Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
S Chen, F-M An, L Yin, A-R Liu, D-K Yin, W-B Yao, X-D Ga. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience. vol 256. 2014-08-27. PMID:24183963. |
additionally, glucose-bsa alone did not induce significant cytotoxicity in pc12 cells, but resulted in tau hyperphosphorylation in primary hippocampal neurons in 24h. |
2014-08-27 |
2023-08-12 |
rat |
R Killick, E M Ribe, R Al-Shawi, B Malik, C Hooper, C Fernandes, R Dobson, P M Nolan, A Lourdusamy, S Furney, K Lin, G Breen, R Wroe, A W M To, K Leroy, M Causevic, A Usardi, M Robinson, W Noble, R Williamson, K Lunnon, S Kellie, C H Reynolds, C Bazenet, A Hodges, J-P Brion, J Stephenson, J Paul Simons, Simon Loveston. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular psychiatry. vol 19. issue 1. 2014-08-26. PMID:23164821. |
neuronal overexpression of dkk1 in transgenic mice mimicked this aβ-induced pathway and resulted in age-dependent increases in tau phosphorylation in hippocampus and cognitive impairment. |
2014-08-26 |
2023-08-12 |
mouse |
A S R Sierksma, D L A van den Hove, F Pfau, M Philippens, O Bruno, E Fedele, R Ricciarelli, H W M Steinbusch, T Vanmierlo, J Prickaert. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. vol 77. 2014-08-26. PMID:24067928. |
appswe/ps1de9 mice displayed lower levels of creb phosphorylation, which remained unaltered after chronic gebr-7b treatment, and higher levels of tau in the hippocampus. |
2014-08-26 |
2023-08-12 |
mouse |
A S R Sierksma, D L A van den Hove, F Pfau, M Philippens, O Bruno, E Fedele, R Ricciarelli, H W M Steinbusch, T Vanmierlo, J Prickaert. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. vol 77. 2014-08-26. PMID:24067928. |
hippocampal brain-derived neurotrophic factor levels and synaptic densities were not different between experimental groups and no effects were observed on hippocampal gsk3β and tau phosphorylation or aβ levels. |
2014-08-26 |
2023-08-12 |
mouse |
Zhi-yong Hu, Hai-yan Jin, Li-li Xu, Zhi-rui Zhu, Yi-lei Jiang, Robert Sea. Effects of sevoflurane on the expression of tau protein mRNA and Ser396/404 site in the hippocampus of developing rat brain. Paediatric anaesthesia. vol 23. issue 12. 2014-08-25. PMID:24102683. |
effects of sevoflurane on the expression of tau protein mrna and ser396/404 site in the hippocampus of developing rat brain. |
2014-08-25 |
2023-08-12 |
rat |
Zhi-yong Hu, Hai-yan Jin, Li-li Xu, Zhi-rui Zhu, Yi-lei Jiang, Robert Sea. Effects of sevoflurane on the expression of tau protein mRNA and Ser396/404 site in the hippocampus of developing rat brain. Paediatric anaesthesia. vol 23. issue 12. 2014-08-25. PMID:24102683. |
the current study sought to investigate the effects of sevoflurane on the levels of tau phosphorylation at phosphor-ser396/404 and total tau mrna in the hippocampus of neonatal rats. |
2014-08-25 |
2023-08-12 |
rat |
Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poo. Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain. PloS one. vol 8. issue 12. 2014-08-18. PMID:24312462. |
co-localization of the napoecf antibody with phf-1, a general marker for pick bodies, as well as with an antibody to caspase-cleaved tau (tauc3) was evident within the hippocampus. |
2014-08-18 |
2023-08-12 |
Not clear |
Dantao Peng, Xiuqing Pan, Ju Cui, Yueqin Ren, Jiewen Zhan. Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 32. issue 5. 2014-08-14. PMID:24335173. |
hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. |
2014-08-14 |
2023-08-12 |
rat |
Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
microtubule-associated protein tau is essential for long-term depression in the hippocampus. |
2014-08-11 |
2023-08-12 |
mouse |
Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
to investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (ltd) in tau knockout mice in vivo and in vitro, an effect that was replicated by rnai knockdown of tau in vitro. |
2014-08-11 |
2023-08-12 |
mouse |
Isabel Carreras, Ann C McKee, Ji-Kyung Choi, Nurgul Aytan, Neil W Kowall, Bruce G Jenkins, Alpaslan Dedeogl. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain research. vol 1541. 2014-07-28. PMID:24161403. |
to further understand the effects of nsaids in 3xtg-ad mice, we treated 3xtg-ad mice with r-flurbiprofen, an enantiomer of the nsaid flurbiprofen that maintains the gsm activity but has greatly reduced anti-inflammatory activity, and analyzed its effect on cognition, aß, tau, and the neurochemical profile of the hippocampus. |
2014-07-28 |
2023-08-12 |
mouse |
Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
overexpression of 14-3-3z promotes tau phosphorylation at ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. |
2014-07-28 |
2023-08-12 |
rat |
Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
when overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in ser(262) phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. |
2014-07-28 |
2023-08-12 |
rat |
Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
nmda reduces tau phosphorylation in rat hippocampal slices by targeting nr2a receptors, gsk3β, and pkc activities. |
2014-07-22 |
2023-08-12 |
rat |
Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
in the present study, pharmacological inhibitors were deployed to investigate potential processes by which the n-methyl-d-aspartate (nmda) subtype of glutamate receptors modulates tau phosphorylation in rat hippocampal slices. |
2014-07-22 |
2023-08-12 |
rat |
Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
our results demonstrated that tau phosphorylation at ser199-202 residues was decreased in nmda-treated hippocampal slices, an effect that was not reproduced at ser262 and ser404 epitopes. |
2014-07-22 |
2023-08-12 |
rat |
Ye-Nan Chi, Xu Zhang, Jie Cai, Feng-Yu Liu, Guo-Gang Xing, You Wa. Formaldehyde increases intracellular calcium concentration in primary cultured hippocampal neurons partly through NMDA receptors and T-type calcium channels. Neuroscience bulletin. vol 28. issue 6. 2014-07-21. PMID:23160928. |
formaldehyde induces mis-folding and aggregation of neuronal tau protein, hippocampal neuronal apoptosis, cognitive impairment and loss of memory functions, as well as excitation of peripheral nociceptive neurons in cancer pain models. |
2014-07-21 |
2023-08-12 |
Not clear |
Yuanxin Deng, Yanwen Zhang, Shujie Jia, Junkang Liu, Yanxia Liu, Weiwei Xu, Lei Li. Effects of aluminum and extremely low frequency electromagnetic radiation on oxidative stress and memory in brain of mice. Biological trace element research. vol 156. issue 1-3. 2014-07-21. PMID:24158621. |
secondly are the pathologic abnormalities including neuronal cell loss and overexpression of phosphorylated tau protein in the hippocampus and cerebral cortex. |
2014-07-21 |
2023-08-12 |
mouse |
Erika Calvo-Ochoa, Karina Hernández-Ortega, Patricia Ferrera, Sumiko Morimoto, Clorinda Aria. Short-term high-fat-and-fructose feeding produces insulin signaling alterations accompanied by neurite and synaptic reduction and astroglial activation in the rat hippocampus. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 34. issue 6. 2014-07-21. PMID:24667917. |
our results show that 7 days of hffd feeding induce obesity and insres, associated with the following alterations in the hippocampus: (1) a decreased insulin signaling; (2) a decreased hippocampal weight; (3) a reduction in dendritic arborization in ca1 and microtubule-associated protein 2 (map-2) levels; (4) a decreased dendritic spine number in ca1 and synaptophysin content, along with an increase in tau phosphorylation; and finally, (5) an increase in reactive astrocyte associated with microglial changes. |
2014-07-21 |
2023-08-12 |
rat |
Qiu-Lan Ma, Xiaohong Zuo, Fusheng Yang, Oliver J Ubeda, Dana J Gant, Mher Alaverdyan, Nicolae C Kiosea, Sean Nazari, Ping Ping Chen, Fatiha Nothias, Piu Chan, Edmond Teng, Sally A Frautschy, Greg M Col. Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 21. 2014-07-11. PMID:24849348. |
we report that old (19-20 months; oko) but not middle-aged (8-9 months; mko) tau knock-out mice develop morris water maze (mwm) deficits and loss of hippocampal acetylated α-tubulin and excitatory synaptic proteins. |
2014-07-11 |
2023-08-13 |
mouse |