Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Zita Wachal, Mariann Bombicz, Dániel Priksz, Csaba Hegedűs, Diána Kovács, Adrienn Mónika Szabó, Rita Kiss, József Németh, Béla Juhász, Zoltán Szilvássy, Balázs Varg. Retinoprotection by BGP-15, a Hydroximic Acid Derivative, in a Type II Diabetic Rat Model Compared to Glibenclamide, Metformin, and Pioglitazone. International journal of molecular sciences. vol 21. issue 6. 2020-12-07. PMID:32204537. |
the mechanism of retinoprotective action may include sirtuin 1 (sirt1) and matrix metalloproteinase 9 (mmp9) enzymes, as bgp-15 was able to elevate sirt1 and decrease mmp9 expression in the eye. |
2020-12-07 |
2023-08-13 |
rat |
M Skorvanova, T Matakova, M Skerenova, M Sarlinova, H Drobkova, M Petras, M Janickova, M Halasa, V Repiska, E Halasov. Methylation of MMP2, TIMP2, MMP9 and TIMP1 in abdominal aortic aneurysm. Bratislavske lekarske listy. vol 121. issue 10. 2020-12-07. PMID:32955903. |
the aim of this pilot study is to explore the relationship between the methylation of matrix metalloproteinases and tissue inhibitors of the metalloproteinases genes' promoter region, and abdominal aortic aneurysm (aaa) through the detection of the methylation status of mmp2, timp2, timp1, and mmp9 genes in peripheral blood. |
2020-12-07 |
2023-08-13 |
Not clear |
Xiaolin Pu, Hua Jiang, Wei Li, Lin Xu, Lin Wang, Yongqian Sh. Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-11-24. PMID:32004259. |
the further functional analysis included detection of protein expression for cyclin d1, tissue inhibitor matrix metalloproteinase-1 (timp-1), matrix metallopeptidase 9 (mmp9), bcl-2, and bax, to verify the role of mir-335-3p targeting by copb2 in lung adenocarcinoma cells. |
2020-11-24 |
2023-08-13 |
human |
Mengyun Su, Fang Miao, Shan Jiang, Ying Shi, Longfei Luo, Xiaolei He, Jing Wan, Shizheng Xu, Tie-Chi Le. Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation. International journal of molecular medicine. vol 45. issue 4. 2020-11-23. PMID:31985026. |
while it is known that matrix metalloprotease 9 (mmp9) is involved in the degradation of the extracellular matrix in physiological or pathological processes, little is known about whether mmp9 affects melanocyte migration in vitiligo repigmentation. |
2020-11-23 |
2023-08-13 |
human |
Na-Hyun Hwang, Jae-Eun Jung, Jae-Sun Lee, Seong-Ho Jeong, Eun-Sang Dhong, Seung-Kyu Ha. Effects of Granulocyte Macrophage Colony-Stimulating Factor Inhibition on the Skin/Nerve Cell Model In Vitro. The Journal of craniofacial surgery. vol 31. issue 5. 2020-11-19. PMID:32502102. |
when human blastoma cells (sh-sy5y) were treated with 10 ng/ml of gm-csf, the levels of regulatory rnas associated with aging, such as matrix metalloproteinase-9 (mmp9), nuclear factor nf-kappa-b p50 subunit (nfkb), inducible nitric oxide synthase (inos), and interleukin 1 beta (il-1β) increased, whereas gm-csf inhibition caused their expression to decrease. |
2020-11-19 |
2023-08-13 |
human |
Ashley M Woodward, Antonio Di Zazzo, Stefano Bonini, Pablo Argües. Endoplasmic reticulum stress promotes inflammation-mediated proteolytic activity at the ocular surface. Scientific reports. vol 10. issue 1. 2020-11-18. PMID:32042069. |
here, we demonstrate that the proinflammatory cytokine tnfα stimulates matrix metalloproteinase 9 (mmp9) at the ocular surface through a c-fos-dependent mechanism of er stress. |
2020-11-18 |
2023-08-13 |
human |
Heyu Zhang, Yanzhe Wang, Ling Lian, Cheng Zhang, Zhiyi H. Glycine-Histidine-Lysine (GHK) Alleviates Astrocytes Injury of Intracerebral Hemorrhage via the Akt/miR-146a-3p/AQP4 Pathway. Frontiers in neuroscience. vol 14. 2020-11-17. PMID:33192260. |
matrix metalloproteinase 2 (mmp2), mmp9, tissue inhibitors of metalloproteinase-1 (timp1), aqp4 expression were detected/assessed using western blot. |
2020-11-17 |
2023-08-13 |
human |
L Zhang, Y Wang, H S. Long non-coding RNA LINC00152/miR-613/CD164 axis regulates cell proliferation, apoptosis, migration and invasion in glioma via PI3K/AKT pathway. Neoplasma. vol 67. issue 4. 2020-11-16. PMID:32726126. |
western blot was used to detect the expression of cd164, phosphatidylinositol 3' -kinase (pi3k), phosphorylated pi3k (p-pi3k), protein kinase b (akt), phosphorylated akt (p-akt), matrix metalloproteinase 9 (mmp9), bcl2-associated x (bax) and c-myc. |
2020-11-16 |
2023-08-13 |
Not clear |
Zhijin He, Limin Jia, Yanhong Lyu, Guogang Dong, Yourong Jiang, Jinhua Zhen. [Increased expression of transendothelial migration-related molecules CCL4, ICAM-1 and VCAM-1 in lung tissue after surgical removal of mouse tumor-bearing lymph node]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 36. issue 8. 2020-11-10. PMID:32958126. |
objective to detect the expression of chemokine and adhesion molecules related to leukocytes' transendothelial migration, meanwhile, to investigate changes of reticular fibers and the expression of vimentin and matrix metalloproteinase-9 (mmp9) in lung tissues after surgical removal of mouse tumor-bearing lymph node, revealing their changes and roles in the formation of pre-metastatic microenvironment in the lung. |
2020-11-10 |
2023-08-13 |
mouse |
Audrey Coilly, Christophe Desterke, Catherine Guettier, Didier Samuel, Franck Chiappin. FABP4 and MMP9 levels identified as predictive factors for poor prognosis in patients with nonalcoholic fatty liver using data mining approaches and gene expression analysis. Scientific reports. vol 9. issue 1. 2020-11-05. PMID:31874999. |
we identified two genes, fatty acid binding protein-4 (fabp4) and matrix metalloproteinase-9 (mmp9), which respectively allowed distinguishing patients at risk of progression from nafl to nash and from nash to cirrhosis and hcc. |
2020-11-05 |
2023-08-13 |
human |
Zhaoxia Shen, Kailin Jiao, Mengying Teng, Zhong L. Activation of STAT-3 signalling by RECK downregulation Free radical research. vol 54. issue 2-3. 2020-11-05. PMID:31933392. |
here, we showed that 27hc caused the accumulation of cellular ros, which upregulated matrix metalloproteinase 9 (mmp9) and increased the invasive ability of mcf7 and t47d cells. |
2020-11-05 |
2023-08-13 |
Not clear |
Lingyun Wu, Sugandha Saxena, Paran Goel, Dipakkumar R Prajapati, Cheng Wang, Rakesh K Sing. Breast Cancer Cell-Neutrophil Interactions Enhance Neutrophil Survival and Pro-Tumorigenic Activities. Cancers. vol 12. issue 10. 2020-11-03. PMID:33049964. |
breast cancer cell-derived supernatant treated neutrophils significantly expressed high levels of interleukin-1β (il-1β), cc-chemokine ligand-2-4 (ccl2, ccl3, ccl4), inducible nitric oxide synthase (inos), and matrix metallopeptidase-9 (mmp9), and formed extracellular traps (nets). |
2020-11-03 |
2023-08-13 |
human |
Li-Han Chen, Che-Yu Liao, Liang-Chuan Lai, Mong-Hsun Tsai, Eric Y Chuan. Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis. Scientific reports. vol 9. issue 1. 2020-10-29. PMID:31527696. |
moreover, silencing of the cellular homeostasis protein heme-oxygenase-1 (hmox1) and/or the transcription factor nuclear factor, erythroid-2-like-2 (nrf2) reversed the migration-suppressing effect of sema6a and the sema6a-driven alterations in expression of urokinase insulin-like-growth-factor-binding-protein-3, matrix metalloproteinase (mmp)-1, and mmp9, the downstream effectors of hmox1. |
2020-10-29 |
2023-08-13 |
Not clear |
Zohreh Safari, Sara Soudi, Nazli Jafarzadeh, Ahmad Zavaran Hosseini, Elham Vojoudi, Majid Sadeghizade. Promotion of angiogenesis by M13 phage and RGD peptide in vitro and in vivo. Scientific reports. vol 9. issue 1. 2020-10-27. PMID:31371773. |
in addition, the expression of vascular endothelial growth factor a (vegf-a), vegf receptors 2 and 3, matrix metalloproteinase 9 (mmp9), and epithelial nitric oxide synthase (enos) transcripts were significantly upregulated due to the huvecs culturing on m13 phage-rgd coated surface. |
2020-10-27 |
2023-08-13 |
Not clear |
Antonella D'Amore, Ali Ahmed Hanbashi, Silvia Di Agostino, Fioretta Palombi, Andrea Sacconi, Aniruddha Voruganti, Marilena Taggi, Rita Canipari, Giovanni Blandino, John Parrington, Antonio Filippin. Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry. Cancers. vol 12. issue 9. 2020-10-27. PMID:32846966. |
tpc2 ko increased these cells' ability to invade the extracelullar matrix and was associated with the increased expression of mesenchymal markers zeb-1, vimentin and n-cadherin, and the enhanced secretion of mmp9. |
2020-10-27 |
2023-08-13 |
human |
Nicholas H Russell, Raiford T Black, Nancy N Lee, Adele E Doperalski, Thomas M Reeves, Linda L Phillip. Time-dependent hemeoxygenase-1, lipocalin-2 and ferritin induction after non-contusion traumatic brain injury. Brain research. vol 1725. 2020-10-23. PMID:31539545. |
lcn2 elevation supported not only its role in iron transport, but also mediation of matrix metalloproteinase 9 (mmp9) activity. |
2020-10-23 |
2023-08-13 |
rat |
Mingjing Yuan, Fuan Xie, Xianyuan Xia, Kai Zhong, Lanlan Lian, Shihui Zhang, Li Yuan, Jun Y. UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway. International journal of oncology. vol 56. issue 1. 2020-10-23. PMID:31789389. |
the mechanism involved a unc5c‑knockdown‑induced enhancement of matrix metalloproteinase (mmp)3, mmp7, mmp9 and mmp10 expression via activation of the pi3k/akt, erk and p38 mapk signaling pathways. |
2020-10-23 |
2023-08-13 |
Not clear |
Bo Fan, Yiying Jin, Hongshuo Zhang, Rui Zhao, Man Sun, Mengfan Sun, Xiaoying Yuan, Wei Wang, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Na Yu, Qun Wang, Tingjiao Liu, Xiancheng L. MicroRNA‑21 contributes to renal cell carcinoma cell invasiveness and angiogenesis via the PDCD4/c‑Jun (AP‑1) signalling pathway. International journal of oncology. vol 56. issue 1. 2020-10-23. PMID:31789394. |
in in vitro experiments, we demonstrated that a mir‑21 inhibitor decreased the number of migrating and invading a498 and 786‑o rcc cells, along with a decrease in pdcd4, c‑jun, matrix metalloproteinase (mmp)2 and mmp9 expression. |
2020-10-23 |
2023-08-13 |
Not clear |
Zbigniew Baster, Liqing Li, Zenon Rajfur, Cai Huan. Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation. Biochimica et biophysica acta. Molecular cell research. vol 1867. issue 7. 2020-10-23. PMID:32198023. |
here we show that ablation of talin2 in mda-mb-231 cells inhibited the secretion of matrix metallopeptidase 9 (mmp9), a proteinase involved in extracellular matrix degradation in invadopodium maturation and metastasis. |
2020-10-23 |
2023-08-13 |
Not clear |
Yongle Zhang, Xiliang Cong, Zhiguo Li, Yingwei Xu. Estrogen facilitates gastric cancer cell proliferation and invasion through promoting the secretion of interleukin-6 by cancer-associated fibroblasts. International immunopharmacology. vol 78. 2020-10-21. PMID:31753587. |
results indicated that the expression of matrix metalloproteinase 2 (mmp2) and mmp9 were enhanced by estrogen-cafs-cm. |
2020-10-21 |
2023-08-13 |
Not clear |