| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Zhang, Liyun Chen, Guangli Shen, Qian Zhao, Lijuan Shangguan, Maolin H. GRK5 dysfunction accelerates tau hyperphosphorylation in APP (swe) mice through impaired cholinergic activity. Neuroreport. vol 25. issue 7. 2014-11-28. PMID:24598771. |
moreover, treatment with methoctramine, a selective m2 antagonist, partially corrected the difference between wild-type control mice and grk5-dysfunctional app (swe) mice in hippocampal ach release, pkc and gsk3β activities, as well as tau hyperphosphorylation. |
2014-11-28 |
2023-08-12 |
mouse |
| Kristyn Bates, Robert Vink, Ralph Martins, Alan Harve. Aging, cortical injury and Alzheimer's disease-like pathology in the guinea pig brain. Neurobiology of aging. vol 35. issue 6. 2014-11-25. PMID:24360504. |
diffuse deposits of aβ were found in the hippocampal region of the oldest animals and alterations in amyloid precursor protein processing and tau immunoreactivity were observed with age. |
2014-11-25 |
2023-08-12 |
human |
| T L Briones, H Darwis. Decrease in age-related tau hyperphosphorylation and cognitive improvement following vitamin D supplementation are associated with modulation of brain energy metabolism and redox state. Neuroscience. vol 262. 2014-11-24. PMID:24412233. |
tau phosphorylation, markers of brain energy metabolism (adp/atp ratio and adenosine monophosphate-activated protein kinase) and redox state (levels of reactive oxygen species, activity of superoxide dismutase, and glutathione levels) as well as pp2a activity were measured in hippocampal tissues. |
2014-11-24 |
2023-08-12 |
rat |
| Lai-Ling Du, Jia-Zhao Xie, Xiang-Shu Cheng, Xiao-Hong Li, Fan-Li Kong, Xia Jiang, Zhi-Wei Ma, Jian-Zhi Wang, Chen Chen, Xin-Wen Zho. Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi. Age (Dordrecht, Netherlands). vol 36. issue 2. 2014-11-18. PMID:24142524. |
in conclusion, sirt1 protects hippocampus neurons from tau hyperphosphorylation and prevents cognitive impairment induced by icv-stz brain insulin resistance with decreased hippocampus erk1/2 activity. |
2014-11-18 |
2023-08-12 |
rat |
| Huda S Darusman, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A Putri, Otto H Kalliokoski, Josep Call, Klas S P Abelson, Steven J Schapiro, Albert Gjedde, Jann Ha. Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. In vivo (Athens, Greece). vol 28. issue 2. 2014-11-06. PMID:24632970. |
poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. |
2014-11-06 |
2023-08-12 |
monkey |
| Pamela Salcedo-Tello, Karina Hernández-Ortega, Clorinda Aria. Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after Wnt signaling inhibition. Journal of Alzheimer's disease : JAD. vol 39. issue 4. 2014-10-30. PMID:24270208. |
susceptibility to gsk3β-induced tau phosphorylation differs between the young and aged hippocampus after wnt signaling inhibition. |
2014-10-30 |
2023-08-12 |
rat |
| Pamela Salcedo-Tello, Karina Hernández-Ortega, Clorinda Aria. Susceptibility to GSK3β-induced tau phosphorylation differs between the young and aged hippocampus after Wnt signaling inhibition. Journal of Alzheimer's disease : JAD. vol 39. issue 4. 2014-10-30. PMID:24270208. |
here, we report that the wnt antagonist dkk-1 selectively increases tau phosphorylation in the hippocampus of aged rats at ser199/202, ser396/404, and ser214 sites. |
2014-10-30 |
2023-08-12 |
rat |
| Mar Pérez, Raquel Cuadros, Noemi Pallas-Bazarra, Carlos García, Elena Langa, Jerónimo Jurado-Arjona, Félix Hernández, Jesús Avil. Boronate-tau mediated uptake in neurons. Journal of Alzheimer's disease : JAD. vol 40. issue 1. 2014-10-30. PMID:24366920. |
our results indicate that the incorporated tau promotes the formation of cytoplasmic extensions in non-neuronal cells, as well as the appearance of neurites in cultured tau knockout hippocampal neurons. |
2014-10-30 |
2023-08-12 |
mouse |
| Mar Pérez, Raquel Cuadros, Noemi Pallas-Bazarra, Carlos García, Elena Langa, Jerónimo Jurado-Arjona, Félix Hernández, Jesús Avil. Boronate-tau mediated uptake in neurons. Journal of Alzheimer's disease : JAD. vol 40. issue 1. 2014-10-30. PMID:24366920. |
in addition, boronated tau is incorporated into hippocampal neurons of tau knockout mice after intracranial injection in vivo. |
2014-10-30 |
2023-08-12 |
mouse |
| Zhong-Sen Qu, Liang Li, Xiao-Jiang Sun, Yu-Wu Zhao, Jin Zhang, Zhi Geng, Jian-Liang Fu, Qing-Guo Re. Glycogen synthase kinase-3 regulates production of amyloid-β peptides and tau phosphorylation in diabetic rat brain. TheScientificWorldJournal. vol 2014. 2014-10-28. PMID:24983010. |
and a β 40 and a β 42 were found overproduced and the microtubule-associated protein tau was hyperphosphorylated in the hippocampus. |
2014-10-28 |
2023-08-13 |
rat |
| Natalia A Stefanova, Oyuna S Kozhevnikova, Anton O Vitovtov, Kseniya Yi Maksimova, Sergey V Logvinov, Ekaterina A Rudnitskaya, Elena E Korbolina, Natalia A Muraleva, Nataliya G Kolosov. Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease. Cell cycle (Georgetown, Tex.). vol 13. issue 6. 2014-10-22. PMID:24552807. |
we have shown that this deterioration happens against the background of overproduction of amyloid precursor protein (aβpp), accumulation of β-amyloid (aβ), and hyperphosphorylation of the tau protein in the hippocampus and cortex. |
2014-10-22 |
2023-08-12 |
human |
| Haijian Liu, Hao Wen. Up-regulation of Alzheimer's disease-associated proteins may cause enflurane anesthesia induced cognitive decline in aged rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 2. 2014-10-21. PMID:23934553. |
in addition, we analyzed the expression level of β-amyloid and phosphorylation level of tau in the hippocampus by immunoblotting. |
2014-10-21 |
2023-08-12 |
rat |
| Haijian Liu, Hao Wen. Up-regulation of Alzheimer's disease-associated proteins may cause enflurane anesthesia induced cognitive decline in aged rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 2. 2014-10-21. PMID:23934553. |
interestingly, the levels of β-amyloid and phosphorylated tau in the hippocampus increased significantly at early stage and then restored to pre-anesthetic levels. |
2014-10-21 |
2023-08-12 |
rat |
| Yan-Fang Xian, Qing-Qiu Mao, Justin C Y Wu, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Siu-Po Ip, Zhi-Xiu Li. Isorhynchophylline treatment improves the amyloid-β-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation. Journal of Alzheimer's disease : JAD. vol 39. issue 2. 2014-10-21. PMID:24164737. |
in the present study, we aimed to investigate the effect of irn on cognitive function, neuronal apoptosis, and tau protein hyperphosphorylation in the hippocampus of the aβ25-35-treated rats and to elucidate its action mechanisms. |
2014-10-21 |
2023-08-12 |
rat |
| Yan-Fang Xian, Qing-Qiu Mao, Justin C Y Wu, Zi-Ren Su, Jian-Nan Chen, Xiao-Ping Lai, Siu-Po Ip, Zhi-Xiu Li. Isorhynchophylline treatment improves the amyloid-β-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation. Journal of Alzheimer's disease : JAD. vol 39. issue 2. 2014-10-21. PMID:24164737. |
in addition, irn attenuated the aβ25-35-induced neuronal apoptosis in hippocampus by down-regulating the protein and mrna levels of the ratio of bcl-2/bax, cleaved caspase-3 and caspase-9, as well as suppressing the tau protein hyperphosphorylation at the ser396, ser404, and thr205 sites. |
2014-10-21 |
2023-08-12 |
rat |
| Tetsuro Tago, Shozo Furumoto, Nobuyuki Okamura, Ryuichi Harada, Yoichi Ishikawa, Hiroyuki Arai, Kazuhiko Yanai, Ren Iwata, Yukitsuka Kud. Synthesis and preliminary evaluation of 2-arylhydroxyquinoline derivatives for tau imaging. Journal of labelled compounds & radiopharmaceuticals. vol 57. issue 1. 2014-10-09. PMID:24448742. |
the binding affinities of compounds for tau were evaluated by fluorescent staining of the ad hippocampal section and a competitive binding assay using [(18) f]thk-523. |
2014-10-09 |
2023-08-12 |
mouse |
| Xiao-Tian Huang, Zhong-Ming Qian, Xuan He, Qi Gong, Ka-Chun Wu, Li-Rong Jiang, Li-Na Lu, Zhou-Jing Zhu, Hai-Yan Zhang, Wing-Ho Yung, Ya K. Reducing iron in the brain: a novel pharmacologic mechanism of huperzine A in the treatment of Alzheimer's disease. Neurobiology of aging. vol 35. issue 5. 2014-10-06. PMID:24332448. |
hupa treatment reduced insoluble and soluble beta amyloid levels, ameliorated amyloid plaques formation, and hyperphosphorylated tau in the cortex and hippocampus of appswe/ps1de9 transgenic ad mice. |
2014-10-06 |
2023-08-12 |
mouse |
| Ilie-Cosmin Stancu, Laurence Ris, Bruno Vasconcelos, Claudia Marinangeli, Léonie Goeminne, Vincent Laporte, Laetitia E Haylani, Julien Couturier, Olivier Schakman, Philippe Gailly, Nathalie Pierrot, Pascal Kienlen-Campard, Jean-Noël Octave, Ilse Dewachte. Tauopathy contributes to synaptic and cognitive deficits in a murine model for Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 28. issue 6. 2014-10-06. PMID:24604080. |
our data indicate for the first time that pathological aβ species (or app/ps1) induced changes in tau contribute to cognitive deficits correlating with synaptic deficits and hippocampal atrophy in an ad model. |
2014-10-06 |
2023-08-12 |
mouse |
| Mikio Shoj. [Alzheimer's disease: a type of cerebral amyloidosis]. Brain and nerve = Shinkei kenkyu no shinpo. vol 66. issue 7. 2014-10-06. PMID:24998828. |
diagnosis is defined by the presence of dementia, the exclusion of non-alzheimer type dementia, progressive atrophy of the hippocampus and temporoparietal cortex, decreased blood flow and glucose metabolism in the posterior cingulate gyrus and precuneus, decreased levels of aβ42, and increased levels of tau in the cerebrospinal fluid accompanied by positive amyloid proton emission tomography. |
2014-10-06 |
2023-08-13 |
Not clear |
| Julia Banzhaf-Strathmann, Eva Benito, Stephanie May, Thomas Arzberger, Sabina Tahirovic, Hans Kretzschmar, André Fischer, Dieter Edbaue. MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease. The EMBO journal. vol 33. issue 15. 2014-09-30. PMID:25001178. |
injecting mir-125b into the hippocampus of mice impairs associative learning and is accompanied by downregulation of bcl-w, dusp6, and ppp1ca, resulting in increased tau phosphorylation in vivo. |
2014-09-30 |
2023-08-13 |
mouse |