| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dae-Young Kim, Sun-Young Jung, Tae-Woon Kim, Kwang-Sik Lee, Kijeong Ki. Treadmill exercise decreases incidence of Alzheimer's disease by suppressing glycogen synthase kinase-3β expression in streptozotocin-induced diabetic rats. Journal of exercise rehabilitation. vol 11. issue 2. 2015-05-11. PMID:25960981. |
in the present study, treadmill exercise suppressed hyperphosphorylation of tau in the hippocampus by decreased gsk-3β activity through pi3k/akt pathway activation in the diabetic rats. |
2015-05-11 |
2023-08-13 |
rat |
| Joëlle Rosseels, Jeff Van den Brande, Marie Violet, Dirk Jacobs, Pierre Grognet, Juan Lopez, Isabelle Huvent, Marina Caldara, Erwin Swinnen, Anthony Papegaey, Raphaëlle Caillierez, Valerie Buée-Scherrer, Sebastiaan Engelborghs, Guy Lippens, Morvane Colin, Luc Buée, Marie-Christine Galas, Eugeen Vanmechelen, Joris Winderick. Tau monoclonal antibody generation based on humanized yeast models: impact on Tau oligomerization and diagnostics. The Journal of biological chemistry. vol 290. issue 7. 2015-05-08. PMID:25540200. |
in hippocampal homogenates from thy-tau22 mice and cortex homogenates obtained from alzheimer patients, adx215 consistently stained specific low order tau oligomers in diseased brain, which in size correspond to tau dimers. |
2015-05-08 |
2023-08-13 |
mouse |
| Jingheng Cheng, Daoyun J. Rigid firing sequences undermine spatial memory codes in a neurodegenerative mouse model. eLife. vol 2. 2015-04-23. PMID:23805379. |
we propose that tau pathology and/or neurodegeneration renders hippocampal circuits overwhelmed by internal information and therefore prevents them from encoding spatial memories. |
2015-04-23 |
2023-08-12 |
mouse |
| Hong-Bin Luo, Yi-Yuan Xia, Xi-Ji Shu, Zan-Chao Liu, Ye Feng, Xing-Hua Liu, Guang Yu, Gang Yin, Yan-Si Xiong, Kuan Zeng, Jun Jiang, Keqiang Ye, Xiao-Chuan Wang, Jian-Zhi Wan. SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination. Proceedings of the National Academy of Sciences of the United States of America. vol 111. issue 46. 2015-04-23. PMID:25378699. |
furthermore, the enhanced sumo-immunoreactivity, costained with the hyperphosphorylated tau, is detected in cerebral cortex of the ad brains, and β-amyloid exposure of rat primary hippocampal neurons induces a dose-dependent sumoylation of the hyperphosphorylated tau. |
2015-04-23 |
2023-08-13 |
rat |
| Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Paha. A physically-modified saline suppresses neuronal apoptosis, attenuates tau phosphorylation and protects memory in an animal model of Alzheimer's disease. PloS one. vol 9. issue 8. 2015-04-14. PMID:25089827. |
similarly, rns60 treatment suppressed neuronal apoptosis, attenuated tau phosphorylation, inhibited glial activation, and reduced the burden of aβ in the hippocampus and protected memory and learning in 5xfad transgenic mouse model of ad. |
2015-04-14 |
2023-08-13 |
mouse |
| Alison Spilsbury, Satomi Miwa, Johannes Attems, Gabriele Saretzk. The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 4. 2015-04-07. PMID:25632141. |
intriguingly, hippocampal neurons expressing tert did not contain hyperphosphorylated tau. |
2015-04-07 |
2023-08-13 |
mouse |
| Claire Boutet, Marie Chupin, Stéphane Lehéricy, Linda Marrakchi-Kacem, Stéphane Epelbaum, Cyril Poupon, Christopher Wiggins, Alexandre Vignaud, Dominique Hasboun, Bénédicte Defontaines, Olivier Hanon, Bruno Dubois, Marie Sarazin, Lucie Hertz-Pannier, Olivier Collio. Detection of volume loss in hippocampal layers in Alzheimer's disease using 7 T MRI: a feasibility study. NeuroImage. Clinical. vol 5. 2015-03-31. PMID:25161900. |
in alzheimer's disease (ad), the hippocampus is an early site of tau pathology and neurodegeneration. |
2015-03-31 |
2023-08-13 |
human |
| Meifeng Yang, Jing Lu, Junye Miao, Joshua Rizak, Jianzhen Yang, Rongwei Zhai, Jun Zhou, Jiagui Qu, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Xintian Hu, Rongqiao H. Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787915. |
immunohistochemical analysis of the mouse brains found increased neuronal tau phosphorylation in the hippocampus and an increased cellular apoptotic marker in hippocampal ca1 neurons (~10% of neurons displayed chromatin condensation) in the methanol-fed groups. |
2015-03-30 |
2023-08-13 |
mouse |
| Meifeng Yang, Jing Lu, Junye Miao, Joshua Rizak, Jianzhen Yang, Rongwei Zhai, Jun Zhou, Jiagui Qu, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Xintian Hu, Rongqiao H. Alzheimer's disease and methanol toxicity (part 1): chronic methanol feeding led to memory impairments and tau hyperphosphorylation in mice. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787915. |
the in vitro experiments suggested that formaldehyde was most likely the detrimental component of methanol toxicity related to hippocampal tau phosphorylation and the subsequent impaired memory in the mice. |
2015-03-30 |
2023-08-13 |
mouse |
| Meifeng Yang, Junye Miao, Joshua Rizak, Rongwei Zhai, Zhengbo Wang, Tanzeel Huma, Ting Li, Na Zheng, Shihao Wu, Yingwei Zheng, Xiaona Fan, Jianzhen Yang, Jianhong Wang, Shangchuan Yang, Yuanye Ma, Longbao Lü, Rongqiao He, Xintian H. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787917. |
this change coincided with increases in tau protein phosphorylation at residues t181 and s396 in cerebrospinal fluid during feeding as well as with increases in tau phosphorylated aggregates and amyloid plaques in four brain regions postmortem: the frontal lobe, parietal lobe, temporal lobe, and the hippocampus. |
2015-03-30 |
2023-08-13 |
mouse |
| Li Lin, Shu-Sheng Yang, Jiang Chu, Lu Wang, Lin-Na Ning, Teng Zhang, Qian Jiang, Qing Tian, Jian-Zhi Wan. Region-specific expression of tau, amyloid-β protein precursor, and synaptic proteins at physiological condition or under endoplasmic reticulum stress in rats. Journal of Alzheimer's disease : JAD. vol 41. issue 4. 2015-03-30. PMID:24787918. |
simultaneously, levels of phosphorylated tau at all of the above sites were significantly increased with the activation of glycogen synthase kinase-3β in temporal cortex, frontal cortex, and/or hippocampus, but not cerebellum. |
2015-03-30 |
2023-08-13 |
rat |
| Holly C Hunsberger, Carolyn C Rudy, Seth R Batten, Greg A Gerhardt, Miranda N Ree. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25319522. |
p301l tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. |
2015-03-16 |
2023-08-13 |
mouse |
| Holly C Hunsberger, Carolyn C Rudy, Seth R Batten, Greg A Gerhardt, Miranda N Ree. P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway. Journal of neurochemistry. vol 132. issue 2. 2015-03-16. PMID:25319522. |
here, we used a tau mouse model of ad (rtg(taup301l)4510) to examine the effects of tau pathology on hippocampal glutamate regulation. |
2015-03-16 |
2023-08-13 |
mouse |
| b' Andrea \\xc5\\xa0polcov\\xc3\\xa1, Barbora Mikul\\xc3\\xa1\\xc5\\xa1kov\\xc3\\xa1, Katar\\xc3\\xadna Kr\\xc5\\xa1kov\\xc3\\xa1, Lucia Gajdo\\xc5\\xa1echov\\xc3\\xa1, \\xc5\\xa0tefan Z\\xc3\\xb3rad, Rafa\\xc5\\x82 Olszanecki, Maciej Suski, Beata Bujak-Gi\\xc5\\xbcycka, Blanka \\xc5\\xbdelezn\\xc3\\xa1, Lenka Malet\\xc3\\xadnsk\\xc3\\xa. Deficient hippocampal insulin signaling and augmented Tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in Zucker rats. BMC neuroscience. vol 15. 2015-03-12. PMID:25257559.' |
deficient hippocampal insulin signaling and augmented tau phosphorylation is related to obesity- and age-induced peripheral insulin resistance: a study in zucker rats. |
2015-03-12 |
2023-08-13 |
rat |
| Cyril Laurent, Sabiha Eddarkaoui, Maxime Derisbourg, Antoine Leboucher, Dominique Demeyer, Sébastien Carrier, Marion Schneider, Malika Hamdane, Christa E Müller, Luc Buée, David Blu. Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology. Neurobiology of aging. vol 35. issue 9. 2015-02-12. PMID:24780254. |
improved memory was associated with reduced hippocampal tau phosphorylation and proteolytic fragments. |
2015-02-12 |
2023-08-13 |
mouse |
| Sarah A L Martin, Christine H Jameson, Stuart M Allan, Catherine B Lawrenc. Maternal high-fat diet worsens memory deficits in the triple-transgenic (3xTgAD) mouse model of Alzheimer's disease. PloS one. vol 9. issue 6. 2015-02-02. PMID:24918775. |
these effects of a maternal high-fat diet on memory were accompanied by a significant increase (50%) in the number of tau positive neurones in the hippocampus. |
2015-02-02 |
2023-08-13 |
mouse |
| Guoli Song, Zhonghao Zhang, Lei Wen, Chen Chen, Qingxue Shi, Yu Zhang, Jiazuan Ni, Qiong Li. Selenomethionine ameliorates cognitive decline, reduces tau hyperphosphorylation, and reverses synaptic deficit in the triple transgenic mouse model of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 41. issue 1. 2015-01-29. PMID:24577479. |
se-met treatment significantly reduced the level of total tau and phosphorylated tau, mitigated the decrease of synaptic proteins including synaptophysin and postsynaptic density protein 95 in the hippocampus and cortex of the 3 × tg-ad mice. |
2015-01-29 |
2023-08-12 |
mouse |
| E Orta-Salazar, A Aguilar-Vázquez, H Martínez-Coria, S Luquín-De Anda, M Rivera-Cervantes, C Beas-Zarate, A Feria-Velasco, S Díaz-Cintr. REST/NRSF-induced changes of ChAT protein expression in the neocortex and hippocampus of the 3xTg-AD mouse model for Alzheimer's disease. Life sciences. vol 116. issue 2. 2015-01-28. PMID:25261598. |
the objective of this work was to determine the rest/nrsf involvement in altered chat expression in the neocortex and hippocampus of an ad transgenic mouse (homozygous 3xtg-ad) that over-expresses 3 proteins, amyloid-β precursor protein, presenilin-1, and tau, all of which are associated with ad and cause cellular degeneration. |
2015-01-28 |
2023-08-13 |
mouse |
| Wenqing Yang, Jing Ma, Zheng Liu, Yongliang Lu, Bin Hu, Huarong Y. Effect of naringenin on brain insulin signaling and cognitive functions in ICV-STZ induced dementia model of rats. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 35. issue 5. 2015-01-27. PMID:24337945. |
in addition, nar reversed icv-stz induced tau hyper-phosphorylation in both hippocampus and cerebral cortex through downregulation of glycogen synthase kinase-3β (gsk-3β) activity, a key kinase in the insulin signaling. |
2015-01-27 |
2023-08-12 |
rat |
| Li-Feng Zhang, Lv Shi, Hui Liu, Fan-Tao Meng, Ya-Jing Liu, Hui-Mei Wu, Xin Du, Jiang-Ning Zho. Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21418733. |
increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress. |
2015-01-22 |
2023-08-12 |
mouse |