| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rosaliana Libro, Placido Bramanti, Emanuela Mazzo. Endogenous glucocorticoids: role in the etiopathogenesis of Alzheimer's disease. Neuro endocrinology letters. vol 38. issue 1. 2017-08-29. PMID:28456142. |
ad is the most common form of dementia, characterized by the pathological accumulation of two proteins: the amyloid beta (aβ) and the microtubule-associated protein tau in the neurons of the hippocampus and prefrontal cortex. |
2017-08-29 |
2023-08-13 |
Not clear |
| Xu-Ying Sun, Qing-Zhang Tuo, Zhen-Yu Liuyang, Ao-Ji Xie, Xiao-Long Feng, Xiong Yan, Mei Qiu, Shen Li, Xiu-Lian Wang, Fu-Yuan Cao, Xiao-Chuan Wang, Jian-Zhi Wang, Rong Li. Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK phosphorylation. Cell death & disease. vol 7. issue 11. 2017-08-28. PMID:27809304. |
activation of e-nmdars in wild-type mouse brains resulted in neuron loss in hippocampus, whereas tau deletion in neuronal cultures and in the mouse brains rescued the e-nmdars-induced neuronal death and degeneration. |
2017-08-28 |
2023-08-13 |
mouse |
| X-L Zhi, C-Y Li, M Xue, Y Hu, Y J. Changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of Tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum S100β levels. European review for medical and pharmacological sciences. vol 20. issue 10. 2017-08-23. PMID:27249618. |
changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum s100β levels. |
2017-08-23 |
2023-08-13 |
Not clear |
| X-L Zhi, C-Y Li, M Xue, Y Hu, Y J. Changes in cognitive function due to combined propofol and remifentanil treatment are associated with phosphorylation of Tau in the hippocampus, abnormal total water and calcium contents of the brain, and elevated serum S100β levels. European review for medical and pharmacological sciences. vol 20. issue 10. 2017-08-23. PMID:27249618. |
we hypothesized that combined treatment with these drugs would exert its effect via increased phosphorylation of tau protein in the brain hippocampus. |
2017-08-23 |
2023-08-13 |
Not clear |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
capsaicin reduces alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. |
2017-08-17 |
2023-08-13 |
rat |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
the results revealed that the levels of phosphorylated tau protein at sites ser199, ser202 and ser396 in hippocampus of t2d+cap group were decreased significantly, but these phospho-sites in t2d+pf group didn't show such improvements compared with t2d group. |
2017-08-17 |
2023-08-13 |
rat |
| Weijie Xu, Juanhong Liu, Delin Ma, Gang Yuan, Yan Lu, Yan Yan. Capsaicin reduces Alzheimer-associated tau changes in the hippocampus of type 2 diabetes rats. PloS one. vol 12. issue 2. 2017-08-17. PMID:28225806. |
these results demonstrated that dietary capsaicin appears to prevent the hyperphosphorylation of ad-associated tau protein by increasing the activity of pi3k/akt and inhibiting gsk-3β in hippocampus of t2d rats, which supported that dietary capsaicin might have a potential use for the prevention of ad in t2d. |
2017-08-17 |
2023-08-13 |
rat |
| Frédéric St-Cyr Giguère, Suzanne Attiori Essis, Laure Chagniel, Marc Germain, Michel Cyr, Guy Massicott. The sphingosine-1-phosphate receptor 1 agonist SEW2871 reduces Tau-Ser262 phosphorylation in rat hippocampal slices. Brain research. vol 1658. 2017-08-08. PMID:28104351. |
the present work compared the effects of more selective s1pr agonists on tau properties, using rat hippocampal slices as model system. |
2017-08-08 |
2023-08-13 |
rat |
| Maria Klingebiel, Maja Dinekov, Christoph Köhle. Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. Brain research. vol 1659. 2017-08-07. PMID:28119058. |
analysis of ribosomal protein s6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus. |
2017-08-07 |
2023-08-13 |
mouse |
| Eunhee Kim, Kazuko Sakata, Francesca-Fang Lia. Bidirectional interplay of HSF1 degradation and UPR activation promotes tau hyperphosphorylation. PLoS genetics. vol 13. issue 7. 2017-08-01. PMID:28678786. |
in addition, permanent hsf1 loss reversely causes chronic upr activation, leading to aberrant tau phosphorylation and aggregation in the hippocampus of aged hsf1 heterozygous knock-out mice. |
2017-08-01 |
2023-08-13 |
mouse |
| Wencheng Liu, Lingzhi Zhao, Brittany Blackman, Mayur Parmar, Man Ying Wong, Thomas Woo, Fangmin Yu, Maria J Chiuchiolo, Dolan Sondhi, Stephen M Kaminsky, Ronald G Crystal, Steven M Pau. Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 49. 2017-07-28. PMID:27927959. |
in contrast to systemic passive immunization, we observed markedly reduced (≥80-90%) hippocampal insoluble pathological tau species and neurofibrillary tangles following a single dose of aav-vectored phf1 compared with mice treated with an aav-igg control vector. |
2017-07-28 |
2023-08-13 |
mouse |
| Ting Cui, Hong-Mei Qiu, Dan Huang, Qi-Xin Zhou, Xiao-Yan Fu, Hai-Yan Li, Xin-Hui Jian. Abnormal levels of seven amino neurotransmitters in depressed rat brain and determination by HPLC-FLD. Biomedical chromatography : BMC. vol 31. issue 8. 2017-07-26. PMID:28097679. |
the results showed that asp, gly, tau and gaba significantly decreased with increasing gln in the hippocampus of depressed rats, compared with that of the control group, among which obviously lower level of asp and higher level of gln in cortex were observed. |
2017-07-26 |
2023-08-13 |
rat |
| Ting Yang, Shaomin Li, Huixin Xu, Dominic M Walsh, Dennis J Selko. Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 1. 2017-07-24. PMID:28053038. |
soluble oligomers of amyloid β-protein (oaβ) isolated from the brains of alzheimer's disease (ad) patients have been shown experimentally (in the absence of amyloid plaques) to impair hippocampal synaptic plasticity, decrease synapses, induce tau hyperphosphorylation and neuritic dystrophy, activate microglial inflammation, and impair memory in normal adult rodents. |
2017-07-24 |
2023-08-13 |
mouse |
| L E Gardner, J D White, M J Eimerbrink, G W Boehm, M J Chumle. Imatinib methanesulfonate reduces hyperphosphorylation of tau following repeated peripheral exposure to lipopolysaccharide. Neuroscience. vol 331. 2017-07-11. PMID:27320209. |
our results may provide support for the hypothesis that enhanced expression of tau following lps administration is a protective measure by hippocampal neurons to compensate for the loss of the microtubule-stabilizing protein due to phosphorylation. |
2017-07-11 |
2023-08-13 |
mouse |
| V Cubinková, B Valachová, V Brezováková, R Szabó, I Zimová, Z Kostecká, S Jadha. Next generation tau models in Alzheimer's disease research - virus based gene delivery systems. Acta virologica. vol 61. issue 1. 2017-06-29. PMID:28105850. |
major advantage of aav as a delivery system is the site specific expression of tau, mostly in hippocampus and cortex, and thus elimination of unwanted ectopic transgene expression. |
2017-06-29 |
2023-08-13 |
Not clear |
| Michael F Almeida, Carolliny M Silva, Aline M D'Unhao, Merari F R Ferrar. Aged Lewis rats exposed to low and moderate doses of rotenone are a good model for studying the process of protein aggregation and its effects upon central nervous system cell physiology. Arquivos de neuro-psiquiatria. vol 74. issue 9. 2017-06-28. PMID:27706423. |
hyperphosphorylated tau, alpha-synuclein, amyloid-beta peptide and protein carbonylation (indicative of oxidative stress) were evaluated in the hippocampus, substantia nigra and locus coeruleus through immunohistochemistry or western blot. |
2017-06-28 |
2023-08-13 |
rat |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
novel function of tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. |
2017-06-26 |
2023-08-13 |
mouse |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
here, we show that tau plays a novel in vivo role in the morphological and synaptic maturation of newborn hippocampal granule neurons under basal conditions. |
2017-06-26 |
2023-08-13 |
mouse |
| Noemí Pallas-Bazarra, Jerónimo Jurado-Arjona, Marta Navarrete, Jose A Esteban, Félix Hernández, Jesús Ávila, María Llorens-Martí. Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis. The EMBO journal. vol 35. issue 13. 2017-06-26. PMID:27198172. |
thus, our data demonstrate that tau(-/-) mice show impairments in the maturation of newborn granule neurons under basal conditions and that they are insensitive to the modulation of adult hippocampal neurogenesis exerted by both stimulatory and detrimental stimuli. |
2017-06-26 |
2023-08-13 |
mouse |
| Mohammad A Yousuf, Chunfeng Tan, Melissa I Torres-Altoro, Fang-Min Lu, Erik Plautz, Shanrong Zhang, Masaya Takahashi, Adan Hernandez, Steven G Kernie, Florian Plattner, James A Bib. Involvement of aberrant cyclin-dependent kinase 5/p25 activity in experimental traumatic brain injury. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:26998748. |
here, we show that mice subjected to controlled cortical impact (cci), a well-established experimental tbi model, exhibit increased p25 levels and consistently elevated cdk5-dependent phosphorylation of microtubule-associated protein tau and retinoblastoma (rb) protein in hippocampal lysates. |
2017-06-23 |
2023-08-13 |
mouse |