| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhicheng Zhao, Li Lu, Weidong L. TAGLN2 promotes the proliferation, invasion, migration and epithelial-mesenchymal transition of colorectal cancer cells by activating STAT3 signaling through ANXA2. Oncology letters. vol 22. issue 4. 2021-09-03. PMID:34466149. |
the expression levels of matrix metalloproteinase (mmp)2, mmp9 and proteins associated with epithelial-mesenchymal transition (emt), including n-cadherin (n-cad), vimentin, zinc finger e-box binding homeobox 2 (zeb2) and e-cadherin (e-cad), were also evaluated by western blotting. |
2021-09-03 |
2023-08-13 |
Not clear |
| Jing Ma, Yue Ren, Jia-Ning Zhang, Li Lin, Yan-Ling Zhan. [Analysis on targets of regulating Qi and activating blood based on activity spectrum of targets]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 46. issue 15. 2021-09-03. PMID:34472274. |
the enrichment analysis of topology, go and kegg showed that tcm for activating blood circulation mainly exerted its anti-inflammatory, neuroprotective and angiogenic effects on signaling cascade pathway mediated by vegf/vegfr2, erk signaling pathway, calcium signaling pathway and pi3 k-akt signaling pathway, and the key targets included mitogen activated protein kinases 3(mapk3), proto-oncogene tyrosine-protein kinase src(src), mitogen activated protein kinases 1(mapk1), epidermal growth factor receptor(egfr), phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(pik3 ca), peroxisome proliferators-activated receptor gamma(pparg), nitric oxide synthase 3(nos3), prostaglandin g/h synthetase 2(ptgs2), matrix metalloproteinase-9(mmp9), and vascular endothelial growth factor a(vegfa). |
2021-09-03 |
2023-08-13 |
Not clear |
| Chun Liu, Miao Li, Zhao-Xia Dong, Dong Jiang, Xiaojing Li, Shuibin Lin, Demeng Chen, Xuenong Zou, Xing-Ding Zhang, Gary D Luke. Heterogeneous microenvironmental stiffness regulates pro-metastatic functions of breast cancer cells. Acta biomaterialia. vol 131. 2021-08-31. PMID:34246802. |
we discovered that tumor cells in a soft environment enriched yap1 and ap1 signaling related genes, whereas tumor cells in a stiff environment became more pro-angiogenic by upregulating fibronectin 1 (fn1) and matrix metalloproteinase 9 (mmp9) expression. |
2021-08-31 |
2023-08-13 |
Not clear |
| Wangquan Ji, Peiyu Zhu, Ruonan Liang, Liang Zhang, Yu Zhang, Yuexia Wang, Weiguo Zhang, Ling Tao, Shuaiyin Chen, Haiyan Yang, Yuefei Jin, Guangcai Dua. Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model. Viruses. vol 13. issue 8. 2021-08-31. PMID:34452454. |
cva2 infection also led to the disruption of cell-matrix interactions in heart tissues, including the increases of matrix metalloproteinase (mmp)3, mmp8, mmp9, connective tissue growth factor (ctgf) and tissue inhibitors of metalloproteinases (timp)4. |
2021-08-31 |
2023-08-13 |
mouse |
| Mengshi Zhao, Hongjie Ji, Qiang Fu, Qian Cheng, Yu Zhang, Yu Yan. MicroRNA-134-3p inhibits ovarian cancer progression by targeting flap structure-specific endonuclease 1 in vitro. Oncology reports. vol 45. issue 1. 2021-08-30. PMID:33169800. |
furthermore, transfection using a mir-134-3p mimic inhibited the migration and invasion of skov-3 and ovcar-3 cells, and decreased the protein expression levels of cyclooxygenase-2, matrix metalloproteinase (mmp)2 and mmp9. |
2021-08-30 |
2023-08-13 |
Not clear |
| Mingmin Wang, Shuangjie Yang, Mingyan Shao, Qian Zhang, Xiaoping Wang, Linghui Lu, Sheng Gao, Yong Wang, Wei Wan. Identification of Potential Bioactive Ingredients and Mechanisms of the Guanxin Suhe Pill on Angina Pectoris by Integrating Network Pharmacology and Molecular Docking. Evidence-based complementary and alternative medicine : eCAM. vol 2021. 2021-08-24. PMID:34422068. |
protein-protein interaction identified vegfa (vascular endothelial growth factor a), tnf (tumor necrosis factor), ccl2 (c-c motif chemokine ligand 2), fn1 (fibronectin 1), mmp9 (matrix metallopeptidase 9), ptgs2 (prostaglandin-endoperoxide synthase 2), il10 (interleukin 10), cxcl8 (c-x-c motif chemokine ligand 8), il6 (interleukin 6), and ins (insulin) as hub targets for gsp, which were involved in the inflammatory process, ecm proteolysis, glucose metabolism, and lipid metabolism. |
2021-08-24 |
2023-08-13 |
Not clear |
| Claudia Kusmic, Alessio Vizzoca, Monia Taranta, Lorena Tedeschi, Lisa Gherardini, Gualtiero Pelosi, Ambra Giannetti, Sara Tombelli, Settimio Grimaldi, Francesco Baldini, Claudio Domenici, Maria Giovanna Trivella, Caterina Cint. Silencing Survivin: a Key Therapeutic Strategy for Cardiac Hypertrophy. Journal of cardiovascular translational research. 2021-08-19. PMID:34409583. |
surv down-regulation determines the tuning down of mmp9, timp1 and timp4 extracellular matrix remodeling factors while induces the overexpression of the cardioprotective mcad factor, which counterbalance the absence of pro-survival and anti-apoptotic surv activity to protect cardiomyocytes from death. |
2021-08-19 |
2023-08-13 |
mouse |
| Silvia Martinelli, Elmira A Anderzhanova, Thomas Bajaj, Svenja Wiechmann, Frederik Dethloff, Katja Weckmann, Daniel E Heinz, Tim Ebert, Jakob Hartmann, Thomas M Geiger, Michael Döngi, Kathrin Hafner, Max L Pöhlmann, Lee Jollans, Alexandra Philipsen, Susanne V Schmidt, Ulrike Schmidt, Giuseppina Maccarrone, Valentin Stein, Felix Hausch, Christoph W Turck, Mathias V Schmidt, Anne-Kathrin Gellner, Bernhard Kuster, Nils C Gasse. Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature communications. vol 12. issue 1. 2021-08-17. PMID:34330919. |
we identify the matrix metalloproteinase 9 (mmp9) as one of the proteins secreted in response to stress. |
2021-08-17 |
2023-08-13 |
Not clear |
| Yuanyuan Hao, Jinghai Hu, Hao Wang, Chunxi Wan. Gold nanoparticles regulate the antitumor secretome and have potent cytotoxic effects against prostate cancer cells. Journal of applied toxicology : JAT. vol 41. issue 8. 2021-08-16. PMID:33355407. |
secretome determinations using two-dimensional difference in-gel electrophoresis (2d-dige), followed by enzyme-linked immunosorbent assay and quantitative reverse transcriptase-polymerase chain reaction validations, have identified a series of secretory proteins that were dysregulated by aunp treatment in prostate cancer cells, many of which are highly involved in cytokine-chemokine functions, including cxcl3, interleukin-10, ccl2, and matrix metalloproteinase 9 (mmp9). |
2021-08-16 |
2023-08-13 |
Not clear |
| Soundara Viveka Thangaraj, Vidyarani Shyamsundar, Arvind Krishnamurthy, Vijayalakshmi Ramshanka. Deregulation of extracellular matrix modeling with molecular prognostic markers revealed by transcriptome sequencing and validations in Oral Tongue squamous cell carcinoma. Scientific reports. vol 11. issue 1. 2021-08-16. PMID:33420101. |
the up-regulation of a panel of 6 genes namely, matrix metalloproteinase 9 (mmp9), laminin subunit gamma 2 (lamc2), desmoglein 2 (dsg2), plasminogen activator urokinase (plau), forkhead box m1 (foxm1), and myosin 1b (myo1b) was associated with failure of treatment in the early stage (t1, t2). |
2021-08-16 |
2023-08-13 |
Not clear |
| Tianyue Huang, Lingling Zuo, Katarzyna S Walczyńska, Mengying Zhu, Yujun Lian. Essential roles of matrix metalloproteinases in axolotl digit regeneration. Cell and tissue research. vol 385. issue 1. 2021-08-16. PMID:33783606. |
in this study, it was evident that matrix metalloproteinases (mmps) including mmp9, mmp3/10a, and mmp3/10b, which play a crucial role in tissue remodeling, are highly expressed during early stages of digit regeneration in axolotl. |
2021-08-16 |
2023-08-13 |
Not clear |
| Yinhui Wang, Kun Yu, Chengcheng Zhao, Ling Zhou, Jia Cheng, Dao Wen Wang, Chunxia Zha. Follistatin Attenuates Myocardial Fibrosis in Diabetic Cardiomyopathy Frontiers in pharmacology. vol 12. 2021-08-14. PMID:34385917. |
furthermore, fst reduced cardiac fibrosis and the production of reactive oxygen species (ros), and enhanced matrix metallopeptidase 9 (mmp9) activities in db/db mouse hearts. |
2021-08-14 |
2023-08-13 |
mouse |
| Wenkai Yang, Hanjian Tu, Kai Tang, Haozhong Huang, Shi Ou, Jianguo W. Reynoutrin Improves Ischemic Heart Failure in Rats Via Targeting S100A1. Frontiers in pharmacology. vol 12. 2021-08-10. PMID:34366855. |
western blotting was used to determine protein expression levels of s100 calcium-binding protein a1 (s100a1), matrix metallopeptidase 2(mmp2), mmp9, phosphorylated (p-) p65, and transforming growth factor -β1 (tgf-β1) in myocardial tissue of the left ventricle. |
2021-08-10 |
2023-08-13 |
rat |
| Yuji Maenohara, Ryota Chijimatsu, Naohiro Tachibana, Kosuke Uehara, Fengjun Xuan, Daisuke Mori, Yasutaka Murahashi, Hideki Nakamoto, Takeshi Oichi, Song Ho Chang, Takumi Matsumoto, Yasunori Omata, Fumiko Yano, Sakae Tanaka, Taku Sait. Lubricin Contributes to Homeostasis of Articular Cartilage by Modulating Differentiation of Superficial Zone Cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. vol 36. issue 4. 2021-08-09. PMID:33617044. |
rna sequencing identified matrix metalloproteinase 9 (mmp9) as the top upregulated gene by prg4 knockout. |
2021-08-09 |
2023-08-13 |
mouse |
| Renu Venugopal, Namrata Sharma, Seema Sen, Sujata Mohanty, Seema Kashyap, Tushar Agarwal, Jasbir Kaur, Rasik B Vajpaye. Prognostic significance of matrix metalloproteinase 9 in COMET operated chronic ocular Stevens-Johnson syndrome. The British journal of ophthalmology. 2021-08-07. PMID:34362775. |
the present study investigates the expression of matrix metalloproteinase 2 (mmp2), mmp3, mmp9, mmp11 and timp1 (tissue inhibittor of matrix metalloproteinase 1) in pannus tissues of chronic ocular sjs undergoing cultivated oral mucosal epithelial transplantation (comet) and their prognostic relevance. |
2021-08-07 |
2023-08-13 |
Not clear |
| Huanru Wang, Meng Yuan, Enhui Yang, Deyan Chen, Airong Su, Zhiwei W. Enterovirus 71 infection induced Aquaporin-4 depolarization by increasing matrix metalloproteinase-9 activity. Neuroscience letters. vol 759. 2021-08-06. PMID:34126180. |
elevated activity or expression of matrix metalloproteinase 9 (mmp9) upon infection was found in both mouse brains and patient cerebrospinal fluid (csf) samples. |
2021-08-06 |
2023-08-13 |
mouse |
| Jing An, Weiwei Yao, Waner Tang, Jingjing Jiang, Yu Shan. Hormesis Effect of Methyl Triclosan on Cell Proliferation and Migration in Human Hepatocyte L02 Cells. ACS omega. vol 6. issue 29. 2021-08-03. PMID:34337230. |
furthermore, expressions of tumor-related genes, mouse double minute 2 (mdm2), matrix metalloproteinase 9 (mmp9), and proliferating cell nuclear antigen ( |
2021-08-03 |
2023-08-13 |
mouse |
| b' Marija \\xc4\\x90or\\xc4\\x91i\\xc4\\x87 Crnogorac, Ivana Z Mati\\xc4\\x87, Ana Damjanovi\\xc4\\x87, Nenad Jankovi\\xc4\\x87, Ana Krivoku\\xc4\\x87a, Tatjana Stanojkovi\\xc4\\x8. 3D HeLa spheroids as a model for investigating the anticancer activity of Biginelli-hybrids. Chemico-biological interactions. vol 345. 2021-08-02. PMID:34161784.' |
the invasion potential of treated hela cells in spheroids was monitored by imaging of spheroids embedded in a matrix made of matrigel and collagen and by determination of mmp2, mmp9, and vegf gene expression levels. |
2021-08-02 |
2023-08-13 |
Not clear |
| Yuming Xu, Erhui Jiang, Zhe Shao, Zhengjun Shan. LncRNA FENDRR in Carcinoma-Associated Fibroblasts Regulates the Angiogenesis of Oral Squamous Cell Carcinoma Through the PI3K/AKT Pathway. Frontiers in oncology. vol 11. 2021-07-31. PMID:34327132. |
further experiments confirmed that the downregulation of fendrr can activate the pi3k/akt pathway in nfs and enhances the expression of matrix metalloproteinase 9 (mmp9). |
2021-07-31 |
2023-08-13 |
human |
| Hossam El-Sheikh Ali, Kirsten E Scoggin, Rebecca Ruby, Alan Loynachan, Yatta Boakari, Claudia Fernandes, Pouya Dini, Carleigh Elizabeth Fedorka, Shavahn C Loux, Alejandro Esteller-Vico, Barry A Bal. Equine cervical remodeling during placentitis and the prepartum period: a transcriptomic approach. Reproduction (Cambridge, England). vol 161. issue 6. 2021-07-30. PMID:33780349. |
these pathways were accompanied by upregulation of several proteases, including matrix metalloproteinases (mmp1, mmp2, and mmp9), cathepsins (ctsb, ctsc, and ctsd) and a disintegrin and metalloproteinase with thrombospondin type 1 motifs (adamts1, adamts4, and adamts5), which are crucial for degradation of cervical collagens during remodeling. |
2021-07-30 |
2023-08-13 |
Not clear |