| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Noriyuki Matsukaw. [The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. vol 34. issue 3. 2014-09-08. PMID:25076779. |
crmp-2 is one of microtubule-associated proteins such as tau protein, and its phosphorylated form increased in the hippocampus of alzheimer brains. |
2014-09-08 |
2023-08-13 |
mouse |
| Céline Héraud, Doris Goufak, Kunie Ando, Karelle Leroy, Valérie Suain, Zehra Yilmaz, Robert De Decker, Michèle Authelet, Vincent Laporte, Jean-Noël Octave, Jean-Pierre Brio. Increased misfolding and truncation of tau in APP/PS1/tau transgenic mice compared to mutant tau mice. Neurobiology of disease. vol 62. 2014-09-03. PMID:24076100. |
despite this reduction of aβ, a significant hippocampal neuronal loss was observed in 5xfad×tg30 but not in 5xfad mice indicating its closer association with increased tau pathology. |
2014-09-03 |
2023-08-12 |
mouse |
| G Amadoro, V Corsetti, F Florenzano, A Atlante, M T Ciotti, M P Mongiardi, R Bussani, V Nicolin, S L Nori, M Campanella, P Calissan. AD-linked, toxic NH2 human tau affects the quality control of mitochondria in neurons. Neurobiology of disease. vol 62. 2014-09-03. PMID:24411077. |
we reported that a 20-22kda nh2-tau fragment (aka nh2htau), mapping between 26 and 230 amino acids of the longest human tau isoform, is detected in cellular and animal ad models and is neurotoxic in hippocampal neurons. |
2014-09-03 |
2023-08-12 |
human |
| Russell Palm, Jaewon Chang, Jeffrey Blair, Yoelvis Garcia-Mesa, Hyoung-Gon Lee, Rudy J Castellani, Mark A Smith, Xiongwei Zhu, Gemma Casadesu. Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice. Journal of neurochemistry. vol 130. issue 1. 2014-08-28. PMID:24601954. |
contrasting previous studies in younger mice, estrogen replacement was not able to rescue behavioral deficits, reduced glycogen synthase kinase-3 beta inhibition and increased hippocampal phosphorylation of tau. |
2014-08-28 |
2023-08-12 |
mouse |
| S Chen, F-M An, L Yin, A-R Liu, D-K Yin, W-B Yao, X-D Ga. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience. vol 256. 2014-08-27. PMID:24183963. |
glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. |
2014-08-27 |
2023-08-12 |
rat |
| S Chen, F-M An, L Yin, A-R Liu, D-K Yin, W-B Yao, X-D Ga. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience. vol 256. 2014-08-27. PMID:24183963. |
herein, we investigated the effects of glp-1 receptor mediates on cell toxicity and tau hyperphosphorylation induced by advanced glycation end products (ages), which are associated with glucose toxicity, and the molecular mechanism in pc12 cells and the primary hippocampal neurons. |
2014-08-27 |
2023-08-12 |
rat |
| S Chen, F-M An, L Yin, A-R Liu, D-K Yin, W-B Yao, X-D Ga. Glucagon-like peptide-1 protects hippocampal neurons against advanced glycation end product-induced tau hyperphosphorylation. Neuroscience. vol 256. 2014-08-27. PMID:24183963. |
additionally, glucose-bsa alone did not induce significant cytotoxicity in pc12 cells, but resulted in tau hyperphosphorylation in primary hippocampal neurons in 24h. |
2014-08-27 |
2023-08-12 |
rat |
| R Killick, E M Ribe, R Al-Shawi, B Malik, C Hooper, C Fernandes, R Dobson, P M Nolan, A Lourdusamy, S Furney, K Lin, G Breen, R Wroe, A W M To, K Leroy, M Causevic, A Usardi, M Robinson, W Noble, R Williamson, K Lunnon, S Kellie, C H Reynolds, C Bazenet, A Hodges, J-P Brion, J Stephenson, J Paul Simons, Simon Loveston. Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway. Molecular psychiatry. vol 19. issue 1. 2014-08-26. PMID:23164821. |
neuronal overexpression of dkk1 in transgenic mice mimicked this aβ-induced pathway and resulted in age-dependent increases in tau phosphorylation in hippocampus and cognitive impairment. |
2014-08-26 |
2023-08-12 |
mouse |
| A S R Sierksma, D L A van den Hove, F Pfau, M Philippens, O Bruno, E Fedele, R Ricciarelli, H W M Steinbusch, T Vanmierlo, J Prickaert. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. vol 77. 2014-08-26. PMID:24067928. |
appswe/ps1de9 mice displayed lower levels of creb phosphorylation, which remained unaltered after chronic gebr-7b treatment, and higher levels of tau in the hippocampus. |
2014-08-26 |
2023-08-12 |
mouse |
| A S R Sierksma, D L A van den Hove, F Pfau, M Philippens, O Bruno, E Fedele, R Ricciarelli, H W M Steinbusch, T Vanmierlo, J Prickaert. Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology. vol 77. 2014-08-26. PMID:24067928. |
hippocampal brain-derived neurotrophic factor levels and synaptic densities were not different between experimental groups and no effects were observed on hippocampal gsk3β and tau phosphorylation or aβ levels. |
2014-08-26 |
2023-08-12 |
mouse |
| Zhi-yong Hu, Hai-yan Jin, Li-li Xu, Zhi-rui Zhu, Yi-lei Jiang, Robert Sea. Effects of sevoflurane on the expression of tau protein mRNA and Ser396/404 site in the hippocampus of developing rat brain. Paediatric anaesthesia. vol 23. issue 12. 2014-08-25. PMID:24102683. |
effects of sevoflurane on the expression of tau protein mrna and ser396/404 site in the hippocampus of developing rat brain. |
2014-08-25 |
2023-08-12 |
rat |
| Zhi-yong Hu, Hai-yan Jin, Li-li Xu, Zhi-rui Zhu, Yi-lei Jiang, Robert Sea. Effects of sevoflurane on the expression of tau protein mRNA and Ser396/404 site in the hippocampus of developing rat brain. Paediatric anaesthesia. vol 23. issue 12. 2014-08-25. PMID:24102683. |
the current study sought to investigate the effects of sevoflurane on the levels of tau phosphorylation at phosphor-ser396/404 and total tau mrna in the hippocampus of neonatal rats. |
2014-08-25 |
2023-08-12 |
rat |
| Troy T Rohn, Ryan J Day, Lindsey W Catlin, Raquel J Brown, Alexander J Rajic, Wayne W Poo. Immunolocalization of an amino-terminal fragment of apolipoprotein E in the Pick's disease brain. PloS one. vol 8. issue 12. 2014-08-18. PMID:24312462. |
co-localization of the napoecf antibody with phf-1, a general marker for pick bodies, as well as with an antibody to caspase-cleaved tau (tauc3) was evident within the hippocampus. |
2014-08-18 |
2023-08-12 |
Not clear |
| Dantao Peng, Xiuqing Pan, Ju Cui, Yueqin Ren, Jiewen Zhan. Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 32. issue 5. 2014-08-14. PMID:24335173. |
hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment. |
2014-08-14 |
2023-08-12 |
rat |
| Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
microtubule-associated protein tau is essential for long-term depression in the hippocampus. |
2014-08-11 |
2023-08-12 |
mouse |
| Tetsuya Kimura, Daniel J Whitcomb, Jihoon Jo, Philip Regan, Thomas Piers, Seonghoo Heo, Christopher Brown, Tsutomu Hashikawa, Miyuki Murayama, Heon Seok, Ioannis Sotiropoulos, Eunjoon Kim, Graham L Collingridge, Akihiko Takashima, Kwangwook Ch. Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 369. issue 1633. 2014-08-11. PMID:24298146. |
to investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (ltd) in tau knockout mice in vivo and in vitro, an effect that was replicated by rnai knockdown of tau in vitro. |
2014-08-11 |
2023-08-12 |
mouse |
| Isabel Carreras, Ann C McKee, Ji-Kyung Choi, Nurgul Aytan, Neil W Kowall, Bruce G Jenkins, Alpaslan Dedeogl. R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease. Brain research. vol 1541. 2014-07-28. PMID:24161403. |
to further understand the effects of nsaids in 3xtg-ad mice, we treated 3xtg-ad mice with r-flurbiprofen, an enantiomer of the nsaid flurbiprofen that maintains the gsm activity but has greatly reduced anti-inflammatory activity, and analyzed its effect on cognition, aß, tau, and the neurochemical profile of the hippocampus. |
2014-07-28 |
2023-08-12 |
mouse |
| Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
overexpression of 14-3-3z promotes tau phosphorylation at ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. |
2014-07-28 |
2023-08-12 |
rat |
| Hamid Y Qureshi, Dong Han, Ryen MacDonald, Hemant K Paude. Overexpression of 14-3-3z promotes tau phosphorylation at Ser262 and accelerates proteosomal degradation of synaptophysin in rat primary hippocampal neurons. PloS one. vol 8. issue 12. 2014-07-28. PMID:24367683. |
when overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in ser(262) phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. |
2014-07-28 |
2023-08-12 |
rat |
| Audrée De Montigny, Ismaël Elhiri, Julie Allyson, Michel Cyr, Guy Massicott. NMDA reduces Tau phosphorylation in rat hippocampal slices by targeting NR2A receptors, GSK3β, and PKC activities. Neural plasticity. vol 2013. 2014-07-22. PMID:24349798. |
nmda reduces tau phosphorylation in rat hippocampal slices by targeting nr2a receptors, gsk3β, and pkc activities. |
2014-07-22 |
2023-08-12 |
rat |