| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li-Feng Zhang, Lv Shi, Hui Liu, Fan-Tao Meng, Ya-Jing Liu, Hui-Mei Wu, Xin Du, Jiang-Ning Zho. Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21418733. |
crh receptor 1 antagonist (cp154,526) treatment, not glucocorticoid receptor antagonist (ru486) treatment, decreased tau phosphorylation and synaptosomal mitochondrial levels in the hippocampus of the mouse model. |
2015-01-22 |
2023-08-12 |
mouse |
| Li-Feng Zhang, Lv Shi, Hui Liu, Fan-Tao Meng, Ya-Jing Liu, Hui-Mei Wu, Xin Du, Jiang-Ning Zho. Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21418733. |
consistent with an in-vivo model, when hyperphosphorylated tau was inhibited by lithium in cultured primary hippocampal neurons, mitochondrial transport monitored by live imaging was also decreased. |
2015-01-22 |
2023-08-12 |
mouse |
| Li-Feng Zhang, Lv Shi, Hui Liu, Fan-Tao Meng, Ya-Jing Liu, Hui-Mei Wu, Xin Du, Jiang-Ning Zho. Increased hippocampal tau phosphorylation and axonal mitochondrial transport in a mouse model of chronic stress. The international journal of neuropsychopharmacology. vol 15. issue 3. 2015-01-22. PMID:21418733. |
we show here for the first time that phosphorylated tau in the hippocampus of a chronic stress model, accompanied by increased mitochondrial transport, was mediated by crh receptor 1, not by glucocorticoid receptors, which suggests that centrally derived crh may be involved in the process of mitochondrial axon transport and hence play an important role in hippocampus of a chronic stress model. |
2015-01-22 |
2023-08-12 |
mouse |
| Ming-Jang Chiu, Ya-Fang Chen, Ta-Fu Chen, Shieh-Yueh Yang, Fan-Pei Gloria Yang, Tien-Wen Tseng, Jen-Jie Chieh, Jia-Chun Rare Chen, Kai-Yuan Tzen, Mau-Sun Hua, Herng-Er Horn. Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer's disease. Human brain mapping. vol 35. issue 7. 2015-01-22. PMID:24129926. |
neurofibrillary tangles are associated with cognitive dysfunction, and hippocampal atrophy with increased csf tau markers. |
2015-01-22 |
2023-08-12 |
Not clear |
| Ming-Jang Chiu, Ya-Fang Chen, Ta-Fu Chen, Shieh-Yueh Yang, Fan-Pei Gloria Yang, Tien-Wen Tseng, Jen-Jie Chieh, Jia-Chun Rare Chen, Kai-Yuan Tzen, Mau-Sun Hua, Herng-Er Horn. Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer's disease. Human brain mapping. vol 35. issue 7. 2015-01-22. PMID:24129926. |
plasma tau levels were negatively associated with the performance of logical memory, visual reproduction, and verbal fluency; also negatively associated with volume of total gray matter, hippocampus, amygdala; and gray matter densities of various regions. |
2015-01-22 |
2023-08-12 |
Not clear |
| Ming-Jang Chiu, Ya-Fang Chen, Ta-Fu Chen, Shieh-Yueh Yang, Fan-Pei Gloria Yang, Tien-Wen Tseng, Jen-Jie Chieh, Jia-Chun Rare Chen, Kai-Yuan Tzen, Mau-Sun Hua, Herng-Er Horn. Plasma tau as a window to the brain-negative associations with brain volume and memory function in mild cognitive impairment and early Alzheimer's disease. Human brain mapping. vol 35. issue 7. 2015-01-22. PMID:24129926. |
regression analyses indicated that logical memory explained 0.394 and hippocampus volume predicted .608 of the variance of plasma tau levels, both p < 0.001. |
2015-01-22 |
2023-08-12 |
Not clear |
| Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Il-Sun Kwon, Duc M Duong, Nicholas T Seyfried, William T Hu, Zhixue Liu, Jian-Zhi Wang, Liming Cheng, Yi E Sun, Shan Ping Yu, Allan I Levey, Keqiang Y. Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease. Nature medicine. vol 20. issue 11. 2015-01-19. PMID:25326800. |
tau p301s-transgenic mice with deletion of the gene encoding aep show substantially reduced tau hyperphosphorylation, less synapse loss and rescue of impaired hippocampal synaptic function and cognitive deficits. |
2015-01-19 |
2023-08-13 |
mouse |
| Kunie Ando, Anna Kabova, Virginie Stygelbout, Karelle Leroy, Céline Heraud, Christelle Frédérick, Valérie Suain, Zehra Yilmaz, Michèle Authelet, Robert Dedecker, Marie-Claude Potier, Charles Duyckaerts, Jean-Pierre Brio. Vaccination with Sarkosyl insoluble PHF-tau decrease neurofibrillary tangles formation in aged tau transgenic mouse model: a pilot study. Journal of Alzheimer's disease : JAD. vol 40 Suppl 1. 2015-01-16. PMID:24614899. |
immunized mutant tau mice had a lower density of hippocampal gallyas-positive neurons. |
2015-01-16 |
2023-08-12 |
mouse |
| Yu-Jing Liu, Yu F. [Progress of experimental research on treating Alzheimer's disease by acupuncture]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 34. issue 3. 2015-01-05. PMID:24758091. |
senile dementia rats' cognitive capabilities and memory could be improved by reduction of beta-amyloid protein, attenuation of excessive phosphorylation of tau protein, regulation of center neurotransmitter dysmetabolism, oxidation of anti-free radicals, reduction of neuron apoptosis in the cortex and the hippocampus, inhibition of glial cells' differentiation, adjustment of g protein signaling transduction, and improvement of the mitochondrial dysfunction, thus providing experimental evidence for treating ad by acupuncture. |
2015-01-05 |
2023-08-13 |
rat |
| João Carlos Diegues, José Rodrigo Pauli, Eliete Luciano, José Alexandre Curiacos de Almeida Leme, Leandro Pereira de Moura, Rodrigo Augusto Dalia, Michel Barbosa de Araújo, Clarice Yoshiko Sibuya, Maria Alice Rostom de Mello, Ricardo José Gome. Spatial memory in sedentary and trained diabetic rats: molecular mechanisms. Hippocampus. vol 24. issue 6. 2015-01-02. PMID:24916112. |
hippocampus was extracted to determinate protein expression (ir, igf-1r, and app) and phosphorylation (akt-1, akt-2, tau, and β-amyloide proteins) by western blot analysis. |
2015-01-02 |
2023-08-13 |
rat |
| João Carlos Diegues, José Rodrigo Pauli, Eliete Luciano, José Alexandre Curiacos de Almeida Leme, Leandro Pereira de Moura, Rodrigo Augusto Dalia, Michel Barbosa de Araújo, Clarice Yoshiko Sibuya, Maria Alice Rostom de Mello, Ricardo José Gome. Spatial memory in sedentary and trained diabetic rats: molecular mechanisms. Hippocampus. vol 24. issue 6. 2015-01-02. PMID:24916112. |
aerobic exercise decreased tau phosphorylation and app expression, and increased some proteins related to insulin/igf-1 pathway in hippocampus of diabetic rats. |
2015-01-02 |
2023-08-13 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
role of nmda receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
the aim of the present study was to evaluate the role of nmda receptors in noise-induced tau hyperphosphorylation in the rat hippocampus and prefrontal cortex. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
the levels of tau phosphorylated at ser202 and ser396, and proteins involved in hyperphosphorylation, namely glycogen synthase kinase 3β (gsk3β) and protein phosphatase 2a (pp2a), were measured in the hippocampus and prefrontal cortex (pfc) after the last noise exposure. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
we showed that phosphorylated tau levels were enhanced in noise-exposed-rat hippocampus and pfc. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
mk-801 decreased the hyperphosphorylation of tau at ser202 and ser396 sites in the hippocampus and pfc. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
this suggests that mk-801 protects against chronic-noise-induced tau hyperphosphorylation in the hippocampus and pfc. |
2014-12-22 |
2023-08-12 |
rat |
| Kang Li, Hengchuan Jia, Xiaojun She, Bo Cui, Na Zhang, Xuewei Chen, Chuanxiang Xu, Gaihong An, Qiang M. Role of NMDA receptors in noise-induced tau hyperphosphorylation in rat hippocampus and prefrontal cortex. Journal of the neurological sciences. vol 340. issue 1-2. 2014-12-22. PMID:24685355. |
these findings demonstrate that glu-nmdar signaling may be involved in triggering aberrant tau hyperphosphorylation in the hippocampus and pfc after chronic noise exposure. |
2014-12-22 |
2023-08-12 |
rat |
| Ken C Walls, Rahasson R Ager, Vitaly Vasilevko, Dave Cheng, Rodrigo Medeiros, Frank M LaFerl. p-Tau immunotherapy reduces soluble and insoluble tau in aged 3xTg-AD mice. Neuroscience letters. vol 575. 2014-12-22. PMID:24887583. |
to determine the effectiveness of targeting pathological tau, with aβ pathology present, we administered a single injection of at8, or control antibody, into the hippocampus of aged 3xtg-ad mice. |
2014-12-22 |
2023-08-13 |
mouse |
| C Yang, X Guo, G H Wang, H L Wang, Z C Liu, H Liu, Z X Zhu, Y L. Changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 47. issue 3. 2014-12-19. PMID:24652321. |
changes in tau phosphorylation levels in the hippocampus and frontal cortex following chronic stress. |
2014-12-19 |
2023-08-12 |
rat |