| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Helgi B Schiöth, Suzanne Craft, Samantha J Brooks, William H Frey, Christian Benedic. Brain insulin signaling and Alzheimer's disease: current evidence and future directions. Molecular neurobiology. vol 46. issue 1. 2013-01-31. PMID:22205300. |
considering that insulin mitigates hippocampal synapse vulnerability to amyloid beta and inhibits the phosphorylation of tau, pharmacological strategies bolstering brain insulin signaling, such as intranasal insulin, could have significant therapeutic potential to deter ad pathogenesis. |
2013-01-31 |
2023-08-12 |
Not clear |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
chronic noise exposure causes persistence of tau hyperphosphorylation and formation of nft tau in the rat hippocampus and prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
the aim of the current study was to explore the effects of cne [100 db sound pressure level (spl) white noise, 4 h/d×14 d] on tau phosphorylation in the rat hippocampus and the prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
the levels of radioimmunoprecipitation assay (ripa)-soluble and ripa-insoluble phosphorylated tau at ser202, ser396, ser404, and ser422 in the hippocampus and the prefrontal cortex were measured at different time points (days 0, 3, 7, and 14) after the end of the last noise exposure. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
exposure to white noise for 14 consecutive days significantly increased the levels of tau phosphorylation at ser202, ser396, ser404, and ser422, the sites typically phosphorylated in ad brains, in the hippocampus and the prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Bo Cui, Lixing Zhu, Xiaojun She, Mingquan Wu, Qiang Ma, Tianhui Wang, Na Zhang, Chuanxiang Xu, Xuewei Chen, Gaihong An, Hongtao Li. Chronic noise exposure causes persistence of tau hyperphosphorylation and formation of NFT tau in the rat hippocampus and prefrontal cortex. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22971273. |
the results of this study show that cne leads to long-lasting increases in non-nft hyperphosphorylated tau and delayed formation of misfolded nft tau in the hippocampus and the prefrontal cortex. |
2013-01-21 |
2023-08-12 |
rat |
| Seok Soon Park, Hyun-Jung Jung, Yoon-Jeong Kim, Tae Kwan Park, Chaeyoung Kim, Heesun Choi, In Hee Mook-Jung, Edward H Koo, Sun Ah Par. Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. Journal of neurochemistry. vol 123. issue 5. 2013-01-10. PMID:23020770. |
we found that asp664 cleavage of app increased tau phosphorylation at thr212 and ser262 in n2a cells and primary cultured hippocampal neurons. |
2013-01-10 |
2023-08-12 |
Not clear |
| Angela L Rachubinski, Kenneth N Maclean, Jeffrey R Evans, Kimberly B Bjugsta. Modulating cognitive deficits and tau accumulation in a mouse model of aging Down syndrome through neonatal implantation of neural progenitor cells. Experimental gerontology. vol 47. issue 9. 2012-12-10. PMID:22776132. |
twelve months later, implanted and unimplanted mice were assessed for long-term survival of npc, for cognitive function, hippocampal cell density, and the presence of extracellular tau accumulation. |
2012-12-10 |
2023-08-12 |
mouse |
| Johannes Attems, Dietmar R Thal, Kurt A Jellinge. The relationship between subcortical tau pathology and Alzheimer's disease. Biochemical Society transactions. vol 40. issue 4. 2012-12-07. PMID:22817721. |
the stepwise progression of tau pathology [nfts (neurofibrillary tangles) and nts (neuropil threads)] in ad (alzheimer's disease) is generally assumed to begin in the transentorhinal region (entorhinal stage) from which it progresses to the hippocampus (limbic stage) and to neocortical regions (neocortical stage). |
2012-12-07 |
2023-08-12 |
Not clear |
| Arthur L Nikkel, Brenda Martino, Stella Markosyan, Jill-Desiree Brederson, Rodrigo Medeiros, Achim Moeller, Robert S Bitne. The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo. Neuropharmacology. vol 63. issue 4. 2012-11-30. PMID:22613839. |
in hippocampal slices in vitro, lowering medium temperature to 33 °c increased tau phosphorylation in which incubation with a-705253 blocked low temperature-induced tau phosphorylation as measured by western blot analysis. |
2012-11-30 |
2023-08-12 |
mouse |
| Jianbin Zhang, Tongjian Cai, Fang Zhao, Ting Yao, Yaoming Chen, Xinqin Liu, Wenjing Luo, Jingyuan Che. The role of α-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury. International journal of biological sciences. vol 8. issue 7. 2012-11-28. PMID:22811615. |
we used immunohistofluorescence and western blotting to detect the level of tau phosphorylation, accumulation of α-synuclein, autophagy and related signaling molecules in hippocampus. |
2012-11-28 |
2023-08-12 |
human |
| Jianbin Zhang, Tongjian Cai, Fang Zhao, Ting Yao, Yaoming Chen, Xinqin Liu, Wenjing Luo, Jingyuan Che. The role of α-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury. International journal of biological sciences. vol 8. issue 7. 2012-11-28. PMID:22811615. |
we demonstrated that pb can cause abnormally hyperphosphorylation of tau and accumulation of α-synuclein, and these can induce hippocampal injury and the ability of learning and memory damage. |
2012-11-28 |
2023-08-12 |
human |
| Dong-Hou Kim, Jae-Wan Huh, Mi Jang, Jung-Hyun Suh, Tae-Wan Kim, Jeong-Su Park, Seung-Yong Yoo. Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures. Neurobiology of disease. vol 46. issue 1. 2012-11-20. PMID:22245388. |
sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures. |
2012-11-20 |
2023-08-12 |
rat |
| Dong-Hou Kim, Jae-Wan Huh, Mi Jang, Jung-Hyun Suh, Tae-Wan Kim, Jeong-Su Park, Seung-Yong Yoo. Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures. Neurobiology of disease. vol 46. issue 1. 2012-11-20. PMID:22245388. |
unexpectedly, we found that sitagliptin was not effective against pathological tau phosphorylation in the hippocampus of oletf type 2 diabetes rats, and instead aggravated it. |
2012-11-20 |
2023-08-12 |
rat |
| Denise Orozco, Sabina Tahirovic, Kristin Rentzsch, Benjamin M Schwenk, Christian Haass, Dieter Edbaue. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO reports. vol 13. issue 8. 2012-11-07. PMID:22710833. |
in mouse brain, fus directly binds to tau pre-mrna, and knockdown of fus in hippocampal neurons leads to preferential inclusion of tau exons 3 and 10. |
2012-11-07 |
2023-08-12 |
mouse |
| Francisco García-Sierra, Jose J Jarero-Basulto, Zdena Kristofikova, Emerich Majer, Lester I Binder, Daniela Ripov. Ubiquitin is associated with early truncation of tau protein at aspartic acid(421) during the maturation of neurofibrillary tangles in Alzheimer's disease. Brain pathology (Zurich, Switzerland). vol 22. issue 2. 2012-11-06. PMID:21919991. |
for this reason, we sought to determine whether ubiquitin-targeting of tau is associated with particular tau modifications that herald specific stages of nfts maturation in the hippocampus of alzheimer's disease cases. |
2012-11-06 |
2023-08-12 |
Not clear |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561128. |
adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. |
2012-11-05 |
2023-08-12 |
mouse |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561128. |
in fact, density of tau neurofibrillary tangles (nfts) in the hippocampus strongly correlates with severity of cognitive impairments in ad. |
2012-11-05 |
2023-08-12 |
mouse |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561128. |
in the present study, we employed a somatic cell gene transfer technique to create a rodent model of tauopathy by injecting a recombinant adeno-associated viral vector with a mutated human tau gene (p301l) into the hippocampus of adult rats. |
2012-11-05 |
2023-08-12 |
mouse |
| Martina L Mustroph, Michael A King, Ronald L Klein, Julio J Ramire. Adult-onset focal expression of mutated human tau in the hippocampus impairs spatial working memory of rats. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561128. |
it was hypothesized that adult-onset, spatially restricted tau expression in the hippocampus would produce progressive spatial working memory deficits on a learned alternation task. |
2012-11-05 |
2023-08-12 |
mouse |