| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sylvia E Perez, Muhammad Nadeem, Katherine R Sadleir, Joanna Matras, Christy M Kelley, Scott E Counts, Robert Vassar, Elliott J Mufso. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International journal of physiology, pathophysiology and pharmacology. vol 4. issue 3. 2012-10-17. PMID:23071869. |
in the present study, we evaluated the effects of dimebon upon β-amyloid (aβ), tau and astrocytes in the hippocampus of triple transgenic (3xtg-ad) mice, which develop ad-like pathology in an age-dependent manner. |
2012-10-17 |
2023-08-12 |
mouse |
| Sylvia E Perez, Muhammad Nadeem, Katherine R Sadleir, Joanna Matras, Christy M Kelley, Scott E Counts, Robert Vassar, Elliott J Mufso. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International journal of physiology, pathophysiology and pharmacology. vol 4. issue 3. 2012-10-17. PMID:23071869. |
dimebon did not alter hippocampal tau levels. |
2012-10-17 |
2023-08-12 |
mouse |
| Tara L Spires-Jones, Leora M Fox, Anete Rozkalne, Rose Pitstick, George A Carlson, Aleksey G Kazantse. Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia. Frontiers in pharmacology. vol 3. 2012-10-02. PMID:22416232. |
the rtg4510 mouse model, which expresses a mutant form of the tau protein associated with ftd with parkinsonism-17, undergoes dramatic hippocampal and cortical neuronal loss making it an ideal model to study treatments for ftd-related neuronal loss. |
2012-10-02 |
2023-08-12 |
mouse |
| Almudena Fuster-Matanzo, María Llorens-Martín, Jerónimo Jurado-Arjona, Jesús Avila, Félix Hernánde. Tau protein and adult hippocampal neurogenesis. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22787440. |
tau protein and adult hippocampal neurogenesis. |
2012-10-02 |
2023-08-12 |
Not clear |
| Almudena Fuster-Matanzo, María Llorens-Martín, Jerónimo Jurado-Arjona, Jesús Avila, Félix Hernánde. Tau protein and adult hippocampal neurogenesis. Frontiers in neuroscience. vol 6. 2012-10-02. PMID:22787440. |
here, we review recent findings suggesting that axonal outgrowth in subgranular zone during adult hippocampal neurogenesis requires a dynamic microtubule network and tau protein facilitates to maintain that dynamic cytoskeleton. |
2012-10-02 |
2023-08-12 |
Not clear |
| Lourdes Orejana, Lucía Barros-Miñones, Joaquín Jordán, Elena Puerta, Norberto Aguirr. Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:21546125. |
tau hyperphosphorylation (at8 but not phf-1 epitope) shown by samp8 mice at this age was also decreased in the hippocampus of sildenafil-treated mice, an effect probably related to a decrease in cyclin-dependent kinase 5 protein expression and activity (p25/p35 ratio). |
2012-09-28 |
2023-08-12 |
mouse |
| B S Hemanth Kumar, Sushanta Kumar Mishra, Poonam Rana, Sadhana Singh, Subash Khush. Neurodegenerative evidences during early onset of depression in CMS rats as detected by proton magnetic resonance spectroscopy at 7 T. Behavioural brain research. vol 232. issue 1. 2012-09-27. PMID:22449862. |
the results revealed a significant decrease of glutamate (glu), glutamine (gln), naa+naag, glx and gaba levels in both hippocampus and prefrontal cortex of cms animals and an elevated level of myo-ionisitol (mi) and taurine (tau) was observed only in hippocampus. |
2012-09-27 |
2023-08-12 |
rat |
| Ann Van der Jeugd, Katja Hochgräfe, Tariq Ahmed, Jochen M Decker, Astrid Sydow, Anne Hofmann, Dan Wu, Lars Messing, Detlef Balschun, Rudi D'Hooge, Eva-Maria Mandelko. Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta neuropathologica. vol 123. issue 6. 2012-09-24. PMID:22532069. |
we correlated hippocampal tau pathology with learning/memory performance and synaptic plasticity. |
2012-09-24 |
2023-08-12 |
mouse |
| Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334661. |
to explore this possibility, we treated cultured hippocampal slices or primary neurons with glutamate or bic/4-ap to increase the synaptic activity with or without pretreatment of zinc chelators, and then detected the phosphorylation levels of tau. |
2012-09-20 |
2023-08-12 |
Not clear |
| Xu-Ying Sun, Yu-Ping Wei, Yan Xiong, Xiao-Chuan Wang, Ao-Ji Xie, Xiu-Lian Wang, Yang Yang, Qun Wang, You-Ming Lu, Rong Liu, Jian-Zhi Wan. Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). The Journal of biological chemistry. vol 287. issue 14. 2012-09-20. PMID:22334661. |
the zinc release and translocation of excitatory synapses in the hippocampus were detected, and zinc-induced tau hyperphosphorylation was also observed in cultured brain slices incubated with exogenously supplemented zinc. |
2012-09-20 |
2023-08-12 |
Not clear |
| Abdur Rahman, Khalid M Khan, Ghanim Al-Khaledi, Islam Khan, Tahany Al-Shemar. Over activation of hippocampal serine/threonine protein phosphatases PP1 and PP2A is involved in lead-induced deficits in learning and memory in young rats. Neurotoxicology. vol 33. issue 3. 2012-09-18. PMID:22387731. |
pb exposure increased the expression and activity of pp1 and decreased phosphorylation of tau at threonine-231 in hippocampus at both pnd21 and pnd30. |
2012-09-18 |
2023-08-12 |
rat |
| Yuen-Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hui-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jianzhi Wang, Larry Baum, Kwok-Fai So, Raymond Chuen-Chung Chan. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. Journal of Alzheimer's disease : JAD. vol 28. issue 4. 2012-09-17. PMID:22101233. |
in this study, we found that high levels of phosphorylated pkr-like er-resident kinase (p-perk) and phosphorylated eukaryotic initiation factor 2 alpha (p-eif2α) as markers for activation of upr in the hippocampus of aged p301l mutant tau transgenic mice. |
2012-09-17 |
2023-08-12 |
mouse |
| Abderazzak Mouiha, Simon Duchesn. Toward a dynamic biomarker model in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22398375. |
we included 576 subjects (229 controls, 193 ad, and 154 mild cognitive impairment subjects who converted to ad) from the adni study, for whom baseline data on cerebrospinal fluid amyloid-β (aβ)42, phosphorylated tau (p-tau), and total-tau (t-tau), hippocampal volumes, and fdg-pet were available. |
2012-09-10 |
2023-08-12 |
human |
| Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406441. |
euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and exhibited reduced aβ, tau, and phosphorylated tau accumulation in amygdala and hippocampus, as well as brain levels of aβ42, oxidized nucleic acids, and lipid peroxidation. |
2012-09-10 |
2023-08-12 |
mouse |
| Aaron Clausen, Xiaobo Xu, Xiaoning Bi, Michel Baudr. Effects of the superoxide dismutase/catalase mimetic EUK-207 in a mouse model of Alzheimer's disease: protection against and interruption of progression of amyloid and tau pathology and cognitive decline. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406441. |
euk-207-treated 3xtg-ad mice did not display any deficit in fear conditioning and were protected against increases in brain levels of oxidized nucleic acids and lipid peroxidation; they also had reduced aβ, tau, and hyperphosphorylated tau accumulation in amygdala and hippocampus. |
2012-09-10 |
2023-08-12 |
mouse |
| Jaya R P Prasanthi, Matthew Schrag, Bhanu Dasari, Gurdeep Marwarha, April Dickson, Wolff M Kirsch, Othman Ghrib. Deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. Journal of Alzheimer's disease : JAD. vol 30. issue 1. 2012-09-10. PMID:22406440. |
deferiprone reduces amyloid-β and tau phosphorylation levels but not reactive oxygen species generation in hippocampus of rabbits fed a cholesterol-enriched diet. |
2012-09-10 |
2023-08-12 |
rabbit |
| Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272617. |
hippocampal bdnf expression in a tau transgenic mouse model. |
2012-09-07 |
2023-08-12 |
mouse |
| Sylvie Burnouf, Karim Belarbi, Laetitia Troquier, Maxime Derisbourg, Dominique Demeyer, Antoine Leboucher, Cyril Laurent, Malika Hamdane, Luc Buee, David Blu. Hippocampal BDNF expression in a tau transgenic mouse model. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272617. |
in the present study, we have evaluated this relationship using quantitative pcr, western blot and elisa in the thy-tau22 transgenic strain, known to display a progressive development of both hippocampal ad-like tau pathology and memory impairments. |
2012-09-07 |
2023-08-12 |
mouse |
| Laetitia Troquier, Raphaelle Caillierez, Sylvie Burnouf, Francisco J Fernandez-Gomez, Marie-Eve Grosjean, Nadege Zommer, Nicolas Sergeant, Susanna Schraen-Maschke, David Blum, Luc Bue. Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach. Current Alzheimer research. vol 9. issue 4. 2012-09-07. PMID:22272619. |
starting from 3-6 months of age, thy-tau22 mice develop hippocampal neurofibrillary tangle-like inclusions and exhibit phosphorylation of tau on several ad-relevant tau epitopes. |
2012-09-07 |
2023-08-12 |
mouse |
| Ben A Bahr, Meagan L Wisniewski, David Butle. Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases. Rejuvenation research. vol 15. issue 2. 2012-09-06. PMID:22533430. |
such positive modulators of the lysosomal system have been studied in the well-characterized hippocampal slice model of protein accumulation that exhibits the pathogenic cascade of tau aggregation, tubulin breakdown, microtubule destabilization, transport failure, and synaptic decline. |
2012-09-06 |
2023-08-12 |
mouse |