhan. miR‑802 inhibits the epithelial‑mesenchymal transition, migration and invasion of cervical cancer by regulating BTF3. Molecular medicine reports. vol 22. issue 3. 2021-04-20. PMID:32582971. |
simultaneously, the overexpression of mir‑802 significantly suppressed epithelial‑mesenchymal transition, and the expression levels of matrix metallopeptidase (mmp)2 and mmp9 in cells through regulating btf3. |
2021-04-20 |
2023-08-13 |
Not clear |
| Santosh K Yadav, Tyler N Kambis, Sumit Kar, Song Y Park, Paras K Mishr. MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell death & disease. vol 11. issue 3. 2021-04-13. PMID:32170070. |
matrix metalloproteinase-9 (mmp9), a collagenase, is upregulated in the diabetic heart, and ablation of mmp9 decreases infarct size in the non-diabetic myocardial infarction heart. |
2021-04-13 |
2023-08-13 |
human |
| Joo-Young Im, Da-Mi Kim, Hyunkyung Park, Mi-Jung Kang, Da-Yoon Kim, Kwan Young Chang, Bo-Kyung Kim, Misun Wo. VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling. Biochimica et biophysica acta. Molecular cell research. vol 1868. issue 1. 2021-04-13. PMID:33069758. |
mutation of vgll1 at s84 suppressed vgll1-tead4 binding and the subsequent transcriptional activation of matrix metalloprotease 9 (mmp9). |
2021-04-13 |
2023-08-13 |
Not clear |
| Zhen Zhao, Yan Xing, Yan Liu, Shanghua Jin. Lung cancer‑associated transcript 1 facilitates tumorigenesis in laryngeal squamous cell carcinoma through the targeted inhibition of miR‑493. Molecular medicine reports. vol 23. issue 1. 2021-04-12. PMID:33215214. |
reverse transcription‑quantitative pcr and western blotting were used to investigate the expression of lucat1 and mir‑493, as well as the protein expression of cyclin‑dependent kinase 2, cyclin e1, p21, matrix metalloproteinase (mmp)2, mmp9, vascular endothelial growth factor‑c, bcl‑2, bax, cleaved caspase‑3 and procaspase‑3. |
2021-04-12 |
2023-08-13 |
Not clear |
| Ailing Sui, Xiuping Chen, Jikui Shen, Anna M Demetriades, Yiyun Yao, Yixuan Yao, Yanji Zhu, Xi Shen, Bing Xi. Inhibiting the NLRP3 inflammasome with MCC950 ameliorates retinal neovascularization and leakage by reversing the IL-1β/IL-18 activation pattern in an oxygen-induced ischemic retinopathy mouse model. Cell death & disease. vol 11. issue 10. 2021-04-09. PMID:33093455. |
moreover, mcc950 could regulate the expression of endothelial cell- and pericyte function-associated molecules, such as vascular endothelial growth factor (vegf), vegf receptor (vegfr)1, vegfr2, matrix metalloproteinase (mmp)2, mmp9, tissue inhibitor of metalloproteinases (timp)1, timp2, platelet-derived growth factor receptor-β (pdgfr-β), platelet-derived growth factor-b (pdgf-b), and angiopoietin2 (ang2). |
2021-04-09 |
2023-08-13 |
mouse |
| Yuanyuan Liu, Yingying Tian, Weizhen Cai, Yao Guo, Changhu Xue, Jingfeng Wan. DHA/EPA-Enriched Phosphatidylcholine Suppresses Tumor Growth and Metastasis via Activating Peroxisome Proliferator-Activated Receptor γ in Lewis Lung Cancer Mice. Journal of agricultural and food chemistry. vol 69. issue 2. 2021-04-06. PMID:33406839. |
in addition, dha-pc and epa-pc significantly decreased the levels of nf-κb-mediated matrix metallopeptidase 9 (mmp9) and heparanase (hpa), which block the extracellular matrix (ecm) degradation, thereby suppressing lung metastasis. |
2021-04-06 |
2023-08-13 |
mouse |
| Yan Chen, Jian Cao, Weixia Peng, Wen Che. Neurotrophin-3 accelerates reendothelialization through inducing EPC mobilization and homing. Open life sciences. vol 15. issue 1. 2021-04-06. PMID:33817212. |
besides, nt-3 promoted the expression of stromal cell-derived factor-1α (sdf-1α), matrix metalloproteinase-9 (mmp9), and chemokine (c-x-c motif) receptor 4 (cxcr4) in epcs, which increased by 59.89%, 74.46%, and 107.7%, respectively, compared with the control group. |
2021-04-06 |
2023-08-13 |
Not clear |