| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rowan Pentz, M Florencia Iulita, Adriana Ducatenzeiler, David A Bennett, A Claudio Cuell. The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease. Molecular psychiatry. 2021-06-02. PMID:32488129. |
matrix metalloproteinase 9 (mmp9), which degrades ngf, was overactive in mci and ad. |
2021-06-02 |
2023-08-13 |
human |
| Firas Khathayer, Swapan K Ra. Diosgenin as a Novel Alternative Therapy for Inhibition of Growth, Invasion, and Angiogenesis Abilities of Different Glioblastoma Cell Lines. Neurochemical research. vol 45. issue 10. 2021-06-01. PMID:32683533. |
further, the diosgenin-induced suppression of cell migration was correlated with the decrease in expression of matrix metalloproteinase 2 (mmp2) and mmp9; and the inhibition of angiogenesis, as determined by the tube formation assay, was correlated with a decrease in the protein levels of vascular endothelial growth factor (vegf) and fibroblast growth factor 2 (fgf2). |
2021-06-01 |
2023-08-13 |
human |
| Lieke Jäkel, H Bea Kuiperij, Lara P Gerding, Emma E M Custers, Emma van den Berg, Wilmar M T Jolink, Floris H B M Schreuder, Benno Küsters, Catharina J M Klijn, Marcel M Verbee. Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related intracerebral haemorrhage. Acta neuropathologica communications. vol 8. issue 1. 2021-05-31. PMID:32631441. |
mmp9 plays a role in the degradation of various components of the extracellular matrix as well as of aβ and increased mmp9 expression has been previously associated with caa. |
2021-05-31 |
2023-08-13 |
Not clear |
| Thiago Jacomasso, Hennrique Taborda Ribas, Marina Trombetta-Lima, Michelle Silberspitz Konig, Edvaldo da Silva Trindade, Glaucia Regina Martinez, Mari Cleide Sogayar, Sheila Maria Brochado Winnischofe. The alternatively spliced RECK transcript variant 3 is a predictor of poor survival for melanoma patients being upregulated in aggressive cell lines and modulating MMP gene expression in vitro. Melanoma research. vol 30. issue 3. 2021-05-28. PMID:31764436. |
finally, we show that overexpression of the reckvar3 protein upregulates matrix metalloproteinases (mmp)-9 and mmp-14 mrna, while downregulating their inhibitor, tissue inhibitor of metalloproteinase (timp)3, and that reckvar3-specific knockdown in the 1205lu melanoma cell line hampered upregulation of the mmp9 mrna promoted by the mek1/2 inhibitor u0126. |
2021-05-28 |
2023-08-13 |
Not clear |
| Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing M. Inhalational Anesthetics Inhibit Neuroglioma Cell Proliferation and Migration via miR-138, -210 and -335. International journal of molecular sciences. vol 22. issue 9. 2021-05-28. PMID:33919449. |
the mirna downstream proteins, hypoxia inducible factor-1α (hif-1α) and matrix metalloproteinase 9 (mmp9), were also determined with immunofluorescent staining. |
2021-05-28 |
2023-08-13 |
Not clear |
| Minbiao Chen, Xiuming Huang, Liang Li, Mingfang Huang, Renzhong Cai, Xuqiang Lia. A Regulatory Axis of circ_0008193/miR-1180-3p/TRIM62 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Lung Adenocarcinoma Cells Under Hypoxia. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-26. PMID:32782238. |
functionally, circ_0008193 overexpression inhibited cell viability, glucose uptake, lactate production, migration, and invasion, as well as expression of hexokinase ii, lactate dehydrogenase a, matrix metalloproteinase 2 (mmp2), and mmp9 in hypoxic luad cells in vitro. |
2021-05-26 |
2023-08-13 |
human |
| Wenjing Li, Zhumei Cui, Yan Kong, Xiangyu Liu, Xiangyu Wan. Serum Levels of S100A11 and MMP-9 in Patients with Epithelial Ovarian Cancer and Their Clinical Significance. BioMed research international. vol 2021. 2021-05-26. PMID:33763485. |
to investigate the serum levels of calgizzarin (s100a11) and matrix metalloproteinase-9 (mmp9) in patients with epithelial ovarian cancer (eoc) and determine their clinical significance. |
2021-05-26 |
2023-08-13 |
Not clear |
| Qiu-Ju Han, Xiao-Tong Lan, Ying Wen, Chuan-Zeng Zhang, Michael Cleary, Yasra Sayyed, Guangdong Huang, Xiaoling Tuo, Long Yi, Zhen Xi, Lu-Yuan Li, Qiang-Zhe Zhan. Matrix Metalloproteinase-9-Responsive Surface Charge-Reversible Nanocarrier to Enhance Endocytosis as Efficient Targeted Delivery System for Cancer Diagnosis and Therapy. Advanced healthcare materials. vol 10. issue 9. 2021-05-21. PMID:33694329. |
here, a nanoparticle, which is capable of charge reversal from negative to positive in response to matrix metalloproteinase 9 (mmp9) in tumor microenvironment is reported. |
2021-05-21 |
2023-08-13 |
mouse |
| Fang Zhou, Meng Wang, Mijiti Aibaidula, Zhiguo Zhang, Abudusaimaiti Aihemaiti, Rezhake Aili, Hao Chen, Shuangfeng Dong, Wei Wei, Abulizi Maimaitiail. TPX2 Promotes Metastasis and Serves as a Marker of Poor Prognosis in Non-Small Cell Lung Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:32748897. |
further results indicated that tpx2 significantly activated the epithelial-mesenchymal transition process and promoted the expression and activities of matrix metalloproteinase (mmp)2 and mmp9. |
2021-05-20 |
2023-08-13 |
Not clear |
| Jiangning Li, Haidan Diao, Xin Guan, Xiaofang Tia. Kinesin Family Member C1 (KIFC1) Regulated by Centrosome Protein E (CENPE) Promotes Proliferation, Migration, and Epithelial-Mesenchymal Transition of Ovarian Cancer. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2021-05-20. PMID:33361741. |
further, the knockdown of kifc1 suppressed cell migration and epithelial-mesenchymal transition (emt) and regulated the expression of matrix metalloproteinase (mmp)2, mmp9, e-cadherin, n-cadherin, snail, and zeb1. |
2021-05-20 |
2023-08-13 |
human |
| Aotong Zhang, Xin Qi, Fu Du, Guojian Zhang, Dehai Li, Jing L. PNSA, a Novel C-Terminal Inhibitor of HSP90, Reverses Epithelial-Mesenchymal Transition and Suppresses Metastasis of Breast Cancer Cells In Vitro. Marine drugs. vol 19. issue 2. 2021-05-20. PMID:33672529. |
pnsa increases e-cadherin expression followed by decreasing amounts of n-cadherin, vimentin, and matrix metalloproteinases9 (mmp9) and proteolytic activity of matrix metalloproteinases2 (mmp2) and mmp9. |
2021-05-20 |
2023-08-13 |
Not clear |
| Yun Xue, Huilian Chen, Shenghao Zhang, Li Bao, Beidong Chen, Huan Gong, Yanyang Zhao, Ruomei Q. Resveratrol Confers Vascular Protection by Suppressing TLR4/Syk/NLRP3 Signaling in Oxidized Low-Density Lipoprotein-Activated Platelets. Oxidative medicine and cellular longevity. vol 2021. 2021-05-20. PMID:33728029. |
this study investigated the effect of resveratrol on toll-like receptor 4- (tlr4-) mediated matrix metalloproteinase 3 (mmp3) and mmp9 expression in oxidized low-density lipoprotein- (ox-ldl-) activated platelets and the potential molecule mechanism. |
2021-05-20 |
2023-08-13 |
human |
| Xiumei Chen, Yanfang Wang, Lianjun Zhang, Yujun Ga. Hydroxysafflor Yellow A of Carthamus Tinctorius L., Represses the Malignant Development of Esophageal Cancer Cells via Regulating NF-κB Signaling Pathway. Cell biochemistry and biophysics. vol 78. issue 4. 2021-05-19. PMID:32705535. |
relative protein expression of intercellular adhesion molecule 1 (icam1), matrix metallopeptidase 9 (mmp9), tumor necrosis factor (tnf), and vascular cell adhesion molecule 1 (vcam1) were all upregulated in ec tissues compared with normal tissues and they might be the target gene of hsya according to bioinformatics analysis. |
2021-05-19 |
2023-08-13 |
Not clear |
| Xiangrong Wang, Tianquan Che. CUL4A regulates endometrial cancer cell proliferation, invasion and migration by interacting with CSN6. Molecular medicine reports. vol 23. issue 1. 2021-05-19. PMID:33179082. |
the expression levels of matrix metallopeptidase (mmp)2, mmp9 and p53 were evaluated via western blotting. |
2021-05-19 |
2023-08-13 |
human |
| Nikolett Bódi, Diána Mezei, Payal Chakraborty, Zita Szalai, Bence Pál Barta, János Balázs, Zsolt Rázga, Edit Hermesz, Mária Bagyánszk. Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia. World journal of diabetes. vol 12. issue 5. 2021-05-18. PMID:33995853. |
among the matrix degrading proteinases, matrix metalloproteinase 9 (mmp9) and its tissue inhibitor (timp1) are essential in regulating extracellular matrix remodelling. |
2021-05-18 |
2023-08-13 |
Not clear |
| Xiwu Ouyang, Lemeng Feng, Lei Yao, Yao Xiao, Xianyu Hu, Gewen Zhang, Guodong Liu, Zhiming Wan. Testicular orphan receptor 4 (TR4) promotes papillary thyroid cancer invasion via activating circ-FNLA/miR-149-5p/MMP9 signaling. Molecular therapy. Nucleic acids. vol 24. 2021-05-18. PMID:33996257. |
mechanistically, tr4 transcriptionally regulated the expression level of circ-filamin a (flna), which competed with matrix metalloproteinase 9 (mmp9) for microrna (mir)-149-5p binding and led to an increased protein level of mmp9. |
2021-05-18 |
2023-08-13 |
mouse |
| Ming Li, Meng Wu, Hong-Ju Xie, Hong-Wei Li. Identification of transcriptomic characteristics during nasal capsular contracture progression using RNA deep sequencing. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 3. 2021-05-17. PMID:33608978. |
the top 30 up-regulated genes included many chemokines (e.g., ccl18, ccl13, ccl17 and ccl8), matrix metallopeptidases (e.g., mmp9 and mmp12) and integrin proteins (e.g., itgam and itgb2). |
2021-05-17 |
2023-08-13 |
Not clear |
| Y Lan, Y Wang, H L. Opsin 3 is a key regulator of ultraviolet A-induced photoageing in human dermal fibroblast cells. The British journal of dermatology. vol 182. issue 5. 2021-05-14. PMID:31380578. |
chronic exposure to ultraviolet (uv) radiation (mainly uva) induces a sustained increase of matrix metalloproteinases (mmps), especially mmp1, mmp2, mmp3 and mmp9 in human skin fibroblasts. |
2021-05-14 |
2023-08-13 |
human |
| Jialong Fan, Bin Liu, Ying Long, Zhou Wang, Chunyi Tong, Wei Wang, Peidong You, Xuanming Li. Sequentially-targeted biomimetic nano drug system for triple-negative breast cancer ablation and lung metastasis inhibition. Acta biomaterialia. vol 113. 2021-05-14. PMID:32569637. |
moreover, comparing with the control, the average number of lung metastatic nodules in tumor-bearing mice reduced 84%, the molecular mechanism of which is related to the down expression of cox-2, matrix metalloproteinase 9 (mmp9) and vascular endothelial growth factor (vegf). |
2021-05-14 |
2023-08-13 |
mouse |
| Jose Alejandro Guerrero, Raquel Souto Silva, Izabella Lucas de Abreu Lima, Bianca Cristina Duffles Rodrigues, Breno Rocha Barrioni, Flávio Almeida Amaral, André Petenuci Tabanez, Gustavo Pompermaier Garlet, Diego Alexander Garzon Alvarado, Tarcília Aparecida Silva, Estevam Barbosa de Las Casas, Soraia Macar. Maxillary suture expansion: A mouse model to explore the molecular effects of mechanically-induced bone remodeling. Journal of biomechanics. vol 108. 2021-05-14. PMID:32635995. |
rme yielded increased expression of bone remodeling markers as osteocalcin (ocn), dentin matrix acidic phosphoprotein-1 (dmp1), runt-related transcription factor 2 (runx2), collagen type i alpha 1 (col1a1), alkaline phosphatase (alp), receptor activator of nuclear factor kappa b (rank), receptor activator of nuclear factor kappa b ligand (rankl), osteoprotegerin (opg), cathepsin k (ctsk), matrix metalloproteinases 9 and 13 (mmp9 and 13), transforming growth fator beta 1, 2 and 3 (tgfb 1, tgfb 2 and tgfb3), bone morphogenetic protein 2 (bmp-2), sclerostin (sost), beta-catenin-like protein 1 (ctnnbl) and wnt signaling pathways 3, 3a and 5a (wnt 3, wnt 3a and wnt 5a). |
2021-05-14 |
2023-08-13 |
mouse |