| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert John Hatch, Yan Wei, Di Xia, Jürgen Göt. Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment. Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28091722. |
furthermore, using mutagenesis and primary hippocampal neuronal cultures, we reveal that this reduction in neuronal excitability results from the relocation of the axon initial segment (ais) down the axon in a tau phosphorylation-dependent manner. |
2017-04-20 |
2023-08-13 |
mouse |
| Keith A Josephs, Melissa E Murray, Nirubol Tosakulwong, Jennifer L Whitwell, David S Knopman, Mary M Machulda, Stephen D Weigand, Bradley F Boeve, Kejal Kantarci, Leonard Petrucelli, Val J Lowe, Clifford R Jack, Ronald C Petersen, Joseph E Parisi, Dennis W Dickso. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART). Acta neuropathologica. vol 133. issue 5. 2017-04-20. PMID:28160067. |
tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (part). |
2017-04-20 |
2023-08-13 |
Not clear |
| Zhao-Xu Zhang, Rui-Ping Zhao, De-Sheng Wang, Yan-Bing L. Fuzhisan Ameliorates the Memory Deficits in Aged SAMP8 Mice via Decreasing Aβ Production and Tau Hyperphosphorylation of the Hippocampus. Neurochemical research. vol 41. issue 11. 2017-04-05. PMID:27518086. |
fuzhisan ameliorates the memory deficits in aged samp8 mice via decreasing aβ production and tau hyperphosphorylation of the hippocampus. |
2017-04-05 |
2023-08-13 |
mouse |
| Xia-Chun Li, Yu Hu, Zhi-hao Wang, Yu Luo, Yao Zhang, Xiu-Ping Liu, Qiong Feng, Qun Wang, Keqiang Ye, Gong-Ping Liu, Jian-Zhi Wan. Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusins. Scientific reports. vol 6. 2017-03-07. PMID:27099072. |
here we report that overexpression of human wild-type full-length tau (termed htau) disrupted mitochondrial dynamics by enhancing fusion and induced their perinuclear accumulation in hek293 cells and rat primary hippocampal neurons. |
2017-03-07 |
2023-08-13 |
mouse |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
ameliorative effects of antioxidants on the hippocampal accumulation of pathologic tau in a rat model of blast-induced traumatic brain injury. |
2017-03-03 |
2023-08-13 |
rat |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
in the current study, we examined the localization patterns of normal tau and the potential blast-induced accumulation of neurotoxic variants of this microtubule-associated protein that are believed to potentiate the neurodegenerative effects associated with synaptic dysfunction in the hippocampus following three successive blast overpressure exposures in nontransgenic rats. |
2017-03-03 |
2023-08-13 |
rat |
| Xiaoping Du, Matthew B West, Weihua Cheng, Donald L Ewert, Wei Li, Debra Saunders, Rheal A Towner, Robert A Floyd, Richard D Kopk. Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury. Oxidative medicine and cellular longevity. vol 2016. 2017-03-03. PMID:27034735. |
we observed a marked increase in the number of both hyperphosphorylated and oligomeric tau-positive hilar mossy cells and somatic accumulation of endogenous tau in oligodendrocytes in the hippocampus. |
2017-03-03 |
2023-08-13 |
rat |
| Yanjing Cao, Lizhen Liang, Jian Xu, Jiali Wu, Yongxing Yan, Ping Lin, Qiang Chen, Fengming Zheng, Qin Wang, Qian Ren, Zengmei Gou, Yifeng D. The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats. Acta biochimica et biophysica Sinica. vol 48. issue 5. 2017-02-27. PMID:27118553. |
sstf treatment inhibited the tau phosphorylation in both cortex and hippocampus in vad rats. |
2017-02-27 |
2023-08-13 |
rat |
| Charles Liu, Jon Russin, Christianne Heck, Keisuke Kawata, Radhika Adiga, William Yen, Jonathan Lambert, Benjamin Stear, Meng Law, Yvette Marquez, Peter Crino, David Millett, Dianne Langfor. Dysregulation of PINCH signaling in mesial temporal epilepsy. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 36. 2017-02-06. PMID:27838154. |
resected hippocampal tissue from 7 patients with mesial temporal lobe epilepsy (mtle) was assessed by western analyses to measure levels of pinch and hyperphosphorylated tau, as well as changes in phosphorylation levels of associated kinases akt and gsk3β in comparison to normal control tissue. |
2017-02-06 |
2023-08-13 |
human |
| O Picazo, J Espinosa-Raya, A Briones-Aranda, M Cerbó. Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1. Cognitive processing. vol 17. issue 4. 2017-02-01. PMID:27271684. |
in this study, we explore the expression of tau hyperphosphorylation at hippocampus and the performance of rats in an autoshaping learning task at 5, 10 and 15 months after the ovaries removal. |
2017-02-01 |
2023-08-13 |
rat |
| O Picazo, J Espinosa-Raya, A Briones-Aranda, M Cerbó. Ovariectomy increases the age-induced hyperphosphorylation of Tau at hippocampal CA1. Cognitive processing. vol 17. issue 4. 2017-02-01. PMID:27271684. |
a progressive increase in hippocampal tau phosphorylation at ser-396 was observed in either intact or ovariectomized rats. |
2017-02-01 |
2023-08-13 |
rat |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
roles of o-glcnacylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in alzheimer's disease. |
2017-01-13 |
2023-08-13 |
Not clear |
| Bo-Wen Zheng, Li Yang, Xue-Ling Dai, Zhao-Feng Jiang, Han-Chang Huan. Roles of O-GlcNAcylation on amyloid-β precursor protein processing, tau phosphorylation, and hippocampal synapses dysfunction in Alzheimer's disease. Neurological research. vol 38. issue 2. 2017-01-13. PMID:27078700. |
here, we review the roles of o-glcnacylation in app cleavage, tau phosphorylation and hippocampal synapses function. |
2017-01-13 |
2023-08-13 |
Not clear |
| Xue-Yan Li, Fang Wang, Gui-Hai Chen, Xue-Wei Li, Qi-Gang Yang, Lei Cao, Wen-Wen Ya. Inflammatory insult during pregnancy accelerates age-related behavioral and neurobiochemical changes in CD-1 mice. Age (Dordrecht, Netherlands). vol 38. issue 3. 2017-01-12. PMID:27194408. |
the neurobiochemical results indicated that gestational lps exposure also intensified age-related hippocampal changes, including increased amyloid-β42, phosphorylated tau, synaptotagmin-1 and gfap, and decreased syntaxin-1 and h4k8ac. |
2017-01-12 |
2023-08-13 |
mouse |
| Mario Merlini, Debora Wanner, Roger M Nitsc. Tau pathology-dependent remodelling of cerebral arteries precedes Alzheimer's disease-related microvascular cerebral amyloid angiopathy. Acta neuropathologica. vol 131. issue 5. 2017-01-06. PMID:26988843. |
therefore, we systematically quantified braak tau stage- and cerebral amyloid angiopathy (caa)-dependent alterations in the alpha-smooth muscle actin (α-sma), collagen, and elastin content of leptomeningeal arterioles, small arteries, and medium-sized arteries surrounding the gyrus frontalis medialis (gfm) and hippocampus (hipp), including the sulci, of 17 clinically and pathologically diagnosed ad subjects (braak stage iv-vi) and 28 non-demented control subjects (braak stage i-iv). |
2017-01-06 |
2023-08-13 |
human |
| Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. |
the hippocampus, midbrain, and cerebellum of aged (14 to 18 months old) non-transgenic (ntg) and transgenic mice overexpressing wild-type human tau (tg601 mice) were evaluated after a treatment with stz. |
2016-12-29 |
2023-08-13 |
mouse |
| Montasir Elahi, Zafrul Hasan, Yumiko Motoi, Shin-Ei Matsumoto, Koichi Ishiguro, Nobutaka Hattor. Region-Specific Vulnerability to Oxidative Stress, Neuroinflammation, and Tau Hyperphosphorylation in Experimental Diabetes Mellitus Mice. Journal of Alzheimer's disease : JAD. vol 51. issue 4. 2016-12-29. PMID:26923011. |
tau hyperphosphorylation was also enhanced in the hippocampus, but not in the midbrain or cerebellum. |
2016-12-29 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Jun-Shan Zhou, Xi-Chen Zhu, You-Yong Tian, Hong-Dong Zhao, Huan Lu, Qing Gao, Lan Tan, Jin-Tai Y. Angiotensin-(1-7) is Reduced and Inversely Correlates with Tau Hyperphosphorylation in Animal Models of Alzheimer's Disease. Molecular neurobiology. vol 53. issue 4. 2016-12-26. PMID:26044748. |
more importantly, an inverse correlation was found between ang-(1-7) level and tau hyperphosphorylation, a pathological hallmark of ad, in cerebral cortex and hippocampus of samp8 mice. |
2016-12-26 |
2023-08-13 |
mouse |
| Beatriz E García-Gómez, Francisco J Fernández-Gómez, Encarnación Muñoz-Delgado, Luc Buée, David Blum, Cecilio J Vida. MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. Journal of molecular neuroscience : MN. vol 58. issue 4. 2016-12-26. PMID:26697857. |
the reports showing a hippocampal downregulation of choline acetyltransferase (chat) in samp8 mice, a model of aging, and an upregulation of acetylcholinesterase (ache) in tg-vlw mice, a model of ftdp17 tauopathy, may lead to think that the supply of ach to the hippocampus can be threatened as aging or tau pathology progress. |
2016-12-26 |
2023-08-13 |
mouse |
| Xiao-Ping Hong, Tao Chen, Ni-Na Yin, Yong-Ming Han, Fang Yuan, Yan-Jun Duan, Feng Shen, Yan-Hong Zhang, Ze-Bin Che. Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain. Journal of Alzheimer's disease : JAD. vol 51. issue 2. 2016-12-20. PMID:26890737. |
puerarin ameliorates d-galactose induced enhanced hippocampal neurogenesis and tau hyperphosphorylation in rat brain. |
2016-12-20 |
2023-08-13 |
rat |