| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Bu\\xc3\\xa9e, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
using thy-tau22 transgenic mice, we demonstrated that hippocampal tau pathology is associated with loss of synaptic enhancement normally induced by exogenous bdnf. |
2013-09-30 |
2023-08-12 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Bu\\xc3\\xa9e, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
indeed, we observed a significant reduction of nmda-induced field excitatory postsynaptic potential depression in the hippocampus of tau mice together with a reduced phosphorylation of nr2b at the y1472, known to be critical for nmdar function. |
2013-09-30 |
2023-08-12 |
mouse |
| Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelso. ApoE4 induces A\\xce\\xb242, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23684315. |
apoe4 induces a\xce\xb242, tau, and neuronal pathology in the hippocampus of young targeted replacement apoe4 mice. |
2013-09-20 |
2023-08-12 |
mouse |
| Makoto Hara, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology. Acta neuropathologica. vol 125. issue 4. 2013-09-16. PMID:23407988. |
regional progression of neurofibrillary tangles (nfts) around the hippocampus was traced on thick sections double immunofluorolabeled with rd3 and rd4 antibodies, specific for three- and four-repeat tau, respectively. |
2013-09-16 |
2023-08-12 |
Not clear |
| Samantha Galluzzi, Cristina Geroldi, Giovanni Amicucci, Luisella Bocchio-Chiavetto, Matteo Bonetti, Cristian Bonvicini, Maria Cotelli, Roberta Ghidoni, Barbara Paghera, Orazio Zanetti, Giovanni B Frison. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD. Journal of neurology. vol 260. issue 2. 2013-09-04. PMID:23070466. |
in this study, we enrolled 58 patients with mci, and for each of them ad biomarkers (csf abeta42 and tau, temporoparietal hypometabolism on 18f-fdg pet, and hippocampal volume) were collected. |
2013-09-04 |
2023-08-12 |
Not clear |
| Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D Long. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell. vol 12. issue 2. 2013-08-27. PMID:23362919. |
whereas prcs did not affect the levels of \xce\xb2 amyloid (a\xce\xb2), they decreased tau phosphorylation in the hippocampus and alleviated the age-dependent impairment in cognitive performance. |
2013-08-27 |
2023-08-12 |
mouse |
| Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in \\xce\\xb2-amyloid-infused rats. The Journal of nutrition. vol 143. issue 7. 2013-08-26. PMID:23719224. |
yuzu treatment prevented \xce\xb2-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in ad-c rats. |
2013-08-26 |
2023-08-12 |
rat |
| Hongxia Shuai, Jinghui Zhang, Ji Zhang, Junhui Xie, Muxun Zhang, Ji Ma, Liming Zhang, Xiufeng Wan. Role of stereotaxically injected IgG from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. Brain research. vol 1486. 2013-08-23. PMID:23036273. |
role of stereotaxically injected igg from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. |
2013-08-23 |
2023-08-12 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. |
2013-08-13 |
2023-08-12 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
to this end we established an in vitro model of tauopathy based on regulatable transgenic hippocampal organotypic slice cultures prepared from mice expressing proaggregant tau repeat domain with mutation \xce\x94k280 (tau(rd)\xce\x94k). |
2013-08-13 |
2023-08-12 |
mouse |
| Eduardo Rigon Zimmer, Eduardo Kalinine, Clarissa Branco Haas, Vitor Rocco Torrez, Diogo Onofre Souza, Alexandre Pastoris Muller, Luis Valmor Portel. Pretreatment with memantine prevents Alzheimer-like alterations induced by intrahippocampal okadaic acid administration in rats. Current Alzheimer research. vol 9. issue 10. 2013-08-09. PMID:22515493. |
additionally, we measured glutamate levels in the cerebrospinal fluid (csf) and the immunocontent of cdk5, p35, p25 and phosphorylated tau (ptauser199/202) in the hippocampus. |
2013-08-09 |
2023-08-12 |
rat |
| Min-Young Noh, Kwangwoo Chun, Byung Yong Kang, Heejaung Kim, Ji-Seon Park, Han-Chang Lee, Young-Ha Kim, Saekwang Ku, Seung Hyun Ki. Newly developed glycogen synthase kinase-3 (GSK-3) inhibitors protect neuronal cells death in amyloid-beta induced cell model and in a transgenic mouse model of Alzheimer's disease. Biochemical and biophysical research communications. vol 435. issue 2. 2013-08-06. PMID:23632329. |
in particular, 50 mg/kg c-7a treated mice significantly decreased the level of phosphorylated tau (ser396) in brain hippocampus. |
2013-08-06 |
2023-08-12 |
mouse |
| S Duke Han, Jonathan Gruhl, Laurel Beckett, Hiroko H Dodge, Nikki H Stricker, Sarah Farias, Dan Munga. Beta amyloid, tau, neuroimaging, and cognition: sequence modeling of biomarkers for Alzheimer's Disease. Brain imaging and behavior. vol 6. issue 4. 2013-08-02. PMID:22648764. |
we examined temporal relations among four classes of biomarkers: csf a\xce\xb2, csf tau, neuroimaging variables (hippocampal volume, ventricular volume, fdg pet), and cognitive variables (memory and executive function). |
2013-08-02 |
2023-08-12 |
Not clear |
| Chuang Guo, Pu Wang, Man-Li Zhong, Tao Wang, Xue-Shi Huang, Jia-Yi Li, Zhan-You Wan. Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain. Neurochemistry international. vol 62. issue 2. 2013-07-22. PMID:23262393. |
deferoxamine inhibits iron induced hippocampal tau phosphorylation in the alzheimer transgenic mouse brain. |
2013-07-22 |
2023-08-12 |
mouse |
| Reisuke H Takahashi, Estibaliz Capetillo-Zarate, Michael T Lin, Teresa A Milner, Gunnar K Goura. Accumulation of intraneuronal \\xce\\xb2-amyloid 42 peptides is associated with early changes in microtubule-associated protein 2 in neurites and synapses. PloS one. vol 8. issue 1. 2013-07-22. PMID:23372648. |
we previously provided evidence for early co-localization of a\xce\xb242 peptides and hyperphosphorylated tau within postsynaptic terminals of ca1 dendrites in the hippocampus of ad transgenic mice. |
2013-07-22 |
2023-08-12 |
mouse |
| Cassia R Overk, Sylvia E Perez, Chunqi Ma, Matthew D Taves, Kiran K Soma, Elliott J Mufso. Sex steroid levels and AD-like pathology in 3xTgAD mice. Journal of neuroendocrinology. vol 25. issue 2. 2013-07-12. PMID:22889357. |
the age-related increase in hippocampal testosterone levels correlated positively with increases in the conformational tau isoform, alz50. |
2013-07-12 |
2023-08-12 |
mouse |
| Larry D Sparks, Richard J Kryscio, John C Hunsake. Early age-related progression of AD-like neuropathology in Down's syndrome. American journal of neurodegenerative disease. vol 2. issue 2. 2013-07-11. PMID:23844336. |
50 \xce\xbcm vibratome sections of formalin fixed hippocampal formations were immunohistochemically stained for amyloid-\xce\xb2 (6e10), app (22c11) and phosphorylated tau (at8) using standard methods. |
2013-07-11 |
2023-08-12 |
human |
| Linn Hege Nilsen, Caroline Rae, Lars M Ittner, J\\xc3\\xbcrgen G\\xc3\\xb6tz, Ursula Sonnewal. Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 5. 2013-06-28. PMID:23340677. |
overall, we revealed that astrocytes as well as glutamatergic and gabaergic neurons in the cortex of pr5 mice were in a hypermetabolic state, whereas in the hippocampus, where expression levels of mutant human tau are the highest, glutamate homeostasis was impaired. |
2013-06-28 |
2023-08-12 |
mouse |
| Lei Wang, Anne M Fagan, Aarti R Shah, Mirza Faisal Beg, John G Csernansky, John C Morris, David M Holtzma. Cerebrospinal fluid proteins predict longitudinal hippocampal degeneration in early-stage dementia of the Alzheimer type. Alzheimer disease and associated disorders. vol 26. issue 4. 2013-06-26. PMID:22156755. |
the present study was conducted to assess the relationship between csf a\xce\xb2 and tau protein levels and longitudinal measures of hippocampal structure in individuals with and without very mild dementia of the alzheimer type. |
2013-06-26 |
2023-08-12 |
Not clear |
| Bruno M Jedynak, Andrew Lang, Bo Liu, Elyse Katz, Yanwei Zhang, Bradley T Wyman, David Raunig, C Pierre Jedynak, Brian Caffo, Jerry L Princ. A computational neurodegenerative disease progression score: method and results with the Alzheimer's disease Neuroimaging Initiative cohort. NeuroImage. vol 63. issue 3. 2013-06-25. PMID:22885136. |
the group of biomarkers comprising the volume of the hippocampus and the protein concentration amyloid beta and tau were next in the timeline, and these were followed by three cognitive biomarkers. |
2013-06-25 |
2023-08-12 |
human |