| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
enhanced neurogenesis has been reported in the hippocampus of patients with alzheimer's disease (ad), the most common neurodegenerative disorder characterized with amyloid-β (aβ) aggregation, tau hyperphosphorylation, and progressive neuronal loss. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (gsk-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
in the present study, we found that treatment of d-galactose rats with puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of d-galactose rat brains. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
fgf-2/gsk-3 signaling pathway might be involved in the effects of puerarin on hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-08-13 |
rat |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
our finding provides primary in vivo evidence that puerarin can attenuate ad-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. |
2016-12-20 |
2023-08-13 |
rat |
| F L'Episcopo, J Drouin-Ouellet, C Tirolo, A Pulvirenti, R Giugno, N Testa, S Caniglia, M F Serapide, G Cisbani, R A Barker, F Cicchetti, B Marchett. GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell death & disease. vol 7. 2016-12-15. PMID:27124580. |
gsk-3β-induced tau pathology drives hippocampal neuronal cell death in huntington's disease: involvement of astrocyte-neuron interactions. |
2016-12-15 |
2023-08-13 |
mouse |
| F L'Episcopo, J Drouin-Ouellet, C Tirolo, A Pulvirenti, R Giugno, N Testa, S Caniglia, M F Serapide, G Cisbani, R A Barker, F Cicchetti, B Marchett. GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactions. Cell death & disease. vol 7. 2016-12-15. PMID:27124580. |
we identified a disease and stage-dependent upregulation of gsk-3β mrna and protein levels in the hd hippocampus, with the active isoform pgsk-3β-tyr(216) being strongly expressed in dentate gyrus (dg) neurons and astrocytes at a time when phosphorylation of tau at the at8 epitope was also present in these same neurons. |
2016-12-15 |
2023-08-13 |
mouse |
| Naiara Celarain, Javier Sánchez-Ruiz de Gordoa, María Victoria Zelaya, Miren Roldán, Rosa Larumbe, Laura Pulido, Carmen Echavarri, Maite Mendioro. TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus. Clinical epigenetics. vol 8. 2016-12-14. PMID:27051467. |
we measured trem2 mrna levels in the hippocampus in a cohort of neuropathologically confirmed controls and pure ad cases showing no other protein deposits than β-amyloid and phosphorylated tau. |
2016-12-14 |
2023-08-13 |
human |
| Susanne P Pallo, John DiMaio, Alexis Cook, Bradley Nilsson, Gail V W Johnso. Mechanisms of tau and Aβ-induced excitotoxicity. Brain research. vol 1634. 2016-12-13. PMID:26731336. |
in vivo studies showed that tau knockout (tau(-/-)) mice were significantly protected from seizures and hippocampal superoxide production induced with the glutamate analog, kainic acid (ka). |
2016-12-13 |
2023-08-13 |
mouse |
| Liang Cheng, Shao-Hui Wang, Yun Huang, Xiao-Mei Lia. The hippocampus may be more susceptible to environmental noise than the auditory cortex. Hearing research. vol 333. 2016-12-13. PMID:26773751. |
results showed significant peroxidation and tau hyperphosphorylation in the hippocampus with 1 week of noise exposure. |
2016-12-13 |
2023-08-13 |
mouse |
| Chunxia Huang, Olivia Tsz-Wa Ng, Yuen-Shan Ho, Michael Garnet Irwin, Raymond Chuen-Chung Chang, Gordon Tin-Chun Won. Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control. Journal of Alzheimer's disease : JAD. vol 51. issue 1. 2016-12-13. PMID:26836157. |
propofol with hypothermia significantly increased phosphorylation of tau at at8, at180, thr205, and ser199 in cortex and hippocampus except ser396. |
2016-12-13 |
2023-08-13 |
rat |
| Na Qu, Xiang-Yu Zhou, Li Han, Lei Wang, Jia-Xin Xu, Teng Zhang, Jiang Chu, Qiao Chen, Jian-Zhi Wang, Qi Zhang, Qing Tia. Combination of PPT with LiCl Treatment Prevented Bilateral Ovariectomy-Induced Hippocampal-Dependent Cognition Deficit in Rats. Molecular neurobiology. vol 53. issue 2. 2016-11-14. PMID:25535091. |
after the combination treatment of these two drugs (ppt + licl), the improved learning and memory abilities of ovariectomized rats in morris water maze, increased dendritic spines in ca1 region, and decreased tau phosphorylation at ser-396 in hippocampus were observed. |
2016-11-14 |
2023-08-13 |
rat |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
evidence for an imbalance between tau o-glcnacylation and phosphorylation in the hippocampus of a mouse model of alzheimer's disease. |
2016-11-11 |
2023-08-13 |
mouse |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
in these mice, we showed that tau was hyperphosphorylated on both ser396 and thr205 in the hippocampus, and to a lower extent and exclusively on thr205 in the frontal cortex. |
2016-11-11 |
2023-08-13 |
mouse |
| Eleonora Gatta, Tony Lefebvre, Silvana Gaetani, Marc dos Santos, Jordan Marrocco, Anne-Marie Mir, Tommaso Cassano, Stefania Maccari, Ferdinando Nicoletti, Jérôme Mairess. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacological research. vol 105. 2016-11-11. PMID:26816085. |
tau o-glcnacylation, assessed in tau immunoprecipitates, was substantially reduced in the hippocampus of 3xtg-ad mice, with no changes in the frontal cortex or in the cerebellum. |
2016-11-11 |
2023-08-13 |
mouse |
| Sulana K Schroeder, Aurelie Joly-Amado, Marcia N Gordon, Dave Morga. Tau-Directed Immunotherapy: A Promising Strategy for Treating Alzheimer's Disease and Other Tauopathies. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 11. issue 1. 2016-11-09. PMID:26538351. |
pathological improvements as measured by gallyas staining for fully formed tangles and phosphorylated tau appeared 4 days after intracranial injection into the hippocampus. |
2016-11-09 |
2023-08-13 |
mouse |
| YoungDoo Kim, Hyunwoo Choi, WonJae Lee, Hyejin Park, Tae-In Kam, Se-Hoon Hong, Jihoon Nah, Sunmin Jung, Bora Shin, Huikyong Lee, Tae-Yong Choi, Hyosun Choo, Kyung-Keun Kim, Se-Young Choi, Rakez Kayed, Yong-Keun Jun. Caspase-cleaved tau exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiology of disease. vol 87. 2016-10-20. PMID:26704708. |
injection with rapamycin significantly reduced the amounts of tau oligomers in the hippocampus, rescued spine density, and attenuated memory impairment in tauc3 mice. |
2016-10-20 |
2023-08-13 |
mouse |
| T L Platt, T L Beckett, K Kohler, D M Niedowicz, M P Murph. Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease. Neuroscience. vol 315. 2016-10-19. PMID:26701291. |
the resulting phenotype included a striking increase in tau phosphorylation and the number of neurofibrillary tangles (nfts) found within the hippocampus. |
2016-10-19 |
2023-08-13 |
mouse |
| Roya Behrouzi, Xiawei Liu, Dongyue Wu, Andrew C Robinson, Sayuri Tanaguchi-Watanabe, Sara Rollinson, Jing Shi, Jinzhou Tian, Hisham H M Hamdalla, John Ealing, Anna Richardson, Matthew Jones, Stuart Pickering-Brown, Yvonne S Davidson, Michael J Strong, Masato Hasegawa, Julie S Snowden, David M A Man. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27036121. |
paraffin sections of frontal, entorhinal, temporal and occipital cortex and hippocampus were immunostained for tau pathology using anti-tau antibodies, at8, pthr(175) and pthr(217), and for amyloid β protein (aβ) using 4g8 antibody. |
2016-10-14 |
2023-08-13 |
Not clear |
| Roya Behrouzi, Xiawei Liu, Dongyue Wu, Andrew C Robinson, Sayuri Tanaguchi-Watanabe, Sara Rollinson, Jing Shi, Jinzhou Tian, Hisham H M Hamdalla, John Ealing, Anna Richardson, Matthew Jones, Stuart Pickering-Brown, Yvonne S Davidson, Michael J Strong, Masato Hasegawa, Julie S Snowden, David M A Man. Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy. Acta neuropathologica communications. vol 4. 2016-10-14. PMID:27036121. |
in most instances, this bore the histological characteristics of an alzheimer's disease process involving entorhinal cortex, hippocampus, temporal cortex, frontal cortex and occipital cortex in decreasing frequency, accompanied by a deposition of aβ up to thal phase 3, though 2 patients with mnd, and 1 with ftd did show tau pathology beyond braak stage iii. |
2016-10-14 |
2023-08-13 |
Not clear |