| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun-Qing Ma, Dong-Ke Wu, Jian-Kun Li. mTOR and tau phosphorylated proteins in the hippocampal tissue of rats with type 2 diabetes and Alzheimer's disease. Molecular medicine reports. vol 7. issue 2. 2013-11-04. PMID:23165862. |
t2dm may excessively activate mtor in the hippocampal tissue by impairing insulin signaling, thereby increasing the extent of tau hyperphosphorylation and promoting the occurrence of ad. |
2013-11-04 |
2023-08-12 |
rat |
| Lies Clerx, Ineke A van Rossum, Leah Burns, Dirk L Knol, Philip Scheltens, Frans Verhey, Pauline Aalten, Pablo Lapuerta, Laura van de Pol, Ronald van Schijndel, Remko de Jong, Frederik Barkhof, Robin Wolz, Daniel Rueckert, Martina Bocchetta, Magdalini Tsolaki, Flavio Nobili, Lars-Olaf Wahlund, Lennart Minthon, Lutz Frölich, Harald Hampel, Hilkka Soininen, Pieter Jelle Visse. Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment. Neurobiology of aging. vol 34. issue 8. 2013-11-04. PMID:23540941. |
hippocampal measurements correlated with csf total tau and phosphorylated tau, not with beta-amyloid 1-42. |
2013-11-04 |
2023-08-12 |
human |
| Florence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolna. "Prion-like" templated misfolding in tauopathies. Brain pathology (Zurich, Switzerland). vol 23. issue 3. 2013-10-28. PMID:23587140. |
in alzheimer's disease, tau pathology develops in a stereotypical manner, with the first lesions appearing in the locus coeruleus and entorhinal cortex, from where they appear to spread to the hippocampus and neocortex. |
2013-10-28 |
2023-08-12 |
Not clear |
| Katja Hochgräfe, Astrid Sydow, Eva-Maria Mandelko. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology. The FEBS journal. vol 280. issue 18. 2013-10-25. PMID:23517246. |
while pro-aggregant full-length htau40/Δk280 leads to a 'pre-tangle' pathology, the repeat domain tau(rd)/Δk280 causes massive formation of neurofibrillary tangles and neuronal loss in the hippocampus. |
2013-10-25 |
2023-08-12 |
mouse |
| Akira Nakajima, Yuki Aoyama, Thuy-Ty Lan Nguyen, Eun-Joo Shin, Hyoung-Chun Kim, Shinnosuke Yamada, Tsuyoshi Nakai, Taku Nagai, Akihito Yokosuka, Yoshihiro Mimaki, Yasushi Ohizumi, Kiyofumi Yamad. Nobiletin, a citrus flavonoid, ameliorates cognitive impairment, oxidative burden, and hyperphosphorylation of tau in senescence-accelerated mouse. Behavioural brain research. vol 250. 2013-10-25. PMID:23714077. |
furthermore, nobiletin reduced tau phosphorylation in the hippocampus of samp8 mice. |
2013-10-25 |
2023-08-12 |
mouse |
| C Tackenberg, S Grinschgl, A Trutzel, A C Santuccione, M C Frey, U Konietzko, J Grimm, R Brandt, R M Nitsc. NMDA receptor subunit composition determines beta-amyloid-induced neurodegeneration and synaptic loss. Cell death & disease. vol 4. 2013-10-23. PMID:23618906. |
using mouse organotypic hippocampal slice cultures from arcaβ transgenic mice combined with sindbis virus-mediated expression of human wild-type tau protein (htau), we show that aβ caused dendritic spine loss independently of tau. |
2013-10-23 |
2023-08-12 |
mouse |
| P K Kamat, S Rai, S Swarnkar, R Shukla, S Ali, A K Najmi, C Nat. Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor. Neuroscience. vol 238. 2013-10-17. PMID:23415789. |
oka-induced memory-impaired rats showed increased mrna and protein expression of tau, ca(2+)/calmodulin-dependent protein kinase ii (camkii), calpain and gsk3β in the hippocampus and cerebral cortex. |
2013-10-17 |
2023-08-12 |
rat |
| Maria J Casarejos, Juan Perucho, Ana Gomez, Maria P Muñoz, Marian Fernandez-Estevez, Onintza Sagredo, Javier Fernandez Ruiz, Manuel Guzman, Justo Garcia de Yebenes, Maria A Men. Natural cannabinoids improve dopamine neurotransmission and tau and amyloid pathology in a mouse model of tauopathy. Journal of Alzheimer's disease : JAD. vol 35. issue 3. 2013-10-17. PMID:23478312. |
with regard to tau and amyloid pathology, sativex® reduced the deposition of both in the hippocampus and cerebral cortex of pk-/-/tauvlw mice and increased autophagy. |
2013-10-17 |
2023-08-12 |
mouse |
| Bradford C Dickerson, David A Wol. Biomarker-based prediction of progression in MCI: Comparison of AD signature and hippocampal volume with spinal fluid amyloid-β and tau. Frontiers in aging neuroscience. vol 5. 2013-10-16. PMID:24130528. |
biomarker-based prediction of progression in mci: comparison of ad signature and hippocampal volume with spinal fluid amyloid-β and tau. |
2013-10-16 |
2023-08-12 |
Not clear |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
nmda receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a tau transgenic model. |
2013-09-30 |
2023-08-12 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
using thy-tau22 transgenic mice, we demonstrated that hippocampal tau pathology is associated with loss of synaptic enhancement normally induced by exogenous bdnf. |
2013-09-30 |
2023-08-12 |
mouse |
| Sylvie Burnouf, Alberto Martire, Maxime Derisbourg, Cyril Laurent, Karim Belarbi, Antoine Leboucher, Francisco J Fernandez-Gomez, Laetitia Troquier, Sabiha Eddarkaoui, Marie-Eve Grosjean, Dominique Demeyer, Anne Muhr-Tailleux, Alain Buisson, Nicolas Sergeant, Malika Hamdane, Sandrine Humez, Patrizia Popoli, Luc Buée, David Blu. NMDA receptor dysfunction contributes to impaired brain-derived neurotrophic factor-induced facilitation of hippocampal synaptic transmission in a Tau transgenic model. Aging cell. vol 12. issue 1. 2013-09-30. PMID:23082852. |
indeed, we observed a significant reduction of nmda-induced field excitatory postsynaptic potential depression in the hippocampus of tau mice together with a reduced phosphorylation of nr2b at the y1472, known to be critical for nmdar function. |
2013-09-30 |
2023-08-12 |
mouse |
| Ori Liraz, Anat Boehm-Cagan, Daniel M Michaelso. ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23684315. |
apoe4 induces aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoe4 mice. |
2013-09-20 |
2023-08-12 |
mouse |
| Makoto Hara, Katsuiku Hirokawa, Satoshi Kamei, Toshiki Uchihar. Isoform transition from four-repeat to three-repeat tau underlies dendrosomatic and regional progression of neurofibrillary pathology. Acta neuropathologica. vol 125. issue 4. 2013-09-16. PMID:23407988. |
regional progression of neurofibrillary tangles (nfts) around the hippocampus was traced on thick sections double immunofluorolabeled with rd3 and rd4 antibodies, specific for three- and four-repeat tau, respectively. |
2013-09-16 |
2023-08-12 |
Not clear |
| Samantha Galluzzi, Cristina Geroldi, Giovanni Amicucci, Luisella Bocchio-Chiavetto, Matteo Bonetti, Cristian Bonvicini, Maria Cotelli, Roberta Ghidoni, Barbara Paghera, Orazio Zanetti, Giovanni B Frison. Supporting evidence for using biomarkers in the diagnosis of MCI due to AD. Journal of neurology. vol 260. issue 2. 2013-09-04. PMID:23070466. |
in this study, we enrolled 58 patients with mci, and for each of them ad biomarkers (csf abeta42 and tau, temporoparietal hypometabolism on 18f-fdg pet, and hippocampal volume) were collected. |
2013-09-04 |
2023-08-12 |
Not clear |
| Edoardo Parrella, Tom Maxim, Francesca Maialetti, Lu Zhang, Junxiang Wan, Min Wei, Pinchas Cohen, Luigi Fontana, Valter D Long. Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model. Aging cell. vol 12. issue 2. 2013-08-27. PMID:23362919. |
whereas prcs did not affect the levels of β amyloid (aβ), they decreased tau phosphorylation in the hippocampus and alleviated the age-dependent impairment in cognitive performance. |
2013-08-27 |
2023-08-12 |
mouse |
| Hye Jeong Yang, Jin Taek Hwang, Dae Young Kwon, Min Jung Kim, Suna Kang, Na Rang Moon, Sunmin Par. Yuzu extract prevents cognitive decline and impaired glucose homeostasis in β-amyloid-infused rats. The Journal of nutrition. vol 143. issue 7. 2013-08-26. PMID:23719224. |
yuzu treatment prevented β-amyloid accumulation, increased tau phosphorylation, and attenuated hippocampal insulin signaling observed in ad-c rats. |
2013-08-26 |
2023-08-12 |
rat |
| Hongxia Shuai, Jinghui Zhang, Ji Zhang, Junhui Xie, Muxun Zhang, Ji Ma, Liming Zhang, Xiufeng Wan. Role of stereotaxically injected IgG from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. Brain research. vol 1486. 2013-08-23. PMID:23036273. |
role of stereotaxically injected igg from db/db mice in the phosphorylation of the microtubule-associated protein tau in hippocampus. |
2013-08-23 |
2023-08-12 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. |
2013-08-13 |
2023-08-12 |
mouse |
| Lars Messing, Jochen Martin Decker, Maria Joseph, Eckhard Mandelkow, Eva-Maria Mandelko. Cascade of tau toxicity in inducible hippocampal brain slices and prevention by aggregation inhibitors. Neurobiology of aging. vol 34. issue 5. 2013-08-13. PMID:23158765. |
to this end we established an in vitro model of tauopathy based on regulatable transgenic hippocampal organotypic slice cultures prepared from mice expressing proaggregant tau repeat domain with mutation Δk280 (tau(rd)Δk). |
2013-08-13 |
2023-08-12 |
mouse |