All Relations between microtubule-associated protein tau and hippocampus

Publication Sentence Publish Date Extraction Date Species
Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. blockade of lysosomal acid ceramidase induces glun2b-dependent tau phosphorylation in rat hippocampal slices. 2015-05-11 2023-08-13 rat
Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. from a biochemical perspective, we observed that tau phosphorylation at the ser262 epitope was highly increased in hippocampal slices preincubated with the aci, an effect totally prevented by the global nmda receptor antagonist d/l(-)-2-amino-5-phosphonovaleric acid (ap-5), the calcium chelator 1,2-bis(o-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid (bapta), and the glun2b (but not the glun2a) receptor antagonist ro25-6981. 2015-05-11 2023-08-13 rat
Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. on the other hand, preincubation of hippocampal slices with the compound kn-62, an inhibitor known to interfere with calcium/calmodulin-dependent protein kinase ii (camkii), totally abolished the effect of aci on tau phosphorylation at ser262 epitopes. 2015-05-11 2023-08-13 rat
Marie-Elaine Laurier-Laurin, Audrée De Montigny, Suzanne Attiori Essis, Michel Cyr, Guy Massicott. Blockade of lysosomal acid ceramidase induces GluN2B-dependent Tau phosphorylation in rat hippocampal slices. Neural plasticity. vol 2014. 2015-05-11. PMID:25276436. collectively, these results provide experimental evidence that ceramides play an important role in regulating tau phosphorylation in the hippocampus via a mechanism dependent on glun2b receptor subunits and camkii activation. 2015-05-11 2023-08-13 rat
Dae-Young Kim, Sun-Young Jung, Tae-Woon Kim, Kwang-Sik Lee, Kijeong Ki. Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats. Journal of exercise rehabilitation. vol 11. issue 2. 2015-05-11. PMID:25960981. in the present study, treadmill exercise suppressed hyperphosphorylation of tau in the hippocampus by decreased gsk-3β activity through pi3k/akt pathway activation in the diabetic rats. 2015-05-11 2023-08-13 rat
Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. in hippocampal homogenates from thy-tau22 mice and cortex homogenates obtained from alzheimer patients, adx215 consistently stained specific low order tau oligomers in diseased brain, which in size correspond to tau dimers. 2015-05-08 2023-08-13 mouse
Jingheng Cheng, Daoyun J. Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model. eLife. vol 2. 2015-04-23. PMID:23805379. we propose that tau pathology and/or neurodegeneration renders hippocampal circuits overwhelmed by internal information and therefore prevents them from encoding spatial memories. 2015-04-23 2023-08-12 mouse
Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng, Jun Jiang, Keqiang Ye, Xiao-Chuan Wang, Jian-Zhi Wan. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25378699. furthermore, the enhanced sumo-immunoreactivity, costained with the hyperphosphorylated tau, is detected in cerebral cortex of the ad brains, and β-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent sumoylation of the hyperphosphorylated tau. 2015-04-23 2023-08-13 rat
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Paha. A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease. PloS one. vol 9. issue 8. 2015-04-14. PMID:25089827. similarly, rns60 treatment suppressed neuronal apoptosis, attenuated tau phosphorylation, inhibited glial activation, and reduced the burden of aβ in the hippocampus and protected memory and learning in 5xfad transgenic mouse model of ad. 2015-04-14 2023-08-13 mouse
Alison Spilsbury, Satomi Miwa, Johannes Attems, Gabriele Saretzk. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632141. intriguingly, hippocampal neurons expressing tert did not contain hyperphosphorylated tau. 2015-04-07 2023-08-13 mouse
Claire Boutet, Marie Chupin, Stéphane Lehéricy, Linda Marrakchi-Kacem, Stéphane Epelbaum, Cyril Poupon, Christopher Wiggins, Alexandre Vignaud, Dominique Hasboun, Bénédicte Defontaines, Olivier Hanon, Bruno Dubois, Marie Sarazin, Lucie Hertz-Pannier, Olivier Collio. Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: a feasibility study. NeuroImage. Clinical. vol 5. 2015-03-31. PMID:25161900. in alzheimer's disease (ad), the hippocampus is an early site of tau pathology and neurodegeneration. 2015-03-31 2023-08-13 human
Meifeng Yang, Jing Lu, Junye Miao, Joshua Rizak, Jianzhen Yang, Rongwei Zhai, Jun Zhou, Jiagui Qu, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Xintian Hu, Rongqiao H. Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787915. immunohistochemical analysis of the mouse brains found increased neuronal tau phosphorylation in the hippocampus and an increased cellular apoptotic marker in hippocampal ca1 neurons (~10% of neurons displayed chromatin condensation) in the methanol-fed groups. 2015-03-30 2023-08-13 mouse
Meifeng Yang, Jing Lu, Junye Miao, Joshua Rizak, Jianzhen Yang, Rongwei Zhai, Jun Zhou, Jiagui Qu, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Xintian Hu, Rongqiao H. Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787915. the in vitro experiments suggested that formaldehyde was most likely the detrimental component of methanol toxicity related to hippocampal tau phosphorylation and the subsequent impaired memory in the mice. 2015-03-30 2023-08-13 mouse
Meifeng Yang, Junye Miao, Joshua Rizak, Rongwei Zhai, Zhengbo Wang, Tanzeel Huma, Ting Li, Na Zheng, Shihao Wu, Yingwei Zheng, Xiaona Fan, Jianzhen Yang, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Longbao Lü, Rongqiao He, Xintian H. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787917. this change coincided with increases in tau protein phosphorylation at residues t181 and s396 in cerebrospinal fluid during feeding as well as with increases in tau phosphorylated aggregates and amyloid plaques in four brain regions postmortem: the frontal lobe, parietal lobe, temporal lobe, and the hippocampus. 2015-03-30 2023-08-13 mouse
Li Lin, Shu-Sheng Yang, Jiang Chu, Lu Wang, Lin-Na Ning, Teng Zhang, Qian Jiang, Qing Tian, Jian-Zhi Wan. Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787918. simultaneously, levels of phosphorylated tau at all of the above sites were significantly increased with the activation of glycogen synthase kinase-3β in temporal cortex, frontal cortex, and/or hippocampus, but not cerebellum. 2015-03-30 2023-08-13 rat
Holly C Hunsberger, Carolyn C Rudy, Seth R Batten, Greg A Gerhardt, Miranda N Ree. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25319522. p301l tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. 2015-03-16 2023-08-13 mouse
Holly C Hunsberger, Carolyn C Rudy, Seth R Batten, Greg A Gerhardt, Miranda N Ree. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25319522. here, we used a tau mouse model of ad (rtg(taup301l)4510) to examine the effects of tau pathology on hippocampal glutamate regulation. 2015-03-16 2023-08-13 mouse
b' Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Katar\\xc3\\xadna Kr\\xc5\\xa1kov\\xc3\\xa1, Lucia Gajdo\\xc5\\xa1echov\\xc3\\xa1, \\xc5\\xa0tefan Z\\xc3\\xb3rad, Rafa\\xc5\\x82 Olszanecki, Maciej Suski, Beata Bujak-Gi\\xc5\\xbcycka, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats. BMC neuroscience. vol 15. 2015-03-12. PMID:25257559.' deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in zucker rats. 2015-03-12 2023-08-13 rat
Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E Müller, Luc Buée, David Blu. Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24780254. improved memory was associated with reduced hippocampal tau phosphorylation and proteolytic fragments. 2015-02-12 2023-08-13 mouse
Sarah A L Martin, Christine H Jameson, Stuart M Allan, Catherine B Lawrenc. Maternal high-fat diet worsens memory deficits in the triple-transgenic (3xTgAD) mouse model of Alzheimer's disease. PloS one. vol 9. issue 6. 2015-02-02. PMID:24918775. these effects of a maternal high-fat diet on memory were accompanied by a significant increase (50%) in the number of tau positive neurones in the hippocampus. 2015-02-02 2023-08-13 mouse